{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T06:11:54Z","timestamp":1778393514399,"version":"3.51.4"},"reference-count":52,"publisher":"American Chemical Society (ACS)","issue":"8","funder":[{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["310892"],"award-info":[{"award-number":["310892"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005878","name":"Terveyden Tutkimuksen Toimikunta","doi-asserted-by":"publisher","award":["252215"],"award-info":[{"award-number":["252215"]}],"id":[{"id":"10.13039\/501100005878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005878","name":"Terveyden Tutkimuksen Toimikunta","doi-asserted-by":"publisher","award":["2813001"],"award-info":[{"award-number":["2813001"]}],"id":[{"id":"10.13039\/501100005878","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["PEst-C\/SAU\/LA0002\/2013"],"award-info":[{"award-number":["PEst-C\/SAU\/LA0002\/2013"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/87016\/2012"],"award-info":[{"award-number":["SFRH\/BD\/87016\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biocetrum Helsinki"},{"DOI":"10.13039\/100007798","name":"Helsingin Yliopiston Tiedes??ti?","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007798","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Nano"],"published-print":{"date-parts":[[2015,8,25]]},"DOI":"10.1021\/acsnano.5b02762","type":"journal-article","created":{"date-parts":[[2015,8,2]],"date-time":"2015-08-02T17:20:51Z","timestamp":1438536051000},"page":"8291-8302","source":"Crossref","is-referenced-by-count":105,"title":["Microfluidic Assembly of a Multifunctional Tailorable Composite System Designed for Site Specific Combined Oral Delivery of Peptide Drugs"],"prefix":"10.1021","volume":"9","author":[{"given":"Francisca","family":"Ara\u00fajo","sequence":"first","affiliation":[{"name":"Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland"},{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4150-180 Porto, Portugal"},{"name":"INEB \u2212 Instituto de Engenharia Biom\u00e9dica, University of Porto, 4150-180 Porto, Portugal"},{"name":"ICBAS \u2212 Instituto Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, 4150-180 Porto, Portugal"}]},{"given":"Neha","family":"Shrestha","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland"}]},{"given":"Mohammad-Ali","family":"Shahbazi","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland"}]},{"given":"Dongfei","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland"}]},{"given":"B\u00e1rbara","family":"Herranz-Blanco","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland"}]},{"given":"Ermei M.","family":"M\u00e4kil\u00e4","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland"},{"name":"Laboratory of Industrial Physics, University of Turku, FI-20014 Turku, Finland"}]},{"given":"Jarno J.","family":"Salonen","sequence":"additional","affiliation":[{"name":"Laboratory of Industrial Physics, University of Turku, FI-20014 Turku, Finland"}]},{"given":"Jouni T.","family":"Hirvonen","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland"}]},{"given":"Pedro L.","family":"Granja","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4150-180 Porto, Portugal"},{"name":"INEB \u2212 Instituto de Engenharia Biom\u00e9dica, University of Porto, 4150-180 Porto, Portugal"},{"name":"ICBAS \u2212 Instituto Ci\u00eancias Biom\u00e9dicas Abel Salazar, University of Porto, 4150-180 Porto, Portugal"}]},{"given":"Bruno","family":"Sarmento","sequence":"additional","affiliation":[{"name":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto, 4150-180 Porto, Portugal"},{"name":"INEB \u2212 Instituto de Engenharia Biom\u00e9dica, University of Porto, 4150-180 Porto, Portugal"},{"name":"CESPU, Instituto de Investiga\u00e7\u00e3o e Forma\u00e7\u00e3o Avan\u00e7ada em Ci\u00eancias e Tecnologias da Sa\u00fade, 4585-116 Gandra, Portugal"}]},{"given":"H\u00e9lder A.","family":"Santos","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland"}]}],"member":"316","published-online":{"date-parts":[[2015,8,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.2174\/0929866521666140807114240"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2013.819611"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2006.08.005"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2015.992781"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.8984"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.2217\/nnm.13.223"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.07.026"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S41457"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2012.01.043"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.05.036"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201303740"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.4161\/biom.22347"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2008.06.008"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.2174\/1389201015666140915152330"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/j.progpolymsci.2014.07.010"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2008.12.016"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","DOI":"10.1002\/9781119962977","volume-title":"Chitosan-Based Systems for Biopharmaceuticals: Delivery, Targeting and Polymer Therapeutics","author":"Sarmento B.","year":"2012"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.08.014"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-110254"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2013.11.020"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201400953"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2014.09.031"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1021\/mp500809f"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.2174\/1389450115666140311102638"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1039\/c2lc21164e"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1021\/am403999q"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.10.003"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2012.10.063"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.03.033"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2014.902465"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.08.001"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S34991"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2006.12.022"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201405408"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2012.168"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201404122"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.3109\/02652048.2013.834991"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2012.10.003"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.04.104"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2011.547934"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1002\/smll.200901158"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2009.09.016"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.2131\/jts.10.SupplementII_147"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2009.03.050"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1254\/jjp.88.451"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1460717"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2012.10.010"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2003.12.029"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.5.869"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1021\/jm025522z"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.06.052"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-014-0635-4"}],"container-title":["ACS Nano"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsnano.5b02762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T07:32:00Z","timestamp":1681543920000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsnano.5b02762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,5]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8,25]]}},"alternative-id":["10.1021\/acsnano.5b02762"],"URL":"https:\/\/doi.org\/10.1021\/acsnano.5b02762","relation":{},"ISSN":["1936-0851","1936-086X"],"issn-type":[{"value":"1936-0851","type":"print"},{"value":"1936-086X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,5]]}}}