{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T03:34:06Z","timestamp":1777779246062,"version":"3.51.4"},"reference-count":267,"publisher":"American Chemical Society (ACS)","issue":"11","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico","doi-asserted-by":"publisher","award":["442831\/2023-4"],"award-info":[{"award-number":["442831\/2023-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda??o de Amparo ? Pesquisa do Estado de S?o Paulo","doi-asserted-by":"publisher","award":["2017\/20291-0"],"award-info":[{"award-number":["2017\/20291-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["BD.2023.00566"],"award-info":[{"award-number":["BD.2023.00566"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/50006"],"award-info":[{"award-number":["UID\/50006"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Pharmacol. Transl. Sci."],"published-print":{"date-parts":[[2025,11,14]]},"DOI":"10.1021\/acsptsci.5c00482","type":"journal-article","created":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T02:08:07Z","timestamp":1762222087000},"page":"3729-3756","source":"Crossref","is-referenced-by-count":8,"title":["Lands\u2019 Cycle at the Crossroads: Phospholipid Remodelling, Oxidative Stress, Cellular Toxicity, and Therapeutic Targeting"],"prefix":"10.1021","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4546-8013","authenticated-orcid":true,"given":"Airam","family":"Roggero","sequence":"first","affiliation":[{"name":"LAQV\/REQUIMTE\u2500BioSIM, Department of Biomedicine","place":["Porto, Portugal"]},{"name":"Medicine Faculty of Porto University","place":["Porto, Portugal"]},{"name":"BIOMOLPEP, Department of Biology","place":["S\u00e3o Paulo, Brazil"]},{"name":"Institute of Biosciences UNESP\/CLP","place":["S\u00e3o Paulo, Brazil"]}]},{"given":"Marcos H.","family":"Toyama","sequence":"additional","affiliation":[{"name":"BIOMOLPEP, Department of Biology","place":["S\u00e3o Paulo, Brazil"]},{"name":"Institute of Biosciences UNESP\/CLP","place":["S\u00e3o Paulo, Brazil"]}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-5284","authenticated-orcid":true,"given":"Sergio F.","family":"Sousa","sequence":"additional","affiliation":[{"name":"LAQV\/REQUIMTE\u2500BioSIM, Department of Biomedicine","place":["Porto, Portugal"]},{"name":"Medicine Faculty of Porto University","place":["Porto, Portugal"]},{"name":"Department of Chemical Engineering, Faculty of Science and Technology","place":["Coimbra, Portugal"]},{"name":"University of Coimbra","place":["Coimbra, Portugal"]}]}],"member":"316","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)70453-5"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2330"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-020518-114444"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v37.i2-6.20"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31963-4"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-80941-7"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1403764"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a016311"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.11.010"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2013.07.006"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.3390\/md22070288"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1080\/10937404.2023.2261848"},{"key":"ref13\/cit13","unstructured":"Inflammation - Cellular Changes | Britannica. https:\/\/www.britannica.com\/science\/inflammation\/Cellular-changes. (accessed June 02, 2025)."},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800033-JLR200"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(00)00105-0"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/cr200085w"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.673502"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2014.934814"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.2174\/1389557510909030368"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2023.08.004"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.04.006"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.04.015"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M706326200"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.10.002"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.06557"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2238"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2239"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3064"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02130-4"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120143"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2022.100680"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22862"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2022.101529"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-024-01825-7"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.RA120000737"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2014.05.019"