{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T13:39:43Z","timestamp":1775396383232,"version":"3.50.1"},"reference-count":81,"publisher":"American Chemical Society (ACS)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2011,5,12]]},"DOI":"10.1021\/jm101182s","type":"journal-article","created":{"date-parts":[[2011,4,19]],"date-time":"2011-04-19T19:47:30Z","timestamp":1303242450000},"page":"3175-3187","source":"Crossref","is-referenced-by-count":25,"title":["Synthesis of Tetrahydronaphthalene Lignan Esters by Intramolecular Cyclization of Ethyl <i>p<\/i>-Azidophenyl-2-phenylalkanoates and Evaluation of the Growth Inhibition of Human Tumor Cell Lines"],"prefix":"10.1021","volume":"54","author":[{"given":"Orlando","family":"Pinto","sequence":"first","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Ci\u00eancias, Centro de Qu\u00edmica e Bioqu\u00edmica\/Departamento de Qu\u00edmica e Bioqu\u00edmica (CQB\/DQB), Ed. C8, Piso 5, 1749-016 Lisboa, Portugal"}]},{"given":"Jo\u00e3o","family":"Sardinha","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Ci\u00eancias, Centro de Qu\u00edmica e Bioqu\u00edmica\/Departamento de Qu\u00edmica e Bioqu\u00edmica (CQB\/DQB), Ed. C8, Piso 5, 1749-016 Lisboa, Portugal"}]},{"given":"Pedro D.","family":"Vaz","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Ci\u00eancias, Centro de Qu\u00edmica e Bioqu\u00edmica\/Departamento de Qu\u00edmica e Bioqu\u00edmica (CQB\/DQB), Ed. C8, Piso 5, 1749-016 Lisboa, Portugal"}]},{"given":"F\u00e1tima","family":"Piedade","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Ci\u00eancias, Centro de Qu\u00edmica e Bioqu\u00edmica\/Departamento de Qu\u00edmica e Bioqu\u00edmica (CQB\/DQB), Ed. C8, Piso 5, 1749-016 Lisboa, Portugal"}]},{"given":"Maria J.","family":"Calhorda","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Ci\u00eancias, Centro de Qu\u00edmica e Bioqu\u00edmica\/Departamento de Qu\u00edmica e Bioqu\u00edmica (CQB\/DQB), Ed. C8, Piso 5, 1749-016 Lisboa, Portugal"}]},{"given":"Rudolph","family":"Abramovitch","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Clemson University, Clemson, South Carolina 29634-0973, United States"}]},{"given":"Nair","family":"Nazareth","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), Departamento de Ci\u00eancias Qu\u00edmicas, Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua An\u00edbal Cunha 164, 4050-047 Porto, Portugal"}]},{"given":"Madalena","family":"Pinto","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), Departamento de Ci\u00eancias Qu\u00edmicas, Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua An\u00edbal Cunha 164, 4050-047 Porto, Portugal"}]},{"given":"Maria S. J.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Centro de Estudos de Qu\u00edmica Medicinal da Universidade do Porto (CEQUIMED-UP), Departamento de Ci\u00eancias Qu\u00edmicas, Laborat\u00f3rio de Qu\u00edmica Org\u00e2nica e Farmac\u00eautica, Faculdade de Farm\u00e1cia, Universidade do Porto, Rua An\u00edbal Cunha 164, 4050-047 Porto, Portugal"}]},{"given":"Am\u00e9lia P.","family":"Rauter","sequence":"additional","affiliation":[{"name":"Universidade de Lisboa, Faculdade de Ci\u00eancias, Centro de Qu\u00edmica e Bioqu\u00edmica\/Departamento de Qu\u00edmica e Bioqu\u00edmica (CQB\/DQB), Ed. C8, Piso 5, 1749-016 Lisboa, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2011,4,19]]},"reference":[{"key":"ref1\/cit1a","first-page":"149","volume-title":"Studies in Natural Product Chemistry","volume":"26","author":"Moraes R. M.","year":"2002"},{"key":"ref1\/cit1b","first-page":"183","volume-title":"Studies in Natural Product Chemistry","volume":"26","author":"Rios J. L.","year":"2002"},{"key":"ref1\/cit1c","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1039\/a705992b","volume":"16","author":"Ward R. S.","year":"1999","journal-title":"Nat. Prod. Rep."