{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:56:19Z","timestamp":1791478579765,"version":"4.3.4"},"reference-count":142,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2023KY120"],"award-info":[{"award-number":["2023KY120"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY107"],"award-info":[{"award-number":["2024KY107"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LQ24H030007"],"award-info":[{"award-number":["LQ24H030007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["82500808"],"award-info":[{"award-number":["82500808"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In recent years, with the rapid advancement of tissue engineering and regenerative medicine, cell-laden 3D bioprinting has emerged as a key driving force in the construction of functional artificial skin grafts. By precisely controlling the three-dimensional spatial distribution of cells, biomaterials, and growth factors, this technology can replicate the complex hierarchical structure and physiological functions of native skin. This review aims to provide a comprehensive overview of the key research advances recently achieved in the field of cell-laden 3D bioprinting of artificial skin. In this review, we summarize the physiological architecture of native skin, the selection and enhancement of common bioinks, strategies to improve cellular responses during printing, analysis of 3D bioprinting technologies and fabrication approaches, and the opportunities and challenges of clinical translation, aiming to provide optimized insights for the preparation of cell-laden 3D bioprinted artificial skin grafts. It systematically examines the biomimetic structural principles of engineered skin, innovative bioink formulations and their cytocompatibility, the evolution of 3D bioprinting technologies and improvements in resolution, breakthroughs in skin tissue functionalization including vascularization, innervation, appendage and pigmentation regeneration, the opportunities and challenges facing clinical translation and future perspectives.<\/jats:p>","DOI":"10.1021\/acsbiomaterials.6c01007","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:02:53Z","timestamp":1791475373000},"source":"Crossref","is-referenced-by-count":0,"title":["Cell-Laden 3D-Bioprinted Artificial Skin Grafts for Tissue Engineering Wound Healing"],"prefix":"10.1021","author":[{"given":"Xiaofeng","family":"Wang","sequence":"first","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310016"]},{"name":"Zhejiang Key Laboratory of Medical Additive Manufacturing and Information Fusion , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhichao","family":"Ye","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310016"]},{"name":"National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments , ,","place":["Hangzhou, China, 310016"]},{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310016"]},{"name":"National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments , ,","place":["Hangzhou, China, 310016"]},{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310016"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichun","family":"Gu","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310016"]},{"name":"Zhejiang Key Laboratory of Medical Additive Manufacturing and Information Fusion , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4951-0960","authenticated-orcid":true,"given":"Weiqiang","family":"Tan","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310016"]},{"name":"Zhejiang Key Laboratory of Medical Additive Manufacturing and Information Fusion , ,","place":["Hangzhou, China, 310018"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5236-811X","authenticated-orcid":true,"given":"Jianing","family":"Yan","sequence":"additional","affiliation":[{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310016"]},{"name":"National Engineering Research Center of Innovation and Application of Minimally Invasive Instruments , ,","place":["Hangzhou, China, 310016"]},{"name":"Zhejiang University , , ,","place":["Hangzhou, China, 310016"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"issue":"4","key":"2026100812021958200_cit1","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1046\/j.1523-1747.2001.01463.x","article-title":"Skin barrier structure and function: the single gel phase model","volume":"117","author":"Norl\u00e9n","year":"2001","journal-title":"J. Invest. Dermatol."},{"issue":"10","key":"2026100812021958200_cit2","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1056\/NEJM199909023411006","article-title":"Cutaneous wound healing","volume":"341","author":"Singer","year":"1999","journal-title":"N. Engl. J. Med."},{"issue":"15","key":"2026100812021958200_cit3","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.3390\/cells11152439","article-title":"Innovative Treatment Strategies to Accelerate Wound Healing: Trajectory and Recent Advancements","volume":"11","author":"Kolimi","year":"2022","journal-title":"Cells"},{"issue":"1","key":"2026100812021958200_cit4","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1186\/s13287-019-1212-2","article-title":"Skin tissue engineering: wound healing based on stem-cell-based therapeutic strategies","volume":"10","author":"Nourian Dehkordi","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"1","key":"2026100812021958200_cit5","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.bioactmat.2020.08.003","article-title":"Flexible electrical stimulation device with Chitosan-Vaseline\u00ae dressing accelerates wound healing in diabetes","volume":"6","author":"Wang","year":"2021","journal-title":"Bioact. Mater."},{"key":"2026100812021958200_cit6","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1146\/annurev-chembioeng-061010-114257","article-title":"Tissue engineering and regenerative medicine: history, progress, and challenges","volume":"2","author":"Berthiaume","year":"2011","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"2026100812021958200_cit7","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.bioactmat.2023.06.005","article-title":"One-step fabrication of cell sheet-laden hydrogel for accelerated wound healing","volume":"28","author":"Wang","year":"2023","journal-title":"Bioact. Mater."