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Agents Chemother."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"5344","DOI":"10.1128\/AAC.00790-10","volume":"54","author":"Carvalho L.","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/S0140-6736(00)02352-7","volume":"355","author":"Lell B.","year":"2000","journal-title":"Lancet"},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1021\/jm00351a017","volume":"25","author":"LaMontagne M. P.","year":"1982","journal-title":"J. Med. Chem."},{"key":"ref52\/cit52","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1128\/AAC.00645-07","volume":"52","author":"Nanayakkara N. P. D","year":"2008","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1016\/j.bmc.2005.04.034","volume":"13","author":"Jain M.","year":"2005","journal-title":"Bioorg. Med. 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Res"},{"key":"ref59\/cit59","doi-asserted-by":"crossref","first-page":"6186","DOI":"10.1016\/j.bmc.2008.04.033","volume":"16","author":"Carraz M.","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref60\/cit60","doi-asserted-by":"crossref","first-page":"e513","DOI":"10.1371\/journal.pmed.0030513","volume":"3","author":"Carraz M.","year":"2006","journal-title":"PLoS Med."},{"key":"ref61\/cit61","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0001-706X(97)00138-1","volume":"69","author":"Singh N.","year":"1998","journal-title":"Acta Trop."},{"key":"ref62\/cit62","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1080\/00034983.1999.11813440","volume":"93","author":"Singh N.","year":"1999","journal-title":"Ann. Trop. Med. 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Parasitol."},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0035-9203(01)90027-6","volume":"95","author":"Pukrittayakamee S.","year":"2001","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4269\/ajtmh.2011.10-0285","volume":"84","author":"Tan K. R.","year":"2011","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/1471-2164-10-270","volume":"10","author":"Albuquerque S. S.","year":"2009","journal-title":"BMC Genomics"},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.molbiopara.2007.01.005","volume":"152","author":"Goodman C. D.","year":"2007","journal-title":"Mol. Biochem. 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Hyg."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"e18162","DOI":"10.1371\/journal.pone.0018162","volume":"6","author":"Dembele L.","year":"2011","journal-title":"PLoS One"},{"key":"ref77\/cit77","first-page":"51","volume":"67","author":"Pang L. W.","year":"1989","journal-title":"Bull. W.H.O."},{"key":"ref78\/cit78","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0035-9203(90)90380-W","volume":"84","author":"Karwacki J. J.","year":"1990","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.exppara.2004.05.005","volume":"107","author":"Neerja J.","year":"2004","journal-title":"Exp. Parasitol."},{"key":"ref80\/cit80","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1086\/498249","volume":"192","author":"Thera M. A.","year":"2005","journal-title":"J. Infect. Dis."},{"key":"ref81\/cit81","first-page":"155","volume":"9","author":"Martin D. C.","year":"1969","journal-title":"J. Clin. Pharmacol."},{"key":"ref82\/cit82","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1086\/514710","volume":"27","author":"Shanks G. D.","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"ref83\/cit83","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4269\/ajtmh.1996.54.62","volume":"54","author":"Looareesuwan S.","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref84\/cit84","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1086\/321817","volume":"33","author":"Kain K. C.","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"ref85\/cit85","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0035-9203(96)90266-7","volume":"90","author":"Fleck S. L.","year":"1996","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref86\/cit86","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/0006-2952(92)90213-3","volume":"43","author":"Fry M.","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"ref87\/cit87","doi-asserted-by":"crossref","first-page":"831","DOI":"10.4269\/ajtmh.1999.60.831","volume":"60","author":"Shapiro T. A.","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref88\/cit88","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1128\/AAC.50.4.1586-1589.2006","volume":"50","author":"Gego A.","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref89\/cit89","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0031182000074746","volume":"106","author":"Davies C. S.","year":"1993","journal-title":"Parasitology"},{"key":"ref90\/cit90","doi-asserted-by":"crossref","first-page":"452","DOI":"10.2307\/3283831","volume":"81","author":"Fowler R. E.","year":"1995","journal-title":"J. Parasitol."},{"key":"ref91\/cit91","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.2307\/3276988","volume":"54","author":"Berberian D. A.","year":"1968","journal-title":"J. Parasitol."},{"key":"ref92\/cit92","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.molbiopara.2011.01.002","volume":"177","author":"Hughes L. M.","year":"2011","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref93\/cit93","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1124\/mol.108.045120","volume":"73","author":"Biagini G. A.","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"ref94\/cit94","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1128\/AAC.16.4.475","volume":"16","author":"Schmidt L. H.","year":"1979","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref95\/cit95","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1021\/jm0705760","volume":"51","author":"Yeates C. L.