{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T08:17:34Z","timestamp":1776327454098,"version":"3.50.1"},"reference-count":31,"publisher":"American Chemical Society (ACS)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ind. Eng. Chem. Res."],"published-print":{"date-parts":[[2008,11,5]]},"DOI":"10.1021\/ie8003495","type":"journal-article","created":{"date-parts":[[2008,10,4]],"date-time":"2008-10-04T07:01:03Z","timestamp":1223103663000},"page":"8083-8089","source":"Crossref","is-referenced-by-count":106,"title":["Solubility of Antibiotics in Different Solvents. Part II. Non-Hydrochloride Forms of Tetracycline and Ciprofloxacin"],"prefix":"10.1021","volume":"47","author":[{"given":"Ana I.","family":"Ca\u00e7o","sequence":"first","affiliation":[{"name":"CICECO, Departamento de Qu\u00edmica, Universidade de Aveiro, 3810-193 Aveiro, Portugal, 3IBB-Instituto de Biotecnologia e Bioengenharia, Centro de Engenharia Biol\u00f3gica, Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Portugal, and Thermophysical Properties, Bayer Technology Services GmbH, CHEMPARK, Building B310, 51368 Leverkusen, Germany"}]},{"given":"F\u00e1tima","family":"Varanda","sequence":"additional","affiliation":[{"name":"CICECO, Departamento de Qu\u00edmica, Universidade de Aveiro, 3810-193 Aveiro, Portugal, 3IBB-Instituto de Biotecnologia e Bioengenharia, Centro de Engenharia Biol\u00f3gica, Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Portugal, and Thermophysical Properties, Bayer Technology Services GmbH, CHEMPARK, Building B310, 51368 Leverkusen, Germany"}]},{"given":"Maria J.","family":"Pratas de Melo","sequence":"additional","affiliation":[{"name":"CICECO, Departamento de Qu\u00edmica, Universidade de Aveiro, 3810-193 Aveiro, Portugal, 3IBB-Instituto de Biotecnologia e Bioengenharia, Centro de Engenharia Biol\u00f3gica, Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Portugal, and Thermophysical Properties, Bayer Technology Services GmbH, CHEMPARK, Building B310, 51368 Leverkusen, Germany"}]},{"given":"Ana M. A.","family":"Dias","sequence":"additional","affiliation":[{"name":"CICECO, Departamento de Qu\u00edmica, Universidade de Aveiro, 3810-193 Aveiro, Portugal, 3IBB-Instituto de Biotecnologia e Bioengenharia, Centro de Engenharia Biol\u00f3gica, Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Portugal, and Thermophysical Properties, Bayer Technology Services GmbH, CHEMPARK, Building B310, 51368 Leverkusen, Germany"}]},{"given":"Ralf","family":"Dohrn","sequence":"additional","affiliation":[{"name":"CICECO, Departamento de Qu\u00edmica, Universidade de Aveiro, 3810-193 Aveiro, Portugal, 3IBB-Instituto de Biotecnologia e Bioengenharia, Centro de Engenharia Biol\u00f3gica, Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Portugal, and Thermophysical Properties, Bayer Technology Services GmbH, CHEMPARK, Building B310, 51368 Leverkusen, Germany"}]},{"given":"Isabel M.","family":"Marrucho","sequence":"additional","affiliation":[{"name":"CICECO, Departamento de Qu\u00edmica, Universidade de Aveiro, 3810-193 Aveiro, Portugal, 3IBB-Instituto de Biotecnologia e Bioengenharia, Centro de Engenharia Biol\u00f3gica, Universidade do Minho, Campus de Gualtar, 4710-057, Braga, Portugal, and Thermophysical Properties, Bayer Technology Services GmbH, CHEMPARK, Building B310, 51368 Leverkusen, Germany"}]}],"member":"316","published-online":{"date-parts":[[2008,10,4]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0924-8579(00)00192-8","volume":"16","author":"Appelbaum P. C.","year":"2000","journal-title":"Int. J. Antimicrobial Agents"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1111\/j.1469-0691.2005.01131.x","volume":"11","author":"Van Bambeke F.","year":"2005","journal-title":"Clin. Microbiol. Inf."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/aic.690360303","volume":"36","author":"Gupta R. B.","year":"1990","journal-title":"AIChE J."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1021\/i160070a003","volume":"18","author":"Yalkowsky S. H.","year":"1979","journal-title":"Ind. Eng. Chem. Fundam."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1021\/i160068a008","volume":"17","author":"Gmehling J. G.","year":"1978","journal-title":"Ind. Eng. Chem. Fundam."