{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:01:15Z","timestamp":1790352075006,"version":"4.1.0"},"reference-count":49,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30-CA14051"],"award-info":[{"award-number":["P30-CA14051"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009210","name":"Food and Drug Administration","doi-asserted-by":"publisher","award":["75F40122C00200"],"award-info":[{"award-number":["75F40122C00200"]}],"id":[{"id":"10.13039\/100009210","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lipid nanoparticles (LNPs) are the leading vehicles for encapsulating and delivering nucleic acid therapeutics. Yet, their process development remains labor-intensive and empirical, constrained by coupled quality attributes and limited mechanistic insight. We present an autonomous, pilot-scale platform for accelerating LNP process development by identifying critical process parameters (CPPs) that produce LNPs with target size attributes. The platform combines a size-control production method with inline dynamic light scattering (DLS) for real-time feedback, enabling closed-loop experimentation and accelerated optimization. With built-in automated design of experiments, dynamic parameter sweeps, and Bayesian optimization, the platform enables rapid, data-rich exploration of complex design spaces. We demonstrate that the platform rapidly maps complex process\u2013property relationships for loaded LNPs, while minimizing experimental burden. The resulting data-rich outputs were used to develop a predictive model that quantitatively links process parameters to particle quality attributes. Operable in fully autonomous mode, the platform provides a scalable and flexible framework for rational LNP manufacturing and accelerates the broader development of nucleic acid therapeutics.<\/jats:p>","DOI":"10.1021\/acsnano.6c15600","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:02:28Z","timestamp":1790348548000},"source":"Crossref","is-referenced-by-count":0,"title":["Autonomous\nLipid Nanoparticle Engineering"],"prefix":"10.1021","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-1775","authenticated-orcid":true,"given":"Peter","family":"Sagmeister","sequence":"first","affiliation":[{"name":"Massachusetts Institute of Technology , , 77 Massachusetts Avenue , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9958-412X","authenticated-orcid":true,"given":"Aniket","family":"Udepurkar","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , 77 Massachusetts Avenue , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8154-4872","authenticated-orcid":true,"given":"Cedric","family":"Devos","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , 77 Massachusetts Avenue , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy I.","family":"Ren","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , 77 Massachusetts Avenue , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4458-3221","authenticated-orcid":true,"given":"Konstantinos","family":"Zinelis","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , 77 Massachusetts Avenue , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofiya","family":"Chubich","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , 77 Massachusetts Avenue , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystian","family":"Ganko","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , 77 Massachusetts Avenue , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy Y.","family":"Liu","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , 77 Massachusetts Avenue , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , 77 Massachusetts Avenue , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4304-3484","authenticated-orcid":true,"given":"Richard D.","family":"Braatz","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , 77 Massachusetts Avenue , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7468-8093","authenticated-orcid":true,"given":"Allan S.","family":"Myerson","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology , , 77 Massachusetts Avenue , , ,","place":["Cambridge, Massachusetts, United States, 02139"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"2026092511021529200_cit1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3002105","article-title":"Biotechnology: Overcoming biological\nbarriers to nucleic acid delivery using lipid nanoparticles","volume":"21","author":"Hamilton","year":"2023","journal-title":"PLoS Biol"},{"key":"2026092511021529200_cit2","doi-asserted-by":"publisher","first-page":"21206","DOI":"10.1021\/acsnano.4c18274","article-title":"Structure and Morphology\nof Lipid Nanoparticles for\nNucleic Acid Drug Delivery: A Review","volume":"19","author":"Udepurkar","year":"2025","journal-title":"ACS Nano"},{"key":"2026092511021529200_cit3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering\nprecision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat.\nRev. 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