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F.","year":"2009","journal-title":"Mol. Neurodegener."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0962-8924(98)01363-4","volume":"8","author":"Selkoe D. J.","year":"1998","journal-title":"Trends Cell Biol."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1017\/S1092852900014164","volume":"10","author":"Francis P. T.","year":"2005","journal-title":"CNS Spectrums"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1002\/jnr.490270419","volume":"27","author":"Reinikainen K. J.","year":"1990","journal-title":"J. Neurosci. Res."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.neurobiolaging.2005.09.012","volume":"27","author":"Scheff S. W.","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"e12853","DOI":"10.1371\/journal.pone.0012853","volume":"5","author":"Desikan R. S.","year":"2010","journal-title":"PloS One"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ng0993-95","volume":"5","author":"Wasco W.","year":"1993","journal-title":"Nat. Genet."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0197-0186(99)00125-4","volume":"36","author":"Coulson E. J.","year":"2000","journal-title":"Neurochem. Int."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1038\/sj.mp.4000552","volume":"4","author":"Bayer T. A.","year":"1999","journal-title":"Mol. Psychiatry"},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/nm0997-1016","volume":"3","author":"Hartmann T.","year":"1997","journal-title":"Nat. Med."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1073\/pnas.96.2.742","volume":"96","author":"Greenfield J. P.","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1073\/pnas.89.13.6075","volume":"89","author":"Sisodia S. S.","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0021-9258(18)54194-6","volume":"268","author":"Nordstedt C.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1523\/JNEUROSCI.14-05-03122.1994","volume":"14","author":"Caporaso G. L.","year":"1994","journal-title":"J. Neurosci."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.286.5440.735","volume":"286","author":"Vassar R.","year":"1999","journal-title":"Science"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/990107","volume":"402","author":"Yan R.","year":"1999","journal-title":"Nature"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/85064","volume":"4","author":"Cai H.","year":"2001","journal-title":"Nat. Neurosci."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/85059","volume":"4","author":"Luo Y.","year":"2001","journal-title":"Nat. Neurosci."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/hmg\/10.12.1317","volume":"10","author":"Roberds S. L.","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1074\/jbc.M309219200","volume":"279","author":"Kao S. C.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0896-6273(03)00810-9","volume":"41","author":"Ohno M.","year":"2004","journal-title":"Neuron"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/nm0103-3","volume":"9","author":"Yang L. B.","year":"2003","journal-title":"Nat. Med."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1042\/BST0331096","volume":"33","author":"Johnston J. A.","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1471-4159.2006.04260.x","volume":"100","author":"Hussain I.","year":"2007","journal-title":"J. Neurochem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1126\/science.1132341","volume":"314","author":"Willem M.","year":"2006","journal-title":"Science"},{"key":"ref27\/cit27","first-page":"21","volume":"7","author":"Fox N.","year":"1996","journal-title":"Rev. Neurosci."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbadis.2004.06.015","volume":"1739","author":"Hyman B. T.","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3233\/JAD-2003-5201","volume":"5","author":"Garcia-Sierra F.","year":"2003","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1073\/pnas.94.1.298","volume":"94","author":"Alonso A. D.","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1083\/jcb.143.3.777","volume":"143","author":"Ebneth A.","year":"1998","journal-title":"J. Cell Biol."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.neurobiolaging.2013.03.015","volume":"34","author":"Rodriguez-Martin T.","year":"2013","journal-title":"Neurobiol. Aging"},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1385\/JMN:23:1-2:123","volume":"23","author":"da Cruz e Silva O. A.","year":"2004","journal-title":"J. Mol. Neurosci."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/j.1365-2443.2006.00968.x","volume":"11","author":"Nakaya T.","year":"2006","journal-title":"Genes Cells"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1083\/jcb.200301115","volume":"163","author":"Lee M. S.","year":"2003","journal-title":"J. Cell Biol."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1023\/A:1025630627319","volume":"28","author":"da Cruz e Silva E. F.","year":"2003","journal-title":"Neurochem. Res."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000101831","volume":"4","author":"Rebelo S.","year":"2007","journal-title":"Neurodegener. Dis."