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.4c00084"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2017-0146"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800035-JLR200"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2019.110817"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.7150\/jca.71619"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.9.3783.bloodjournal8793783"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16112115"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1042\/bj0640192"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25230"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.03.015"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1139\/o03-073"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.R800046200"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-3084(03)00101-4"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1665"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.12.034"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-021-00972-y"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26071850"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)70453-5"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M087890"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200708010"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174621"},{"key":"ref58\/cit58","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2977"},{"key":"ref59\/cit59","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00428-9"},{"key":"ref60\/cit60","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.10.014"},{"key":"ref61\/cit61","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"ref62\/cit62","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00242"},{"key":"ref63\/cit63","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/360438"},{"key":"ref64\/cit64","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.E600002-JLR200"},{"key":"ref65\/cit65","doi-asserted-by":"publisher","DOI":"10.1038\/35036052"},{"key":"ref66\/cit66","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.70253"},{"key":"ref67\/cit67","doi-asserted-by":"publisher","DOI":"10.3390\/cells12141820"},{"key":"ref68\/cit68","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1707-0"},{"key":"ref69\/cit69","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.09.014"},{"key":"ref70\/cit70","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0164-5"},{"key":"ref71\/cit71","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2020.02.009"},{"key":"ref72\/cit72","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2015.158"},{"key":"ref73\/cit73","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101107"},{"key":"ref74\/cit74","doi-asserted-by":"publisher","DOI":"10.1038\/nature14344"},{"key":"ref75\/cit75","unstructured":"Ferroptosis in cancer:\nfrom molecular mechanisms to therapeutic strategies\n| Signal Transduction and Targeted Therapy. https:\/\/www.nature.com\/articles\/s41392-024-01769-5. (accessed June 27, 2025)."},{"key":"ref76\/cit76","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201904197"},{"key":"ref77\/cit77","doi-asserted-by":"publisher","DOI":"10.24272\/j.issn.2095-8137.2020.042"},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.910292"},{"key":"ref79\/cit79","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.01.021"},{"key":"ref80\/cit80","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114147"},{"key":"ref81\/cit81","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00976"},{"key":"ref82\/cit82","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2023.166788"},{"key":"ref83\/cit83","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01606-1"},{"key":"ref84\/cit84","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.3c10132"},{"key":"ref85\/cit85","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-008-6133-8"},{"key":"ref86\/cit86","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2013.05.001"},{"key":"ref87\/cit87","doi-asserted-by":"publisher","DOI":"10.1038\/nri3859"},{"key":"ref88\/cit88","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.02.009"},{"key":"ref89\/cit89","doi-asserted-by":"publisher","DOI":"10.1016\/0166-2236(93)90133-7"},{"key":"ref90\/cit90","volume-title":"Protein Structure","author":"Toyama M.","year":"2012"},{"key":"ref91\/cit91","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7827(02)00049-8"},{"key":"ref92\/cit92","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709737104"},{"key":"ref93\/cit93","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03413-0"},{"key":"ref94\/cit94","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2016.12.003"},{"key":"ref95\/cit95","volume-title":"Fundamentals of Inflammation","author":"Ayoub