{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:28:18Z","timestamp":1773275298026,"version":"3.50.1"},"reference-count":60,"publisher":"American Chemical Society (ACS)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomacromolecules"],"published-print":{"date-parts":[[2013,5,13]]},"DOI":"10.1021\/bm400015b","type":"journal-article","created":{"date-parts":[[2013,3,20]],"date-time":"2013-03-20T20:17:34Z","timestamp":1363810654000},"page":"1379-1387","source":"Crossref","is-referenced-by-count":17,"title":["Nonviral Gene Delivery to Neural Stem Cells with Minicircles by Microporation"],"prefix":"10.1021","volume":"14","author":[{"given":"Catarina","family":"Madeira","sequence":"first","affiliation":[{"name":"Department of Bioengineering and Institute for Biotechnology and Bioengineering (IBB), Instituto Superior T\u00e9cnico, Technical University of Lisboa, Av. Rovisco Pais, 1049-001, Lisboa, Portugal"}]},{"given":"Carlos A. V.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Institute for Biotechnology and Bioengineering (IBB), Instituto Superior T\u00e9cnico, Technical University of Lisboa, Av. Rovisco Pais, 1049-001, Lisboa, Portugal"}]},{"given":"M\u00f3nica S. C.","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Institute for Biotechnology and Bioengineering (IBB), Instituto Superior T\u00e9cnico, Technical University of Lisboa, Av. Rovisco Pais, 1049-001, Lisboa, Portugal"}]},{"given":"Filipa F. C. G.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Institute for Biotechnology and Bioengineering (IBB), Instituto Superior T\u00e9cnico, Technical University of Lisboa, Av. Rovisco Pais, 1049-001, Lisboa, Portugal"}]},{"given":"Raquel E. S. M.","family":"Correia","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Institute for Biotechnology and Bioengineering (IBB), Instituto Superior T\u00e9cnico, Technical University of Lisboa, Av. Rovisco Pais, 1049-001, Lisboa, Portugal"}]},{"given":"Maria M.","family":"Diogo","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Institute for Biotechnology and Bioengineering (IBB), Instituto Superior T\u00e9cnico, Technical University of Lisboa, Av. Rovisco Pais, 1049-001, Lisboa, Portugal"}]},{"given":"Joaquim M. S.","family":"Cabral","sequence":"additional","affiliation":[{"name":"Department of Bioengineering and Institute for Biotechnology and Bioengineering (IBB), Instituto Superior T\u00e9cnico, Technical University of Lisboa, Av. Rovisco Pais, 1049-001, Lisboa, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2013,4,2]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nrn2761","volume":"11","author":"Conti L.","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1371\/journal.pbio.0030283","volume":"3","author":"Conti L.","year":"2005","journal-title":"Plos Biol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2174\/156720509790147151","volume":"6","author":"Taupin P.","year":"2009","journal-title":"Curr. Alzheimer Res."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s12015-010-9154-1","volume":"7","author":"Kim S. U.","year":"2011","journal-title":"Stem Cell Rev. Rep."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1021\/bm1010323","volume":"11","author":"Yucel D.","year":"2010","journal-title":"Biomacromolecules"},{"key":"ref6\/cit6","first-page":"1457","volume":"6","author":"Zhang S.","year":"2011","journal-title":"Neural Reg. Res."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1042\/CBI20110028","volume":"35","author":"Tan X. F.","year":"2011","journal-title":"Cell Biol. Int."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"3186","DOI":"10.1002\/jnr.22149","volume":"87","author":"Lee S. I.","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/jgm.584","volume":"6","author":"Tinsley R. B.","year":"2004","journal-title":"J. Gene Med."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1002\/jgm.823","volume":"8","author":"Tinsley R. B.","year":"2006","journal-title":"J. Gene Med."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2144\/000113628","volume":"50","author":"Sapet C.","year":"2011","journal-title":"Biotechniques"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1016\/j.biomaterials.2010.12.007","volume":"32","author":"Pickard M. R.","year":"2011","journal-title":"Biomaterials"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1089\/cell.2011.0093","volume":"14","author":"Ribeiro S.","year":"2012","journal-title":"Cell. Reprogr."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1089\/ten.tea.2009.0155","volume":"15","author":"Dhara S. K.","year":"2009","journal-title":"Tissue Eng., A"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1634\/stemcells.2006-0176","volume":"24","author":"Cesnulevicius K.","year":"2006","journal-title":"Stem Cells"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jneumeth.2012.06.024","volume":"209","author":"Bertram B.","year":"2012","journal-title":"J. Neurosci. Meth."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1472-6750-10-38","volume":"10","author":"Lim J. Y.","year":"2010","journal-title":"BMC Biotechnol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jbiotec.2010.11.002","volume":"151","author":"Madeira C.","year":"2011","journal-title":"J. Biotechnol."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"671","DOI":"10.2174\/156652306779010688","volume":"6","author":"Vaughan E. E.","year":"2006","journal-title":"Curr. Gene Ther."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/jps.10286","volume":"92","author":"Wiethoff C. M.","year":"2003","journal-title":"J. Pharm. Sci."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1007\/s11095-010-0364-7","volume":"28","author":"Perez-Martinez F. C.","year":"2011","journal-title":"Pharm. Res."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/jgm.1031","volume":"9","author":"Azzoni A. R.","year":"2007","journal-title":"J. Gene Med."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1038\/mt.2011.182","volume":"19","author":"Vandermeulen G.","year":"2011","journal-title":"Mol. Ther."