{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:17:05Z","timestamp":1773937025094,"version":"3.50.1"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"19","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","award":["Norte-01-0145-FEDER-000008"],"award-info":[{"award-number":["Norte-01-0145-FEDER-000008"]}],"id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda????o para a Ci??ncia e a Tecnologia","doi-asserted-by":"publisher","award":["2020.01423.CEECIND"],"award-info":[{"award-number":["2020.01423.CEECIND"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda????o para a Ci??ncia e a Tecnologia","doi-asserted-by":"publisher","award":["POCI-01-0145-FEDER-007274"],"award-info":[{"award-number":["POCI-01-0145-FEDER-007274"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda????o para a Ci??ncia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/QUI-QFI\/29914\/2017"],"award-info":[{"award-number":["PTDC\/QUI-QFI\/29914\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda????o para a Ci??ncia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/129921\/2017"],"award-info":[{"award-number":["SFRH\/BD\/129921\/2017"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda????o para a Ci??ncia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/136746\/2018"],"award-info":[{"award-number":["SFRH\/BD\/136746\/2018"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Chem. Neurosci."],"published-print":{"date-parts":[[2021,10,6]]},"DOI":"10.1021\/acschemneuro.1c00432","type":"journal-article","created":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T13:32:40Z","timestamp":1631280760000},"page":"3708-3718","source":"Crossref","is-referenced-by-count":10,"title":["A\u03b2<sub>31\u201335<\/sub> Decreases Neprilysin-Mediated Alzheimer\u2019s Amyloid-\u03b2 Peptide Degradation"],"prefix":"10.1021","volume":"12","author":[{"given":"Jos\u00e9 P.","family":"Leite","sequence":"first","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Rua Alfredo Allen, 208, Porto 4200-135, Portugal"},{"name":"IBMC\u2014Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua Alfredo Allen, 208, Porto 4200-135, Portugal"},{"name":"Programa Doutoral em Biologia Molecular e Celular (MCbiology), ICBAS\u2014Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Rua de Jorge Viterbo Ferreira 228, Porto 4050-313, Portugal"},{"name":"ICBAS\u2014Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9654-7881","authenticated-orcid":true,"given":"Marta G.","family":"Lete","sequence":"additional","affiliation":[{"name":"CIC bioGUNE, Bizkaia Technology Park, Building 801A, Derio 48170, Spain"}]},{"given":"Susan B.","family":"Fowler","sequence":"additional","affiliation":[{"name":"Antibody Discovery & Protein Engineering R&D, AstraZeneca, Cambridge CB21 6GH, U.K."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9668-2605","authenticated-orcid":true,"given":"Ana","family":"Gimeno","sequence":"additional","affiliation":[{"name":"CIC bioGUNE, Bizkaia Technology Park, Building 801A, Derio 48170, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7686-4433","authenticated-orcid":true,"given":"Juliana F.","family":"Rocha","sequence":"additional","affiliation":[{"name":"UCIBIO\/REQUIMTE, BioSIM-Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, Porto 4200-319, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-5284","authenticated-orcid":true,"given":"S\u00e9rgio F.","family":"Sousa","sequence":"additional","affiliation":[{"name":"UCIBIO\/REQUIMTE, BioSIM-Department of Biomedicine, Faculty of Medicine, University of Porto, Alameda Prof. Hern\u00e2ni Monteiro, Porto 4200-319, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2513-2256","authenticated-orcid":true,"given":"Carl I.","family":"Webster","sequence":"additional","affiliation":[{"name":"Antibody Discovery & Protein Engineering R&D, AstraZeneca, Cambridge CB21 6GH, U.K."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5421-8513","authenticated-orcid":true,"given":"Jes\u00fas J.","family":"Jim\u00e9nez-Bar\u0300bero","sequence":"additional","affiliation":[{"name":"CIC bioGUNE, Bizkaia Technology Park, Building 801A, Derio 48170, Spain"},{"name":"Ikerbasque, Basque Foundation for Science, Bilbao 48013, Spain"},{"name":"Department of Organic Chemistry II, Faculty of Science and Technology, UPV-EHU, 48940 Leioa, Spain"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8352-6539","authenticated-orcid":true,"given":"Lu\u00eds","family":"Gales","sequence":"additional","affiliation":[{"name":"i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Rua Alfredo Allen, 208, Porto 4200-135, Portugal"},{"name":"IBMC\u2014Instituto de Biologia Molecular e Celular, Universidade do Porto, Rua Alfredo Allen, 208, Porto 4200-135, Portugal"},{"name":"ICBAS\u2014Instituto de Ci\u00eancias Biom\u00e9dicas Abel Salazar, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026619666191203113745"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.11.4040"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-291x(84)80190-4"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606210"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0690-1"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nm1438"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1126\/science.1197623"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710823105"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.07.027"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1172\/jci66541"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m111.288373"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1159\/000113692"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1134"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.m008511200"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.3233\/jad-181134"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1059946"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.2174\/1874609809666161111101111"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21944"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2009.115"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1385\/jmn:22:1-2:5"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3940(03)00898-x"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0104001"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awt308"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8112-4"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.04.060"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/B978-0-12-803959-5.50013-1","volume-title":"Drug Design and Discovery in Alzheimer\u2019s Disease","author":"Pope D.","year":"2014"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1093\/protein\/12.2.141"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/bi00402a014"},{"key":"ref29\/cit29","first-page":"87","volume":"45","author":"Roques B. P.","year":"1993","journal-title":"Pharmacol. Rev."},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1042\/bj3110623"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13285"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1021\/acs.inorgchem.8b00391"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00098"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(84)90425-1"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-8793-1_15"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2089"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/288286a0"},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/B978-0-12-417205-0.00008-0","volume-title":"The Practice of Medicinal Chemistry","author":"Ciapetti P.","year":"2008","edition":"4"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.13602"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1107\/s2053230x19006046"},{"key":"ref41\/cit41","unstructured":"Schrodinger, L. L. C. The PyMOL Molecular Graphics System, version 1.8, 2015."},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911281106"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.02.009"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.1999.0816"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/jmr.699"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04426.x"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1016\/s0306-4522(98)00727-1"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2005.01.001"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.47.28022"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.30.18032"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.08.023"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2010.72"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav9518"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsb.2018.06.004"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.dyepig.2018.07.049"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/ct100578z"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00255"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20035"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1021\/ct300418h"}],"container-title":["ACS Chemical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acschemneuro.1c00432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T21:31:04Z","timestamp":1682458264000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acschemneuro.1c00432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,10]]},"references-count":59,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2021,10,6]]}},"alternative-id":["10.1021\/acschemneuro.1c00432"],"URL":"https:\/\/doi.org\/10.1021\/acschemneuro.1c00432","relation":{},"ISSN":["1948-7193","1948-7193"],"issn-type":[{"value":"1948-7193","type":"print"},{"value":"1948-7193","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,10]]}}}