{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T18:07:22Z","timestamp":1778177242267,"version":"3.51.4"},"reference-count":62,"publisher":"American Chemical Society (ACS)","issue":"11","funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-000024"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000024"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["POCI\/01\/0145\/FEDER\/007728"],"award-info":[{"award-number":["POCI\/01\/0145\/FEDER\/007728"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["IF\/01310\/2013"],"award-info":[{"award-number":["IF\/01310\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["NORTE-01-0145-FEDER-000024"],"award-info":[{"award-number":["NORTE-01-0145-FEDER-000024"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/115396\/2016"],"award-info":[{"award-number":["SFRH\/BD\/115396\/2016"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/MULTI\/04378\/2013"],"award-info":[{"award-number":["UID\/MULTI\/04378\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Catal."],"published-print":{"date-parts":[[2018,11,2]]},"DOI":"10.1021\/acscatal.8b02321","type":"journal-article","created":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T18:02:19Z","timestamp":1537293739000},"page":"10096-10110","source":"Crossref","is-referenced-by-count":40,"title":["Catalytic Mechanism of the Serine Hydroxymethyltransferase: A Computational ONIOM QM\/MM Study"],"prefix":"10.1021","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9280-1838","authenticated-orcid":true,"given":"Henrique S.","family":"Fernandes","sequence":"first","affiliation":[{"name":"UCIBIO@REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade do Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7554-8324","authenticated-orcid":true,"given":"Maria Jo\u00e3o","family":"Ramos","sequence":"additional","affiliation":[{"name":"UCIBIO@REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade do Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]},{"given":"Nuno M. F. S. A.","family":"Cerqueira","sequence":"additional","affiliation":[{"name":"UCIBIO@REQUIMTE, Departamento de Qu\u00edmica e Bioqu\u00edmica, Faculdade de Ci\u00eancias da Universidade do Porto, Rua do Campo Alegre s\/n, 4169-007 Porto, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2018,9,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2017.161"},{"key":"ref2\/cit2","volume-title":"World Malaria Report 2017","year":"2017"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/nature14451"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30171-8"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/108516"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00008"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201703244"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2875-11-387"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.118"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2004.12.002"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1021\/ct1002219"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1021\/ja204229m"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06761.x"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcatb.2014.10.007"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2005.08.017"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/bi049791y"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.3453"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01667.x"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1016\/S0021-9258(18)96350-7","volume":"241","author":"Kallen R. G.","year":"1966","journal-title":"J. Biol. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1107\/S1399004714005598"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.04945.x"},{"key":"ref23\/cit23","unstructured":"Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Scalmani, G.; Barone, V.; Mennucci, B.; Petersson, G. A.; Nakatsuji, H.; Caricato, M.; Li, X.; Hratchian, H. P.; Izmaylov, A. F.; Bloino, J.; Zheng, G.; Sonnenberg, J. L.; Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Vreven, T.; Montgomery, J. A., Jr.; Peralta, J. E.; Ogliaro, F.; Bearpark, M. J.; Heyd, J.; Brothers, E. N.; Kudin, K. N.; Staroverov, V. N.; Kobayashi, R.; Normand, J.; Raghavachari, K.; Rendell, A. P.; Burant, J. C.; Iyengar, S. S.; Tomasi, J.; Cossi, M.; Rega, N.; Millam, N. J.; Klene, M.; Knox, J. E.; Cross, J. B.; Bakken, V.; Adamo, C.; Jaramillo, J.; Gomperts, R.; Stratmann, R. E.; Yazyev, O.; Austin, A. J.; Cammi, R.; Pomelli, C.; Ochterski, J. W.; Martin, R. L.; Morokuma, K.; Zakrzewski, V. G.; Voth, G. A.; Salvador, P.; Dannenberg, J. J.; Dapprich, S.; Daniels, A. D.; Farkas, \u00d6.; Foresman, J. B.; Ortiz, J. V.; Cioslowski, J.; Fox, D. J. Gaussian 09; Gaussian, Inc.: Wallingford, CT, USA, 2009."},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1063\/1.481505"},{"key":"ref25\/cit25","volume-title":"AMBER 12","author":"Case D. A.","year":"2012"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/ct200133y"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1021\/ct100578z"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20035"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21123"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.25189"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/0263-7855(96)00018-5"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/cphc.201700339"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-1280(98)00475-8"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/jp962071j"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540160911"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cplett.2004.06.011"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201701375"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5b00759"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1039\/C6CY00356G"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.5b01928"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201600305"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/ja310165u"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.5b00333"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1039\/C5OB00690B"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1021\/ar00072a001"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1063\/1.4773581"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1063\/1.4821834"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1021\/ct501129s"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00359"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00050A"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/acscatal.8b00577"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.8b00348"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1002\/wcms.1327"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1063\/1.456153"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1039\/B415208E"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1063\/1.1445115"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-2614(98)00866-5"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1107\/S1399004713031283"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/9780470122808.ch3"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/458571"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1126\/science.1218595"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.55.4.712"}],"container-title":["ACS Catalysis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acscatal.8b02321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T13:30:46Z","timestamp":1682256646000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acscatal.8b02321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,18]]},"references-count":62,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11,2]]}},"alternative-id":["10.1021\/acscatal.8b02321"],"URL":"https:\/\/doi.org\/10.1021\/acscatal.8b02321","relation":{},"ISSN":["2155-5435","2155-5435"],"issn-type":[{"value":"2155-5435","type":"print"},{"value":"2155-5435","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,18]]}}}