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/s00109-010-0713-3","volume":"89","author":"Argyros O.","year":"2011","journal-title":"J. Mol. Med."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/978-1-59745-561-9_4","volume":"542","author":"Mayrhofer P.","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1038\/sj.gt.3300540","volume":"4","author":"Darquet A. M.","year":"1997","journal-title":"Gene Ther."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jconrel.2010.01.003","volume":"143","author":"Lesina E.","year":"2010","journal-title":"J. Controlled Release"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.addr.2010.03.006","volume":"62","author":"Nishikawa M.","year":"2010","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nbt1399","volume":"26","author":"Hyde S. C.","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1089\/hum.2009.212","volume":"22","author":"Schuttrumpf J.","year":"2011","journal-title":"Hum. Gene Ther."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/jgm.2618","volume":"14","author":"Kwon M. J.","year":"2012","journal-title":"J. Gene Med."},{"key":"ref32\/cit32","first-page":"S230","volume":"120","author":"Huang M.","year":"2009","journal-title":"Circulation"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/cgt.2011.72","volume":"19","author":"Xu B. L.","year":"2012","journal-title":"Cancer Gene Ther."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nmeth.1426","volume":"7","author":"Jia F. J.","year":"2010","journal-title":"Nat. Methods"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0065-2776(08)60790-7","volume":"73","author":"Wagner H.","year":"1999","journal-title":"Adv. Immunol."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ymthe.2004.04.018","volume":"10","author":"Hodges B. L.","year":"2004","journal-title":"Mol. Ther."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S1525-0016(03)00168-0","volume":"8","author":"Chen Z. Y.","year":"2003","journal-title":"Mol. Ther."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/gt.2011.215","volume":"20","author":"Chabot S.","year":"2013","journal-title":"Gene Ther."},{"key":"ref39\/cit39","first-page":"1490","volume":"20","author":"Madeira C.","year":"2009","journal-title":"Hum. Gene Ther."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.nbd.2009.02.007","volume":"34","author":"Spiliotopoulos D.","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1039\/b819201d","volume":"1","author":"Lee W. G.","year":"2009","journal-title":"Integr. Biol."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1093\/nar\/gnh176","volume":"32","author":"Yamauchi F.","year":"2004","journal-title":"Nucleic Acid Res."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/j.bios.2007.12.009","volume":"23","author":"Kim J. A.","year":"2008","journal-title":"Biosens. Bioelectron."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.jconrel.2008.12.016","volume":"135","author":"Cohen R. N.","year":"2009","journal-title":"J. Controlled Release"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","volume":"408","author":"Hemmi H.","year":"2000","journal-title":"Nature"},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S1074-7613(01)00144-3","volume":"14","author":"Wagner H.","year":"2001","journal-title":"Immunity"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.neuron.2009.08.038","volume":"64","author":"Carpentier P. A.","year":"2009","journal-title":"Neuron"},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1007\/s00018-010-0347-1","volume":"67","author":"Stock K.","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005586"},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1002\/btpr.451","volume":"26","author":"Ribeiro S. C.","year":"2010","journal-title":"Biotechnol. Prog."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/gt.2010.31","volume":"17","author":"Lam A. P.","year":"2010","journal-title":"Gene Ther."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/jgm.1406","volume":"12","author":"Glover D. J.","year":"2010","journal-title":"J. Gene Med."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1089\/hum.1995.6.5-565","volume":"6","author":"Horn N. A.","year":"1995","journal-title":"Hum. Gene Ther."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jgm.218","volume":"3","author":"Diogo M. M.","year":"2001","journal-title":"J. Gene Med."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/jgm.1272","volume":"11","author":"Sousa F.","year":"2009","journal-title":"J. Gene Med."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.ygeno.2007.02.006","volume":"89","author":"McLenachan S.","year":"2007","journal-title":"Genomics"},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1038\/sj.gt.3302231","volume":"11","author":"Chen Z. Y.","year":"2004","journal-title":"Gene Ther."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1089\/10430349950019011","volume":"10","author":"Yew N. S.","year":"1999","journal-title":"Hum. Gene Ther."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1006\/mthe.2002.0598","volume":"5","author":"Yew N. S.","year":"2002","journal-title":"Mol. Ther."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1006\/mthe.2000.0036","volume":"1","author":"Yew N. S.","year":"2000","journal-title":"Mol. Ther."}],"container-title":["Biomacromolecules"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/bm400015b","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,23]],"date-time":"2023-04-23T00:38:42Z","timestamp":1682210322000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/bm400015b"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,2]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5,13]]}},"alternative-id":["10.1021\/bm400015b"],"URL":"https:\/\/doi.org\/10.1021\/bm400015b","relation":{},"ISSN":["1525-7797","1526-4602"],"issn-type":[{"value":"1525-7797","type":"print"},{"value":"1526-4602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,2]]}}}