{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T08:13:01Z","timestamp":1776759181252,"version":"3.51.2"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2013,6,13]]},"DOI":"10.1021\/jm400246e","type":"journal-article","created":{"date-parts":[[2013,5,23]],"date-time":"2013-05-23T14:13:23Z","timestamp":1369318403000},"page":"4811-4815","source":"Crossref","is-referenced-by-count":22,"title":["Quinolin-4(1<i>H<\/i>)-imines are Potent Antiplasmodial Drugs Targeting the Liver Stage of Malaria"],"prefix":"10.1021","volume":"56","author":[{"given":"Tiago","family":"Rodrigues","sequence":"first","affiliation":[{"name":"Research Institute for Medicines\rand Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University\rof Lisbon, Avenida Prof. Gama Pinto, 1649-019 Lisbon, Portugal"},{"name":"ETH Z\u00fcrich, Institute\rof Pharmaceutical Sciences, Wolfgang-Pauli-Strasse 10, 8093 Z\u00fcrich,\rSwitzerland"}]},{"given":"Filipa P.","family":"da Cruz","sequence":"additional","affiliation":[{"name":"Unidade de Mal\u00e1ria,\rInstituto\rde Medicina Molecular, Faculty of Medicine, University of Lisbon,\rAvenida Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"given":"Maria J.","family":"Lafuente-Monasterio","sequence":"additional","affiliation":[{"name":"Tres Cantos Medicines Development\rCampus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos,\r28760 Madrid, Spain"}]},{"given":"Daniel","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines\rand Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University\rof Lisbon, Avenida Prof. Gama Pinto, 1649-019 Lisbon, Portugal"}]},{"given":"Ana S.","family":"Ressurrei\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines\rand Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University\rof Lisbon, Avenida Prof. Gama Pinto, 1649-019 Lisbon, Portugal"}]},{"given":"Ana R.","family":"Sitoe","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines\rand Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University\rof Lisbon, Avenida Prof. Gama Pinto, 1649-019 Lisbon, Portugal"}]},{"given":"Maria R.","family":"Bronze","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines\rand Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University\rof Lisbon, Avenida Prof. Gama Pinto, 1649-019 Lisbon, Portugal"}]},{"given":"Jiri","family":"Gut","sequence":"additional","affiliation":[{"name":"Department\rof Medicine, San\rFrancisco General Hospital, University of California, San Francisco,\rBox 0811, San Francisco, California, 94143, United States"}]},{"given":"Gisbert","family":"Schneider","sequence":"additional","affiliation":[{"name":"ETH Z\u00fcrich, Institute\rof Pharmaceutical Sciences, Wolfgang-Pauli-Strasse 10, 8093 Z\u00fcrich,\rSwitzerland"}]},{"given":"Maria M.","family":"Mota","sequence":"additional","affiliation":[{"name":"Unidade de Mal\u00e1ria,\rInstituto\rde Medicina Molecular, Faculty of Medicine, University of Lisbon,\rAvenida Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"given":"Philip J.","family":"Rosenthal","sequence":"additional","affiliation":[{"name":"Department\rof Medicine, San\rFrancisco General Hospital, University of California, San Francisco,\rBox 0811, San Francisco, California, 94143, United States"}]},{"given":"Miguel","family":"Prud\u00eancio","sequence":"additional","affiliation":[{"name":"Unidade de Mal\u00e1ria,\rInstituto\rde Medicina Molecular, Faculty of Medicine, University of Lisbon,\rAvenida Prof. Egas Moniz, 1649-028 Lisbon, Portugal"}]},{"given":"Francisco-Javier","family":"Gamo","sequence":"additional","affiliation":[{"name":"Tres Cantos Medicines Development\rCampus, Diseases of the Developing World, GlaxoSmithKline, Tres Cantos,\r28760 Madrid, Spain"}]},{"given":"Francisca","family":"Lopes","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines\rand Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University\rof Lisbon, Avenida Prof. Gama Pinto, 1649-019 Lisbon, Portugal"}]},{"given":"Rui","family":"Moreira","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines\rand Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University\rof Lisbon, Avenida Prof. Gama Pinto, 1649-019 Lisbon, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2013,5,23]]},"reference":[{"key":"ref1\/cit1","unstructured":"World Malaria Report 2011;World Health Organization:Geneva, 2011."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nature09107","volume":"465","author":"Gamo F.-J.","year":"2010","journal-title":"Nature"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature09099","volume":"465","author":"Guiguemde W. A.","year":"2010","journal-title":"Nature"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"e1000402","DOI":"10.1371\/journal.pmed.1000402","volume":"8","author":"The malERA Consultive Group on Drugs.","year":"2011","journal-title":"PLoS Med."