},{"issue":"38","key":"2026100812021958200_cit8","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202406434","article-title":"In Situ Triggered Self-Contraction Bioactive Microgel Assembly Accelerates Diabetic Skin Wound Healing by Activating Mechanotransduction and Biochemical Pathway","volume":"36","author":"Xie","year":"2024","journal-title":"Adv. Mater."},{"key":"2026100812021958200_cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.112041","article-title":"3D bioprinting for fabricating artificial skin tissue","volume":"208","author":"Gao","year":"2021","journal-title":"Colloids Surf., B"},{"issue":"1","key":"2026100812021958200_cit10","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3390\/jfb16010028","article-title":"Three-Dimensional Printing\/Bioprinting and Cellular Therapies for Regenerative Medicine: Current Advances","volume":"16","author":"Sousa","year":"2025","journal-title":"J. Funct. Biomater."},{"key":"2026100812021958200_cit11","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120201","article-title":"Sweat gland regeneration: Current strategies and future opportunities","volume":"255","author":"Chen","year":"2020","journal-title":"Biomaterials"},{"key":"2026100812021958200_cit12","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.addr.2018.07.016","article-title":"3D bioprinting of skin tissue: From pre-processing to final product evaluation","volume":"132","author":"Yan","year":"2018","journal-title":"Adv. Drug Deliv. Rev."},{"key":"2026100812021958200_cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.mmr.2026.100006","article-title":"3D bioprinting of tissues and organs for systemic diseases and localized injuries","volume":"13","author":"Ng","year":"2026","journal-title":"Mil. Med. Res."},{"key":"2026100812021958200_cit14","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbac105","article-title":"Advances in 3D skin bioprinting for wound healing and disease modeling","volume":"10","author":"Zhang","year":"2023","journal-title":"Regen Biomater"},{"issue":"10","key":"2026100812021958200_cit15","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.3390\/pharmaceutics17101342","article-title":"In Vitro Skin Models as Non-Animal Methods for Dermal Drug Development and Safety Assessment","volume":"17","author":"Costa Gagosian","year":"2025","journal-title":"Pharmaceutics"},{"key":"2026100812021958200_cit16","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbad060","article-title":"3D bioprinting-a model for skin aging","volume":"10","author":"Ansaf","year":"2023","journal-title":"Regen. Biomater."},{"key":"2026100812021958200_cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.120776","article-title":"Engineering of diseased human skin equivalent using 3D cell printing for representing pathophysiological hallmarks of type 2 diabetes in vitro","volume":"272","author":"Kim","year":"2021","journal-title":"Biomaterials"},{"issue":"4","key":"2026100812021958200_cit18","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/adfe1d","article-title":"Construction of a 3D bioprinted skin model for psoriasis research and drug evaluation","volume":"17","author":"Peng","year":"2025","journal-title":"Biofabrication"},{"issue":"27","key":"2026100812021958200_cit19","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401136","article-title":"Biofabrication and Monitoring of a 3D Printed Skin Model for Melanoma","volume":"13","author":"V\u00e1zquez-Aristizabal","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"2026100812021958200_cit20","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adz5003","article-title":"3D organotypic skin models recapitulate autoantibody-driven pemphigus pathomechanisms and targeted therapeutic response","volume":"12","author":"Zhai","year":"2026","journal-title":"Sci. Adv."},{"issue":"Pt 1","key":"2026100812021958200_cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.131281","article-title":"Three-dimensional bioprinting of tissue-engineered skin: Biomaterials, fabrication techniques, challenging difficulties, and future directions: A review","volume":"266","author":"Wei","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"2026100812021958200_cit22","doi-asserted-by":"publisher","DOI":"10.1177\/20417314211028574","article-title":"3D bioprinting for skin tissue engineering: Current status and perspectives","volume":"12","author":"Weng","year":"2021","journal-title":"J. Tissue Eng."},{"issue":"1","key":"2026100812021958200_cit23","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1021\/acssynbio.1c00547","article-title":"3D Bioprinting in Skin Related Research: Recent Achievements and Application Perspectives","volume":"11","author":"Olejnik","year":"2022","journal-title":"ACS Synth. Biol."},{"issue":"8","key":"2026100812021958200_cit24","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1038\/nbt.2958","article-title":"3D bioprinting of tissues and organs","volume":"32","author":"Murphy","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"4","key":"2026100812021958200_cit25","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.biotechadv.2015.12.011","article-title":"3D bioprinting for engineering complex tissues","volume":"34","author":"Mandrycky","year":"2016","journal-title":"Biotechnol. Adv."