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref96\/cit96","first-page":"30","volume":"73","author":"Hez-Deroubaix S.","year":"2005","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref97\/cit97","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/0035-9203(90)90066-N","volume":"84","author":"Puri S. K.","year":"1990","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref98\/cit98","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1021\/cb200105d","volume":"6","author":"Nam T.-g.","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"ref99\/cit99","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1128\/AAC.47.8.2636-2639.2003","volume":"47","author":"Mahmoudi N.","year":"2003","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref100\/cit100","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1196\/annals.1352.037","volume":"1056","author":"Mi-Ichi F.","year":"2005","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"ref101\/cit101","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1128\/AAC.38.7.1470","volume":"38","author":"Chen M.","year":"1994","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref102\/cit102","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0005-2728(02)00361-4","volume":"1556","author":"Salvi M.","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"ref103\/cit103","doi-asserted-by":"crossref","first-page":"473","DOI":"10.4269\/ajtmh.1993.49.473","volume":"49","author":"Corcoran K. D.","year":"1993","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref104\/cit104","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.bmc.2004.10.052","volume":"13","author":"Guan J.","year":"2005","journal-title":"Bioorg. Med. Chem."},{"key":"ref105\/cit105","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1021\/jm0504252","volume":"48","author":"Zhang Q.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref106\/cit106","doi-asserted-by":"crossref","first-page":"6226","DOI":"10.1021\/jm7009815","volume":"50","author":"Guan J.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref107\/cit107","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/j.bmc.2010.12.028","volume":"19","author":"Zhang L.","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"ref108\/cit108","unstructured":"Lin, A. J.; Kozar, M. P.; O\u2019Neil, M. T.; Magill, A. G.; Saunders, D. L.New Imidazolidinedione Derivatives as Antimalarial Agents, Preparation Thereof, and Methods of Use. WO 2010\/051129."},{"key":"ref109\/cit109","doi-asserted-by":"crossref","first-page":"4523","DOI":"10.1021\/jm200111g","volume":"54","author":"Liu X.","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref110\/cit110","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0024-3205(96)00514-0","volume":"59","author":"Adovelande J.","year":"1996","journal-title":"Life Sci."},{"key":"ref111\/cit111","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1128\/AAC.41.3.523","volume":"41","author":"Gumila C.","year":"1997","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref112\/cit112","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.exppara.2010.05.012","volume":"126","author":"Leitao R.","year":"2010","journal-title":"Exp. Parasitol."},{"key":"ref113\/cit113","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1182\/blood.V79.2.308.308","volume":"79","author":"Gordeuk V. R.","year":"1992","journal-title":"Blood"},{"key":"ref114\/cit114","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/jac\/dkl117","volume":"57","author":"Pradines B.","year":"2006","journal-title":"J. Antimicrob. Chemother."},{"key":"ref115\/cit115","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4269\/ajtmh.1988.39.236","volume":"39","author":"Stahel E.","year":"1988","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref116\/cit116","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/expr.1998.4371","volume":"91","author":"Loyevsky M.","year":"1999","journal-title":"Exp. Parasitol."},{"key":"ref117\/cit117","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1086\/594369","volume":"199","author":"Hobbs C. V.","year":"2009","journal-title":"J. Infect. Dis."},{"key":"ref118\/cit118","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/329351a0","volume":"329","author":"Pearl L. H.","year":"1987","journal-title":"Nature"},{"key":"ref119\/cit119","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1084\/jem.20040989","volume":"201","author":"Coppi A.","year":"2005","journal-title":"J. Exp. Med."},{"key":"ref120\/cit120","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1128\/AAC.50.5.1731-1737.2006","volume":"50","author":"Coppi A.","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref121\/cit121","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1111\/j.1462-5822.2008.01270.x","volume":"11","author":"Vaughan A. M.","year":"2009","journal-title":"Cell. Microbiol."},{"key":"ref122\/cit122","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/iub.237","volume":"61","author":"Singh A. P.","year":"2009","journal-title":"IUBMB Life"},{"key":"ref123\/cit123","unstructured":"Kappe, S. H. I.; Tarun, A.; Vaughan, A.Malaria Liver Stage Drugs. WO 2008\/147826, 2008."},{"key":"ref124\/cit124","doi-asserted-by":"crossref","first-page":"7475","DOI":"10.1016\/j.bmc.2010.08.055","volume":"18","author":"Tasdemir D.","year":"2010","journal-title":"Bioorg. Med. Chem."