{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T16:28:06Z","timestamp":1771259286275,"version":"3.50.1"},"reference-count":59,"publisher":"American Chemical Society (ACS)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2011,2,10]]},"DOI":"10.1021\/jm101383f","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T14:45:28Z","timestamp":1294238728000},"page":"734-750","source":"Crossref","is-referenced-by-count":62,"title":["Incorporation of Basic Side Chains into Cryptolepine Scaffold: Structure\u2212Antimalarial Activity Relationships and Mechanistic Studies"],"prefix":"10.1021","volume":"54","author":[{"given":"Jo\u00e3o","family":"Lavrado","sequence":"first","affiliation":[{"name":"Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon. Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal"}]},{"given":"Ghislain G.","family":"Cabal","sequence":"additional","affiliation":[{"name":"Unidade de Mal\u00e1ria, Instituto de Medicina Molecular, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"given":"Miguel","family":"Prud\u00eancio","sequence":"additional","affiliation":[{"name":"Unidade de Mal\u00e1ria, Instituto de Medicina Molecular, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"given":"Maria M.","family":"Mota","sequence":"additional","affiliation":[{"name":"Unidade de Mal\u00e1ria, Instituto de Medicina Molecular, Universidade de Lisboa, 1649-028 Lisboa, Portugal"}]},{"given":"Jiri","family":"Gut","sequence":"additional","affiliation":[{"name":"Department of Medicine, San Francisco General Hospital, University of California, San Francisco, Box 0811, San Francisco, California 94143, United States"}]},{"given":"Philip J.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department of Medicine, San Francisco General Hospital, University of California, San Francisco, Box 0811, San Francisco, California 94143, United States"}]},{"given":"Cec\u00edlia","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Escuela de Medicina and Instituto Clodomiro Picado, Universidad de Costa Rica, 2060 San Jos\u00e9, Costa Rica"}]},{"given":"Rita C.","family":"Guedes","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon. Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal"}]},{"given":"Daniel J. V. A.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon. Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal"}]},{"given":"Elena","family":"Bichenkova","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom"}]},{"given":"Kenneth T.","family":"Douglas","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom"}]},{"given":"Rui","family":"Moreira","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon. Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal"}]},{"given":"Alexandra","family":"Paulo","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon. Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2011,1,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2174\/138955708783744092","volume":"8","author":"Martinelli A.","year":"2008","journal-title":"Mini Rev. Med. Chem."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.pt.2008.09.005","volume":"24","author":"Fidock D. A.","year":"2008","journal-title":"Trends Parasitol."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/415686a","volume":"415","author":"Ridley R. G.","year":"2002","journal-title":"Nature"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1016\/j.bmc.2009.02.050","volume":"17","author":"Kaur K.","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/j.bmc.2008.10.072","volume":"17","author":"Kumar V.","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2174\/138945009787581203","volume":"10","author":"Krettli A. U.","year":"2009","journal-title":"Curr. Drug Targets"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0165-6147(99)01302-4","volume":"20","author":"van Agtmael M. A.","year":"1999","journal-title":"Trends Pharmacol. Sci."},{"key":"ref8\/cit8","first-page":"3","volume":"295","author":"Bray P. G.","year":"2005","journal-title":"Malar.: Drugs Dis. Post-Genom. Biol."},{"key":"ref9\/cit9","first-page":"627","volume":"12","author":"Clinquart E.","year":"1929","journal-title":"Bull. Acad. R. Med. Belg."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"538","DOI":"10.2174\/138955708784534418","volume":"8","author":"Kumar E.","year":"2008","journal-title":"Mini Rev. Med. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1211\/jpp.59.6.0017","volume":"59","author":"Wright C. W.","year":"2007","journal-title":"J. Pharm. Pharmacol."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nsb729","volume":"9","author":"Lisgarten J. N.","year":"2002","journal-title":"Nature Struct. Biol."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"7719","DOI":"10.1021\/bi990094t","volume":"38","author":"Dassonneville L.","year":"1999","journal-title":"Biochemistry"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/toxsci\/70.2.245","volume":"70","author":"Ansah C.","year":"2002","journal-title":"Toxicol. Sci."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1055\/s-2000-11106","volume":"66","author":"Paulo A.","year":"2000","journal-title":"Planta Med."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.tox.2004.11.026","volume":"208","author":"Ansah C.","year":"2005","journal-title":"Toxicology"},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1124\/mol.54.1.170","volume":"54","author":"Bray P. G.","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0163-7258(97)00084-3","volume":"77","author":"O\u2019Neill P. M.","year":"1998","journal-title":"Pharmacol. Ther."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1128\/AAC.42.3.682","volume":"42","author":"Hawley S. R.","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1021\/jm010929+","volume":"44","author":"Wright C. W.","year":"2001","journal-title":"J. Med. Chem."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1021\/cr078274t","volume":"108","author":"Weissbuch I.","year":"2008","journal-title":"Chem. Rev."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1021\/cg025550i","volume":"2","author":"Buller R.","year":"2002","journal-title":"Cryst. Growth Des."