{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T07:02:04Z","timestamp":1771570924611,"version":"3.50.1"},"reference-count":71,"publisher":"American Chemical Society (ACS)","issue":"6","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a Telov\u00fdchovy","doi-asserted-by":"publisher","award":["LM2023050"],"award-info":[{"award-number":["LM2023050"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["203134\/Z\/16\/Z"],"award-info":[{"award-number":["203134\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["204697\/Z\/16\/Z"],"award-info":[{"award-number":["204697\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["218448\/Z\/19\/Z"],"award-info":[{"award-number":["218448\/Z\/19\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2024,6,14]]},"DOI":"10.1021\/acsinfecdis.4c00009","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T18:24:51Z","timestamp":1715883891000},"page":"2002-2017","source":"Crossref","is-referenced-by-count":6,"title":["Identification and Validation of Compounds Targeting <i>Leishmania major<\/i> Leucyl-Aminopeptidase M17"],"prefix":"10.1021","volume":"10","author":[{"given":"Mirtha E.","family":"Aguado","sequence":"first","affiliation":[{"name":"Center for Protein Studies, Faculty of Biology, University of Havana, 10400 Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Anti-Infective Research, School of Life Sciences, University of Dundee, DD1 4HN Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario E.","family":"Vald\u00e9s-Tresanco","sequence":"additional","affiliation":[{"name":"Centre for Molecular Simulations, University of Calgary, Calgary, AB T2N 1N4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De","family":"Lin","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Anti-Infective Research, School of Life Sciences, University of Dundee, DD1 4HN Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5492-7926","authenticated-orcid":true,"given":"Norma","family":"Padilla-Mejia","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Anti-Infective Research, School of Life Sciences, University of Dundee, DD1 4HN Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoriano","family":"Corpas-Lopez","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Anti-Infective Research, School of Life Sciences, University of Dundee, DD1 4HN Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Tesa\u0159ov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julius","family":"Luke\u0161","sequence":"additional","affiliation":[{"name":"Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"},{"name":"Faculty of Sciences, University of South Bohemia, 37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gray","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Anti-Infective Research, School of Life Sciences, University of Dundee, DD1 4HN Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Gonz\u00e1lez-Bacerio","sequence":"additional","affiliation":[{"name":"Center for Protein Studies, Faculty of Biology, University of Havana, 10400 Havana, Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8810-5605","authenticated-orcid":true,"given":"Susan","family":"Wyllie","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Anti-Infective Research, School of Life Sciences, University of Dundee, DD1 4HN Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4866-2885","authenticated-orcid":true,"given":"Mark C.","family":"Field","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Anti-Infective Research, School of Life Sciences, University of Dundee, DD1 4HN Scotland, U.K."},{"name":"Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 37005 \u010cesk\u00e9 Bud\u011bjovice, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"316","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31204-2"},{"key":"ref2\/cit2","unstructured":"World Health Organization. Leishmaniasis. 2023, Retrieved from https:\/\/apps.who.int\/neglected_diseases\/ntddata\/leishmaniasis\/leishmaniasis.html."},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(01)90223-8"},{"key":"ref4\/cit4","unstructured":"World Health\nOrganization. Leishmaniasis. 2023, Retrieved\nfrom https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/leishmaniasis."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/B978-0-7020-5101-2.00048-0","volume-title":"Manson\u2019s Tropical Diseases","author":"Boelaert M.","year":"2014","edition":"23"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1007\/s40475-021-00232-7"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.03.004"},{"key":"ref8\/cit8","unstructured":"World Health Organization. Neglected tropical diseases. 2021, Retrieved from https:\/\/www.who.int\/health-topics\/neglected-tropical-diseases\/#tab=tab_1."},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5070.129142"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.2174\/092986709787458489"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2013.05.013"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2006.191"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2091-12-46"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1105601108"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.2174\/1389450124666230224140724"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.80813"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00226-17"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202779200"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2002.02795.x"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(93)90111-A"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01261.x"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2021.105877"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1177\/2472555220923367"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0011956"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","DOI":"10.1002\/0471220639","volume-title":"Enzymes, A Practical Introduction to Structure, Mechanism, and Data Analysis","author":"Copeland R. A.","year":"2000","edition":"2"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-023-00499-0"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2021.100704"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.2c00364"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1128\/EC.05118-11"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4419-8414-2_7"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.2174\/1389450123666220316085859"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.70"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0030367"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006310"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-022-01295-6"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/jm061169b"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2019.01.007"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.01.015"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpddr.2019.02.002"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1820175116"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01437"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.2174\/0929867331666230823094737"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adh9902"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1086\/679720"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty1057"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3988"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1110\/ps.9.9.1753"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btg362"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1186\/1758-2946-4-17"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1021\/ci500209e"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-020-00267-2"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jctc.5b00255"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1063\/5.0019056"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(20000130)21:2<132::AID-JCC5>3.0.CO;2-P"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.10128"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1063\/1.445869"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2017.1364669"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.1021\/ct700200b"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540130805"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1021\/ct3010485"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jpcb.2c07079"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-007-6115-5"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008668"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2021.02.008"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1106"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3901"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1896"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.4c00009","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.4c00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T09:12:19Z","timestamp":1718356339000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.4c00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,16]]},"references-count":71,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6,14]]}},"alternative-id":["10.1021\/acsinfecdis.4c00009"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.4c00009","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,16]]}}}