{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:54:08Z","timestamp":1760853248827},"reference-count":51,"publisher":"American Chemical Society (ACS)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Bioconjugate Chem."],"published-print":{"date-parts":[[2007,3,1]]},"DOI":"10.1021\/bc060234t","type":"journal-article","created":{"date-parts":[[2007,1,13]],"date-time":"2007-01-13T13:00:27Z","timestamp":1168693227000},"page":"530-537","source":"Crossref","is-referenced-by-count":58,"title":["In Vitro and In Vivo Evaluation of a Novel <sup>99m<\/sup>Tc(CO)<sub>3<\/sub>-Pyrazolyl Conjugate of <i>cyclo-<\/i>(Arg-Gly-Asp-<scp>d<\/scp>-Tyr-Lys)"],"prefix":"10.1021","volume":"18","author":[{"given":"Susana","family":"Alves","sequence":"first","affiliation":[{"name":"Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri-Columbia School of Medicine, Columbia, Missouri 65211, University of Missouri Research Reactor Center, University of Missouri-Columbia, Columbia, Missouri 65211, Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri 65201, Departamento de Qu\u00edmica, Instituto Tecnol\u00f3gico e Nuclear, 2686-953, Sacav\u00e9m, Portugal, Department of Nuclear Medicine,..."}]},{"given":"Jo\u00e3o D. G.","family":"Correia","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri-Columbia School of Medicine, Columbia, Missouri 65211, University of Missouri Research Reactor Center, University of Missouri-Columbia, Columbia, Missouri 65211, Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri 65201, Departamento de Qu\u00edmica, Instituto Tecnol\u00f3gico e Nuclear, 2686-953, Sacav\u00e9m, Portugal, Department of Nuclear Medicine,..."}]},{"given":"Lurdes","family":"Gano","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri-Columbia School of Medicine, Columbia, Missouri 65211, University of Missouri Research Reactor Center, University of Missouri-Columbia, Columbia, Missouri 65211, Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri 65201, Departamento de Qu\u00edmica, Instituto Tecnol\u00f3gico e Nuclear, 2686-953, Sacav\u00e9m, Portugal, Department of Nuclear Medicine,..."}]},{"given":"Tammy L.","family":"Rold","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri-Columbia School of Medicine, Columbia, Missouri 65211, University of Missouri Research Reactor Center, University of Missouri-Columbia, Columbia, Missouri 65211, Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri 65201, Departamento de Qu\u00edmica, Instituto Tecnol\u00f3gico e Nuclear, 2686-953, Sacav\u00e9m, Portugal, Department of Nuclear Medicine,..."}]},{"given":"Adam","family":"Prasanphanich","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri-Columbia School of Medicine, Columbia, Missouri 65211, University of Missouri Research Reactor Center, University of Missouri-Columbia, Columbia, Missouri 65211, Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri 65201, Departamento de Qu\u00edmica, Instituto Tecnol\u00f3gico e Nuclear, 2686-953, Sacav\u00e9m, Portugal, Department of Nuclear Medicine,..."}]},{"given":"Roland","family":"Haubner","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri-Columbia School of Medicine, Columbia, Missouri 65211, University of Missouri Research Reactor Center, University of Missouri-Columbia, Columbia, Missouri 65211, Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri 65201, Departamento de Qu\u00edmica, Instituto Tecnol\u00f3gico e Nuclear, 2686-953, Sacav\u00e9m, Portugal, Department of Nuclear Medicine,..."}]},{"given":"Marco","family":"Rupprich","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri-Columbia School of Medicine, Columbia, Missouri 65211, University of Missouri Research Reactor Center, University of Missouri-Columbia, Columbia, Missouri 65211, Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri 65201, Departamento de Qu\u00edmica, Instituto Tecnol\u00f3gico e Nuclear, 2686-953, Sacav\u00e9m, Portugal, Department of Nuclear Medicine,..."