},{"issue":"5","key":"ref1\/cit1d","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1021\/cr50005a003","volume":"55","author":"Hearon W. M.","year":"1955","journal-title":"Chem. Rev."},{"issue":"8","key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1351\/pac200072081493","volume":"72","author":"Moss G. P.","year":"2000","journal-title":"Pure Appl. Chem."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1002\/ejoc.200700097","author":"Sellars J. D.","year":"2007","journal-title":"Eur. J. Org. Chem."},{"key":"ref4\/cit4a","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1016\/j.tet.2009.12.042","volume":"66","author":"Tanaka K.","year":"2010","journal-title":"Tetrahedron"},{"key":"ref4\/cit4b","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1002\/ejoc.200801101","author":"Benda K.","year":"2009","journal-title":"Eur. J. Org. Chem."},{"key":"ref4\/cit4c","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1039\/B713904G","volume":"6","author":"Lucarini S.","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"ref4\/cit4d","doi-asserted-by":"crossref","first-page":"7557","DOI":"10.1002\/anie.200802611","volume":"47","author":"Stadler D.","year":"2008","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref4\/cit4e","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1039\/b709318g","volume":"5","author":"Hughes N. J.","year":"2007","journal-title":"Org. Biomol. Chem."},{"key":"ref4\/cit4f","doi-asserted-by":"crossref","first-page":"6640","DOI":"10.1016\/j.bmc.2006.05.077","volume":"14","author":"Ghoneim O. M.","year":"2006","journal-title":"Bioorg. Med. Chem."},{"issue":"1","key":"ref4\/cit4g","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1124\/jpet.104.070086","volume":"311","author":"Moniri N. H.","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref4\/cit4h","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1016\/S0968-0896(02)00158-X","volume":"10","author":"Agrawal V. K.","year":"2002","journal-title":"Bioorg. Med. Chem."},{"key":"ref4\/cit4i","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1016\/S0040-4039(00)00327-0","volume":"41","author":"Harris M. C. J.","year":"2000","journal-title":"Tetrahedron Lett."},{"key":"ref4\/cit4j","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1039\/cs9821100075","volume":"11","author":"Ward R. S.","year":"1982","journal-title":"Chem. Soc. Rev."},{"key":"ref5\/cit5a","doi-asserted-by":"crossref","first-page":"6289","DOI":"10.1016\/j.bmcl.2009.09.092","volume":"19","author":"Dong Y.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref5\/cit5b","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1023\/B:PHYT.0000045495.59732.58","volume":"2","author":"Lee K.-H.","year":"2003","journal-title":"Phytochem. Rev."},{"key":"ref5\/cit5c","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1021\/jm020158p","volume":"46","author":"LaLonde R. T.","year":"2003","journal-title":"J. Med. Chem."},{"issue":"22","key":"ref5\/cit5d","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1002\/anie.200351086","volume":"42","author":"Engelhardt U.","year":"2003","journal-title":"Angew. Chem.-Int. Ed."},{"issue":"7","key":"ref6\/cit6a","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.bmcl.2006.11.070","volume":"17","author":"Chen S. W.","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"10","key":"ref6\/cit6b","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.ejmech.2003.05.001","volume":"38","author":"Castro M. A.","year":"2003","journal-title":"Eur. J. Med. Chem."},{"issue":"8","key":"ref6\/cit6c","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/aid.1997.13.695","volume":"13","author":"Hara H.","year":"1997","journal-title":"Aids Res. Hum. Retroviruses"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1021\/np0604533","volume":"70","author":"Li N.","year":"2007","journal-title":"J. Nat. Prod."