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Psychiat. Nurs."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.2042-7158.2012.01567.x","volume":"65","author":"Tacar O.","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.addr.2013.04.011","volume":"65","author":"Yin Q.","year":"2013","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nmat2569","volume":"8","author":"MacKay J. A.","year":"2009","journal-title":"Nat. Mater."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1039\/b702538f","volume":"17","author":"Yang J.","year":"2007","journal-title":"J. Mater. Chem."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"5362","DOI":"10.1002\/anie.200800857","volume":"47","author":"Yu M. K.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jhep.2004.12.035","volume":"42","author":"Barraud L.","year":"2005","journal-title":"J. Hepatol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/mabi.201300241","volume":"14","author":"Gon\u00e7alves M.","year":"2013","journal-title":"Macromol. Biosci."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1002\/cncr.11407","volume":"97","author":"Swain S. M.","year":"2003","journal-title":"Cancer"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"16649","DOI":"10.1073\/pnas.0607705103","volume":"103","author":"Lee C. C.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1200\/JCO.2001.19.5.1444","volume":"19","author":"Batist G.","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jconrel.2004.02.003","volume":"96","author":"Yoo H. S.","year":"2004","journal-title":"J. Controlled Release"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1021\/la4001363","volume":"29","author":"Wang S.","year":"2013","journal-title":"Langmuir"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"6041","DOI":"10.1016\/j.biomaterials.2009.07.025","volume":"30","author":"Zhang X.","year":"2009","journal-title":"Biomaterials"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1021\/la053158b","volume":"22","author":"Yu S. Y.","year":"2006","journal-title":"Langmuir"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1016\/j.biomaterials.2013.01.084","volume":"34","author":"Cheng R.","year":"2013","journal-title":"Biomaterials"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.addr.2012.09.033","volume":"64","author":"Brannon-Peppas L.","year":"2012","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.clay.2010.01.007","volume":"48","author":"Viseras C.","year":"2010","journal-title":"Appl. .Clay Sci."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0021-9797(92)90254-J","volume":"151","author":"Thompson D. W.","year":"1992","journal-title":"J. Colloid Interface Sci."},{"issue":"1","key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1016\/j.jconrel.2011.08.119","volume":"152","author":"Li Y.","year":"2011","journal-title":"J. Controlled Release"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"3329","DOI":"10.1002\/adma.201300584","volume":"25","author":"Gaharwar A. K.","year":"2013","journal-title":"Adv. Mater."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"4069","DOI":"10.1002\/adma.201301034","volume":"25","author":"Dawson J. I.","year":"2013","journal-title":"Adv. Mater."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1002\/mame.200600260","volume":"291","author":"Okada A.","year":"2006","journal-title":"Macromol. Mater. Eng."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.actbio.2013.09.013","volume":"10","author":"Goncalves M.","year":"2014","journal-title":"Acta Biomater."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ijpharm.2007.08.008","volume":"349","author":"Jung H.","year":"2008","journal-title":"Int. J. Pharm."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jconrel.2005.03.031","volume":"107","author":"Takahashi T.","year":"2005","journal-title":"J. Controlled Release"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.addr.2010.04.009","volume":"63","author":"Fang J.","year":"2011","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref28\/cit28","first-page":"31","volume":"11","author":"Moghimi S. M.","year":"1994","journal-title":"Crit. Rev. Ther. Drug Carrier Syst."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.addr.2011.04.006","volume":"64","author":"Li Y. H.","year":"2012","journal-title":"Adv. Drug Deliver. Rev."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejpb.2010.12.001","volume":"78","author":"Delair T.","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.jconrel.2006.08.021","volume":"115","author":"Douglas K. L.","year":"2006","journal-title":"J. Controlled Release"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1039\/C1CS15203C","volume":"41","author":"Li Y. L.","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s12645-010-0006-0","volume":"1","author":"Parveen S.","year":"2010","journal-title":"Cancer Nanotechnol."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.msec.2010.01.006","volume":"30","author":"Kayal S.","year":"2010","journal-title":"Mater. Sci. Eng., C"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"6393","DOI":"10.1021\/am302130b","volume":"4","author":"Wang S. G.","year":"2012","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"5163","DOI":"10.1002\/pola.26930","volume":"51","author":"Wang D. K.","year":"2013","journal-title":"J. Polym. Sci., Part A: Polym. Chem."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1002\/anie.200902672","volume":"49","author":"Knop K.","year":"2010","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1039\/c0nr00156b","volume":"2","author":"Rosenholm J. M.","year":"2010","journal-title":"Nanoscale"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jconrel.2011.09.098","volume":"161","author":"Bertrand N.","year":"2012","journal-title":"J. Controlled Release"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1046\/j.1365-2125.2003.02007.x","volume":"57","author":"Mangoni A. A.","year":"2004","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.biomaterials.2011.10.061","volume":"33","author":"Ernsting M. J.","year":"2012","journal-title":"Biomaterials"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"6408","DOI":"10.1016\/j.biomaterials.2012.05.047","volume":"33","author":"Zhang X. D.","year":"2012","journal-title":"Biomaterials"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/jbm.a.30711","volume":"78","author":"Vonarbourg A.","year":"2006","journal-title":"J. Biomed. Mater. Res., Part A"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"6629","DOI":"10.1021\/nn101990a","volume":"4","author":"Hamad I.","year":"2010","journal-title":"ACS Nano"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.biomaterials.2011.10.064","volume":"33","author":"Cho H. J.","year":"2012","journal-title":"Biomaterials"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"E90","DOI":"10.1016\/j.jconrel.2010.07.066","volume":"148","author":"Naeye B.","year":"2010","journal-title":"J. Controlled Release"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0378-5173(03)00132-7","volume":"257","author":"Bhadra D.","year":"2003","journal-title":"Int. J. Pharm."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/S0006-2952(03)00467-2","volume":"66","author":"Mahoney B. P.","year":"2003","journal-title":"Biochem. Pharmacol."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1021\/mp200292c","volume":"8","author":"Wojtkowiak J. W.","year":"2011","journal-title":"Mol. 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