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J."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/jac\/32.2.195","volume":"32","author":"Mortimer P. G.","year":"1993","journal-title":"J. Antimicrob. Chemother."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1139\/w00-052","volume":"46","author":"Berlanga M.","year":"2000","journal-title":"Can. J. Microbiol."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1139\/W07-018","volume":"53","author":"Begic S.","year":"2007","journal-title":"Can. J. Microbiol."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1051\/vetres:2001124","volume":"32","author":"Webber M.","year":"2001","journal-title":"Vet. res."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1128\/AAC.29.3.535","volume":"29","author":"Hirai K.","year":"1986","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1128\/AAC.32.4.438","volume":"32","author":"Chapman J. S.","year":"1988","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1042\/bj3480223","volume":"348","author":"Chevalier J.","year":"2000","journal-title":"Biochem. J."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bpc.2004.08.004","volume":"113","author":"Neves P.","year":"2005","journal-title":"Biophys. Chem."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"9789","DOI":"10.1073\/pnas.152206799","volume":"99","author":"Nestorovich E. M.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0006-3495(02)75442-8","volume":"82","author":"Kullman L.","year":"2002","journal-title":"Biophys. 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R.","year":"2006"},{"key":"ref27\/cit27","volume-title":"Gaussian 03","author":"Frisch M. J.","year":"2003"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"10269","DOI":"10.1021\/j100142a004","volume":"97","author":"Bayly C. I.","year":"1993","journal-title":"J. Phys. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"12562","DOI":"10.1073\/pnas.202427399","volume":"99","author":"Laio A.","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1529\/biophysj.105.075192","volume":"90","author":"Danelon C.","year":"2006","journal-title":"Biophys. J."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1073\/pnas.69.12.3561","volume":"69","author":"Montal M.","year":"1972","journal-title":"Proc. Natl. Acad. Sci. 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M.","year":"1994","journal-title":"Nature"},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0006-3495(94)80929-4","volume":"66","author":"Nekolla S.","year":"1994","journal-title":"Biophys. J."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0927-7757(98)00290-8","volume":"149","author":"Winterhalter M.","year":"1999","journal-title":"Colloids Surfaces A."},{"key":"ref39\/cit39","volume-title":"Biophysical Chemistry: Part II: Techniques for the Study of Biological Structure and Function","author":"Cantor C. R.","year":"1980"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/andp.19484370105","volume":"437","author":"Forster Th.","year":"1948","journal-title":"Ann. Physik"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0005-2736(00)00211-X","volume":"1467","author":"Loura L. M.","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/S0006-3495(01)76057-2","volume":"80","author":"Loura L. M.","year":"2001","journal-title":"Biophys. J."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0304-4165(02)00528-7","volume":"1620","author":"Rodrigues C.","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0006-3495(79)85171-1","volume":"28","author":"Wolber P. K.","year":"1979","journal-title":"Biophys. J."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1529\/biophysj.107.114843","volume":"94","author":"Bensikaddour H.","year":"2008","journal-title":"Biophys. J."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"11446","DOI":"10.1073\/pnas.0601769103","volume":"103","author":"Bauer W. R.","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"9952","DOI":"10.1063\/1.1475758","volume":"116","author":"Berezhkovskii A. M.","year":"2002","journal-title":"J. Chem. Phys."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"115101","DOI":"10.1063\/1.2766720","volume":"127","author":"Bezrukov S. M.","year":"2007","journal-title":"J. Chem. Phys."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/jac\/43.suppl_2.83","volume":"43","author":"Stass H.","year":"1999","journal-title":"J. Antimicrob. Chemother."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"8019","DOI":"10.1016\/S0021-9258(19)42066-8","volume":"249","author":"Rosenbusch J. P.","year":"1974","journal-title":"J. Biol. Chem."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2165\/00003495-200464020-00004","volume":"64","author":"Li X. Z.","year":"2004","journal-title":"Drugs"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1126\/science.8153625","volume":"264","author":"Nikaido H.","year":"1994","journal-title":"Science"},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0076-6879(86)25027-2","volume":"125","author":"Garavito R. M.","year":"1986","journal-title":"Methods Enzymol."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1574-6968.1998.tb13027.x","volume":"163","author":"Prilipov A.","year":"1998","journal-title":"FEMS Microbiol. Lett."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","volume":"150","author":"Smith P. K.","year":"1985","journal-title":"Anal. Biochem."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0003-2697(88)90383-1","volume":"175","author":"Wiechelman K. J.","year":"1988","journal-title":"Anal. Biochem."},{"key":"ref57\/cit57","first-page":"603","volume":"28","author":"Staroscik R.","year":"1971","journal-title":"Acta Pol. Pharm."},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0378-5173(90)90130-V","volume":"63","author":"Ross D. L.","year":"1990","journal-title":"Int. J. Pharm."},{"key":"ref59\/cit59","volume-title":"Techniques of Solubilization of Drugs","author":"Yalkowsky S. H.","year":"1981"},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"35542","DOI":"10.1074\/jbc.M305434200","volume":"278","author":"Danelon C.","year":"2003","journal-title":"J. Biol. Chem."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/358727a0","volume":"358","author":"Cowan S. 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