{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T22:33:07Z","timestamp":1768516387109,"version":"3.49.0"},"reference-count":43,"publisher":"American Chemical Society (ACS)","issue":"51","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Langmuir"],"published-print":{"date-parts":[[2013,12,23]]},"DOI":"10.1021\/la4032927","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T15:08:46Z","timestamp":1385564926000},"page":"15926-15935","source":"Crossref","is-referenced-by-count":32,"title":["Encapsulation of DNA in Macroscopic and Nanosized Calcium Alginate Gel Particles"],"prefix":"10.1021","volume":"29","author":[{"given":"Alexandra H. E.","family":"Machado","sequence":"first","affiliation":[{"name":"Division\rof Physical Chemistry, Center for Chemistry and Chemical Engineering, Lund University, P.O.\rBox 124, SE-221 00 Lund, Sweden"},{"name":"Center\rfor Pharmaceutical Studies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Dan","family":"Lundberg","sequence":"additional","affiliation":[{"name":"Division\rof Physical Chemistry, Center for Chemistry and Chemical Engineering, Lund University, P.O.\rBox 124, SE-221 00 Lund, Sweden"},{"name":"Department\rof Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"},{"name":"CR\rCompetence AB, Center for Chemistry and Chemical Engineering, Lund University, P.O.\rBox 124, 221 00 Lund, Sweden"}]},{"given":"Ant\u00f3nio J.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Center\rfor Pharmaceutical Studies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Francisco J.","family":"Veiga","sequence":"additional","affiliation":[{"name":"Center\rfor Pharmaceutical Studies, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal"}]},{"given":"Maria G.","family":"Miguel","sequence":"additional","affiliation":[{"name":"Department\rof Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"given":"Bj\u00f6rn","family":"Lindman","sequence":"additional","affiliation":[{"name":"Division\rof Physical Chemistry, Center for Chemistry and Chemical Engineering, Lund University, P.O.\rBox 124, SE-221 00 Lund, Sweden"},{"name":"Department\rof Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal"}]},{"given":"Ulf","family":"Olsson","sequence":"additional","affiliation":[{"name":"Division\rof Physical Chemistry, Center for Chemistry and Chemical Engineering, Lund University, P.O.\rBox 124, SE-221 00 Lund, Sweden"}]}],"member":"316","published-online":{"date-parts":[[2013,12,11]]},"reference":[{"key":"ref1\/cit1","volume-title":"Pharmaceutical Chemistry: Therapeutic Aspects of Biomacromolecules","author":"Bladon C. M.","year":"2002"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.nano.2006.04.009","volume":"2","author":"Pinto Reis C.","year":"2006","journal-title":"Nanomedicine"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/bk-2004-0879.ch001","volume-title":"Carrier-Based Drug Delivery","volume":"879","author":"Svenson S.","year":"2004"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/71889","volume":"18","author":"Luo D.","year":"2000","journal-title":"Nat. Biotechnol."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0168-3659(95)00011-V","volume":"34","author":"Chickering D. E.","year":"1995","journal-title":"J. Controlled Release"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0169-409X(97)00124-5","volume":"31","author":"Gombotz W. R.","year":"1998","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jconrel.2008.08.010","volume":"132","author":"Murua A.","year":"2008","journal-title":"J. Controlled Release"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0167-7799(90)90139-O","volume":"8","author":"Smidsr\u00f8d O.","year":"1990","journal-title":"Trends Biotechnol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1016\/j.biomaterials.2012.01.007","volume":"33","author":"Pawar S. N.","year":"2012","journal-title":"Biomaterials"},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/mabi.200600069","volume":"6","author":"Augst A. D.","year":"2006","journal-title":"Macromol. Biosci."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/978-3-540-92679-5_8","volume-title":"Alginates: Biology and Applications","volume":"13","author":"Prasad K.","year":"2009"},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/bit.260330111","volume":"33","author":"Martinsen A.","year":"1989","journal-title":"Biotechnol. Bioeng."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0966-7822(94)00043-7","volume":"3","author":"Velings N. M.","year":"1995","journal-title":"Polym. Gels Networks"},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0928-0987(97)10007-0","volume":"6","author":"McClean S.","year":"1998","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0168-3659(00)00358-8","volume":"71","author":"Zauner W.","year":"2001","journal-title":"J. Controlled Release"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj20031253","volume":"377","author":"Rejman J.","year":"2004","journal-title":"Biochem. J."