}]},{"given":"Roger","family":"Alberto","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri-Columbia School of Medicine, Columbia, Missouri 65211, University of Missouri Research Reactor Center, University of Missouri-Columbia, Columbia, Missouri 65211, Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri 65201, Departamento de Qu\u00edmica, Instituto Tecnol\u00f3gico e Nuclear, 2686-953, Sacav\u00e9m, Portugal, Department of Nuclear Medicine,..."}]},{"given":"Clemens","family":"Decristoforo","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri-Columbia School of Medicine, Columbia, Missouri 65211, University of Missouri Research Reactor Center, University of Missouri-Columbia, Columbia, Missouri 65211, Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri 65201, Departamento de Qu\u00edmica, Instituto Tecnol\u00f3gico e Nuclear, 2686-953, Sacav\u00e9m, Portugal, Department of Nuclear Medicine,..."}]},{"given":"Isabel","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri-Columbia School of Medicine, Columbia, Missouri 65211, University of Missouri Research Reactor Center, University of Missouri-Columbia, Columbia, Missouri 65211, Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri 65201, Departamento de Qu\u00edmica, Instituto Tecnol\u00f3gico e Nuclear, 2686-953, Sacav\u00e9m, Portugal, Department of Nuclear Medicine,..."}]},{"given":"Charles J.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Radiology, Department of Internal Medicine, and The Radiopharmaceutical Sciences Institute, University of Missouri-Columbia School of Medicine, Columbia, Missouri 65211, University of Missouri Research Reactor Center, University of Missouri-Columbia, Columbia, Missouri 65211, Research Division, Harry S. Truman Memorial Veterans' Hospital, Columbia, Missouri 65201, Departamento de Qu\u00edmica, Instituto Tecnol\u00f3gico e Nuclear, 2686-953, Sacav\u00e9m, Portugal, Department of Nuclear Medicine,..."}]}],"member":"316","published-online":{"date-parts":[[2007,1,13]]},"reference":[{"key":"bc060234tb00001\/bc060234tb00001_1","author":"Haubner R.","year":"2006","journal-title":"J. Nucl. Med. Mol. Imaging, in press."},{"key":"bc060234tb00002\/bc060234tb00002_1","volume-title":"Radiolabeled tracers for imaging of tumor angiogenesis and evaluation of anti-angiogenic therapies. Curr. Pharm. Des. 10, 1439\u22121455","author":"Haubner R.","year":"2004"},{"key":"bc060234tb00003\/bc060234tb00003_1","volume-title":"Peptide ligands for integrin \u03b1V\u03b23 selected from random phage display libraries. Biochemistry 34, 3948\u22123955","author":"Healy J. M.","year":"1995"},{"key":"bc060234tb00004\/bc060234tb00004_1","volume-title":"Cancer Res. 63","author":"Reinmuth N.","year":"2003"},{"key":"bc060234tb00005\/bc060234tb00005_1","volume-title":"Small molecule \u03b1V integrin antagonists:\u2009 novel anticancer agents. Exp. Opin. Invest. Drugs 9, 1271\u22121279","author":"Kerr J. S.","year":"2000"},{"key":"bc060234tb00006\/bc060234tb00006_1","doi-asserted-by":"crossref","DOI":"10.1007\/s002590050312","volume":"25","author":"Sivolapenko G. B.","year":"1998","journal-title":"Eur. J. Nucl. Med."},{"key":"bc060234tb00007\/bc060234tb00007_1","doi-asserted-by":"crossref","DOI":"10.1007\/s00259-001-0756-3","volume":"29","author":"Sutcliffe-Goulden J. L.","year":"2002","journal-title":"Eur. J. Nucl. Med."},{"key":"bc060234tb00008\/bc060234tb00008_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)45376-8","volume":"262","author":"Pierschbacher M. D.","year":"1987","journal-title":"J. Biol. Chem."