{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:35:09Z","timestamp":1760852109103},"reference-count":44,"publisher":"American Chemical Society (ACS)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemistry"],"published-print":{"date-parts":[[2005,3,1]]},"DOI":"10.1021\/bi048417v","type":"journal-article","created":{"date-parts":[[2005,2,22]],"date-time":"2005-02-22T05:24:55Z","timestamp":1109049895000},"page":"2781-2789","source":"Crossref","is-referenced-by-count":10,"title":["Probing the Cruzain S<sub>2<\/sub> Recognition Subsite:\u2009 A Kinetic and Binding Energy Calculation Study"],"prefix":"10.1021","volume":"44","author":[{"given":"Fabio","family":"Polticelli","sequence":"first","affiliation":[{"name":"Dipartimento di Biologia and Laboratorio Interdipartimentale per la Microscopia Elettronica, Viale Guglielmo Marconi 446, I-00146 Roma, Italy, Laboratorio di Parassitologia, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, I-00161 Rome, Italy, and Istituto Nazionale per le Malattie Infettive I.R.C.C.S. \u201cLazzaro Spallanzani\u201d, Via Portuense 292, I-00149 Roma, Italy"}]},{"given":"Germano","family":"Zaini","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia and Laboratorio Interdipartimentale per la Microscopia Elettronica, Viale Guglielmo Marconi 446, I-00146 Roma, Italy, Laboratorio di Parassitologia, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, I-00161 Rome, Italy, and Istituto Nazionale per le Malattie Infettive I.R.C.C.S. \u201cLazzaro Spallanzani\u201d, Via Portuense 292, I-00149 Roma, Italy"}]},{"given":"Alessandro","family":"Bolli","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia and Laboratorio Interdipartimentale per la Microscopia Elettronica, Viale Guglielmo Marconi 446, I-00146 Roma, Italy, Laboratorio di Parassitologia, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, I-00161 Rome, Italy, and Istituto Nazionale per le Malattie Infettive I.R.C.C.S. \u201cLazzaro Spallanzani\u201d, Via Portuense 292, I-00149 Roma, Italy"}]},{"given":"Giovanni","family":"Antonini","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia and Laboratorio Interdipartimentale per la Microscopia Elettronica, Viale Guglielmo Marconi 446, I-00146 Roma, Italy, Laboratorio di Parassitologia, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, I-00161 Rome, Italy, and Istituto Nazionale per le Malattie Infettive I.R.C.C.S. \u201cLazzaro Spallanzani\u201d, Via Portuense 292, I-00149 Roma, Italy"}]},{"given":"Luigi","family":"Gradoni","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia and Laboratorio Interdipartimentale per la Microscopia Elettronica, Viale Guglielmo Marconi 446, I-00146 Roma, Italy, Laboratorio di Parassitologia, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, I-00161 Rome, Italy, and Istituto Nazionale per le Malattie Infettive I.R.C.C.S. \u201cLazzaro Spallanzani\u201d, Via Portuense 292, I-00149 Roma, Italy"}]},{"given":"Paolo","family":"Ascenzi","sequence":"additional","affiliation":[{"name":"Dipartimento di Biologia and Laboratorio Interdipartimentale per la Microscopia Elettronica, Viale Guglielmo Marconi 446, I-00146 Roma, Italy, Laboratorio di Parassitologia, Istituto Superiore di Sanit\u00e0, Viale Regina Elena 299, I-00161 Rome, Italy, and Istituto Nazionale per le Malattie Infettive I.R.C.C.S. \u201cLazzaro Spallanzani\u201d, Via Portuense 292, I-00149 Roma, Italy"}]}],"member":"316","published-online":{"date-parts":[[2005,2,5]]},"reference":[{"key":"bi048417vb00001\/bi048417vb00001_1","volume-title":"Protozoal Diseases","author":"Gilles H. M.","year":"1999"},{"key":"bi048417vb00002\/bi048417vb00002_1","volume-title":"Parasitol. Today 11, 279\u2212282.","author":"McKerrow J. H.","year":"1995"},{"key":"bi048417vb00003\/bi048417vb00003_1","first-page":"10","volume":"378","author":"Cazzulo J. J.","year":"1997","journal-title":"Biol. Chem."