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/masy.200550113","volume":"219","author":"You J.-O.","year":"2005","journal-title":"Macromol. Symp."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1002\/jps.23104","volume":"101","author":"Nesamony J.","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1021\/la204944j","volume":"28","author":"Machado A. H. E.","year":"2012","journal-title":"Langmuir"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0021-9797(69)80012-3","volume":"30","author":"Shinoda K.","year":"1969","journal-title":"J. Colloid Interface Sci."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1021\/la903401g","volume":"26","author":"Roger K.","year":"2009","journal-title":"Langmuir"},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"6200","DOI":"10.1021\/ma060669b","volume":"39","author":"Makita N.","year":"2006","journal-title":"Macromolecules"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","DOI":"10.1002\/9780470286364","volume-title":"DNA Interactions with Polymers and Surfactants","author":"Dias R.","year":"2008"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1093\/nar\/3.11.2985","volume":"3","author":"Ordahl C. P.","year":"1976","journal-title":"Nucleic Acids Res."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1134\/S0026893306020142","volume":"40","author":"Grokhovsky S.","year":"2006","journal-title":"Mol. Biol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1021\/bm030063k","volume":"5","author":"Donati I.","year":"2003","journal-title":"Biomacromolecules"},{"key":"ref27\/cit27","volume-title":"Molecular Cloning: A Laboratory Manual","volume":"1","author":"Sambrook J.","year":"2001","edition":"3"},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/B978-012088546-6\/50008-7","volume-title":"Molecular Biology and Genomics","author":"M\u00fclhardt C.","year":"2007"},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"13102","DOI":"10.1021\/la101403j","volume":"26","author":"Machado A. H. E.","year":"2010","journal-title":"Langmuir"},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"3589","DOI":"10.1021\/ma00066a017","volume":"26","author":"Moe S. T.","year":"1993","journal-title":"Macromolecules"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1002\/bip.360221103","volume":"22","author":"Klein B. J.","year":"1983","journal-title":"Biopolymers"},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0001-8686(92)80011-L","volume":"41","author":"Piculell L.","year":"1992","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/(SICI)1097-0290(19980220)57:4<438::AID-BIT7>3.0.CO;2-N","volume":"57","author":"Quong D.","year":"1998","journal-title":"Biotechnol. Bioeng."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-540-92679-5_1","volume-title":"Alginates: Biology and Applications","volume":"13","author":"Donati I.","year":"2009"},{"key":"ref35\/cit35","volume-title":"CRC Handbook of Chemistry and Physics, Internet Version 2007","author":"Lide D.","year":"2007","edition":"87"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1385\/ABAB:81:1:67","volume":"81","author":"Quong D.","year":"1999","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/S0006-3495(93)81263-3","volume":"65","author":"Duguid J.","year":"1993","journal-title":"Biophys. J."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(01)00239-3","volume":"54","author":"Hoffman A. S.","year":"2002","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1002\/(SICI)1097-4636(199910)47:1<46::AID-JBM6>3.0.CO;2-N","volume":"47","author":"LeRoux M. A.","year":"1999","journal-title":"J. Biomed. Mater. Res."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0144-8617(89)90030-1","volume":"10","author":"Skj\u00e5k-Br\u00e6k G.","year":"1989","journal-title":"Carbohydr. Polym."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/(SICI)1097-0282(200001)53:1<60::AID-BIP6>3.0.CO;2-F","volume":"53","author":"Thu B.","year":"2000","journal-title":"Biopolymers"},{"key":"ref42\/cit42","volume-title":"NCL Method PCC-2: Measuring Zeta Potential of Nanoparticles","author":"Clogston J. D.","year":"2009"},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/jgm.695","volume":"7","author":"You J.-O.","year":"2005","journal-title":"J. Gene Med."}],"container-title":["Langmuir"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/la4032927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T00:37:01Z","timestamp":1681605421000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/la4032927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12,11]]},"references-count":43,"journal-issue":{"issue":"51","published-print":{"date-parts":[[2013,12,23]]}},"alternative-id":["10.1021\/la4032927"],"URL":"https:\/\/doi.org\/10.1021\/la4032927","relation":{},"ISSN":["0743-7463","1520-5827"],"issn-type":[{"value":"0743-7463","type":"print"},{"value":"1520-5827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12,11]]}}}