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nrmicro1529","volume":"4","author":"Prud\u00eancio M.","year":"2006","journal-title":"Nature Rev. Microbiol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1021\/jm201095h","volume":"55","author":"Rodrigues T.","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.pt.2009.12.005","volume":"26","author":"Wells T. N. C.","year":"2010","journal-title":"Trends Parasitol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrd2960","volume":"8","author":"Mazier D.","year":"2009","journal-title":"Nature Rev. Drug Discovery"},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/eesa.1999.1868","volume":"45","author":"Srivastava P.","year":"2000","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"402","DOI":"10.4269\/ajtmh.2006.75.402","volume":"75","author":"Hill D. R.","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1093\/infdis\/jis184","volume":"205","author":"da Cruz F. P.","year":"2012","journal-title":"J. Infect. Dis."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"8511","DOI":"10.1073\/pnas.1118370109","volume":"109","author":"Derbyshire E. R.","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1021\/jm301654b","volume":"56","author":"P\u00e9rez B. C.","year":"2013","journal-title":"J. Med. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"8298","DOI":"10.1073\/pnas.1205651109","volume":"109","author":"Biagini G. A.","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"4205","DOI":"10.1021\/jm201642z","volume":"55","author":"Zhang Y.","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1128\/AAC.00793-12","volume":"57","author":"LaCrue A. N.","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.exppara.2007.10.016","volume":"118","author":"Winter R. W.","year":"2008","journal-title":"Exp. Parasitol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"7076","DOI":"10.1021\/jm1007903","volume":"53","author":"Cross R. M.","year":"2010","journal-title":"J. Med. Chem."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"177ra37","DOI":"10.1126\/scitranslmed.3005029","volume":"5","author":"Nilsen A.","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1002\/cmdc.201200045","volume":"7","author":"Derbyshire E. R.","year":"2012","journal-title":"ChemMedChem"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1016\/j.bmcl.2009.05.017","volume":"19","author":"Rodrigues T.","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"O283","DOI":"10.1107\/S1600536809000324","volume":"65","author":"Rodrigues T.","year":"2009","journal-title":"Acta Crystallogr., Sect. E: Struct. Rep. Online"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"7663","DOI":"10.1016\/j.tetlet.2004.08.093","volume":"45","author":"Lopes F.","year":"2004","journal-title":"Tetrahedron Lett."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1126\/science.1211936","volume":"334","author":"Meister S.","year":"2011","journal-title":"Science"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1021\/cr00002a004","volume":"91","author":"Hansch C.","year":"1991","journal-title":"Chem. Rev."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1021\/jm00269a003","volume":"16","author":"Hansch C.","year":"1973","journal-title":"J. Med. Chem."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1021\/jm0705760","volume":"51","author":"Yeates C. L.","year":"2008","journal-title":"J. Med. Chem."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"929","DOI":"10.2174\/092986710790820660","volume":"17","author":"Rodrigues T.","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1039\/C1MD00183C","volume":"3","author":"Cowley R.","year":"2012","journal-title":"Med. Chem. Commun."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1021\/jm201179h","volume":"55","author":"Pidathala C.","year":"2012","journal-title":"J. Med. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature05572","volume":"446","author":"Painter H. J.","year":"2007","journal-title":"Nature"},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"7800","DOI":"10.1021\/jm900738c","volume":"52","author":"Vale N.","year":"2009","journal-title":"J. Med. Chem."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1073\/pnas.0710780104","volume":"115","author":"Tarun A. S.","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1016\/j.bmcl.2006.01.027","volume":"16","author":"Andricopuloa A. D.","year":"2006","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrmicro843","volume":"2","author":"Ralph S. A.","year":"2004","journal-title":"Nature Rev. Microbiol."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.chom.2008.11.001","volume":"4","author":"Yu M.","year":"2008","journal-title":"Cell Host Microbe"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.jinorgbio.2005.11.005","volume":"100","author":"Egan T.","year":"2006","journal-title":"J. Inorg. Biochem."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0162-0134(97)00086-X","volume":"68","author":"Egan T. F.","year":"1997","journal-title":"J. Inorg. Biochem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ddtec.2005.05.024","volume":"2","author":"Li A. P.","year":"2005","journal-title":"Drug Discovery Today: Technol."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S1359-6446(04)03069-7","volume":"15","author":"Hopkins A. L.","year":"2004","journal-title":"Drug Discovery Today"}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm400246e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T14:47:54Z","timestamp":1680706074000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm400246e"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,23]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,6,13]]}},"alternative-id":["10.1021\/jm400246e"],"URL":"https:\/\/doi.org\/10.1021\/jm400246e","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,23]]}}}