},{"key":"2026100812021958200_cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119536","article-title":"Progress in 3D bioprinting technology for tissue\/organ regenerative engineering","volume":"226","author":"Matai","year":"2020","journal-title":"Biomaterials"},{"issue":"1","key":"2026100812021958200_cit27","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/s43586-021-00073-8","article-title":"3D extrusion bioprinting","volume":"1","author":"Zhang","year":"2021","journal-title":"Nat. Rev. Methods Primers"},{"issue":"15","key":"2026100812021958200_cit28","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901648","article-title":"Advances in Extrusion 3D Bioprinting: A Focus on Multicomponent Hydrogel-Based Bioinks","volume":"9","author":"Cui","year":"2020","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"2026100812021958200_cit29","doi-asserted-by":"publisher","DOI":"10.1515\/ntrev-2025-0165","article-title":"Research progress in 3D bioprinting of skin: Challenges and opportunities","volume":"14","author":"Gupta","year":"2025","journal-title":"Nanotechnol. Rev."},{"issue":"4","key":"2026100812021958200_cit30","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1007\/s40005-025-00740-y","article-title":"Recent advances in 3D cell culture models in cancer drug development","volume":"55","author":"Cha","year":"2025","journal-title":"J. Pharm. Investig."},{"key":"2026100812021958200_cit31","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.tibtech.2025.06.008","article-title":"3D extrusion bioprinting: rational bioink design and advanced fabrication techniques","volume":"44","author":"Jergitsch","year":"2026","journal-title":"Trends Biotechnol."},{"issue":"19","key":"2026100812021958200_cit32","doi-asserted-by":"publisher","first-page":"10793","DOI":"10.1021\/acs.chemrev.0c00008","article-title":"Inkjet Bioprinting of Biomaterials","volume":"120","author":"Li","year":"2020","journal-title":"Chem. Rev."},{"key":"2026100812021958200_cit33","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s12967-016-1028-0","article-title":"Recent advances in bioprinting techniques: approaches, applications and future prospects","volume":"14","author":"Li","year":"2016","journal-title":"J. Transl. Med."},{"key":"2026100812021958200_cit34","doi-asserted-by":"publisher","DOI":"10.1088\/2631-7990\/ad878c","article-title":"Advancements in 3D skin bioprinting: processes, bioinks, applications and sensor integration","volume":"7","author":"Derman","year":"2025","journal-title":"Int. J. Extreme Manuf."},{"issue":"47","key":"2026100812021958200_cit35","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202404580","article-title":"3D Printing-Based Hydrogel Dressings for Wound Healing","volume":"11","author":"Zhou","year":"2024","journal-title":"Adv. Sci."},{"key":"2026100812021958200_cit36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0050973","article-title":"Resistance to fluid shear stress is a conserved biophysical property of malignant cells","volume":"7","author":"Barnes","year":"2012","journal-title":"PLoS One"},{"key":"2026100812021958200_cit37","doi-asserted-by":"publisher","first-page":"7250","DOI":"10.1016\/j.biomaterials.2010.05.055","article-title":"Laser assisted bioprinting of engineered tissue with high cell density and microscale organization","volume":"31","author":"Guillotin","year":"2010","journal-title":"Biomaterials"},{"key":"2026100812021958200_cit38","doi-asserted-by":"publisher","first-page":"672","DOI":"10.18063\/ijb.v9i2.672","article-title":"344Laser bioprinting of human iPSC-derived neural stem cells and neurons: Effect on cell survival, multipotency, differentiation, and neuronal activity","volume":"9","author":"Koch","year":"2023","journal-title":"Int. J. Bioprint."},{"key":"2026100812021958200_cit39","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/adhm.201500677","article-title":"Controlling Shear Stress in 3D Bioprinting is a Key Factor to Balance Printing Resolution and Stem Cell Integrity","volume":"5","author":"Blaeser","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"2026100812021958200_cit40","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1146\/annurev-matsci-070909-104502","article-title":"Inkjet Printing of Functional and Structural Materials: Fluid Property Requirements, Feature Stability, and Resolution","volume":"40","author":"Derby","year":"2010","journal-title":"Annu. Rev. Mater. Res."},{"key":"2026100812021958200_cit41","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s42242-024-00313-2","article-title":"Jetting-based bioprinting: process, dispense physics, and applications","volume":"7","author":"Ng","year":"2024","journal-title":"Bio-Des. Manuf."},{"key":"2026100812021958200_cit42","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1038\/s43586-023-00231-0","article-title":"Light-based vat-polymerization bioprinting","volume":"3","author":"Levato","year":"2023","journal-title":"Nat. Rev. Methods Primers."},{"issue":"6","key":"2026100812021958200_cit43","doi-asserted-by":"publisher","first-page":"5526","DOI":"10.3390\/ijms24065526","article-title":"Advances in Cartilage Tissue Engineering Using Bioinks with Decellularized Cartilage and Three-Dimensional Printing","volume":"24","author":"Stone","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"2026100812021958200_cit44","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119679","article-title":"Digital light processing 3D printed silk fibroin hydrogel for cartilage tissue engineering","volume":"232","author":"Hong","year":"2020","journal-title":"Biomaterials"},{"issue":"1","key":"2026100812021958200_cit45","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.1038\/s41467-018-03759-y","article-title":"Precisely printable and biocompatible silk fibroin bioink for digital light processing 3D printing","volume":"9","author":"Kim","year":"2018","journal-title":"Nat. Commun."},{"key":"2026100812021958200_cit46","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1631\/bdm.2400058","article-title":"3D bioprinting of a dermal scaffold for full-thickness skin tissue regeneration","volume":"8","author":"Han","year":"2024","journal-title":"Bio-Des. Manuf."