},{"key":"bi048417vb00004\/bi048417vb00004_1","volume-title":"Chem. 7, 639\u2212644.","author":"McKerrow J. H.","year":"1999"},{"key":"bi048417vb00005\/bi048417vb00005_1","doi-asserted-by":"crossref","DOI":"10.1016\/S0020-7519(99)00044-2","volume":"29","author":"McKerrow J. H.","year":"1999","journal-title":"Int. J. Parasitol."},{"key":"bi048417vb00006\/bi048417vb00006_1","volume-title":"Curr. Protein Pept. Sci. 2, 137\u2212153.","author":"Ascenzi P.","year":"2001"},{"key":"bi048417vb00007\/bi048417vb00007_1","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S1471-4922(01)02191-2","volume":"17","author":"Colasanti M.","year":"2001","journal-title":"Trends Parasitol."},{"key":"bi048417vb00008\/bi048417vb00008_1","volume-title":"Chem. 2, 1261\u22121271.","author":"Cazzulo J. J.","year":"2002"},{"key":"bi048417vb00009\/bi048417vb00009_1","volume-title":"Handbook of Proteolytic Enzymes","author":"Barrett A. J.","year":"2004","edition":"2"},{"key":"bi048417vb00010\/bi048417vb00010_1","doi-asserted-by":"crossref","DOI":"10.1111\/j.1432-1033.1992.tb16654.x","volume":"204","author":"Bode W.","year":"1992","journal-title":"Eur. J. Biochem."},{"key":"bi048417vb00011\/bi048417vb00011_1","volume-title":"Protein Sci. 4, 337\u2212360.","author":"Perona J. J.","year":"1995"},{"key":"bi048417vb00012\/bi048417vb00012_1","volume-title":"Protein Sci. 8, 2621\u22122629.","author":"Polticelli F.","year":"1999"},{"key":"bi048417vb00013\/bi048417vb00013_1","volume-title":"Curr. Protein Pept. Sci. 4, 231\u2212251.","author":"Ascenzi P.","year":"2003"},{"key":"bi048417vb00014\/bi048417vb00014_1","volume-title":"Protein Sci. 6, 1603\u22121611.","author":"Gillmor S. A.","year":"1997"},{"key":"bi048417vb00015\/bi048417vb00015_1","doi-asserted-by":"crossref","DOI":"10.1006\/jmbi.1994.0137","volume":"247","author":"McGrath M. E.","year":"1995","journal-title":"J. Mol. Biol."},{"key":"bi048417vb00016\/bi048417vb00016_1","volume-title":"Struct. Fold Des. 8, 831\u2212840.","author":"Brinen L. S.","year":"2000"},{"key":"bi048417vb00017\/bi048417vb00017_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj2500761","volume":"250","author":"Brocklehurst K.","year":"1988","journal-title":"Biochem. J."},{"key":"bi048417vb00018\/bi048417vb00018_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj2870881","volume":"287","author":"Patel M.","year":"1992","journal-title":"Biochem. J."},{"key":"bi048417vb00019\/bi048417vb00019_1","doi-asserted-by":"crossref","DOI":"10.1042\/bj3470123","volume":"347","author":"Portaro F. C.","year":"2000","journal-title":"Biochem. J."},{"key":"bi048417vb00020\/bi048417vb00020_1","first-page":"29","volume":"11","author":"Huang L.","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"bi048417vb00021\/bi048417vb00021_1","volume-title":"Biochem. Biophys. Res. Commun. 309, 659\u2212665.","author":"Ascenzi P.","year":"2003"},{"key":"bi048417vb00022\/bi048417vb00022_1","doi-asserted-by":"crossref","DOI":"10.1111\/j.1432-1033.1971.tb19691.x","volume":"24","author":"Hollaway M. R.","year":"1971","journal-title":"Eur. J. Biochem."},{"key":"bi048417vb00023\/bi048417vb00023_1","doi-asserted-by":"crossref","DOI":"10.1016\/0167-4838(87)90090-2","volume":"912","author":"Ascenzi P.","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"bi048417vb00024\/bi048417vb00024_1","doi-asserted-by":"crossref","DOI":"10.1046\/j.1432-1327.2001.02223.x","volume":"268","author":"Salvati L.","year":"2001","journal-title":"Eur. J. Biochem."