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E.","year":"2007","journal-title":"J. Mol. Biol."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/84152","volume":"8","author":"Wu C. K.","year":"2001","journal-title":"Nat. Struct. Biol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"13499","DOI":"10.1021\/bi0260785","volume":"41","author":"Karlberg T.","year":"2002","journal-title":"Biochemistry"},{"key":"ref22\/cit22","author":"Davidson R. E.","journal-title":"J. Biol. Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"23685","DOI":"10.1074\/jbc.M803372200","volume":"283","author":"Hunter G. A.","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.tibs.2006.01.001","volume":"31","author":"Al-Karadaghi S.","year":"2006","journal-title":"Trends Biochem. 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Biochem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"7766","DOI":"10.1021\/j100019a065","volume":"99","author":"Sato S.","year":"1995","journal-title":"J. Phys. Chem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/BF01081064","volume":"59","author":"Sato S.","year":"1994","journal-title":"Appl. Phys. B: Laser Opt."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1021\/ja00380a005","volume":"104","author":"Choi S.","year":"1982","journal-title":"J. Am. Chem. Soc."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"12446","DOI":"10.1021\/ja00079a028","volume":"115","author":"Hu S.","year":"1993","journal-title":"J. Am. Chem. Soc."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"12638","DOI":"10.1021\/ja962239e","volume":"118","author":"Hu S.","year":"1996","journal-title":"J. Am. Chem. 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