{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T03:33:44Z","timestamp":1773977624406,"version":"3.50.1"},"reference-count":56,"publisher":"American Chemical Society (ACS)","issue":"50","license":[{"start":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T00:00:00Z","timestamp":1517529600000},"content-version":"vor","delay-in-days":59,"URL":"http:\/\/pubs.acs.org\/page\/policy\/authorchoice_ccby_termsofuse.html"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom?a y Competitividad","doi-asserted-by":"publisher","award":["CTQ2015-67727-R"],"award-info":[{"award-number":["CTQ2015-67727-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom?a y Competitividad","doi-asserted-by":"publisher","award":["CTQ2015-70524-R"],"award-info":[{"award-number":["CTQ2015-70524-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom?a y Competitividad","doi-asserted-by":"publisher","award":["RYC2013-14706"],"award-info":[{"award-number":["RYC2013-14706"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005370","name":"Gates Cambridge Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005370","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sklodowska-Curie Actions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci?n, Cultura y Deporte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda??o para a Ci?ncia e a Tecnologia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Am. Chem. Soc."],"published-print":{"date-parts":[[2017,12,20]]},"DOI":"10.1021\/jacs.7b10702","type":"journal-article","created":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T16:22:36Z","timestamp":1512490956000},"page":"18365-18375","source":"Crossref","is-referenced-by-count":97,"title":["Chemoselective Installation of Amine Bonds on Proteins through Aza-Michael Ligation"],"prefix":"10.1021","volume":"139","author":[{"given":"Allyson M.","family":"Freedy","sequence":"first","affiliation":[{"name":"Department\rof Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, U.K."}]},{"given":"Maria J.","family":"Matos","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, U.K."}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0768-8309","authenticated-orcid":true,"given":"Omar","family":"Boutureira","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, U.K."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5597-8127","authenticated-orcid":true,"given":"Francisco","family":"Corzana","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, U.K."},{"name":"Departamento\rde Qu\u00edmica, Centro de Investigaci\u00f3n en S\u00edntesis\rQu\u00edmica, Universidad de La Rioja, 26006 Logro\u00f1o, Spain"}]},{"given":"Ana","family":"Guerreiro","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal"}]},{"given":"Padma","family":"Akkapeddi","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal"}]},{"given":"V\u00edctor J.","family":"Somovilla","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, U.K."},{"name":"Departamento\rde Qu\u00edmica, Centro de Investigaci\u00f3n en S\u00edntesis\rQu\u00edmica, Universidad de La Rioja, 26006 Logro\u00f1o, Spain"}]},{"given":"Tiago","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal"}]},{"given":"Karl","family":"Nicholls","sequence":"additional","affiliation":[{"name":"Albumedix Ltd., Castle Court, 59\rCastle Boulevard, NG7 1FD Nottingham, U.K."}]},{"given":"Bangwen","family":"Xie","sequence":"additional","affiliation":[{"name":"Li\rKa Shing Centre, Cancer Research UK Cambridge Institute, Robinson Way, CB2 0RE Cambridge, U.K."}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0105-4337","authenticated-orcid":true,"given":"Gonzalo","family":"Jim\u00e9nez-Os\u00e9s","sequence":"additional","affiliation":[{"name":"Departamento\rde Qu\u00edmica, Centro de Investigaci\u00f3n en S\u00edntesis\rQu\u00edmica, Universidad de La Rioja, 26006 Logro\u00f1o, Spain"}]},{"given":"Kevin M.","family":"Brindle","sequence":"additional","affiliation":[{"name":"Departamento\rde Qu\u00edmica, Centro de Investigaci\u00f3n en S\u00edntesis\rQu\u00edmica, Universidad de La Rioja, 26006 Logro\u00f1o, Spain"},{"name":"Li\rKa Shing Centre, Cancer Research UK Cambridge Institute, Robinson Way, CB2 0RE Cambridge, U.K."}]},{"given":"Andr\u00e9 A.","family":"Neves","sequence":"additional","affiliation":[{"name":"Li\rKa Shing Centre, Cancer Research UK Cambridge Institute, Robinson Way, CB2 0RE Cambridge, U.K."}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6594-8917","authenticated-orcid":true,"given":"Gon\u00e7alo J. L.","family":"Bernardes","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, U.K."