{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:40:54Z","timestamp":1792791654997,"version":"4.5.0"},"reference-count":66,"publisher":"American Chemical Society (ACS)","license":[{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:00:00Z","timestamp":1792713600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-045"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["553513584"],"award-info":[{"award-number":["553513584"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011447","name":"Science and Technology Department of Henan Province","doi-asserted-by":"publisher","award":["242300420202"],"award-info":[{"award-number":["242300420202"]}],"id":[{"id":"10.13039\/501100011447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011447","name":"Science and Technology Department of Henan Province","doi-asserted-by":"publisher","award":["252102521002"],"award-info":[{"award-number":["252102521002"]}],"id":[{"id":"10.13039\/501100011447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011447","name":"Science and Technology Department of Henan Province","doi-asserted-by":"publisher","award":["25B150023"],"award-info":[{"award-number":["25B150023"]}],"id":[{"id":"10.13039\/501100011447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017664","name":"Henan Province Foundation for University Key Teacher","doi-asserted-by":"publisher","award":["2024GGJS116"],"award-info":[{"award-number":["2024GGJS116"]}],"id":[{"id":"10.13039\/501100017664","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21804086"],"award-info":[{"award-number":["21804086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Anisotropic NMR spectroscopy has emerged as a powerful tool for the structural elucidation of complex small molecules. Compared with residual dipolar couplings (RDCs), however, the application of residual chemical shift anisotropies (RCSAs) has remained relatively limited, largely owing to the lack of simple and efficient methods for their acquisition. Here, we report a biphasic polyarylisocyanide lyotropic liquid-crystalline (LLC) system based on single-handed helical polyisocyanides prepared by alkyne-Pd(II)-catalyzed controlled polymerization. The biphasic nature of this medium enables straightforward extraction of \u0394RCSAs from a single one-dimensional 13C NMR experiment on a single sample, without requiring specialized instrumentation, devices, or postcorrection. We demonstrate the broad applicability of this approach by measuring \u0394RCSAs for eight structurally diverse natural products and organic molecules. The resulting 13C \u0394RCSAs are sufficiently large to enable reliable structural verification and stereochemical elucidation. Notably, the method allowed us to unambiguously resolve previously questionable 13C NMR assignments in cryptotanshinone. In addition, the chiral LLC medium exhibits pronounced enantiodiscrimination, as demonstrated for indanol enantiomers as well as significant enantiodifferentiating capabilities for several natural alkaloids. Furthermore, 19F RCSA measurements enable direct differentiation of two enantiomers even within a racemic mixture. Together, these results establish biphasic polyarylisocyanide LLCs as a simple, robust, and broadly applicable alignment platform for \u0394RCSA measurements, thereby expanding the utility of anisotropic NMR for structural elucidation and chiral molecular characterization.<\/jats:p>","DOI":"10.1021\/jacs.6c14664","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:02:02Z","timestamp":1792789322000},"source":"Crossref","is-referenced-by-count":0,"title":["Biphasic Polyarylisocyanide\nLiquid Crystals with Enhanced\nEnantiodiscrimination for Residual Chemical Shift Anisotropy Measurements"],"prefix":"10.1021","author":[{"given":"Gao-Wei","family":"Li","sequence":"first","affiliation":[{"name":"Shangqiu Normal University , , ,","place":["Shangqiu, China, 476000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Juan","family":"Wang","sequence":"additional","affiliation":[{"name":"Shangqiu Normal University , , ,","place":["Shangqiu, China, 476000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shangqiu Normal University , , ,","place":["Shangqiu, China, 476000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5522-1659","authenticated-orcid":true,"given":"Wei-Kang","family":"Zhai","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-0221","authenticated-orcid":true,"given":"Yuan-Yuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Shangqiu Normal University , , ,","place":["Shangqiu, China, 476000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5116-621X","authenticated-orcid":true,"given":"Ming-Liang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shangqiu Normal University , , ,","place":["Shangqiu, China, 476000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Zhu","family":"Li","sequence":"additional","affiliation":[{"name":"Shangqiu Normal University , , ,","place":["Shangqiu, China, 476000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8025-7222","authenticated-orcid":true,"given":"Lan-Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Shangqiu Normal University , , ,","place":["Shangqiu, China, 476000"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-0838","authenticated-orcid":true,"given":"Han","family":"Sun","sequence":"additional","affiliation":[{"name":"Leibniz-Forschungsinstitut fu\u0308r Molekulare Pharmakologie (FMP) , , ,","place":["Berlin, Germany, 13125"]},{"name":"Technische Universita\u0308t Berlin , , ,","place":["Berlin, Germany, 10623"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5635-5375","authenticated-orcid":true,"given":"Xinxiang","family":"Lei","sequence":"additional","affiliation":[{"name":"Lanzhou University , , ,","place":["Lanzhou, China, 730000"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"316","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"issue":"7","key":"2026102317015557300_cit1","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1002\/anie.200460864","article-title":"Chasing Molecules\nThat Were Never There: Misassigned\nNatural Products and the Role of Chemical Synthesis in Modern Structure\nElucidation","volume":"44","author":"Nicolaou","year":"2005","journal-title":"Angew. 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A DMSO Compatible NMR Alignment Medium\nfor Measurement of Residual Dipolar Couplings and Residual Chemical\nShift Anisotropies","volume":"302","author":"Carvalho","year":"2019","journal-title":"J. Magn. Reson."},{"issue":"5","key":"2026102317015557300_cit27","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1002\/mrc.4711","article-title":"Measurement\nof Residual\nChemical Shift Anisotropies in Compressed Polymethylmethacrylate Gels.\nAutomatic Compensation of Gel Isotropic Shift Contribution","volume":"56","author":"Hallwass","year":"2018","journal-title":"Magn. Reson. Chem."},{"issue":"5","key":"2026102317015557300_cit28","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1021\/jacs.9b10961","article-title":"Stereochemical\nElucidation of Natural\nProducts from Residual Chemical Shift Anisotropies in a Liquid Crystalline\nPhase","volume":"142","author":"Li","year":"2020","journal-title":"J. Am. Chem. 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Chem.\nSoc."},{"issue":"10","key":"2026102317015557300_cit42","doi-asserted-by":"publisher","first-page":"10473","DOI":"10.1021\/jacs.5c18068","article-title":"Multiresponsive and Tunable Circularly Polarized Luminescence\nin Aggregation-Induced Emission Static Helical Supramolecular Polyisocyanides","volume":"148","author":"Yu","year":"2026","journal-title":"J. Am. Chem. Soc."},{"issue":"51","key":"2026102317015557300_cit43","doi-asserted-by":"publisher","first-page":"18850","DOI":"10.1021\/acs.analchem.3c04240","article-title":"Polyarylisocyanides Derived from\nan Alkyne-Pd (II) Catalyst as Robust Alignment Media with Excellent\nEnantiodiscimination","volume":"95","author":"Li","year":"2023","journal-title":"Anal. 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