},{"key":"bi048417vb00025\/bi048417vb00025_1","volume-title":"Comput. Appl. Biosci. 9, 563\u2212571.","author":"Mendes P.","year":"1993"},{"key":"bi048417vb00026\/bi048417vb00026_1","volume-title":"Trends Biochem. Sci. 22, 361\u2212363.","author":"Mendes P.","year":"1997"},{"key":"bi048417vb00027\/bi048417vb00027_1","volume-title":"Bioinformatics 14, 869\u2212883.","author":"Mendes P.","year":"1998"},{"key":"bi048417vb00028\/bi048417vb00028_1","doi-asserted-by":"crossref","DOI":"10.1002\/jcc.540040211","volume":"4","author":"Brooks B. R.","year":"1983","journal-title":"J. Comput. Chem."},{"key":"bi048417vb00029\/bi048417vb00029_1","first-page":"A143","volume":"61","author":"MacKerell A. D.","year":"1992","journal-title":"Biophys. J."},{"key":"bi048417vb00030\/bi048417vb00030_1","first-page":"29","volume":"11","author":"Huang L.","year":"2003","journal-title":"Bioorg. Med. Chem."},{"key":"bi048417vb00031\/bi048417vb00031_1","volume-title":"Protein Sci. 6, 1293\u22121301.","author":"Froloff N.","year":"1997"},{"key":"bi048417vb00032\/bi048417vb00032_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/prot.340040104","volume":"4","author":"Gilson M. K.","year":"1988","journal-title":"Proteins"},{"key":"bi048417vb00033\/bi048417vb00033_1","volume-title":"Proteins 18, 119\u2212132.","author":"Smith K. C.","year":"1994"},{"key":"bi048417vb00034\/bi048417vb00034_1","volume-title":"Proteins 11, 281\u2212296.","author":"Nicholls A.","year":"1991"},{"key":"bi048417vb00035\/bi048417vb00035_1","doi-asserted-by":"crossref","DOI":"10.1021\/j100058a043","volume":"98","author":"Sitkoff D.","year":"1994","journal-title":"J. Phys. Chem."},{"key":"bi048417vb00036\/bi048417vb00036_1","volume-title":"Science 252, 106\u2212109.","author":"Sharp K. A.","year":"1991"},{"key":"bi048417vb00037\/bi048417vb00037_1","first-page":"A174","volume":"61","author":"Sridharan S.","year":"1992","journal-title":"Biophys. J."},{"key":"bi048417vb00038\/bi048417vb00038_1","doi-asserted-by":"crossref","DOI":"10.1006\/jmbi.1997.0961","volume":"268","author":"Novotny J.","year":"1997","journal-title":"J. Mol. Biol."},{"key":"bi048417vb00039\/bi048417vb00039_1","doi-asserted-by":"crossref","DOI":"10.1006\/jmbi.1993.1329","volume":"231","author":"Pickett S. P.","year":"1993","journal-title":"J. Mol. Biol."},{"key":"bi048417vb00040\/bi048417vb00040_1","doi-asserted-by":"crossref","DOI":"10.1111\/j.1432-1033.1973.tb02639.x","volume":"32","author":"Hollaway M. R.","year":"1973","journal-title":"Eur. J. Biochem."},{"key":"bi048417vb00041\/bi048417vb00041_1","volume-title":"Mol. Biochem. Parasitol. 117, 137\u2212143.","author":"Alves L. C.","year":"2001"},{"key":"bi048417vb00042\/bi048417vb00042_1","volume-title":"Science 301, 1230\u22121233.","author":"Shao F.","year":"2003"},{"key":"bi048417vb00043\/bi048417vb00043_1","volume-title":"Proc. Natl. Acad. Sci. U.S.A. 101","author":"Zhu M.","year":"2004"},{"key":"bi048417vn00001\/bi048417vn00001_1","volume-title":"N-\u03b1-benzyloxycarbonyl-l-arginyl-l-alanine fluoromethyl-ketone","author":"Abbreviations AMC"}],"container-title":["Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bi048417v","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T17:46:29Z","timestamp":1632073589000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bi048417v"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,5]]},"references-count":44,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,3,1]]}},"alternative-id":["10.1021\/bi048417v"],"URL":"https:\/\/doi.org\/10.1021\/bi048417v","relation":{},"ISSN":["0006-2960","1520-4995"],"issn-type":[{"value":"0006-2960","type":"print"},{"value":"1520-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,5]]}}}