},{"name":"Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Avenida Professor Egas Moniz, 1649-028 Lisboa, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2017,12,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.720"},{"key":"ref2\/cit2","doi-asserted-by":"publisher","DOI":"10.1021\/cr400355w"},{"key":"ref3\/cit3","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5740"},{"key":"ref4\/cit4","doi-asserted-by":"publisher","DOI":"10.1021\/cr500399p"},{"key":"ref5\/cit5","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2393"},{"key":"ref6\/cit6","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1959"},{"key":"ref7\/cit7","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201307628"},{"key":"ref8\/cit8","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2415"},{"key":"ref9\/cit9","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1480"},{"key":"ref10\/cit10","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2005"},{"key":"ref11\/cit11","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3286"},{"key":"ref12\/cit12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.09.013"},{"key":"ref13\/cit13","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1792"},{"key":"ref14\/cit14","doi-asserted-by":"publisher","DOI":"10.1038\/nchem.2413"},{"key":"ref15\/cit15","doi-asserted-by":"publisher","DOI":"10.1002\/asia.200800427"},{"key":"ref16\/cit16","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2289"},{"key":"ref17\/cit17","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.2968"},{"key":"ref18\/cit18","doi-asserted-by":"publisher","DOI":"10.1021\/ja800800p"},{"key":"ref19\/cit19","doi-asserted-by":"publisher","DOI":"10.1039\/c1sc00185j"},{"key":"ref20\/cit20","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201106432"},{"key":"ref21\/cit21","doi-asserted-by":"publisher","DOI":"10.1021\/ja4095318"},{"key":"ref22\/cit22","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2015.993313"},{"key":"ref23\/cit23","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2010.02.008"},{"key":"ref24\/cit24","doi-asserted-by":"publisher","DOI":"10.1021\/ja054686c"},{"key":"ref25\/cit25","doi-asserted-by":"publisher","DOI":"10.1021\/ja502851h"},{"key":"ref26\/cit26","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2003.11.081"},{"key":"ref27\/cit27","doi-asserted-by":"publisher","DOI":"10.1039\/b003353g"},{"key":"ref28\/cit28","doi-asserted-by":"publisher","DOI":"10.1021\/jo034762z"},{"key":"ref29\/cit29","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.7b00341"},{"key":"ref30\/cit30","unstructured":"Bernardes, G. J. L.; Chalker, J. M.; Davis, B. G.PCT\/GB2009\/000194, 2011."},{"key":"ref31\/cit31","unstructured":"Chalker, J. M.D.Phil. Thesis,University of Oxford, 2012."},{"key":"ref32\/cit32","unstructured":"Bernardes, G. J. L.D.Phil. Thesis,University of Oxford, 2008."},{"key":"ref33\/cit33","doi-asserted-by":"publisher","DOI":"10.1007\/s00214-007-0310-x"},{"key":"ref34\/cit34","doi-asserted-by":"publisher","DOI":"10.1021\/ct400773k"},{"key":"ref35\/cit35","doi-asserted-by":"publisher","DOI":"10.1021\/bc9004415"},{"key":"ref36\/cit36","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.143"},{"key":"ref37\/cit37","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1034"},{"key":"ref38\/cit38","doi-asserted-by":"publisher","DOI":"10.1021\/ja504390x"},{"key":"ref39\/cit39","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.11.028"},{"key":"ref40\/cit40","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201508601"},{"key":"ref41\/cit41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2004.04474.x"},{"key":"ref42\/cit42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.549832"},{"key":"ref43\/cit43","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200636556"},{"key":"ref44\/cit44","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2463070471"},{"key":"ref45\/cit45","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.116.183004"},{"key":"ref46\/cit46","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2016.1156829"},{"key":"ref47\/cit47","doi-asserted-by":"publisher","DOI":"10.1021\/jm2007613"},{"key":"ref48\/cit48","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2360"},{"key":"ref49\/cit49","doi-asserted-by":"publisher","DOI":"10.1038\/nature16057"},{"key":"ref50\/cit50","doi-asserted-by":"publisher","DOI":"10.1021\/cb4009292"},{"key":"ref51\/cit51","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1321237111"},{"key":"ref52\/cit52","doi-asserted-by":"publisher","DOI":"10.1002\/anie.197600421"},{"key":"ref53\/cit53","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag1465"},{"key":"ref54\/cit54","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4428"},{"key":"ref55\/cit55","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5388"},{"key":"ref56\/cit56","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.201200714"}],"container-title":["Journal of the American Chemical Society"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.7b10702","content-type":"application\/pdf","content-version":"vor","intended-application":"unspecified"},{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jacs.7b10702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T11:33:08Z","timestamp":1688383988000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jacs.7b10702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,5]]},"references-count":56,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2017,12,20]]}},"alternative-id":["10.1021\/jacs.7b10702"],"URL":"https:\/\/doi.org\/10.1021\/jacs.7b10702","relation":{},"ISSN":["0002-7863","1520-5126"],"issn-type":[{"value":"0002-7863","type":"print"},{"value":"1520-5126","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,5]]}}}