},{"key":"2026100812021958200_cit47","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.cell.2025.11.012","article-title":"Biomaterial-minimalistic photoactivated bioprinting of cell-dense tissues","author":"Wang","year":"2025","journal-title":"Cell"},{"key":"2026100812021958200_cit48","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202000156","article-title":"Recent Advances in Formulating and Processing Biomaterial Inks for Vat Polymerization-Based 3D Printing","volume":"9","author":"Li","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"2026100812021958200_cit49","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1002\/inmd.70078","article-title":"Vat photopolymerization-based bioprinting: Shaping next-generation tissues with light","volume":"4","author":"Ng","year":"2026","journal-title":"Interdisciplinary Medicine"},{"key":"2026100812021958200_cit50","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ab6034","article-title":"Vat polymerization-based bioprinting-process, materials, applications and regulatory challenges","volume":"12","author":"Ng","year":"2020","journal-title":"Biofabrication"},{"issue":"7","key":"2026100812021958200_cit51","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202304940","article-title":"Bio-electrospraying 3-D Organotypic Human Skin Cultures","volume":"20","author":"Jayarajan","year":"2024","journal-title":"Small"},{"issue":"6709","key":"2026100812021958200_cit52","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1126\/science.add8593","article-title":"Regenerative cell therapy with 3D bioprinting","volume":"385","author":"Zhang","year":"2024","journal-title":"Science"},{"issue":"9","key":"2026100812021958200_cit53","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/s41551-020-0568-z","article-title":"Intravital three-dimensional bioprinting","volume":"4","author":"Urciuolo","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"2026100812021958200_cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2023.213570","article-title":"Tissue engineered skin substitutes: A comprehensive review of basic design, fabrication using 3D printing, recent advances and challenges","volume":"153","author":"Balavigneswaran","year":"2023","journal-title":"Biomater. Adv."},{"key":"2026100812021958200_cit55","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202408947","article-title":"Hybrid 3D Bioprinting of Sustainable Biomaterials for Advanced Multiscale Tissue Engineering","volume":"22","author":"Ma","year":"2026","journal-title":"Small"},{"key":"2026100812021958200_cit56","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901798","article-title":"Dynamic Bioinks to Advance Bioprinting","volume":"9","author":"Morgan","year":"2020","journal-title":"Adv. Healthc. Mater."},{"key":"2026100812021958200_cit57","doi-asserted-by":"publisher","first-page":"40","DOI":"10.46382\/MJBAS.2021.5104","article-title":"Advances in the Development of Tissue Engineering Applied to the Skin Using 3D Bio-Printers for the Treatment of Burn Patients","volume":"05","author":"Alcocer","year":"2021","journal-title":"Mediterr. J. Basic Appl. Sci."},{"issue":"7","key":"2026100812021958200_cit58","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1038\/s43587-025-00901-6","article-title":"Skin health and biological aging","volume":"5","author":"Furman","year":"2025","journal-title":"Nat. Aging"},{"issue":"4","key":"2026100812021958200_cit59","first-page":"390","article-title":"Anatomy, histology and immunohistochemistry of normal human skin","volume":"12","author":"Kanitakis","year":"2002","journal-title":"Eur. J. Dermatol."},{"issue":"12","key":"2026100812021958200_cit60","doi-asserted-by":"publisher","first-page":"754","DOI":"10.12968\/bjon.2024.0471","article-title":"Anatomy and physiology of the skin","volume":"34","author":"Harry","year":"2025","journal-title":"Br. J. Nurs."},{"issue":"1","key":"2026100812021958200_cit61","doi-asserted-by":"publisher","first-page":"6","DOI":"10.33235\/wpr.32.1.6-10","article-title":"The anatomy, physiology and function of all skin layers and the impact of ageing on the skin","volume":"32","author":"Lotfollahi","year":"2024","journal-title":"Wound Pract. Res."},{"issue":"5","key":"2026100812021958200_cit62","doi-asserted-by":"publisher","first-page":"787","DOI":"10.3390\/life15050787","article-title":"Three-Dimensional Bioprinting Techniques in Skin Regeneration: Current Insights and Future Perspectives","volume":"15","author":"Di Stefano","year":"2025","journal-title":"Life (Basel)"},{"issue":"14","key":"2026100812021958200_cit63","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.5380","article-title":"Protocol for 3D Bioprinting a Co-culture Skin Model Using a Natural Fibrin-Based Bioink as an Infection Model","volume":"15","author":"D\u00edaz","year":"2025","journal-title":"Bio Protoc."},{"key":"2026100812021958200_cit64","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.biomaterials.2015.08.045","article-title":"Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels","volume":"73","author":"Yue","year":"2015","journal-title":"Biomaterials"},{"issue":"1","key":"2026100812021958200_cit65","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s40580-023-00402-5","article-title":"Nanomaterials-incorporated hydrogels for 3D bioprinting technology","volume":"10","author":"Yoon","year":"2023","journal-title":"Nano Converg"},{"key":"2026100812021958200_cit66","doi-asserted-by":"publisher","first-page":"18503","DOI":"10.1021\/acsnano.4c04088","article-title":"3D Bioprinting of Artificial Skin Substitute with Improved Mechanical Property and Regulated Cell Behavior through Integrating Patterned Nanofibrous Films","volume":"18","author":"Bian","year":"2024","journal-title":"ACS Nano"},{"key":"2026100812021958200_cit67","doi-asserted-by":"publisher","first-page":"2933","DOI":"10.7150\/thno.104854","article-title":"3D bioprinting of prefabricated artificial skin with multicomponent hydrogel for skin and hair follicle regeneration","volume":"15","author":"Ma","year":"2025","journal-title":"Theranostics"},{"key":"2026100812021958200_cit68","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202310556","article-title":"A Spatiotemporal Controllable Biomimetic Skin for Accelerating Wound Repair","volume":"20","author":"Chen","year":"2024","journal-title":"Small"},{"key":"2026100812021958200_cit69","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/aba503","article-title":"Biofabrication of endothelial cell, dermal fibroblast, and multilayered keratinocyte layers for skin tissue engineering","volume":"13","author":"Barros","year":"2021","journal-title":"Biofabrication"},{"key":"2026100812021958200_cit70","doi-asserted-by":"publisher","first-page":"2461","DOI":"10.1039\/D2BM02092K","article-title":"3D bioprinting of heterogeneous tissue-engineered skin containing human dermal fibroblasts and keratinocytes","volume":"11","author":"Li","year":"2023","journal-title":"Biomater. Sci."