S. S.","year":"2010","edition":"1"},{"key":"ref96\/cit96","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2010.12.001"},{"key":"ref97\/cit97","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.69.1.145"},{"key":"ref98\/cit98","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112999"},{"key":"ref99\/cit99","doi-asserted-by":"publisher","DOI":"10.1126\/science.294.5548.1871"},{"key":"ref100\/cit100","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2012.02.004"},{"key":"ref101\/cit101","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)38167-5"},{"key":"ref102\/cit102","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra071371"},{"key":"ref103\/cit103","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)30167-X"},{"key":"ref104\/cit104","volume-title":"Handbook of Toxinology","author":"Shier W. T.","year":"1990"},{"key":"ref105\/cit105","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(00)00107-4"},{"key":"ref106\/cit106","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007029"},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1126\/science.1948070"},{"key":"ref108\/cit108","volume-title":"StatPearls","author":"Casale J.","year":"2025"},{"key":"ref109\/cit109","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)36884-X"},{"key":"ref110\/cit110","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06771.x"},{"key":"ref111\/cit111","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-007-9129-8"},{"key":"ref112\/cit112","doi-asserted-by":"publisher","DOI":"10.1002\/med.21597"},{"key":"ref113\/cit113","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000280571.28102.d4"},{"key":"ref114\/cit114","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.E052886"},{"key":"ref115\/cit115","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315878"},{"key":"ref116\/cit116","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.06.175"},{"key":"ref117\/cit117","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b01214"},{"key":"ref118\/cit118","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.6.3.279"},{"key":"ref119\/cit119","doi-asserted-by":"publisher","DOI":"10.1016\/S1388-1981(00)00108-6"},{"key":"ref120\/cit120","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7827(94)00009-B"},{"key":"ref121\/cit121","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)00322-0"},{"key":"ref122\/cit122","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00501.x"},{"key":"ref123\/cit123","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12366000"},{"key":"ref124\/cit124","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2006.07.007"},{"key":"ref125\/cit125","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90666-E"},{"key":"ref126\/cit126","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R082578"},{"key":"ref127\/cit127","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M700299-JLR200"},{"key":"ref128\/cit128","doi-asserted-by":"publisher","DOI":"10.3390\/antiox7120172"},{"key":"ref129\/cit129","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.08.017"},{"key":"ref130\/cit130","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.03.018"},{"key":"ref131\/cit131","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2010.03.019"},{"key":"ref132\/cit132","unstructured":"GPX4-independent ferroptosis\u2500a new\nstrategy in disease\u2019s\ntherapy | Cell Death Discovery. https:\/\/www.nature.com\/articles\/s41420-022-01212-0. (accessed June 27, 2025)."},{"key":"ref133\/cit133","doi-asserted-by":"publisher","DOI":"10.3390\/v15122373"},{"key":"ref134\/cit134","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01769-5"},{"key":"ref135\/cit135","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23902-6"},{"key":"ref136\/cit136","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.11.048"},{"key":"ref137\/cit137","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(89)90336-6"},{"key":"ref138\/cit138","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41462-9"},{"key":"ref139\/cit139","unstructured":"Bank, R. P. D. RCSB\nPDB - 6HKQ: Human GPX4 in complex with covalent Inhibitor ML162 (S\nenantiomer). https:\/\/www.rcsb.org\/structure\/6HKQ. (accessed June 27, 2025)."},{"key":"ref140\/cit140","unstructured":"Bank, R.\nP. D. RCSB\nPDB - 7U4N: Crystal structure of human GPX4-U46C in complex with RSL3. https:\/\/www.rcsb.org\/structure\/7U4N. (accessed June 27, 2025)."},{"key":"ref141\/cit141","unstructured":"Bank, R.\nP. D. RCSB\nPDB - 8Q8J: Crystal structure of human GPX4-R152H. https:\/\/www.rcsb.org\/structure\/8Q8J. (accessed June 27, 2025)."},{"key":"ref142\/cit142","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09277-9"},{"key":"ref143\/cit143","unstructured":"GPX4\nat the Crossroads of Lipid Homeostasis and Ferroptosis - PubMed. https:\/\/pubmed.ncbi.nlm.nih.gov\/30888116\/. (accessed June 27, 2025)."},{"key":"ref144\/cit144","doi-asserted-by":"publisher","DOI":"10.2174\/092986709788682164"},{"key":"ref145\/cit145","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03193-0"},{"key":"ref146\/cit146","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2023-0125"},{"key":"ref147\/cit147","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b01216"},{"key":"ref148\/cit148","unstructured":"RCSB\nPDB - 1POC: Crystal Structure of Bee-Venom Phospholipase A2\nin a Complex with a Transition-State Analogue. https:\/\/www.rcsb.org\/structure\/1POC. (accessed June 27, 2025)."