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1021\/jm0010419","volume":"44","author":"Arzel E.","year":"2001","journal-title":"J. Med. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.bmcl.2008.01.015","volume":"18","author":"Lavrado J.","year":"2008","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/ardp.19813141008","volume":"314","author":"Gorlitzer K.","year":"1981","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1002\/ardp.19813141009","volume":"314","author":"Gorlitzer K.","year":"1981","journal-title":"Arch. Pharm. (Weinheim, Ger.)"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1021\/jm970735n","volume":"41","author":"Bierer D. E.","year":"1998","journal-title":"J. Med. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1021\/jm9704816","volume":"41","author":"Bierer D. E.","year":"1998","journal-title":"J. Med. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1128\/AAC.40.8.1846","volume":"40","author":"Ridley R. G.","year":"1996","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.1021\/jm980146x","volume":"41","author":"De D. Y. D.","year":"1998","journal-title":"J. Med. Chem."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.bmcl.2004.12.037","volume":"15","author":"Madrid P. B.","year":"2005","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1021\/jm030796n","volume":"46","author":"O\u2019Neill P. M.","year":"2003","journal-title":"J. Med. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2174\/156802606776743147","volume":"6","author":"O\u2019Neill P. M.","year":"2006","journal-title":"Curr. Top. Med. Chem"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1021\/jm8012618","volume":"52","author":"O\u2019Neill P. M.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1021\/jm0600951","volume":"49","author":"Madrid P. B.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1021\/jm040893w","volume":"48","author":"Onyeibor O.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref37\/cit37","first-page":"218","volume":"10","author":"Prudencio M.","year":"2008","journal-title":"Cell. Microbiol."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"6278","DOI":"10.1002\/anie.200604697","volume":"46","author":"Stocks P. A.","year":"2007","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1021\/jm9018383","volume":"53","author":"Wenzel N. I.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1021\/bi972927q","volume":"37","author":"Bonjean K.","year":"1998","journal-title":"Biochemistry"},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/0003-2697(75)90666-1","volume":"68","author":"Ingham K. C.","year":"1975","journal-title":"Anal. Biochem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0076-6879(82)87029-8","volume":"87","author":"Huang C. Y.","year":"1982","journal-title":"Methods Enzymol."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"8870","DOI":"10.1021\/bi00424a027","volume":"27","author":"Strickland J. A.","year":"1988","journal-title":"Biochemistry"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/(SICI)1520-6343(1999)5:5<302::AID-BSPY5>3.0.CO;2-N","volume":"5","author":"Chirvony V. S.","year":"1999","journal-title":"Biospectroscopy"},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1042\/bj3550333","volume":"355","author":"Pandey A. V.","year":"2001","journal-title":"Biochem. J."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0304-4165(00)00058-1","volume":"1475","author":"Vippagunta S. R.","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1021\/jm8012757","volume":"52","author":"O\u2019Neill P. M.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.1021\/ic800440d","volume":"47","author":"Casabianca L. B.","year":"2008","journal-title":"Inorg. Chem."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0162-0134(97)00086-X","volume":"68","author":"Egan T. J.","year":"1997","journal-title":"J. Inorg. Biochem."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jinorgbio.2003.09.007","volume":"98","author":"Egan T. J.","year":"2004","journal-title":"J. Inorg. Biochem."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0020-1693(00)86127-7","volume":"196","author":"Marques H. M.","year":"1992","journal-title":"Inorg. Chim. Acta"},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1128\/AAC.46.1.144-150.2002","volume":"46","author":"Kelly J. X.","year":"2002","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-6851(01)00438-8","volume":"120","author":"Sajid M.","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref54\/cit54","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.molbiopara.2004.11.009","volume":"139","author":"Dahl E. L.","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref55\/cit55","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0968-0896(99)00004-8","volume":"7","author":"Olson J. E.","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"ref56\/cit56","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(86)90368-6","volume":"89","author":"Denizot F.","year":"1986","journal-title":"J. Immunol. Methods"},{"key":"ref57\/cit57","first-page":"113","volume":"9","author":"Job P.","year":"1928","journal-title":"Ann. Chim. (Cachan, Fr.)"},{"key":"ref58\/cit58","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1021\/ed063p162","volume":"63","author":"Hill Z. D.","year":"1986","journal-title":"J. Chem. Educ."},{"key":"ref59\/cit59","unstructured":"Moll, K.; Ljungstr\u00f6m, I.; Perlmann, H.; Scherf, A.; Wahlgren, M.Methods in Malaria Research;Malaria Research and Reference Reagent Resource Center:Manassas, VA, 2008; p330."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm101383f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T19:59:29Z","timestamp":1680724769000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm101383f"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,5]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,2,10]]}},"alternative-id":["10.1021\/jm101383f"],"URL":"https:\/\/doi.org\/10.1021\/jm101383f","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,5]]}}}