},{"key":"2026100812021958200_cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2023.100899","article-title":"3D bioprinting bioglass to construct vascularized full-thickness skin substitutes for wound healing","volume":"24","author":"Liu","year":"2024","journal-title":"Mater. Today Bio"},{"key":"2026100812021958200_cit72","doi-asserted-by":"publisher","DOI":"10.1016\/j.cej.2025.168542","article-title":"Adipose-derived soluble fractions activated bioink promotes cutaneous repair and regeneration via mobilizing endogenous reparative cells","volume":"524","author":"Zhang","year":"2025","journal-title":"Chem. Eng. J."},{"key":"2026100812021958200_cit73","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202301015","article-title":"Engineering of Uniform Epidermal Layers via Sacrificial Gelatin Bioink-Assisted 3D Extrusion Bioprinting of Skin","volume":"12","author":"Ahn","year":"2023","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"2026100812021958200_cit74","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201801651","article-title":"The Collagen Suprafamily: From Biosynthesis to Advanced Biomaterial Development","volume":"31","author":"Sorushanova","year":"2019","journal-title":"Adv. Mater."},{"key":"2026100812021958200_cit75","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.actbio.2023.01.025","article-title":"Mechanochemistry of collagen","volume":"163","author":"Siadat","year":"2023","journal-title":"Acta Biomater."},{"issue":"3","key":"2026100812021958200_cit76","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3390\/gels9030185","article-title":"Application of Collagen-Based Hydrogel in Skin Wound Healing","volume":"9","author":"Zhang","year":"2023","journal-title":"Gels"},{"key":"2026100812021958200_cit77","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.3390\/pharmaceutics15051331","article-title":"Marine Collagen-Based Bioink for 3D Bioprinting of a Bilayered Skin Model","volume":"15","author":"Cavallo","year":"2023","journal-title":"Pharmaceutics"},{"key":"2026100812021958200_cit78","doi-asserted-by":"publisher","first-page":"9200","DOI":"10.1038\/s41467-025-64245-w","article-title":"Limitations of acyclovir and identification of potent HSV antivirals using 3D bioprinted human skin equivalents","volume":"16","author":"Ellison","year":"2025","journal-title":"Nat. Commun."},{"key":"2026100812021958200_cit79","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.bioactmat.2024.11.013","article-title":"Engineering a halloysite nanotube-enhanced hydrogel 3D skin model for modulated inflammation and accelerated wound healing","volume":"45","author":"Xu","year":"2025","journal-title":"Bioact. Mater."},{"key":"2026100812021958200_cit80","doi-asserted-by":"publisher","DOI":"10.1088\/2631-7990\/ad8739","article-title":"Bioengineered skin-substitutes incorporating rete-ridges using a bioprinting process","volume":"7","author":"Chae","year":"2024","journal-title":"Int. J. Extreme Manuf."},{"key":"2026100812021958200_cit81","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.bioactmat.2021.09.014","article-title":"Decellularized extracellular matrix scaffolds: Recent trends and emerging strategies in tissue engineering","volume":"10","author":"Zhang","year":"2022","journal-title":"Bioact. Mater."},{"key":"2026100812021958200_cit82","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2022.100530","article-title":"Functional acellular matrix for tissue repair","volume":"18","author":"Wang","year":"2023","journal-title":"Mater. Today Bio"},{"key":"2026100812021958200_cit83","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2025.123575","article-title":"Exploring the angiogenic potential of skin patches with endothelial cell patterns fabricated via in-bath 3D bioprinting using light-activated bioink for enhanced wound healing","volume":"325","author":"Shukla","year":"2026","journal-title":"Biomaterials"},{"key":"2026100812021958200_cit84","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202419680","article-title":"3D Bioprinting-Assisted Tissue Assembly of Endocrine Adipose Units for Enhanced Skin Regeneration","volume":"35","author":"Lee","year":"2025","journal-title":"Adv. Funct. Mater."},{"key":"2026100812021958200_cit85","doi-asserted-by":"publisher","first-page":"718","DOI":"10.18063\/ijb.718","article-title":"3D-bioprinted human lipoaspirate-derived cell-laden skin constructs for healing of full-thickness skin defects","volume":"9","author":"Zhang","year":"2023","journal-title":"Int J Bioprint"},{"issue":"5","key":"2026100812021958200_cit86","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/s41570-023-00486-x","article-title":"Silk chemistry and biomedical material designs","volume":"7","author":"Sahoo","year":"2023","journal-title":"Nat. Rev. Chem."},{"issue":"3","key":"2026100812021958200_cit87","doi-asserted-by":"publisher","first-page":"1499","DOI":"10.3390\/ijms22031499","article-title":"Silk Fibroin as a Functional Biomaterial for Tissue Engineering","volume":"22","author":"Sun","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2026100812021958200_cit88","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.actbio.2015.11.034","article-title":"Silk protein-based hydrogels: Promising advanced materials for biomedical applications","volume":"31","author":"Kapoor","year":"2016","journal-title":"Acta Biomater."