},{"key":"ref149\/cit149","unstructured":"structure of iPLA2\u03b2\nreveals dimeric active sites and suggests\nmechanisms of regulation and localization | Nature Communications. https:\/\/www.nature.com\/articles\/s41467-018-03193-0. (accessed\nJune 27, 2025)."},{"key":"ref150\/cit150","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021"},{"key":"ref151\/cit151","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202300325"},{"key":"ref152\/cit152","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S472178"},{"key":"ref153\/cit153","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-23-01343"},{"key":"ref154\/cit154","doi-asserted-by":"publisher","DOI":"10.1039\/D3SC02350H"},{"key":"ref155\/cit155","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-022-01212-0"},{"key":"ref156\/cit156","unstructured":"Frontiers | Ferroptosis and its role in\nosteoarthritis: mechanisms,\nbiomarkers, and therapeutic perspectives. https:\/\/www.frontiersin.org\/journals\/cell-and-developmental-biology\/articles\/10.3389\/fcell.2024.1510390\/full. (accessed June 27, 2025)."},{"key":"ref157\/cit157","doi-asserted-by":"publisher","DOI":"10.3390\/cells12081128"},{"key":"ref158\/cit158","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12231"},{"key":"ref159\/cit159","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-00441-1"},{"key":"ref160\/cit160","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4922(01)01901-8"},{"key":"ref161\/cit161","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2435.2010.01695.x"},{"key":"ref162\/cit162","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.04.013"},{"key":"ref163\/cit163","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.10.061"},{"key":"ref164\/cit164","doi-asserted-by":"publisher","DOI":"10.1042\/BST20210579"},{"key":"ref165\/cit165","doi-asserted-by":"publisher","DOI":"10.1186\/s12860-014-0043-3"},{"key":"ref166\/cit166","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.112.104604"},{"key":"ref167\/cit167","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-024-01405-y"},{"key":"ref168\/cit168","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3214-8"},{"key":"ref169\/cit169","unstructured":"Lipid rafts as signaling hubs in cancer cell survival\/death\nand invasion:\nimplications in tumor progression and therapy - PMC. https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC7193951\/. (accessed June 30, 2025)."},{"key":"ref170\/cit170","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38061"},{"key":"ref171\/cit171","unstructured":"LPCAT3 regulates the immune infiltration\nand prognosis of ccRCC patients\nby mediating ferroptosis and endoplasmic reticulum stress | Discover\nOncology. https:\/\/link.springer.com\/article\/10.1007\/s12672-025-02283-y. (accessed June 30, 2025)."},{"key":"ref172\/cit172","unstructured":"LPCAT1 lysophosphatidylcholine\nacyltransferase 1 [Homo sapiens (human)]\n- Gene - NCBI. https:\/\/www.ncbi.nlm.nih.gov\/gene?Db=gene&Cmd=DetailsSearch&Term=79888. (accessed June 30, 2025)."},{"key":"ref173\/cit173","unstructured":"LPCAT3 lysophosphatidylcholine\nacyltransferase 3 [Homo sapiens (human)]\n- Gene - NCBI. https:\/\/www.ncbi.nlm.nih.gov\/gene\/10162. (accessed June 30, 2025)."},{"key":"ref174\/cit174","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00475.2009"},{"key":"ref175\/cit175","unstructured":"Genotype-Tissue Expression (GTEx) project | Nature\nGenetics. https:\/\/www.nature.com\/articles\/ng.2653. (accessed June 30, 2025)."},{"key":"ref176\/cit176","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.06.001"},{"key":"ref177\/cit177","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13111403"},{"key":"ref178\/cit178","unstructured":"Hypoxia-Inducible Factor (HIF)-1 Regulatory\nPathway and its Potential\nfor Therapeutic Intervention in Malignancy and Ischemia - PMCv. https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2140184\/. (accessed June 30, 2025)."},{"key":"ref179\/cit179","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-0977"},{"key":"ref180\/cit180","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4405"},{"key":"ref181\/cit181","unstructured":"Free Radical Biol. Med. | Vol 134, Pages 1714 (April Elsevier 2019 https:\/\/www.sciencedirect.com\/journal\/free-radical-biology-and-medicine\/vol\/134\/suppl\/C. (accessed June 30, 2025)."},{"key":"ref182\/cit182","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2012.04.009"},{"key":"ref183\/cit183","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010"},{"key":"ref184\/cit184","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09277-9"},{"key":"ref185\/cit185","unstructured":"Inflammation\nand tumor progression: signaling pathways and targeted\nintervention | Signal Transduction and Targeted Therapy. https:\/\/www.nature.com\/articles\/s41392-021-00658-5. (accessed\nJune 30, 2025)."