},{"key":"bc060234tb00009\/bc060234tb00009_1","volume-title":"The structures of integrins and integrin-ligand complexes:\u2009 Implications for drug design and signal transduction","author":"Gottschalk K.","year":"2002"},{"key":"bc060234tb00010\/bc060234tb00010_1","volume-title":"Solution structures and integrin binding activities of an RGD peptide with two isomers. Biochemistry 40, 2373\u22122378","author":"Assa-Munt N.","year":"2001"},{"key":"bc060234tb00011\/bc060234tb00011_1","volume-title":"vitro and in vivo evaluation of a technetium-99m-labeled cyclic RGD peptide as a specific marker of \u03b1V\u03b23 integrin for tumor imaging. Bioconjugate Chem. 13, 561\u2212570","author":"Su Z.","year":"2002"},{"key":"bc060234tb00012\/bc060234tb00012_1","volume":"40","author":"Haubner R.","year":"1999","journal-title":"J. Nucl. Med."},{"key":"bc060234tb00013\/bc060234tb00013_1","volume":"42","author":"Haubner R.","year":"2001","journal-title":"J. Nucl. Med."},{"key":"bc060234tb00014\/bc060234tb00014_1","volume-title":"Noninvasive imaging of \u03b1V\u03b23 integrin expression using 18F-labeled RGD-containing glycopeptide and positron emission tomography. Cancer Res. 61, 1781\u22121785","author":"Haubner R.","year":"2001"},{"key":"bc060234tb00015\/bc060234tb00015_1","volume-title":"Noninvasive visualization of the activated \u03b1V\u03b23 integrin in cancer patients by positron emission tomography and [18F]galacto-RGD. PloS Med. 2, 0244\u22120252","author":"Haubner R.","year":"2005"},{"key":"bc060234tb00016\/bc060234tb00016_1","doi-asserted-by":"crossref","DOI":"10.1007\/s00259-003-1452-2","volume":"31","author":"Chen X.","year":"2004","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"bc060234tb00017\/bc060234tb00017_1","doi-asserted-by":"crossref","DOI":"10.1002\/1097-0215(20000820)90:4<186::AID-IJC2>3.0.CO;2-P","volume":"90","author":"van Hagen P. M.","year":"2000","journal-title":"Int. J. Cancer"},{"key":"bc060234tb00018\/bc060234tb00018_1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1021\/bc0300403","volume":"15","author":"Chen X.","year":"2004","journal-title":"Bioconjugate Chem."},{"key":"bc060234tb00019\/bc060234tb00019_1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0014-5793(91)81101-D","volume":"291","author":"Aumailley M.","year":"1991","journal-title":"FEBS Lett."},{"key":"bc060234tb00020\/bc060234tb00020_1","doi-asserted-by":"crossref","unstructured":"Schibli, R., Schwarzbach, R., Alberto, R., Ortner, K., Schmalle, H., Dumas, C., Egli, A., and Schubiger, P. A. (2002) Steps toward specific activity labeling of biomolecules for therapeutic 537 application:\u2009 Preparation of precursor [188Re(H2O)3(CO)3]+and synthesis of tailor-made bifunctional ligand systems.Bioconjugate Chem.13, 750\u2212756.","DOI":"10.1021\/bc015568r"},{"key":"bc060234tb00021\/bc060234tb00021_1","doi-asserted-by":"crossref","DOI":"10.1016\/0022-328X(94)05373-J","volume":"493","author":"Alberto R.","year":"1995","journal-title":"J. Organomet. Chem."},{"key":"bc060234tb00022\/bc060234tb00022_1","author":"Alberto R.","year":"1996","journal-title":"J. Chem. Soc. Chem. Commun. 1291\u22121292."