},{"key":"2026100812021958200_cit89","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.addr.2019.09.003","article-title":"Silk fibroin for skin injury repair: Where do things stand","volume":"153","author":"Gholipourmalekabadi","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"28","key":"2026100812021958200_cit90","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202401458","article-title":"Bioengineered Silk Protein-Based 3D In Vitro Models for Tissue Engineering and Drug Development: From Silk Matrix Properties to Biomedical Applications","volume":"13","author":"Shuai","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"2026100812021958200_cit91","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303312","article-title":"3D Bioprinted Human Skin Model Recapitulating Native-Like Tissue Maturation and Immunocompetence as an Advanced Platform for Skin Sensitization Assessment","volume":"13","author":"Bhar","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"2026100812021958200_cit92","doi-asserted-by":"publisher","DOI":"10.1093\/rb\/rbae033","article-title":"Advances in 3D bioprinting for regenerative medicine applications","volume":"11","author":"Loukelis","year":"2024","journal-title":"Regen. Biomater."},{"key":"2026100812021958200_cit93","doi-asserted-by":"publisher","DOI":"10.1177\/20417314231187113","article-title":"3D Bioprinting tissue analogs: Current development and translational implications","volume":"14","author":"Liu","year":"2023","journal-title":"J. Tissue Eng."},{"issue":"11","key":"2026100812021958200_cit94","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.1039\/d4tb02572e","article-title":"A thermoresponsive PEG-based methacrylate triblock terpolymer as a bioink for 3D bioprinting","volume":"13","author":"Zhang","year":"2025","journal-title":"J. Mater. Chem. B"},{"issue":"11","key":"2026100812021958200_cit95","doi-asserted-by":"publisher","first-page":"975","DOI":"10.2217\/rme-2020-0207","article-title":"Efficacy of adipose-derived stromal vascular fraction cells in the management of chronic ulcers: a randomized clinical trial","volume":"16","author":"Tanios","year":"2021","journal-title":"Regen. Med."},{"key":"2026100812021958200_cit96","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2020\/8810813","article-title":"Adipose-Derived Stem Cells: Current Applications and Future Directions in the Regeneration of Multiple Tissues","volume":"2020","author":"Zhang","year":"2020","journal-title":"Stem Cells Int."},{"issue":"11","key":"2026100812021958200_cit97","doi-asserted-by":"publisher","first-page":"3790","DOI":"10.3390\/ijms21113790","article-title":"The Proliferation and Differentiation of Adipose-Derived Stem Cells in Neovascularization and Angiogenesis","volume":"21","author":"Hutchings","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"2026100812021958200_cit98","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202517409","article-title":"One-Step Coaxial 3D Printing of Pre-Vascularized Skin Organoid Models with ADSC Microspheres for Enhanced Wound Healing","volume":"13","author":"Kunrui","year":"2026","journal-title":"Adv. Sci."},{"key":"2026100812021958200_cit99","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.bioactmat.2024.08.036","article-title":"3-D bioprinted human-derived skin organoids accelerate full-thickness skin defects repair","volume":"42","author":"Zhang","year":"2024","journal-title":"Bioact. Mater."},{"key":"2026100812021958200_cit100","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.bioactmat.2024.11.026","article-title":"3D bioprinting of engineered exosomes secreted from M2-polarized macrophages through immunomodulatory biomaterial promotes in vivo wound healing and angiogenesis","volume":"45","author":"Dutta","year":"2025","journal-title":"Bioact. Mater."},{"issue":"4","key":"2026100812021958200_cit101","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ad5d1a","article-title":"A biopsy-sized 3D skin model with a perifollicular vascular plexus enables studying immune cell trafficking in the skin","volume":"16","author":"Shah","year":"2024","journal-title":"Biofabrication"},{"key":"2026100812021958200_cit102","doi-asserted-by":"publisher","DOI":"10.3389\/fnbot.2020.590241","article-title":"Binary and Hybrid Work-Condition Maps for Interactive Exploration of Ergonomic Human Arm Postures","volume":"14","author":"Peternel","year":"2020","journal-title":"Front. Neurorobot."},{"issue":"4","key":"2026100812021958200_cit103","doi-asserted-by":"publisher","first-page":"362","DOI":"10.3390\/ph14040362","article-title":"3D Bioprinting of Functional Skin Substitutes: From Current Achievements to Future Goals","volume":"14","author":"Manita","year":"2021","journal-title":"Pharmaceuticals (Basel)"},{"issue":"1","key":"2026100812021958200_cit104","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3390\/biom13010055","article-title":"Advances and Innovations of 3D Bioprinting Skin","volume":"13","author":"Kang","year":"2022","journal-title":"Biomolecules"},{"key":"2026100812021958200_cit105","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adf7547","article-title":"Multicellular bioprinted skin facilitates human-like skin architecture in vivo","volume":"15","author":"Jorgensen","year":"2023","journal-title":"Sci. Transl. Med."