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J.","year":"1997","journal-title":"Tetrahedron"},{"key":"ref8\/cit8g","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1021\/ja980407s","volume":"120","author":"Magnus P.","year":"1998","journal-title":"J. Am. Chem. Soc."},{"key":"ref8\/cit8n","doi-asserted-by":"crossref","first-page":"15509","DOI":"10.1016\/S0040-4020(98)00975-2","volume":"54","author":"Magnus P.","year":"1998","journal-title":"Tetrahedron"},{"key":"ref8\/cit8h","doi-asserted-by":"crossref","first-page":"6624","DOI":"10.1021\/ja000930i","volume":"122","author":"Rigby J. H.","year":"2000","journal-title":"J. Am. Chem. Soc."},{"key":"ref8\/cit8i","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.1016\/j.tetlet.2006.03.138","volume":"47","author":"Li M.","year":"2006","journal-title":"Tetrahedron Lett."},{"key":"ref8\/cit8j","doi-asserted-by":"crossref","first-page":"4666","DOI":"10.1002\/ejoc.200900719","author":"Dam J. H.","year":"2009","journal-title":"Eur. J. Org. Chem."},{"key":"ref8\/cit8k","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1021\/jo000710n","volume":"66","author":"Pettit G. R.","year":"2001","journal-title":"J. Org. Chem."},{"key":"ref8\/cit8l","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1021\/ol0256419","volume":"4","author":"Kim S.","year":"2002","journal-title":"Org. Lett."},{"key":"ref8\/cit8o","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1021\/jo035371n","volume":"69","author":"Ko H. J.","year":"2004","journal-title":"J. Org. Chem."},{"key":"ref8\/cit8m","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.1021\/ol202525a","volume":"13","author":"Jung Y.-G.","year":"2011","journal-title":"Org. Lett."},{"key":"ref9\/cit9a","doi-asserted-by":"crossref","first-page":"8798","DOI":"10.1021\/ja0342998","volume":"125","author":"Ohyabu N.","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ref9\/cit9b","doi-asserted-by":"crossref","first-page":"11510","DOI":"10.1021\/ja0368305","volume":"125","author":"Hinman A.","year":"2003","journal-title":"J. Am. Chem. Soc."},{"key":"ref9\/cit9c","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1002\/anie.200460293","volume":"43","author":"Nishikawa T.","year":"2004","journal-title":"Angew. Chem., Int. Ed."},{"key":"ref9\/cit9d","unstructured":"dNoheda, P.Synthesis of tetrodotoxin, its analogues and intermediates thereof. EP 1785427, 2007."},{"key":"ref9\/cit9e","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1021\/jo701655v","volume":"73","author":"Sato K.-i.","year":"2008","journal-title":"J. Org. Chem."},{"key":"ref9\/cit9f","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1246\/bcsj.20090194","volume":"83","author":"Akai S.","year":"2010","journal-title":"Bull. Chem. Soc. 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