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1046\/j.1471-4159.2000.0751085.x","volume":"75","author":"Iijima K.","year":"2000","journal-title":"J. Neurochem."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1046\/j.1471-4159.1996.67020699.x","volume":"67","author":"Aplin A. E.","year":"1996","journal-title":"J. Neurochem."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0014-5793(03)00714-2","volume":"547","author":"Liu F.","year":"2003","journal-title":"FEBS Lett."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1046\/j.1471-4159.2001.00102.x","volume":"76","author":"Standen C. L.","year":"2001","journal-title":"J. Neurochem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"20070","DOI":"10.1074\/jbc.M108372200","volume":"277","author":"Taru H.","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1523\/JNEUROSCI.3316-06.2007","volume":"27","author":"Sontag E.","year":"2007","journal-title":"J. Neurosci."},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.arr.2012.06.003","volume":"12","author":"Martin L.","year":"2013","journal-title":"Ageing Res. reviews"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0165-0173(00)00019-9","volume":"33","author":"Buee L.","year":"2000","journal-title":"Brain Res. Rev."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.2174\/092986708785909111","volume":"15","author":"Gong C. X.","year":"2008","journal-title":"Curr. Med. Chem."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1152\/physrev.00024.2003","volume":"84","author":"Avila J.","year":"2004","journal-title":"Physiol. Rev."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"24374","DOI":"10.1016\/S0021-9258(20)80536-5","volume":"268","author":"Kopke E.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1749-6632.2002.tb02089.x","volume":"959","author":"Galli R. L.","year":"2002","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1093\/jn\/136.4.1043","volume":"136","author":"Haque A. M.","year":"2006","journal-title":"J. Nutr."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/ajcn\/83.2.355","volume":"83","author":"Kuriyama S.","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.exger.2004.03.033","volume":"39","author":"Unno K.","year":"2004","journal-title":"Exp. Gerontol."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/sj.bjp.0706720","volume":"148","author":"Wang Y.","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0891-5849(00)00510-4","volume":"30","author":"Youdim K. A.","year":"2001","journal-title":"Free Radical Biol. Med."},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.06.013"},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"3248S","DOI":"10.1093\/jn\/133.10.3248S","volume":"133","author":"Beecher G. R.","year":"2003","journal-title":"J. Nutr."},{"key":"ref57\/cit57","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1021\/np9904509","volume":"63","author":"Pietta P. G.","year":"2000","journal-title":"J. Nat. Prod."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1017\/S0029665110000054","volume":"69","author":"Spencer J. P.","year":"2010","journal-title":"Proc. Nutr. Soc."},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1039\/b800422f","volume":"38","author":"Spencer J. P.","year":"2009","journal-title":"Chem. Soc. Rev."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jnutbio.2012.07.006","volume":"24","author":"Vepsalainen S.","year":"2013","journal-title":"J. Nutr. Biochem."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1124\/jpet.108.140293","volume":"326","author":"Onozuka H.","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"6388","DOI":"10.1523\/JNEUROSCI.0364-08.2008","volume":"28","author":"Wang J.","year":"2008","journal-title":"J. Neurosci."},{"key":"ref63\/cit63","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1582-4934.2008.00344.x","volume":"13","author":"Rezai-Zadeh K.","year":"2009","journal-title":"J. Cell. Mol. Med."},{"key":"ref64\/cit64","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s12640-009-9000-x","volume":"15","author":"Wang Y. J.","year":"2009","journal-title":"Neurotoxic. Res."},{"key":"ref65\/cit65","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.abb.2008.10.032","volume":"481","author":"Augustin S.","year":"2009","journal-title":"Arch. Biochem. Biophys."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","first-page":"6912","DOI":"10.1074\/jbc.M111.294025","volume":"287","author":"Mori T.","year":"2012","journal-title":"J. Biol. Chem."},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.bbagen.2008.01.017","volume":"1780","author":"Shimmyo Y.","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1097\/WNR.0b013e32830b8ae1","volume":"19","author":"Shimmyo Y.","year":"2008","journal-title":"NeuroReport"},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1523\/JNEUROSCI.1521-05.2005","volume":"25","author":"Rezai-Zadeh K.","year":"2005","journal-title":"J. Neurosci."},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.brainres.2008.02.107","volume":"1214","author":"Rezai-Zadeh K.","year":"2008","journal-title":"Brain Res."