{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T23:06:14Z","timestamp":1768431974667,"version":"3.49.0"},"reference-count":32,"publisher":"American Chemical Society (ACS)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2012,4,26]]},"DOI":"10.1021\/jm300262w","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T17:45:10Z","timestamp":1333561510000},"page":"3992-4002","source":"Crossref","is-referenced-by-count":63,"title":["New Structure\u2013Activity Relationships of A- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis, and Biochemical Evaluation"],"prefix":"10.1021","volume":"55","author":[{"given":"Carla","family":"Varela","sequence":"first","affiliation":[{"name":"CEF, Center for Pharmaceutical Studies, Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Elisi\u00e1rio J.","family":"Tavares da Silva","sequence":"additional","affiliation":[{"name":"CEF, Center for Pharmaceutical Studies, Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Cristina","family":"Amaral","sequence":"additional","affiliation":[{"name":"Biochemistry Laboratory, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"},{"name":"Institute for Molecular and Cellular Biology (IBMC), University of Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal"}]},{"given":"Georgina","family":"Correia da Silva","sequence":"additional","affiliation":[{"name":"Biochemistry Laboratory, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"},{"name":"Institute for Molecular and Cellular Biology (IBMC), University of Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal"}]},{"given":"Teresa","family":"Baptista","sequence":"additional","affiliation":[{"name":"CEF, Center for Pharmaceutical Studies, Bromatology, Pharmacognosy and Analytical Sciences Group, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Stefano","family":"Alcaro","sequence":"additional","affiliation":[{"name":"CCLab, Dipartimento di Scienze della Salute, Universit\u00e0 \u201cMagna Gr\u00e6cia\u201d di Catanzaro, Italy"}]},{"given":"Giosu\u00e8","family":"Costa","sequence":"additional","affiliation":[{"name":"CCLab, Dipartimento di Scienze della Salute, Universit\u00e0 \u201cMagna Gr\u00e6cia\u201d di Catanzaro, Italy"}]},{"given":"Rui A.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Portugal"}]},{"given":"Nat\u00e9rcia A. A.","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Biochemistry Laboratory, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal"},{"name":"Institute for Molecular and Cellular Biology (IBMC), University of Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal"}]},{"given":"Fernanda M. F.","family":"Roleira","sequence":"additional","affiliation":[{"name":"CEF, Center for Pharmaceutical Studies, Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2012,4,18]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1200\/JCO.2005.09.121","volume":"23","author":"Winer E. P.","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1634\/theoncologist.11-10-1058","volume":"11","author":"Perez E. A.","year":"2006","journal-title":"Oncologist"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.steroids.2006.10.009","volume":"72","author":"Jordan V. C.","year":"2007","journal-title":"Steroids"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/092986730301220224161537","volume":"3","author":"O\u2019Reilly J. M.","year":"1996","journal-title":"Curr. Med. Chem."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0079-6468(08)70242-X","volume":"26","author":"Banting L.","year":"1989","journal-title":"Prog. Med. Chem."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0079-6468(08)70305-9","volume":"33","author":"Banting L.","year":"1996","journal-title":"Prog. Med. Chem."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/0960-0760(90)90465-W","volume":"37","author":"Miller W. R.","year":"1990","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s12032-007-9019-x","volume":"25","author":"Dutta U.","year":"2008","journal-title":"Med. Oncol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nature07614","volume":"457","author":"Ghosh D.","year":"2009","journal-title":"Nature"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1021\/jm050129p","volume":"48","author":"Cepa M. D. S.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1021\/jm00123a026","volume":"32","author":"Sherwin P. F.","year":"1989","journal-title":"J. Med. Chem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.steroids.2008.07.001","volume":"73","author":"Cepa M. M. D. S.","year":"2008","journal-title":"Steroids"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1021\/jm00383a017","volume":"28","author":"Marsh D. A.","year":"1985","journal-title":"J. Med. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1021\/jm050540c","volume":"49","author":"Sherman W.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.1074\/jbc.M511464200","volume":"281","author":"Zhao Y.","year":"2006","journal-title":"J. Biol. Chem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1021\/jo00172a060","volume":"48","author":"Parish E. J.","year":"1983","journal-title":"J. Org. Chem."},{"key":"ref17\/cit17","unstructured":"Varela, C. L.; Roleira, F. M. F.; Carvalho, R. A.; Teixeira, N. A. A.; Tavares-da-Silva, E. J.Insights and Mechanisms towards the Reactivity of Steroid A-Ring \u03941- and \u03944\u20133-Ketoenones and Corresponding Allylic Alcohols, unpublished results."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1039\/p19940002237","author":"Oh S. S.","year":"1994","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0006-291X(89)80102-0","volume":"160","author":"Numazawa M.","year":"1989","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1039\/p19790002235","author":"Campbell M. M.","year":"1979","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1021\/jm00338a016","volume":"6","author":"Bowers A.","year":"1963","journal-title":"J. Med. Chem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1080\/10426500390228693","volume":"178","author":"Mohamed N. R.","year":"2003","journal-title":"Phosphorus, Sulfur Silicon Relat. Elem."},{"key":"ref23\/cit23","first-page":"53","volume":"249","author":"Thompson E. A.","year":"1974","journal-title":"Biol. Chem."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1021\/jm960047o","volume":"39","author":"Numazawa M.","year":"1996","journal-title":"J. Med. Chem."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1021\/bi00226a004","volume":"30","author":"Yoshida N.","year":"1991","journal-title":"Biochemistry"},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0039-128X(01)00108-8","volume":"66","author":"Heidrich D.","year":"2001","journal-title":"Steroids"},{"key":"ref27\/cit27","unstructured":"Maestro, version 9.1;Schr\u00f6dinger, LLC:New York, NY, 2010."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1002\/jcc.20292","volume":"26","author":"Banks J. L.","year":"2005","journal-title":"J. Comput. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"11225","DOI":"10.1021\/ja9621760","volume":"118","author":"Jorgensen W. L.","year":"1996","journal-title":"J. Am. Chem. Soc."},{"key":"ref30\/cit30","unstructured":"Delano, W. L.The PyMOL Molecular Graphics System, 2002.http:\/\/www.pymol.org"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/jmr.984","volume":"23","author":"Henrich S.","year":"2010","journal-title":"J. Mol. Recognit."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1021\/ci600253e","volume":"47","author":"Baroni M.","year":"2007","journal-title":"J. Chem. Inf. Model."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm300262w","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T20:07:11Z","timestamp":1713816431000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm300262w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,18]]},"references-count":32,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,4,26]]}},"alternative-id":["10.1021\/jm300262w"],"URL":"https:\/\/doi.org\/10.1021\/jm300262w","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,18]]}}}