},{"key":"2026100812021958200_cit106","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1089\/ten.TEA.2019.0201","article-title":"Three Dimensional Bioprinting of a Vascularized and Perfusable Skin Graft Using Human Keratinocytes, Fibroblasts, Pericytes, and Endothelial Cells","volume":"26","author":"Baltazar","year":"2020","journal-title":"Tissue Eng., Part A"},{"key":"2026100812021958200_cit107","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2025.101974","article-title":"3D bioprinting of a perfusable skin-on-chip model suitable for drug testing and wound healing studies","volume":"33","author":"Maggiotto","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"1","key":"2026100812021958200_cit108","doi-asserted-by":"publisher","first-page":"10977","DOI":"10.1038\/s41598-018-29252-6","article-title":"Prevascularization of dermal substitutes with adipose tissue-derived microvascular fragments enhances early skin grafting","volume":"8","author":"Frueh","year":"2018","journal-title":"Sci. Rep."},{"key":"2026100812021958200_cit109","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2020.120287","article-title":"Rapid printing of bio-inspired 3D tissue constructs for skin regeneration","volume":"258","author":"Zhou","year":"2020","journal-title":"Biomaterials"},{"key":"2026100812021958200_cit110","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.100949","article-title":"Rapid innervation and physiological epidermal regeneration by bioengineered dermis implanted in mouse","volume":"25","author":"Mazio","year":"2024","journal-title":"Mater. Today Bio"},{"issue":"3-4","key":"2026100812021958200_cit111","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s44164-022-00021-0","article-title":"An innervated skin 3D in vitro model for dermatological research","volume":"2","author":"Rousi","year":"2023","journal-title":"In Vitro Model."},{"key":"2026100812021958200_cit112","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/ae0550","article-title":"3D bioprinted cell-laden GrooveNeuroTube: a multifunctional platform forex vivoneural cell migration and growth studies","volume":"17","author":"Litowczenko","year":"2025","journal-title":"Biofabrication"},{"key":"2026100812021958200_cit113","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1038\/s41467-023-37187-4","article-title":"Modeling of three-dimensional innervated epidermal like-layer in a microfluidic chip-based coculture system","volume":"14","author":"Ahn","year":"2023","journal-title":"Nat. Commun."},{"key":"2026100812021958200_cit114","doi-asserted-by":"publisher","first-page":"7034","DOI":"10.1039\/D4TB02823F","article-title":"A 3D-bioprinted dermal-like scaffold incorporating fibroblasts and DRG neurons to investigate peripheral nerve regeneration","volume":"13","author":"Formaggio","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"2026100812021958200_cit115","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1109\/Transducers61432.2025.11110788","article-title":"3D Tissue Models with Penetrating Sensory Neurons Towards Innervated Cultured Skin","volume-title":"2025 23rd International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers)","author":"Li","year":"2025"},{"key":"2026100812021958200_cit116","doi-asserted-by":"publisher","first-page":"7829","DOI":"10.2147\/IJN.S524182","article-title":"Innervated Biomaterials for Improved Cutaneous Wound Healing: A Review of Recent Advancements and Future Prospects","volume":"20","author":"Zhang","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"2026100812021958200_cit117","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.bioactmat.2024.06.015","article-title":"Advanced biomedical and electronic dual-function skin patch created through microfluidic-regulated 3D bioprinting","volume":"40","author":"Dong","year":"2024","journal-title":"Bioact. Mater."},{"issue":"Pt 2","key":"2026100812021958200_cit118","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.131623","article-title":"A review of biomacromolecule-based 3D bioprinting strategies for structure-function integrated repair of skin tissues","volume":"268","author":"Liu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"2026100812021958200_cit119","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.reth.2022.11.003","article-title":"Cells, growth factors and biomaterials used in tissue engineering for hair follicles regeneration","volume":"21","author":"Xu","year":"2022","journal-title":"Regen. Ther."},{"key":"2026100812021958200_cit120","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg0297","article-title":"Incorporation of hair follicles in 3D bioprinted models of human skin","volume":"9","author":"Motter Catarino","year":"2023","journal-title":"Sci. Adv."},{"key":"2026100812021958200_cit121","doi-asserted-by":"publisher","DOI":"10.1016\/j.mtbio.2024.101303","article-title":"Materials-based hair follicle engineering: Basic components and recent advances","volume":"29","author":"Lv","year":"2024","journal-title":"Mater. Today Bio"},{"key":"2026100812021958200_cit122","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkaf016","article-title":"Advances in engineered organoid models of skin for biomedical research","volume":"13","author":"Zeng","year":"2025","journal-title":"Burns Trauma"},{"issue":"49","key":"2026100812021958200_cit123","doi-asserted-by":"publisher","first-page":"19679","DOI":"10.1073\/pnas.1309970110","article-title":"Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth","volume":"110","author":"Higgins","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"2026100812021958200_cit124","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkab013","article-title":"Using bioprinting and spheroid culture to create a skin model with sweat glands and hair follicles","volume":"9","author":"Zhang","year":"2021","journal-title":"Burns Trauma"},{"issue":"7","key":"2026100812021958200_cit125","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaw3963","article-title":"Bioinspired mechanically active adhesive dressings to accelerate wound closure","volume":"5","author":"Blacklow","year":"2019","journal-title":"Sci. Adv."},{"key":"2026100812021958200_cit126","doi-asserted-by":"publisher","first-page":"1","DOI":"10.54448\/mdnt23206","article-title":"3D bioprinting strategies and their application in studies in vivo and in vitro animal models for skin regeneration: a concise systematic review and meta-analysis","volume":"4","author":"Mauro","year":"2023","journal-title":"MedNEXT J. Med. Health Sci."