{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T16:15:22Z","timestamp":1775232922626,"version":"3.50.1"},"reference-count":14,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Med. Chem."],"published-print":{"date-parts":[[2009,1,8]]},"DOI":"10.1021\/jm800981y","type":"journal-article","created":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T13:41:59Z","timestamp":1228484519000},"page":"219-223","source":"Crossref","is-referenced-by-count":43,"title":["The Design, Synthesis, and Antiviral Activity of 4\u2032-Azidocytidine Analogues against Hepatitis C Virus Replication: The Discovery of 4\u2032-Azidoarabinocytidine"],"prefix":"10.1021","volume":"52","author":[{"given":"David B.","family":"Smith","sequence":"first","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Genadiy","family":"Kalayanov","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Christian","family":"Sund","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Anna","family":"Winqvist","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Pedro","family":"Pinho","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Tatiana","family":"Maltseva","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Veronique","family":"Morisson","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Vincent","family":"Leveque","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Sonal","family":"Rajyaguru","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Sophie Le","family":"Pogam","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Isabel","family":"Najera","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Kurt","family":"Benkestock","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Xiao-Xiong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Hans","family":"Maag","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Nick","family":"Cammack","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Joseph A.","family":"Martin","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Steven","family":"Swallow","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Nils Gunnar","family":"Johansson","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Klaus","family":"Klumpp","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]},{"given":"Mark","family":"Smith","sequence":"additional","affiliation":[{"name":"Roche Palo Alto LLC, 3431 Hillview Avenue, Palo Alto, California 94304, Medivir AB, Department of Medicinal Chemistry, Lunastigen 7, SE-141 44 Huddinge, Sweden"}]}],"member":"316","published-online":{"date-parts":[[2008,12,5]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2000-9506","volume":"20","author":"Wasley A.","year":"2000","journal-title":"Semin. Liver Dis."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1056\/NEJMoa020047","volume":"347","author":"Fried M. W.","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1021\/jm0603623","volume":"48","author":"Pierra C.","year":"2006","journal-title":"J. Med. Chem."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"5504","DOI":"10.1021\/jm0502788","volume":"48","author":"Clark J. L.","year":"2005","journal-title":"J. Med. Chem."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1016\/j.bmcl.2007.02.004","volume":"17","author":"Smith D. B.","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1074\/jbc.M510195200","volume":"281","author":"Klumpp K.","year":"2006","journal-title":"J. Biol. Chem."},{"issue":"4","key":"ref7\/cit7","first-page":"311A","volume":"46","author":"Pockros P. J.","year":"2007","journal-title":"Hepatology"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1074\/jbc.M708929200","volume":"283","author":"Klumpp K.","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1021\/jm0613370","volume":"50","author":"Perrone P.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"5463","DOI":"10.1021\/jm070362i","volume":"50","author":"Perrone P.","year":"2007","journal-title":"J. Med. Chem."},{"key":"ref11\/cit11","unstructured":"Connolly, T. K.; Durkin, K.; Sarma, K.; Zhu, J.Processes for Preparing 4\u2032-Azido Nucleoside Derivatives. Patent WO 2005\/000864,2005."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1039\/a803563f","author":"Miah M.","year":"1998","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1039\/P19820001171","author":"Divakar K. J.","year":"1982","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1021\/ja00848a042","volume":"97","author":"Verheyden J. P. H.","year":"1975","journal-title":"J. Am. Chem. Soc."}],"container-title":["Journal of Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/jm800981y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,15]],"date-time":"2023-03-15T15:09:41Z","timestamp":1678892981000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/jm800981y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,12,5]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1,8]]}},"alternative-id":["10.1021\/jm800981y"],"URL":"https:\/\/doi.org\/10.1021\/jm800981y","relation":{},"ISSN":["0022-2623","1520-4804"],"issn-type":[{"value":"0022-2623","type":"print"},{"value":"1520-4804","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,12,5]]}}}