{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T20:29:41Z","timestamp":1771273781392,"version":"3.50.1"},"reference-count":21,"publisher":"American Chemical Society (ACS)","issue":"2","funder":[{"DOI":"10.13039\/501100001342","name":"Department of Science and Technology, Republic of South Africa","doi-asserted-by":"publisher","award":["LMB: UID84627"],"award-info":[{"award-number":["LMB: UID84627"]}],"id":[{"id":"10.13039\/501100001342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001342","name":"Department of Science and Technology, Republic of South Africa","doi-asserted-by":"publisher","award":["KC: UID 64767"],"award-info":[{"award-number":["KC: UID 64767"]}],"id":[{"id":"10.13039\/501100001342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001322","name":"South African Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Infect. Dis."],"published-print":{"date-parts":[[2019,2,8]]},"DOI":"10.1021\/acsinfecdis.8b00272","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T12:58:14Z","timestamp":1544533094000},"page":"303-315","source":"Crossref","is-referenced-by-count":18,"title":["Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action"],"prefix":"10.1021","volume":"5","author":[{"given":"Malkeet","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa"}]},{"given":"John","family":"Okombo","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa"}]},{"given":"Dickson","family":"Mambwe","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa"}]},{"given":"Dale","family":"Taylor","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa"}]},{"given":"Nina","family":"Lawrence","sequence":"additional","affiliation":[{"name":"Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa"}]},{"given":"Janette","family":"Reader","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa"}]},{"given":"Mari\u00ebtte","family":"van der Watt","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa"}]},{"given":"Diana","family":"Fontinha","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal"}]},{"given":"Margarida","family":"Sanches-Vaz","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal"}]},{"given":"Belinda C.","family":"Bezuidenhout","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg 2193, South Africa"}]},{"given":"Sonja B.","family":"Lauterbach","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg 2193, South Africa"}]},{"given":"Dale","family":"Liebenberg","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg 2193, South Africa"}]},{"given":"Lyn-Marie","family":"Birkholtz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa"}]},{"given":"Theresa L.","family":"Coetzer","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg 2193, South Africa"}]},{"given":"Miguel","family":"Prud\u00eancio","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7720-8473","authenticated-orcid":true,"given":"Timothy J.","family":"Egan","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa"},{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa"}]},{"given":"Sergio","family":"Wittlin","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland"},{"name":"University of Basel, 4003 Basel, Switzerland"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1327-4727","authenticated-orcid":true,"given":"Kelly","family":"Chibale","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa"},{"name":"Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa"},{"name":"South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa"}]}],"member":"316","published-online":{"date-parts":[[2018,12,11]]},"reference":[{"key":"ref1\/cit1","volume-title":"World Malaria Report 2017","author":"WHO","year":"2017"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1314981"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.3201\/eid1809.120262"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/cr500098f"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio806"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.430080106"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.11.047"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201300172"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.10.004"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1118370109"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)02031-4"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1993.1566"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007881"},{"issue":"5","key":"ref14\/cit14","first-page":"331","volume":"8","author":"Mann K. V.","year":"1989","journal-title":"Clin. Pharm."},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2004.11.022"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0729-9"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2006.09.016"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1038\/374269a0"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1126\/science.781840"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/0001-706X(93)90083-N"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1186\/s12936-015-0718-z"}],"container-title":["ACS Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsinfecdis.8b00272","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T19:02:13Z","timestamp":1682535733000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsinfecdis.8b00272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,11]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2,8]]}},"alternative-id":["10.1021\/acsinfecdis.8b00272"],"URL":"https:\/\/doi.org\/10.1021\/acsinfecdis.8b00272","relation":{},"ISSN":["2373-8227","2373-8227"],"issn-type":[{"value":"2373-8227","type":"print"},{"value":"2373-8227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,11]]}}}