{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T11:48:23Z","timestamp":1773229703920,"version":"3.50.1"},"reference-count":57,"publisher":"American Chemical Society (ACS)","issue":"4","license":[{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T00:00:00Z","timestamp":1616630400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["ERA-IB-2-6\/0003\/2014"],"award-info":[{"award-number":["ERA-IB-2-6\/0003\/2014"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["PD\/BD\/114151\/2015"],"award-info":[{"award-number":["PD\/BD\/114151\/2015"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","award":["UID\/BIO\/04565\/2019"],"award-info":[{"award-number":["UID\/BIO\/04565\/2019"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"name":"EraNet in Industrial Biotechnology"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ACS Synth. Biol."],"published-print":{"date-parts":[[2021,4,16]]},"DOI":"10.1021\/acssynbio.0c00518","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T15:12:07Z","timestamp":1616685127000},"page":"724-736","source":"Crossref","is-referenced-by-count":16,"title":["Prospecting Biochemical Pathways to Implement Microbe-Based Production of the New-to-Nature Platform Chemical Levulinic Acid"],"prefix":"10.1021","volume":"10","author":[{"given":"Ana","family":"Vila-Santa","sequence":"first","affiliation":[{"name":"Department of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-6263","authenticated-orcid":true,"given":"M. Ahsanul","family":"Islam","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Loughborough University, Leicestershire, LE11 3TU Loughborough, United Kingdom"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5177-6237","authenticated-orcid":true,"given":"Frederico C.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0437-3157","authenticated-orcid":true,"given":"Kristala L. J.","family":"Prather","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering and Center for Integrative Synthetic Biology (CISB), Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-0385","authenticated-orcid":true,"given":"Nuno P.","family":"Mira","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Institute for Bioengineering and Biosciences, Instituto Superior T\u00e9cnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201100069"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00368C"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2007.11.006"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1002\/9781118843796.ch4"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jenvman.2018.03.012"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1002\/bbb.267"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/9783527619849.ch7"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1016\/j.rser.2015.06.032"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/nature24996"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15828"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1002\/bit.25856"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti213"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1002\/bit.22673."},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2017.04.005"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.8b00049"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1021\/acssynbio.6b00054"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-015-0087-1"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw491"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1021\/sb4001273"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.37358\/RC.19.10.7574"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.580"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3505"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2020.123323"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2009.00537.x"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-014-5866-5"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1042\/0264-6021:3420509"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-015-0069-3"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1007\/s11274-017-2366-7"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1186\/s12934-019-1242-6"},{"key":"ref30\/cit30","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(90)90559-H"},{"key":"ref31\/cit31","doi-asserted-by":"publisher","DOI":"10.1016\/j.coisb.2019.04.004"},{"key":"ref32\/cit32","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1058"},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2012.05434.x"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6150-9-10"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)01100-8"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.6.3879"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600306103"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20070765"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcatb.2008.10.005"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/bit.20488"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1039\/b310443p"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2007.00820.x"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01983-12"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1021\/bp010179x"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2055"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.65"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-6-55"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1534\/g3.118.200831"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2019.10.001"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1016\/j.mec.2019.e00087"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2009.10.003"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-57"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq367"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr320"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0098-2"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1186\/1752-0509-8-79"},{"key":"ref57\/cit57","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-020-3377-1"}],"container-title":["ACS Synthetic Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/acssynbio.0c00518","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T23:40:01Z","timestamp":1682206801000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/acssynbio.0c00518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,25]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4,16]]}},"alternative-id":["10.1021\/acssynbio.0c00518"],"URL":"https:\/\/doi.org\/10.1021\/acssynbio.0c00518","relation":{},"ISSN":["2161-5063","2161-5063"],"issn-type":[{"value":"2161-5063","type":"print"},{"value":"2161-5063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,25]]}}}