},{"issue":"5","key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/BF02977649","volume":"30","author":"Kim S. Y.","year":"2007","journal-title":"Arch. Pharm. Res."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1039\/B713904G","volume":"6","author":"Lucarini S.","year":"2008","journal-title":"Org. Biomol. Chem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"3041","DOI":"10.1021\/jm980428x","volume":"42","author":"Bucholtz E. C.","year":"1999","journal-title":"J. Med. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1021\/jm00019a016","volume":"38","author":"Wyrick S. D.","year":"1995","journal-title":"J. Med. Chem."},{"key":"ref12\/cit12a","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1039\/b514045p","volume":"52","author":"Saleem M.","year":"2005","journal-title":"Nat. Prod. Rep"},{"key":"ref12\/cit12b","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1023\/B:PHYT.0000045497.90158.d2","volume":"2","author":"Apers S.","year":"2003","journal-title":"Phytochem. Res."},{"key":"ref13\/cit13a","doi-asserted-by":"crossref","first-page":"5645","DOI":"10.1021\/jp811262x","volume":"113","author":"Qi S. F.","year":"2009","journal-title":"J. Phys. Chem. B"},{"key":"ref13\/cit13b","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1021\/jp804128s","volume":"113","author":"Yang Z. Z.","year":"2009","journal-title":"J. Phys. Chem. B"},{"key":"ref13\/cit13c","first-page":"167","volume":"36","author":"Novak M.","year":"2001","journal-title":"Adv. Phys. Org. Chem."},{"key":"ref13\/cit13d","doi-asserted-by":"crossref","first-page":"8294","DOI":"10.1021\/jo00130a034","volume":"60","author":"Novak M.","year":"1995","journal-title":"J. Org. Chem."},{"key":"ref13\/cit13e","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1021\/ja00106a083","volume":"117","author":"Novak M.","year":"1995","journal-title":"J. Am. Chem. Soc."},{"key":"ref13\/cit13f","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1021\/ja00009a035","volume":"113","author":"Helmick J. S.","year":"1991","journal-title":"J. Am. Chem. Soc."},{"key":"ref14\/cit14a","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1023\/A:1026057212359","volume":"39","author":"Borodkin G. I.","year":"2003","journal-title":"Russ. J. Org. Chem."},{"key":"ref14\/cit14b","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1590\/S0100-40421998000400014","volume":"21","author":"Mota C. J. A.","year":"1998","journal-title":"Qu\u00edm. Nova"},{"key":"ref14\/cit14c","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/anie.199307673","volume":"32","author":"Olah G. A.","year":"1993","journal-title":"Angew. Chem., Int. Ed. Engl."},{"key":"ref15\/cit15a","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1070\/RC2008v077n05ABEH003760","volume":"77","author":"Borodkin G. I.","year":"2008","journal-title":"Russ. Chem. Rev."},{"key":"ref15\/cit15b","doi-asserted-by":"crossref","first-page":"5188","DOI":"10.1002\/anie.200400657","volume":"44","author":"Brase S.","year":"2005","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref15\/cit15c","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1016\/S0040-4020(00)00218-0","volume":"56","author":"Kantorowski E. J.","year":"2000","journal-title":"Tetrahedron"},{"key":"ref16\/cit16a","first-page":"35","volume":"42","author":"Glover S. A.","year":"2007","journal-title":"Adv. Phys. Org. Chem."},{"key":"ref16\/cit16b","doi-asserted-by":"crossref","first-page":"9875","DOI":"10.1021\/jo034505u","volume":"68","author":"Novak M.","year":"2003","journal-title":"J. Org. Chem."},{"key":"ref16\/cit16c","doi-asserted-by":"crossref","first-page":"8003","DOI":"10.1016\/j.tet.2003.08.005","volume":"59","author":"Rajagopal S.","year":"2003","journal-title":"Tetrahedron"},{"key":"ref16\/cit16d","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.1021\/jo980500z","volume":"63","author":"Novak M.","year":"1998","journal-title":"J. Org. Chem."