},{"issue":"6","key":"2026100812021958200_cit127","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1089\/ten.TEC.2018.0318","article-title":"Fully Three-Dimensional Bioprinted Skin Equivalent Constructs with Validated Morphology and Barrier Function","volume":"25","author":"Derr","year":"2019","journal-title":"Tissue Eng. Part C Methods"},{"key":"2026100812021958200_cit128","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1111\/exd.13376","article-title":"Bioprinting of biomimetic skin containing melanocytes","volume":"27","author":"Min","year":"2018","journal-title":"Exp. Dermatol."},{"key":"2026100812021958200_cit129","doi-asserted-by":"publisher","DOI":"10.1088\/1758-5090\/aa9e1e","article-title":"Proof-of-concept: 3D bioprinting of pigmented human skin constructs","volume":"10","author":"Ng","year":"2018","journal-title":"Biofabrication"},{"key":"2026100812021958200_cit130","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3390\/bioengineering12030270","article-title":"Three-Dimensional Printing of Hydrogel as Skin Substitute and Comparative Evaluation of Melanin Production","volume":"12","author":"Zafaryab","year":"2025","journal-title":"Bioengineering"},{"key":"2026100812021958200_cit131","doi-asserted-by":"publisher","first-page":"595","DOI":"10.3390\/biomimetics10090595","article-title":"Bioprinted Scaffolds for Biomimetic Applications: A State-of-the-Art Technology","volume":"10","author":"Gebeshuber","year":"2025","journal-title":"Biomimetics"},{"key":"2026100812021958200_cit132","doi-asserted-by":"publisher","first-page":"10090","DOI":"10.1080\/21655979.2022.2063651","article-title":"Simple and robust 3D bioprinting of full-thickness human skin tissue","volume":"13","author":"Liu","year":"2022","journal-title":"Bioengineered"},{"key":"2026100812021958200_cit133","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.3390\/nano10081484","article-title":"Decellularized Skin Extracellular Matrix (dsECM) Improves the Physical and Biological Properties of Fibrinogen Hydrogel for Skin Bioprinting Applications","volume":"10","author":"Jorgensen","year":"2020","journal-title":"Nanomaterials"},{"key":"2026100812021958200_cit134","doi-asserted-by":"publisher","first-page":"5287","DOI":"10.1039\/D2BM02022J","article-title":"Pre-selection of fibroblast subsets prompts prevascularization of tissue engineered skin analogues","volume":"11","author":"Moreira","year":"2023","journal-title":"Biomater. Sci."},{"key":"2026100812021958200_cit135","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade7923","article-title":"High cell density and high-resolution 3D bioprinting for fabricating vascularized tissues","volume":"9","author":"You","year":"2023","journal-title":"Sci. Adv."},{"key":"2026100812021958200_cit136","doi-asserted-by":"publisher","DOI":"10.1177\/20417314241308022","article-title":"Innovative bioinks for 3D bioprinting: Exploring technological potential and regulatory challenges","volume":"16","author":"Mathur","year":"2025","journal-title":"J. Tissue Eng."},{"key":"2026100812021958200_cit137","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2026.1782511","article-title":"Bioprinted skin: from lab bench to clinic, what matters now and what's next","volume":"14","author":"Haykal","year":"2026","journal-title":"Front. Bioeng. Biotechnol."},{"issue":"1","key":"2026100812021958200_cit138","doi-asserted-by":"publisher","first-page":"369","DOI":"10.30574\/wjbphs.2025.23.1.0694","article-title":"Next-generation 3D-printed bioengineered skin grafts: From experimental validation to clinical implementation","volume":"23","author":"Dandoulakis","year":"2025","journal-title":"World J. Biol. Pharmacy Health Sci."},{"key":"2026100812021958200_cit139","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1217655","article-title":"In vivo efficacy proof of concept of a large-size bioprinted dermo-epidermal substitute for permanent wound coverage","volume":"11","author":"Abellan Lopez","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"2026100812021958200_cit140","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.reth.2025.06.017","article-title":"Current challenges and future directions of ATMPs in regenerative medicine","volume":"30","author":"Kakroodi","year":"2025","journal-title":"Regen. Ther."},{"key":"2026100812021958200_cit141","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.97947","article-title":"Advances and Challenges in 3D Bioprinting for Organ Transplantation: Bridging the Gap Between Research and Clinical Applications","volume":"17","author":"Velu","year":"2025","journal-title":"Cureus"},{"key":"2026100812021958200_cit142","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.3390\/biomedicines11102678","article-title":"Perspectives on the Current State of Bioprinted Skin Substitutes for Wound Healing","volume":"11","author":"S\u00f6rgel","year":"2023","journal-title":"Biomedicines"}],"container-title":["ACS Biomaterials Science &amp; Engineering"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsbiomaterials.6c01007","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/abseba\/article-pdf\/doi\/10.1021\/acsbiomaterials.6c01007\/68791099\/ab-2026-01007h.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pubs.acs.org\/abseba\/article-pdf\/doi\/10.1021\/acsbiomaterials.6c01007\/68791099\/ab-2026-01007h.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:24:37Z","timestamp":1791476677000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/abseba\/article\/doi\/10.1021\/acsbiomaterials.6c01007\/5447202\/Cell-Laden-3D-Bioprinted-Artificial-Skin-Grafts"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":142,"URL":"https:\/\/doi.org\/10.1021\/acsbiomaterials.6c01007","relation":{},"ISSN":["2373-9878"],"issn-type":[{"value":"2373-9878","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]}}}