},{"key":"bc060234tb00023\/bc060234tb00023_1","doi-asserted-by":"crossref","DOI":"10.1016\/0020-1693(96)05014-1","volume":"248","author":"Abram U.","year":"1996","journal-title":"Inorg. Chim. Acta"},{"key":"bc060234tb00024\/bc060234tb00024_1","doi-asserted-by":"crossref","unstructured":"Pietzsch, H. J., Gupta, A., Reisgys, M., Drews, A., Seifert, S., Syhre, R., Spies, H., Alberto, R., Abram, U., Schubiger, P. A., and Johannsen, B. (2000) Chemical and biological characterization of technetium(I) and rhenium(I) tricarbonyl complexes with dithioether ligands serving as linkers for coupling the Tc(CO)3and Re(CO)3moieties to biologically active molecules.Bioconjugate Chem.11, 414\u2212424.","DOI":"10.1021\/bc990162o"},{"key":"bc060234tb00025\/bc060234tb00025_1","volume-title":"vitro and in vivo evaluation of bidentate, water-soluble phosphine ligands as anchor groups for the organometallic fac-[99mTc(CO)3]+-core. Nucl. Med. Biol. 26, 711\u2212716","author":"Schibli R.","year":"1999"},{"key":"bc060234tb00026\/bc060234tb00026_1","doi-asserted-by":"crossref","unstructured":"Schibli, R., Katti, K. V., Volkert, W. A., and Barnes, C. L. (1998) Novel coordination behavior of fac-[ReBr3(CO)3]2-with 1,3,5-triaza-7-phosphaadamantane (PTA). Systematic investigation on stepwise replacement of the halides by PTA ligand. Phase transfer studies and X-ray crystal structure of [NEt4][ReBr2(PTA)(CO)3], [ReBr(PTA)2(CO)3], and [Re(PTA)3(CO)3]PF6.Inorg. Chem.37, 5306\u22125312.","DOI":"10.1021\/ic980373p"},{"key":"bc060234tb00027\/bc060234tb00027_1","unstructured":"Pietzsch, H. J., Reisgys, M., Alberto, R., Hoepping, A., Scheunemann, M., Seifert, S., Wust, F., Spies, H., Schubiger, P. A., and Johannsen, B. (1999) Thioether ligands as anchor groups for coupling the \u201cTc(CO)3\u201d and \u201cRe(CO)3\u201d moieties with biologically active molecules.Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine(Nicolini, M., and Ulderico, M., Eds.) pp 313\u2212316, SGE, Italy."},{"key":"bc060234tb00028\/bc060234tb00028_1","unstructured":"Egli, A., Alberto, R., Tannahill, L., Schibli, R., Abram, U., Schaffland, A., Tourwe, D., and Schubiger, P. A. (1999) [99mTc(OH2)3(CO)3]+labels peptide to an unprecedented high specific activity. A labelling study with amino acids and neurotensin.Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine(Nicolini, M., and Ulderico, M., Eds.) pp 507\u2212512, SGE, Italy."},{"key":"bc060234tb00029\/bc060234tb00029_1","volume-title":"vitro and in vivo evaluation of a 99mTc(I)-labeled bombesin analogue for imaging of gastrin releasing peptide receptor-positive tumors. Nucl. Med. Biol. 29, 553\u2212560","author":"La Bella R.","year":"2002"},{"key":"bc060234tb00030\/bc060234tb00030_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1524\/ract.1997.79.2.99","volume":"79","author":"Alberto R.","year":"1997","journal-title":"Radiochim. Acta"},{"key":"bc060234tb00031\/bc060234tb00031_1","doi-asserted-by":"crossref","unstructured":"Schibli, R., La Bella, R., Alberto, R., Garcia-Garayoa, E., Ortner, K., Abram, U., and Schubiger, P. A. (2000) Influence of the denticity of ligand systems on the in vitro and in vivo behavior of99mTc(I)-tricarbonyl complexes:\u2009 A hint for the future functionalization of biomolecules.Bioconjugate Chem.11, 345\u2212351.","DOI":"10.1021\/bc990127h"},{"key":"bc060234tb00032\/bc060234tb00032_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja990765a","volume":"121","author":"Alberto R.","year":"1999","journal-title":"J. Am. Chem. Soc."},{"key":"bc060234tb00033\/bc060234tb00033_1","doi-asserted-by":"crossref","DOI":"10.1021\/ja980745t","volume":"120","author":"Alberto R.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"bc060234tb00034\/bc060234tb00034_1","volume-title":"From [TcO4]- to an organometallic aqua-ion:\u2009 Synthesis and chemistry of [99mTc(OH2)3(CO)3]+. Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine","author":"Alberto R.","year":"1999"},{"key":"bc060234tb00035\/bc060234tb00035_1","volume":"24","author":"Alves S.","year":"2002","journal-title":"J. Chem. Soc., Dalton Trans."},{"key":"bc060234tb00036\/bc060234tb00036_1","volume-title":"New building blocks for labeling peptides with the [99mTc(CO)3]+ core. Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine 6","author":"Alves S.","year":"2002"},{"key":"bc060234tb00037\/bc060234tb00037_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jorganchem.2004.09.033","volume":"689","author":"Vitor R. F.","year":"2004","journal-title":"J. Organomet. Chem."},{"key":"bc060234tb00038\/bc060234tb00038_1","volume-title":"Re):\u2009 Synthesis, characterization and biological behaviour. Bioconjugate Chem. 16, 438\u2212449.","author":"Alves S.","year":"2005"},{"key":"bc060234tb00039\/bc060234tb00039_1","volume-title":"Pyrazolyl conjugates of bombesin:\u2009 A new tridentate ligand framework for stabilization of the fac-MI(CO)3 moiety. Nucl. Med. Biol. 33, 625\u2212634","author":"Alves S.","year":"2006"},{"key":"bc060234tb00040\/bc060234tb00040_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0021-9258(18)55029-8","volume":"266","author":"Orlando R. A.","year":"1991","journal-title":"J. Biol. Chem."},{"key":"bc060234tb00041\/bc060234tb00041_1","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.10265","volume":"98","author":"Taga T.","year":"2002","journal-title":"Int. J. Cancer"},{"key":"bc060234tb00042\/bc060234tb00042_1","volume-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248\u2212254","author":"Bradford M. M.","year":"1976"},{"key":"bc060234tb00043\/bc060234tb00043_1","volume-title":"Comparison of a monomeric and dimeric radiolabeled RGD-peptide for tumor targeting. Cancer Biother. Radiopharm. 17, 641\u2212646","author":"Janssen M. L.","year":"2002"},{"key":"bc060234tb00044\/bc060234tb00044_1","volume":"45","author":"Poethko T.","year":"2004","journal-title":"J. Nucl. Med."},{"key":"bc060234tb00045\/bc060234tb00045_1","first-page":"32","volume":"43","author":"Haubner R.","year":"2004","journal-title":"Nuklearmedizin"},{"key":"bc060234tb00046\/bc060234tb00046_1","volume-title":"vitro cell studies of technetium-99m labeled RGD-HYNIC peptide, a comparison of tricine and EDDA as co-ligands. Nucl. Med. Biol. 30, 141\u2212149","author":"Su Z. F.","year":"2003"},{"key":"bc060234tb00047\/bc060234tb00047_1","volume-title":"Study of the labeling of two novel RGD-peptidic derivatives with the precursor [99mTc(H2O)3(CO)3]+ and evaluation for early angiogenesis detection in cancer. Appl. Radiat. Isotopes 64, 151\u2212159","author":"Psimadas D.","year":"2006"},{"key":"bc060234tb00048\/bc060234tb00048_1","volume-title":"Comparative evaluation of linear and cyclic 99mTc-RGD peptides for targeting on integrins in tumor angiogenesis. Anticancer Res. 26, 431\u2212434","author":"Fani M.","year":"2006"},{"key":"bc060234tb00049\/bc060234tb00049_1","volume":"46","author":"Line B. R.","year":"2006","journal-title":"J. Nucl. Med."},{"key":"bc060234tb00050\/bc060234tb00050_1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.nucmedbio.2005.09.005","volume":"33","author":"Mitra A.","year":"2006","journal-title":"Nucl. Med. Biol."},{"key":"bc060234tb00051\/bc060234tb00051_1","volume-title":"Tumor targeting with radiolabeled avb3 integrin binding peptides in a nude mouse model. Cancer Res. 36, 6146\u22126151","author":"Janssen M. L.","year":"2002"}],"container-title":["Bioconjugate Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bc060234t","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T22:28:19Z","timestamp":1632090499000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bc060234t"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,13]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,3,1]]}},"alternative-id":["10.1021\/bc060234t"],"URL":"https:\/\/doi.org\/10.1021\/bc060234t","relation":{},"ISSN":["1043-1802","1520-4812"],"issn-type":[{"value":"1043-1802","type":"print"},{"value":"1520-4812","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,13]]}}}