},{"key":"ref16\/cit16e","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1590\/S0100-40421998000400014","volume":"21","author":"Mota C. J. A.","year":"1998","journal-title":"Qu\u00edm. Nova"},{"key":"ref16\/cit16f","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1021\/ja00009a035","volume":"113","author":"Helmick J. S.","year":"1991","journal-title":"J. Am. Chem. Soc."},{"key":"ref17\/cit17a","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.1021\/jo050598z","volume":"70","author":"Kung A. C.","year":"2005","journal-title":"J. Org. Chem."},{"key":"ref17\/cit17b","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1021\/jo030287t","volume":"69","author":"Rodrigues J. A. R.","year":"2004","journal-title":"J. Org. Chem."},{"key":"ref17\/cit17c","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1021\/jo00145a056","volume":"47","author":"Abramovitch R. A.","year":"1982","journal-title":"J. Org. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"4817","DOI":"10.1021\/jo00145a055","volume":"47","author":"Abramovitch R. A.","year":"1982","journal-title":"J. Org. Chem."},{"key":"ref19\/cit19a","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1021\/jo901224k","volume":"74","author":"Stokes B. J.","year":"2009","journal-title":"J. Org. Chem."},{"key":"ref19\/cit19b","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3987\/COM-07-S(W)4","volume":"74","author":"Nagashima A.","year":"2007","journal-title":"Heterocycles"},{"key":"ref19\/cit19c","doi-asserted-by":"crossref","first-page":"10271","DOI":"10.1021\/jo051252r","volume":"70","author":"Wardrop D. J.","year":"2005","journal-title":"J. Org. Chem."},{"key":"ref20\/cit20a","doi-asserted-by":"crossref","first-page":"7271","DOI":"10.1016\/j.tetlet.2006.07.001","volume":"47","author":"Abramovitch R. A.","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"ref20\/cit20b","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1016\/S0040-4039(03)01591-0","volume":"44","author":"Abramovitch R. A.","year":"2003","journal-title":"Tetrahedron Lett."},{"key":"ref20\/cit20c","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1021\/jo990362t","volume":"64","author":"Abramovitch R. A.","year":"1999","journal-title":"J. Org. Chem."},{"key":"ref20\/cit20d","doi-asserted-by":"crossref","first-page":"4819","DOI":"10.1021\/jo00145a056","volume":"47","author":"Abramovitch R. A.","year":"1982","journal-title":"J. Org. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"6739","DOI":"10.1021\/jo0347009","volume":"68","author":"Kikugawa I.","year":"2003","journal-title":"J. Org. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"8277","DOI":"10.1016\/S0040-4020(01)91020-8","volume":"47","author":"Satyanarayana P.","year":"1991","journal-title":"Tetrahedron"},{"key":"ref23\/cit23","volume-title":"Density Functional Theory of Atoms and Molecules","author":"Parr R. G.","year":"1989"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"5429","DOI":"10.1021\/jo034318w","volume":"68","author":"Miyazawa E.","year":"2003","journal-title":"J. Org. Chem."},{"key":"ref25\/ref25_1","unstructured":"Frisch, M. J.; Trucks, G. W.; Schlegel, H. B.; Scuseria, G. E.; Robb, M. A.; Cheeseman, J. R.; Montgomery, J. A., Jr.; Vreven, T.; Kudin, K. N.; Burant, J. C.; Millam, J. M.; Iyengar, S. S.; Tomasi, J.; Barone, V.; Mennucci, B.; Cossi, M.; Scalmani, G.; Rega, N.; Petersson, G. A.; Nakatsuji, H.; Hada, M.; Ehara, M.; Toyota, K.; Fukuda, R.; Hasegawa, J.; Ishida, M.; Nakajima, T.; Honda, Y.; Kitao, O.; Nakai, H.; Klene, M.; Li, X.; Knox, J. E.; Hratchian, H. P.; Cross, J. B.; Bakken, V.; Adamo, C.; Jaramillo, J.; Gomperts, R.; Stratmann, R. E.; Yazyev, O.; Austin, A. J.; Cammi, R.; Pomelli, C.; Ochterski, J. W.; Ayala, P. Y.; Morokuma, K.; Voth, G. A.; Salvador, P.; Dannenberg, J. J.; Zakrzewski, V. G.; Dapprich, S.; Daniels, A. D.; Strain, M. C.; Farkas, O.; Malick, D. K.; Rabuck, A. D.; Raghavachari, K.; Foresman, J. B.; Ortiz, J. V.; Cui, Q.; Baboul, A. G.; Clifford, S.; Cioslowski, J.; Stefanov, B. B.; Liu, G.; Liashenko, A.; Piskorz, P.; Komaromi, I.; Martin, R. L.; Fox, D. J.; Keith, T.; Al-Laham, M. A.; Peng, C. Y.; Nanayakkara, A.; Challacombe, M.; Gill, P. M. W.; Johnson, B.; Chen, W.; Wong, M. W.; Gonzalez, C.; Pople, J. A.Gaussian 