},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"16419","DOI":"10.1074\/jbc.M600617200","volume":"281","author":"Obregon D. F.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1016\/j.febslet.2010.09.022","volume":"584","author":"Fernandez J. W.","year":"2010","journal-title":"FEBS Lett."},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/nsmb.1437","volume":"15","author":"Ehrnhoefer D. E.","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"ref74\/cit74","doi-asserted-by":"crossref","first-page":"7710","DOI":"10.1073\/pnas.0910723107","volume":"107","author":"Bieschke J.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1021\/bi061540x","volume":"46","author":"Hirohata M.","year":"2007","journal-title":"Biochemistry"},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1046\/j.1471-4159.2003.01976.x","volume":"87","author":"Ono K.","year":"2003","journal-title":"J. Neurochem."},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"7614","DOI":"10.1074\/jbc.M408714200","volume":"280","author":"Taniguchi S.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref78\/cit78","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3233\/JAD-2010-101074","volume":"22","author":"Wang J.","year":"2010","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1111\/j.1471-4159.2010.06875.x","volume":"114","author":"Pasinetti G. M.","year":"2010","journal-title":"J. Neurochem."},{"key":"ref80\/cit80","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3233\/JAD-2009-0969","volume":"16","author":"Ho L.","year":"2009","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.neurobiolaging.2010.11.006","volume":"33","author":"Ksiezak-Reding H.","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref82\/cit82","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12263-007-0056-z","volume":"2","author":"Spencer J. P.","year":"2007","journal-title":"Genes Nutr."},{"key":"ref83\/cit83","doi-asserted-by":"crossref","first-page":"34783","DOI":"10.1074\/jbc.M305063200","volume":"278","author":"Spencer J. P.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref84\/cit84","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/mnfr.200900098","volume":"54","author":"Incani A.","year":"2010","journal-title":"Mol. Nutr. Food Res."},{"key":"ref85\/cit85","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bbrc.2007.07.153","volume":"362","author":"Vauzour D.","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref86\/cit86","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1021\/jm950661k","volume":"39","author":"Ji X. D.","year":"1996","journal-title":"J. Med. Chem."},{"key":"ref87\/cit87","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.neuropharm.2008.06.069","volume":"55","author":"Fernandez S. P.","year":"2008","journal-title":"Neuropharmacology"},{"key":"ref88\/cit88","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejphar.2005.12.024","volume":"531","author":"Adachi N.","year":"2006","journal-title":"Eur. J. Pharmacol."},{"key":"ref89\/cit89","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1476-5381.2011.01228.x","volume":"163","author":"Hanrahan J. R.","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref90\/cit90","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1021\/np070194x","volume":"70","author":"Katavic P. L.","year":"2007","journal-title":"J. Nat. Prod."},{"key":"ref91\/cit91","first-page":"H1604","volume":"299","author":"Panneerselvam M.","year":"2010","journal-title":"A. J. Physiol.: Heart Circ. Physiol."},{"key":"ref92\/cit92","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10059-010-0117-9","volume":"30","author":"Lee B. H.","year":"2010","journal-title":"Mol. Cells"},{"key":"ref93\/cit93","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ejphar.2010.09.079","volume":"650","author":"Lee B. H.","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"ref94\/cit94","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1073\/pnas.0913572107","volume":"107","author":"Jang S. W.","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref95\/cit95","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.yexcr.2005.06.011","volume":"309","author":"Nifli A. P.","year":"2005","journal-title":"Exp. Cell Res."},{"key":"ref96\/cit96","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1124\/jpet.106.102319","volume":"318","author":"Han Y. S.","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref97\/cit97","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/10284150410001710410","volume":"7","author":"Goyarzu F.","year":"2004","journal-title":"Nutr. Neurosci."},{"key":"ref98\/cit98","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0306-3623(98)00220-1","volume":"32","author":"Gamet-Payrastre L.","year":"1999","journal-title":"Gen. Pharmacol."},{"key":"ref99\/cit99","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1042\/bj3580547","volume":"358","author":"Schroeter H.","year":"2001","journal-title":"Biochem. J."},{"key":"ref100\/cit100","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/0006-291X(92)90792-J","volume":"186","author":"Matter W. F.","year":"1992","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref101\/cit101","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/S0006-2952(97)82453-7","volume":"53","author":"Agullo G.","year":"1997","journal-title":"Biochem. Pharmacol."