},{"key":"ref186\/cit186","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-20-341"},{"key":"ref187\/cit187","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.678714"},{"key":"ref188\/cit188","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2022.101958"},{"key":"ref189\/cit189","unstructured":"Frontiers | Macrophage Lysophosphatidylcholine Acyltransferase\n3\nDeficiency-Mediated Inflammation Is Not Sufficient to Induce Atherosclerosis\nin a Mouse Model. https:\/\/www.frontiersin.org\/journals\/cardiovascular-medicine\/articles\/10.3389\/fcvm.2018.00192\/full. (accessed June 30, 2025)."},{"key":"ref190\/cit190","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201500149"},{"key":"ref191\/cit191","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-22-985"},{"key":"ref192\/cit192","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27244-1"},{"key":"ref193\/cit193","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-008-3233-y"},{"key":"ref194\/cit194","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M710422200"},{"key":"ref195\/cit195","doi-asserted-by":"publisher","DOI":"10.1038\/srep29637"},{"key":"ref196\/cit196","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.S091371"},{"key":"ref197\/cit197","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvt048"},{"key":"ref198\/cit198","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e13316"},{"key":"ref199\/cit199","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.03.064"},{"key":"ref200\/cit200","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800364200"},{"key":"ref201\/cit201","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13794"},{"key":"ref202\/cit202","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.03.042"},{"key":"ref203\/cit203","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08771-3"},{"key":"ref204\/cit204","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018030619"},{"key":"ref205\/cit205","doi-asserted-by":"publisher","DOI":"10.1186\/s13601-019-0275-6"},{"key":"ref206\/cit206","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.624132"},{"key":"ref207\/cit207","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/978-0-387-30378-9_13","volume-title":"Handbook of Neurochemistry and Molecular Neurobiology","author":"Goracci G.","year":"2009"},{"key":"ref208\/cit208","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2018.07.006"},{"key":"ref209\/cit209","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8662-4"},{"key":"ref210\/cit210","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R057588"},{"key":"ref211\/cit211","doi-asserted-by":"publisher","DOI":"10.1016\/bs.enz.2015.09.006"},{"key":"ref212\/cit212","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7960"},{"key":"ref213\/cit213","doi-asserted-by":"publisher","DOI":"10.1186\/s40880-018-0301-4"},{"key":"ref214\/cit214","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2022.101342"},{"key":"ref215\/cit215","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00378"},{"key":"ref216\/cit216","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2011.04.013"},{"key":"ref217\/cit217","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.09.003"},{"key":"ref218\/cit218","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.142"},{"key":"ref219\/cit219","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2019.104788"},{"key":"ref220\/cit220","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2014.12.007"},{"key":"ref221\/cit221","doi-asserted-by":"publisher","DOI":"10.3390\/biom12121902"},{"key":"ref222\/cit222","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-017-0521-7"},{"key":"ref223\/cit223","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2021.01.006"},{"key":"ref224\/cit224","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2020.101115"},{"key":"ref225\/cit225","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076133"},{"key":"ref226\/cit226","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2015.09.018"},{"key":"ref227\/cit227","doi-asserted-by":"publisher","DOI":"10.1097\/01.mol.0000174153.53683.f2"},{"key":"ref228\/cit228","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25215053"},{"key":"ref229\/cit229","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2014.12.004"},{"key":"ref230\/cit230","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27839"},{"key":"ref231\/cit231","doi-asserted-by":"publisher","DOI":"10.3390\/diabetology3020020"},{"key":"ref232\/cit232","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e15347"},{"key":"ref233\/cit233","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092167"},{"key":"ref234\/cit234","doi-asserted-by":"publisher","DOI":"10.3390\/membranes12121190"},{"key":"ref235\/cit235","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2020.183365"},{"key":"ref236\/cit236","doi-asserted-by":"publisher","DOI":"10.3389\/fphy.2023.1251146"},{"key":"ref237\/cit237","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071711"},{"key":"ref238\/cit238","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.634438"},{"key":"ref239\/cit239","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1515\/9783110544657-021","volume-title":"Characterization