{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:53:23Z","timestamp":1759938803505},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Pharmaceutics"],"published-print":{"date-parts":[[2013,11,4]]},"DOI":"10.1021\/mp400381p","type":"journal-article","created":{"date-parts":[[2013,9,17]],"date-time":"2013-09-17T17:45:18Z","timestamp":1379439918000},"page":"4038-4045","source":"Crossref","is-referenced-by-count":2,"title":["Effect of P-Glycoprotein on the Rat Intestinal Permeability and Metabolism of the BDDCS Class 1 Drug Verapamil"],"prefix":"10.1021","volume":"10","author":[{"given":"Margarida","family":"Estudante","sequence":"first","affiliation":[{"name":"iMed.UL,\rFaculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-019 Lisbon, Portugal"},{"name":"Department\rof Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California 94143-0912, United States"},{"name":"Department\rof Pharmacological Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal"}]},{"given":"Manuela","family":"Maya","sequence":"additional","affiliation":[{"name":"Department\rof Pharmacological Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal"}]},{"given":"Jos\u00e9 G.","family":"Morais","sequence":"additional","affiliation":[{"name":"iMed.UL,\rFaculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-019 Lisbon, Portugal"},{"name":"Department\rof Pharmacological Sciences, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal"}]},{"given":"Gra\u00e7a","family":"Soveral","sequence":"additional","affiliation":[{"name":"iMed.UL,\rFaculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-019 Lisbon, Portugal"},{"name":"Department\rof Biochemistry and Human Biology, Faculty of Pharmacy, University of Lisbon, Lisbon, Portugal"}]},{"given":"Leslie Z.","family":"Benet","sequence":"additional","affiliation":[{"name":"Department\rof Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California 94143-0912, United States"}]}],"member":"316","published-online":{"date-parts":[[2013,9,27]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1007\/s11095-009-9924-0","volume":"26","author":"Shugarts S.","year":"2009","journal-title":"Pharm. Res."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1021\/ci600343x","volume":"47","author":"Hou T.","year":"2007","journal-title":"J. Chem. Inf. Model."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1023\/A:1016212804288","volume":"12","author":"Amidon G. L.","year":"1995","journal-title":"Pharm. Res."},{"key":"ref4\/cit4","first-page":"765","volume":"33","author":"Zhang H. X.","year":"2008","journal-title":"Zhongnan Daxue Xuebao, Yixueban"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1080\/00498250701570251","volume":"37","author":"Oswald S.","year":"2007","journal-title":"Xenobiotica"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/clpt.1992.171","volume":"52","author":"Hebert M. F.","year":"1992","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1021\/mp900253n","volume":"6","author":"Benet L. Z.","year":"2009","journal-title":"Mol. Pharmaceutics"},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1124\/jpet.300.3.1036","volume":"300","author":"Cummins C. L.","year":"2002","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1124\/jpet.102.044719","volume":"305","author":"Cummins C. L.","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2174\/1389200033489389","volume":"4","author":"Benet L. Z.","year":"2003","journal-title":"Curr. Drug Metab."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1124\/dmd.31.11.1292","volume":"31","author":"Wu C. Y.","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1124\/dmd.32.11.1311","volume":"32","author":"Lam J. L.","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1124\/jpet.103.061770","volume":"308","author":"Lau Y. Y.","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1124\/jpet.105.093088","volume":"316","author":"Lau Y. Y.","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1208\/s12248-008-9040-9","volume":"10","author":"Polli J. E.","year":"2008","journal-title":"AAPS J."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s11095-004-9004-4","volume":"22","author":"Wu C. Y.","year":"2005","journal-title":"Pharm. Res."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.addr.2007.08.043","volume":"60","author":"Custodio J. M.","year":"2008","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1023\/A:1016217505990","volume":"12","author":"Saitoh H.","year":"1995","journal-title":"Pharm. Res."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1007\/s004240050829","volume":"437","author":"Golstein P. E.","year":"1999","journal-title":"Pfluegers Arch."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00228-009-0757-x","volume":"66","author":"Choi D. H.","year":"2010","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1211\/0022357011778214","volume":"53","author":"Johnson B. M.","year":"2001","journal-title":"J. Pharm. Pharmacol."},{"key":"ref22\/cit22","first-page":"376","volume":"293","author":"Pauli-Magnus C.","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1023\/A:1015911712079","volume":"5","author":"Grass G. M.","year":"1988","journal-title":"Pharm. Res."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ijpharm.2004.09.023","volume":"288","author":"Guggi D.","year":"2005","journal-title":"Int. J. Pharm."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1124\/dmd.104.000752","volume":"32","author":"Kunta J. R.","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/bmc.102","volume":"16","author":"Campanero M. A.","year":"2002","journal-title":"Biomed. Chromatogr."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/bdd.582","volume":"29","author":"Choi D. H.","year":"2008","journal-title":"Biopharm. Drug Dispos."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/sj.clpt.6100038","volume":"81","author":"Lau Y. Y.","year":"2007","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1124\/jpet.103.058065","volume":"308","author":"Cummins C. L.","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1023\/A:1011916329863","volume":"15","author":"Sandstrom R.","year":"1998","journal-title":"Pharm. Res."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1021\/js980378j","volume":"88","author":"Doppenschmitt S.","year":"1999","journal-title":"J. Pharm. Sci."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1124\/dmd.107.020040","volume":"36","author":"Shirasaka Y.","year":"2008","journal-title":"Drug Metab. Dispos."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1023\/A:1011971303880","volume":"15","author":"Makhey V. D.","year":"1998","journal-title":"Pharm. Res."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1124\/dmd.31.9.1151","volume":"31","author":"Johnson B. M.","year":"2003","journal-title":"Drug Metab. Dispos."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1021\/mp0499104","volume":"2","author":"Cao X.","year":"2005","journal-title":"Mol. Pharmaceutics"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2133\/dmpk.21.238","volume":"21","author":"Ogihara T.","year":"2006","journal-title":"Drug Metab. Pharmacokinet."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1046\/j.1365-2125.1999.00923.x","volume":"47","author":"Tracy T. S.","year":"1999","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ejps.2004.09.002","volume":"23","author":"Lacombe O.","year":"2004","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref39\/cit39","first-page":"584","volume":"296","author":"Stephens R. H.","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1007525616017","volume":"17","author":"Wu X.","year":"2000","journal-title":"Pharm. Res."}],"container-title":["Molecular Pharmaceutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/mp400381p","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,16]],"date-time":"2023-04-16T09:04:10Z","timestamp":1681635850000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/mp400381p"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,27]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11,4]]}},"alternative-id":["10.1021\/mp400381p"],"URL":"https:\/\/doi.org\/10.1021\/mp400381p","relation":{},"ISSN":["1543-8384","1543-8392"],"issn-type":[{"value":"1543-8384","type":"print"},{"value":"1543-8392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,27]]}}}