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Chem."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1246\/bcsj.60.2605","volume":"60","author":"Niazi M. S. K.","year":"1987","journal-title":"Bull. Chem. Soc. Jpn."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1135\/cccc19900072","volume":"55","author":"Cativiela C.","year":"1990","journal-title":"Collect. Czech. Chem. Commun."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1139\/v96-065","volume":"74","author":"Hall\u00e9 J. C.","year":"1996","journal-title":"Can. J. Chem."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/(SICI)1099-1395(199609)9:9<593::AID-POC593>3.0.CO;2-7","volume":"9","author":"Garcia B.","year":"1996","journal-title":"J. Phys. Org. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.1021\/ja963512f","volume":"119","author":"Nagy P. I.","year":"1997","journal-title":"J. Am. Chem. 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