of Biological Membranes","author":"Chan C.","year":"2019"},{"key":"ref240\/cit240","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.37018"},{"key":"ref241\/cit241","doi-asserted-by":"publisher","DOI":"10.1007\/s00894-019-3964-0"},{"key":"ref242\/cit242","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000375"},{"key":"ref243\/cit243","unstructured":"Emerging mechanisms of lipid peroxidation in regulated\ncell death\nand its physiological implications | Cell Death & Disease. https:\/\/www.nature.com\/articles\/s41419-024-07244-x. (accessed\nJune 30, 2025)."},{"key":"ref244\/cit244","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M009449"},{"key":"ref245\/cit245","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2025.118095"},{"key":"ref246\/cit246","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2006.03.014"},{"key":"ref247\/cit247","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/428010"},{"key":"ref248\/cit248","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.09.016"},{"key":"ref249\/cit249","doi-asserted-by":"publisher","DOI":"10.2147\/CIA.S158513"},{"key":"ref250\/cit250","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10030390"},{"key":"ref251\/cit251","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10020393"},{"key":"ref252\/cit252","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1580559"},{"key":"ref253\/cit253","doi-asserted-by":"publisher","DOI":"10.37349\/edd.2024.00057"},{"key":"ref254\/cit254","doi-asserted-by":"publisher","DOI":"10.1021\/ci500588j"},{"key":"ref255\/cit255","doi-asserted-by":"publisher","DOI":"10.1002\/prot.10465"},{"key":"ref256\/cit256","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkj120"},{"key":"ref257\/cit257","doi-asserted-by":"crossref","DOI":"10.1201\/9781420028775","volume-title":"Virtual Screening in Drug Discovery","author":"Alvarez J.","year":"2005"},{"key":"ref258\/cit258","doi-asserted-by":"publisher","DOI":"10.1007\/s10822-010-9352-6"},{"key":"ref259\/cit259","unstructured":"Case, D. A.; Aktulga, H. M.; Belfon, K.; Ben-Shalom, I. Y.; Berryman, J. T.; Brozell, S. R.; Cerutti, D. S.; C, T. E., III; Cisneros, G. A.; Cruzeiro, V. W. D.; Darden, T. A.; Forouzesh, N.; Giambasu, G.; Giese, T.; Gilson, M. K.; Gohlke, H.; Goetz, A. W.; Harris, J.; Izadi, S.; Izmailov, S. A.; Kasavajhala, K.; Kaymak, M. C.; King, E.; Kovalenko, A.; Kurtzman, T.; Lee, T.; Li, P.; Lin, C.; Liu, J.; Luchko, T.; Luo, R.; Machado, M.; Man, V.; Manathunga, M.; Merz, K. M.; Miao, Y.; Mikhailovskii, O.; Monard, G.; Nguyen, H.; O\u2019Hearn, K. A.; Onufriev, A.; Pan, F.; Pantano, S.; Qi, R.; Rahnamoun, A.; Roe, D. R.; Roitberg, A.; Sagui, C.; Schott-Verdugo, S.; Shajan, A.; Shen, J.; Simmerling, C. L.; Skrynnikov, N. R.; Smith, J.; Swails, J.; Walker, R. C.; Wang, J.; Wang, J.; Wei, H.; Wu, X.; Xiong, Y.; Xue, Y.; York, D. M.; Zhao, S.; Zhu, Q.; Kollman, P. A.\n                      Amber 2023\n                      ; University of California: San Francisco, 2023."},{"key":"ref260\/cit260","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252212408"},{"key":"ref261\/cit261","doi-asserted-by":"publisher","DOI":"10.1021\/jacsau.2c00681"},{"key":"ref262\/cit262","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-023-00689-x"},{"key":"ref263\/cit263","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061472"},{"key":"ref264\/cit264","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.941618"},{"key":"ref265\/cit265","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13010088"},{"key":"ref266\/cit266","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000074670.03001.98"},{"key":"ref267\/cit267","unstructured":"Okorie, C. O. The Role of Lysophosphatidylcholine Acyltransferase (LPCAT) 3 in Macrophage Inflammatory Responses."}],"container-title":["ACS Pharmacology &amp; Translational Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00482","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acsptsci.5c00482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T09:11:50Z","timestamp":1763111510000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acsptsci.5c00482"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":267,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11,14]]}},"alternative-id":["10.1021\/acsptsci.5c00482"],"URL":"https:\/\/doi.org\/10.1021\/acsptsci.5c00482","relation":{},"ISSN":["2575-9108","2575-9108"],"issn-type":[{"value":"2575-9108","type":"print"},{"value":"2575-9108","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]}}}