03, revision C.02;Gaussian, Inc.:Wallingford, CT, 2003."},{"key":"ref26\/cit26","volume-title":"CAD4 Data Reduction","author":"Harms K.","year":"1995"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1107\/S0021889892010331","volume":"26","author":"Altomare A.","year":"1993","journal-title":"J. Appl. Crystallogr."},{"key":"ref28\/cit28","volume-title":"SHELX97\u2014Programs for Crystal Structure Analysis (Release 97-2)","author":"Sheldrick G. M.","year":"1998"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1107\/S0021889899006020","volume":"32","author":"Farrugia L. J.","year":"1999","journal-title":"J. Appl. Crystallogr."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0076-6879(97)77028-9","volume":"277","author":"Merritt E. A.","year":"1997","journal-title":"Methods Enzymol."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1103\/PhysRevB.37.785","volume":"37","author":"Lee C.","year":"1988","journal-title":"Phys. Rev. B"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.1063\/1.464913","volume":"98","author":"Becke A. D.","year":"1993","journal-title":"J. Chem. Phys."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/0009-2614(89)87234-3","volume":"157","author":"Miehlich B.","year":"1989","journal-title":"Chem. Phys. Lett."},{"key":"ref34\/cit34a","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1063\/1.1674902","volume":"54","author":"Ditchfield R.","year":"1971","journal-title":"J. Chem. Phys."},{"key":"ref34\/cit34b","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1063\/1.1677527","volume":"56","author":"Hehre W. J.","year":"1972","journal-title":"J. Chem. Phys."},{"key":"ref34\/cit34c","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/00268977400100171","volume":"27","author":"Hariharan P. C.","year":"1974","journal-title":"Mol. Phys."},{"key":"ref34\/cit34d","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0009-2614(80)80628-2","volume":"76","author":"Gordon M. S.","year":"1980","journal-title":"Chem. Phys. Lett."},{"key":"ref34\/cit34e","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF00533485","volume":"28","author":"Hariharan P. C.","year":"1973","journal-title":"Theor. Chim. Acta"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"10024","DOI":"10.1021\/ja00051a040","volume":"114","author":"Rapp\u00e9 A. K.","year":"1992","journal-title":"J. Am. Chem. Soc."},{"key":"ref36\/cit36","unstructured":"http:\/\/www.chemcraftprog.com\/index.html."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","volume":"82","author":"Skehan P.","year":"1990","journal-title":"J. Natl. Cancer Inst."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/jnci\/83.11.757","volume":"83","author":"Monks A.","year":"1991","journal-title":"J. Natl. Cancer Inst."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm101182s","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T02:17:16Z","timestamp":1680833836000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm101182s"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,19]]},"references-count":81,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2011,5,12]]}},"alternative-id":["10.1021\/jm101182s"],"URL":"https:\/\/doi.org\/10.1021\/jm101182s","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,19]]}}}