},{"key":"ref125\/cit125","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1128\/AAC.00198-10","volume":"54","author":"Singh A. P.","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref126\/cit126","first-page":"425","volume":"47","author":"Sodeman T. M.","year":"1972","journal-title":"Bull. W.H.O."},{"key":"ref127\/cit127","first-page":"213","volume":"50","author":"Fink E.","year":"1974","journal-title":"Bull. W.H.O."},{"key":"ref128\/cit128","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1128\/AAC.28.5.612","volume":"28","author":"Schmidt L. H.","year":"1985","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref129\/cit129","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-4894(85)80028-X","volume":"60","author":"Hollingdale M. R.","year":"1985","journal-title":"Exp. Parasitol."},{"key":"ref130\/cit130","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/0035-9203(82)90105-5","volume":"76","author":"Gilleta J. M.","year":"1982","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref131\/cit131","first-page":"301","volume":"66","author":"Lowa P. M.","year":"1986","journal-title":"Ann. Soc. Belg. Med. Trop."},{"key":"ref132\/cit132","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1128\/AAC.42.10.2731","volume":"42","author":"Gantt S. M.","year":"1998","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref133\/cit133","doi-asserted-by":"crossref","first-page":"4928","DOI":"10.1128\/AAC.49.12.4928-4933.2005","volume":"49","author":"Guan J.","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref134\/cit134","doi-asserted-by":"crossref","first-page":"8498","DOI":"10.1002\/chem.200600560","volume":"12","author":"Lena G.","year":"2006","journal-title":"Chem.\u2014Eur. J."},{"key":"ref135\/cit135","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1128\/AAC.00420-10","volume":"54","author":"Panchal D.","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref136\/cit136","unstructured":"Choppin, S.; Colobert, F.; Hanquet, G.; Leroux, F.; Mahmoudi, N.; Mazier, D.New Analogues of Polysphorin and Uses Thereof for Treating or Preventing Malaria. WO 2010\/040730, 2010."},{"key":"ref137\/cit137","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.1087025","volume":"301","author":"Le Roch K. G.","year":"2003","journal-title":"Science"},{"key":"ref138\/cit138","doi-asserted-by":"crossref","first-page":"e653","DOI":"10.1371\/journal.pntd.0000653","volume":"4","author":"Westenberger S. J.","year":"2010","journal-title":"PLoS Neglected Trop. Dis."},{"key":"ref139\/cit139","doi-asserted-by":"crossref","first-page":"e10267","DOI":"10.1371\/journal.pone.0010267","volume":"5","author":"Williams C. T.","year":"2010","journal-title":"PLoS One"},{"key":"ref140\/cit140","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1021\/jm801654y","volume":"52","author":"Patel V.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref141\/cit141","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bbrc.2009.01.165","volume":"381","author":"Sriwilaijaroen N.","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref142\/cit142","doi-asserted-by":"crossref","first-page":"21847","DOI":"10.1074\/jbc.M501100200","volume":"280","author":"Baldwin J.","year":"2005","journal-title":"J. Biol. Chem."},{"key":"ref143\/cit143","doi-asserted-by":"crossref","first-page":"33054","DOI":"10.1074\/jbc.M110.162081","volume":"285","author":"Booker M. L.","year":"2010","journal-title":"J. Biol. Chem."},{"key":"ref144\/cit144","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0166-6851(96)02704-1","volume":"81","author":"Brobey R. K. B.","year":"1996","journal-title":"Mol. Biochem. Parasitol."},{"key":"ref145\/cit145","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1021\/jm901796s","volume":"53","author":"Shahinas D.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref146\/cit146","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1021\/jm8008103","author":"Lee P. J.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref147\/cit147","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1128\/AAC.00124-07","volume":"51","author":"Sharma S.","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref148\/cit148","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature09099","volume":"465","author":"Guiguemde W. A.","year":"2010","journal-title":"Nature"},{"key":"ref149\/cit149","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1128\/AAC.01144-06","volume":"51","author":"Baniecki M. L.","year":"2007","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref150\/cit150","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nature09107","volume":"465","author":"Gamo F.-J.","year":"2010","journal-title":"Nature"},{"key":"ref151\/cit151","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1126\/science.1193225","volume":"329","author":"Rottmann M.","year":"2010","journal-title":"Science"},{"key":"ref152\/cit152","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4269\/ajtmh.1985.34.216","volume":"1985","author":"Hollingdale M. R.","year":"1985","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref153\/cit153","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.4269\/ajtmh.1985.34.1017","volume":"34","author":"Uni S.","year":"1985","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref154\/cit154","doi-asserted-by":"crossref","first-page":"e14275","DOI":"10.1371\/journal.pone.0014275","volume":"5","author":"Chattopadhyay R.","year":"2010","journal-title":"PLoS One"},{"key":"ref155\/cit155","doi-asserted-by":"crossref","first-page":"275","DOI":"10.4269\/ajtmh.1986.35.275","volume":"35","author":"Hollingdale M. R.","year":"1986","journal-title":"Am. J. Trop. Med. 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