},{"key":"ref102\/cit102","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02976458","volume":"23","author":"Kong A. N. T.","year":"2000","journal-title":"Arch. Pharm. Res."},{"key":"ref103\/cit103","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.freeradbiomed.2004.01.001","volume":"36","author":"Williams R. J.","year":"2004","journal-title":"Free. Radical Biol. Med."},{"key":"ref104\/cit104","doi-asserted-by":"crossref","first-page":"14843","DOI":"10.1074\/jbc.270.25.14843","volume":"270","author":"Cobb M. H.","year":"1995","journal-title":"J. Biol. Chem."},{"key":"ref105\/cit105","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","volume":"75","author":"Cargnello M.","year":"2011","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"ref106\/cit106","doi-asserted-by":"crossref","first-page":"C403","DOI":"10.1152\/ajpcell.1999.277.3.C403","volume":"277","author":"Kobuchi H.","year":"1999","journal-title":"Am. J. Physiol.: Cell Physiol."},{"key":"ref107\/cit107","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1111\/j.1471-4159.2006.04434.x","volume":"101","author":"Schroeter H.","year":"2007","journal-title":"J. Neurochem."},{"key":"ref108\/cit108","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1111\/j.1471-4159.2007.04841.x","volume":"103","author":"Vauzour D.","year":"2007","journal-title":"J. Neurochem."},{"key":"ref109\/cit109","doi-asserted-by":"crossref","first-page":"16568","DOI":"10.1073\/pnas.0607822103","volume":"103","author":"Maher P.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref110\/cit110","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/BF02968247","volume":"29","author":"Gopalakrishnan A.","year":"2006","journal-title":"Arch. Pharm. Res."},{"key":"ref111\/cit111","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0014-5793(01)03252-5","volume":"510","author":"Llorens F.","year":"2002","journal-title":"FEBS Lett."},{"key":"ref112\/cit112","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/S0197-4580(02)00075-1","volume":"23","author":"Schroeter H.","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"ref113\/cit113","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/2830","volume":"1","author":"Impey S.","year":"1998","journal-title":"Nat. Neurosci."},{"key":"ref114\/cit114","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0896-6273(00)80395-5","volume":"19","author":"Finkbeiner S.","year":"1997","journal-title":"Neuron"},{"key":"ref115\/cit115","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.freeradbiomed.2008.04.008","volume":"45","author":"Williams C. M.","year":"2008","journal-title":"Free Radical Biol. Med."},{"key":"ref116\/cit116","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.neuroscience.2009.07.014","volume":"163","author":"Li Q.","year":"2009","journal-title":"Neuroscience"},{"key":"ref117\/cit117","doi-asserted-by":"crossref","first-page":"5241","DOI":"10.1016\/S0021-9258(17)37680-9","volume":"269","author":"Vlahos C. J.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"ref118\/cit118","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/0006-2952(89)90309-2","volume":"38","author":"Ferriola P. C.","year":"1989","journal-title":"Biochem. Pharmacol."},{"key":"ref119\/cit119","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S1097-2765(05)00089-4","volume":"6","author":"Walker E. H.","year":"2000","journal-title":"Mol. Cell"},{"key":"ref120\/cit120","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1073\/pnas.042693699","volume":"99","author":"Yin Y.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref121\/cit121","doi-asserted-by":"crossref","first-page":"5484","DOI":"10.1523\/JNEUROSCI.21-15-05484.2001","volume":"21","author":"Waltereit R.","year":"2001","journal-title":"J. Neurosci."},{"key":"ref122\/cit122","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.ne.17.030194.002013","volume":"17","author":"Harris K. M.","year":"1994","journal-title":"Annu. Rev. Neurosci."},{"key":"ref123\/cit123","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1523\/JNEUROSCI.0914-07.2007","volume":"27","author":"van Praag H.","year":"2007","journal-title":"J. Neurosci."},{"key":"ref124\/cit124","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1471-4159.2005.03085.x","volume":"93","author":"Reznichenko L.","year":"2005","journal-title":"J. Neurochem."},{"key":"ref125\/cit125","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1074\/jbc.M002466200","volume":"276","author":"Leclerc S.","year":"2001","journal-title":"J. Biol. Chem."},{"key":"ref126\/cit126","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.nbd.2011.07.005","volume":"44","author":"Gong E. J.","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"ref127\/cit127","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neulet.2012.12.023","volume":"534","author":"Qin L.","year":"2013","journal-title":"Neurosci. 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