{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T04:41:50Z","timestamp":1773204110295,"version":"3.50.1"},"reference-count":25,"publisher":"American Chemical Society (ACS)","issue":"21","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2010,11,11]]},"DOI":"10.1021\/jm1007769","type":"journal-article","created":{"date-parts":[[2010,10,8]],"date-time":"2010-10-08T13:44:40Z","timestamp":1286545480000},"page":"7632-7638","source":"Crossref","is-referenced-by-count":64,"title":["Sterols as Anticancer Agents: Synthesis of Ring-B Oxygenated Steroids, Cytotoxic Profile, and Comprehensive SAR Analysis"],"prefix":"10.1021","volume":"53","author":[{"given":"Jo\u00e3o F. S.","family":"Carvalho","sequence":"first","affiliation":[{"name":"Center for Pharmaceutical Studies, University of Coimbra, Portugal"},{"name":"Faculdade de Farm\u00e1cia, Universidade de Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"M. Manuel Cruz","family":"Silva","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical Studies, University of Coimbra, Portugal"},{"name":"Faculdade de Farm\u00e1cia, Universidade de Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Jo\u00e3o N.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology, University of Coimbra, Portugal"},{"name":"Faculdade de Farm\u00e1cia, Universidade de Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"S\u00e9rgio","family":"Sim\u00f5es","sequence":"additional","affiliation":[{"name":"Center for Neuroscience and Cell Biology, University of Coimbra, Portugal"},{"name":"Faculdade de Farm\u00e1cia, Universidade de Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"M. Luisa","family":"S\u00e1 e Melo","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical Studies, University of Coimbra, Portugal"},{"name":"Faculdade de Farm\u00e1cia, Universidade de Coimbra, 3000-548 Coimbra, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2010,10,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.mam.2009.02.006","volume":"30","author":"Vejux A.","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1152\/physrev.2000.80.1.361","volume":"80","author":"Schroepfer G. J. J.","year":"2000","journal-title":"Physiol. Rev."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.mam.2009.02.004","volume":"30","author":"Olkkonen V. M.","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0014-5793(99)01497-0","volume":"462","author":"Pirillo A.","year":"1999","journal-title":"FEBS Lett."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.freeradbiomed.2006.05.032","volume":"41","author":"Larsson D. A.","year":"2006","journal-title":"Free Radical Biol. Med."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1096\/fj.03-0401fje","volume":"18","author":"Biasi F.","year":"2004","journal-title":"FASEB J."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.freeradbiomed.2006.06.027","volume":"41","author":"Steffen Y.","year":"2006","journal-title":"Free Radical Biol. Med."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"6511","DOI":"10.1073\/pnas.0700899104","volume":"104","author":"Radhakrishnan A.","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s11745-007-3149-y","volume":"43","author":"Ishimaru C.","year":"2008","journal-title":"Lipids"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.yexcr.2004.06.029","volume":"300","author":"Fern\u00e1ndez C.","year":"2004","journal-title":"Exp. Cell Res."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s10565-005-0141-2","volume":"21","author":"Lemaire-Ewing S.","year":"2005","journal-title":"Cell Biol. Toxicol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/S0039-128X(99)00032-X","volume":"64","author":"Aiello A.","year":"1999","journal-title":"Steroids"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.bbalip.2006.02.017","volume":"1761","author":"Wu Q.","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1016\/j.tet.2010.01.089","volume":"66","author":"Carvalho J. F. S.","year":"2010","journal-title":"Tetrahedron"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1016\/j.tet.2009.01.100","volume":"65","author":"Carvalho J. F. S.","year":"2009","journal-title":"Tetrahedron"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1021\/jm9003973","volume":"52","author":"Carvalho J. F. S.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1054\/drup.2000.0122","volume":"3","author":"Gerweck L. E.","year":"2000","journal-title":"Drug Resist. Updates"},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"10747","DOI":"10.1021\/bi060540u","volume":"45","author":"Massey J. B.","year":"2006","journal-title":"Biochemistry"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0009-2797(00)00197-6","volume":"129","author":"Fretland Adrian J.","year":"2000","journal-title":"Chem.-Biol. Interact."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1158\/1535-7163.MCT-06-0024","volume":"5","author":"Gerweck L. E.","year":"2006","journal-title":"Mol. Cancer Ther."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0261-5614(03)00060-8","volume":"22","author":"Qu\u00edlez J.","year":"2003","journal-title":"Clin. Nutr."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/87559120802682797","volume":"25","author":"Ryan E.","year":"2009","journal-title":"Food Rev. Int."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/sj.cdd.4401530","volume":"12","author":"Roussi S.","year":"2005","journal-title":"Cell Death Differ."},{"key":"ref24\/cit24","first-page":"943","volume":"22","author":"Hyun J. W.","year":"2002","journal-title":"Anticancer Res."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1080\/10715760903176919","volume":"43","author":"Li W.","year":"2009","journal-title":"Free Radical Res."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm1007769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T11:24:48Z","timestamp":1680434688000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm1007769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,8]]},"references-count":25,"journal-issue":{"issue":"21","published-print":{"date-parts":[[2010,11,11]]}},"alternative-id":["10.1021\/jm1007769"],"URL":"https:\/\/doi.org\/10.1021\/jm1007769","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,8]]}}}