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1021\/je010063c","volume":"46","author":"Atik Z.","year":"2001","journal-title":"J. Chem. Eng. Data"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0378-3812(02)00260-1","volume":"204","author":"Teodorescu M.","year":"2003","journal-title":"Fluid Phase Equilib."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/S0021-9614(03)00066-1","volume":"35","author":"Domanska U.","year":"2003","journal-title":"J. Chem. Thermodyn."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.fluid.2003.11.011","volume":"218","author":"Domanska U.","year":"2004","journal-title":"Fluid Phase Equilib."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"5114","DOI":"10.1021\/ie011014w","volume":"41","author":"Gracin S.","year":"2002","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1021\/je0255170","volume":"47","author":"Gracin S.","year":"2002","journal-title":"J. Chem. Eng. Data"},{"key":"ref12\/cit12","volume-title":"Chemical and Engineering Thermodynamics","author":"Sandler S. I.","year":"1999","edition":"3"},{"key":"ref13\/cit13","volume-title":"Molecular Thermodynamics of Fluid-Phase Equilibria","author":"Prausnitz J. M.","year":"1999","edition":"3"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.fluid.2007.07.020","volume":"261","author":"Feleilnik L.","year":"2007","journal-title":"Fluid Phase Equilib."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"6368","DOI":"10.1021\/ie060055v","volume":"45","author":"Varanda F.","year":"2006","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/aic.690140124","volume":"14","author":"Renon H.","year":"1968","journal-title":"AIChE J."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1002\/aic.690210115","volume":"21","author":"Abrams D. S.","year":"1975","journal-title":"AIChE J."},{"key":"ref18\/cit18","unstructured":"VTPLAN process simulator.www.bayertechnology.com."},{"key":"ref19\/cit19","unstructured":"Dortmund Data Bank.http:\/\/www.ddbst.de\/new\/Default.htm."},{"key":"ref20\/cit20","volume-title":"The Properties of Gases and Liquids","author":"Poling B. E.","year":"2001","edition":"5"},{"key":"ref21\/cit21","unstructured":"CAPEC database.http:\/\/www.capec.kt.dtu.dk\/, Lynsby, Denmark."},{"key":"ref22\/cit22","volume-title":"Merck Index","author":"O\u2019Neil M. J.","year":"2006","edition":"14"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1023\/B:PHAC.0000048148.54165.55","volume":"38","author":"Dorofeev V. L.","year":"2004","journal-title":"Pharm. Chem. J."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1021\/i160040a009","volume":"10","author":"Tsonopoulos C.","year":"1971","journal-title":"Ind. Eng. Chem. Fundam."},{"key":"ref25\/cit25","unstructured":"DIPPR database.http:\/\/dippr.byu.edu\/."},{"issue":"2","key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1002\/jcc.1168","volume":"23","author":"Klamt A.","year":"2002","journal-title":"J. Comput. Chem."},{"issue":"36","key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"10108","DOI":"10.1002\/chem.200700887","volume":"13","author":"Pavelka M.","year":"2007","journal-title":"Chem.\u2014Eur. J."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"6012","DOI":"10.1021\/ja00435a039","volume":"98","author":"Stezowski J. J.","year":"1976","journal-title":"J. Am. Chem. Soc."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"24766","DOI":"10.1021\/jp064457s","volume":"110","author":"Othersen O. G.","year":"2006","journal-title":"J. Phys. Chem. B"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"13743","DOI":"10.1021\/jp0364506","volume":"107","author":"Othersen O. G.","year":"2003","journal-title":"J. Phys. Chem. B"},{"issue":"1","key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0939-6411(02)00018-8","volume":"54","author":"Sun J.","year":"2002","journal-title":"Eur. J. Pharm. Biopharm."}],"container-title":["Industrial & Engineering Chemistry Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/ie8003495","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T06:12:58Z","timestamp":1633759978000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/ie8003495"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,4]]},"references-count":31,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2008,11,5]]}},"alternative-id":["10.1021\/ie8003495"],"URL":"https:\/\/doi.org\/10.1021\/ie8003495","relation":{},"ISSN":["0888-5885","1520-5045"],"issn-type":[{"value":"0888-5885","type":"print"},{"value":"1520-5045","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,4]]}}}