{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T10:53:38Z","timestamp":1775127218598,"version":"3.50.1"},"reference-count":49,"publisher":"American Chemical Society (ACS)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nano Lett."],"published-print":{"date-parts":[[2010,10,13]]},"DOI":"10.1021\/nl1016909","type":"journal-article","created":{"date-parts":[[2010,8,26]],"date-time":"2010-08-26T13:13:44Z","timestamp":1282828424000},"page":"3933-3939","source":"Crossref","is-referenced-by-count":78,"title":["Chitosan\/siRNA Nanoparticles Biofunctionalize Nerve Implants and Enable Neurite Outgrowth"],"prefix":"10.1021","volume":"10","author":[{"given":"Ursula","family":"Mittnacht","sequence":"first","affiliation":[{"name":"NMI Natural and Medical Sciences Institute at the University of T\u00fcbingen, Markwiesenstrasse 55, 72770 Reutlingen, Germany"}]},{"given":"Hanna","family":"Hartmann","sequence":"additional","affiliation":[{"name":"NMI Natural and Medical Sciences Institute at the University of T\u00fcbingen, Markwiesenstrasse 55, 72770 Reutlingen, Germany"}]},{"given":"San","family":"Hein","sequence":"additional","affiliation":[{"name":"Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology, University of Aarhus, 8000 Aarhus C, Aarhus, Denmark"}]},{"given":"Hugo","family":"Oliveira","sequence":"additional","affiliation":[{"name":"INEB - Instituto de Engenharia Biom\u00e9dica, Divis\u00e3o de Biomateriais, Universidade do Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal"},{"name":"Universidade do Porto, Faculdade de Engenharia, Rua Roberto Frias, s\/n, 4200-465 Porto, Portugal"}]},{"given":"Mingdong","family":"Dong","sequence":"additional","affiliation":[{"name":"Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology, University of Aarhus, 8000 Aarhus C, Aarhus, Denmark"}]},{"given":"Ana","family":"P. P\u00eago","sequence":"additional","affiliation":[{"name":"INEB - Instituto de Engenharia Biom\u00e9dica, Divis\u00e3o de Biomateriais, Universidade do Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal"}]},{"given":"J\u00f8rgen","family":"Kjems","sequence":"additional","affiliation":[{"name":"Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology, University of Aarhus, 8000 Aarhus C, Aarhus, Denmark"}]},{"given":"Kenneth A.","family":"Howard","sequence":"additional","affiliation":[{"name":"Interdisciplinary Nanoscience Center (iNANO) and Department of Molecular Biology, University of Aarhus, 8000 Aarhus C, Aarhus, Denmark"}]},{"given":"Burkhard","family":"Schlosshauer","sequence":"additional","affiliation":[{"name":"NMI Natural and Medical Sciences Institute at the University of T\u00fcbingen, Markwiesenstrasse 55, 72770 Reutlingen, Germany"}]}],"member":"316","published-online":{"date-parts":[[2010,8,26]]},"reference":[{"key":"ref1\/cit1","first-page":"264","volume":"14","author":"Terzis J. K.","year":"1995","journal-title":"Int. Angiol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1146\/annurev.bioeng.5.011303.120731","volume":"5","author":"Schmidt C. E.","year":"2003","journal-title":"Annu. Rev. Biomed. Eng."},{"issue":"27","key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"5839","DOI":"10.1016\/j.biomaterials.2004.01.041","volume":"25","author":"Stokols S.","year":"2004","journal-title":"Biomaterials"},{"issue":"2","key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jconrel.2005.10.019","volume":"110","author":"Goraltchouk A.","year":"2006","journal-title":"J. Controlled Release"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/00000637-199912000-00016","volume":"43","author":"Wu J.","year":"1999","journal-title":"Ann. Plast. Surg."},{"issue":"6768","key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/35000219","volume":"403","author":"Chen M. S.","year":"2000","journal-title":"Nature"},{"issue":"6768","key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/35000226","volume":"403","author":"GrandPre T.","year":"2000","journal-title":"Nature"},{"issue":"5584","key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1126\/science.1073031","volume":"297","author":"Liu B. P.","year":"2002","journal-title":"Science"},{"issue":"4","key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0896-6273(94)90247-X","volume":"13","author":"McKerracher L.","year":"1994","journal-title":"Neuron"},{"issue":"3","key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0896-6273(94)90042-6","volume":"13","author":"Mukhopadhyay G.","year":"1994","journal-title":"Neuron"},{"issue":"6892","key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1038\/nature00867","volume":"417","author":"Wang K. C.","year":"2002","journal-title":"Nature"},{"issue":"3","key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nn1188","volume":"7","author":"Mi S.","year":"2004","journal-title":"Nat. Neurosci."},{"issue":"3","key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neuron.2004.12.040","volume":"45","author":"Park J. B.","year":"2005","journal-title":"Neuron"},{"issue":"3","key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.neuron.2004.12.050","volume":"45","author":"Shao Z.","year":"2005","journal-title":"Neuron"},{"issue":"6911","key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nature01176","volume":"420","author":"Wang K. C.","year":"2002","journal-title":"Nature"},{"issue":"12","key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1038\/nn975","volume":"5","author":"Wong S. T.","year":"2002","journal-title":"Nat. Neurosci."},{"issue":"6836","key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/35078107","volume":"411","author":"Elbashir S. M.","year":"2001","journal-title":"Nature"},{"issue":"3","key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/S0006-291X(03)00029-9","volume":"301","author":"Higuchi H.","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"6669","key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35888","volume":"391","author":"Fire A.","year":"1998","journal-title":"Nature"},{"issue":"1","key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0092-8674(04)00293-4","volume":"117","author":"Tijsterman M.","year":"2004","journal-title":"Cell"},{"issue":"6","key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nrd2310","volume":"6","author":"de Fougerolles A.","year":"2007","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"3","key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/biot.200700215","volume":"3","author":"Shrivastava N.","year":"2008","journal-title":"Biotechnol. J."},{"issue":"7014","key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature03121","volume":"432","author":"Soutschek J.","year":"2004","journal-title":"Nature"},{"issue":"8","key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1349-7006.2006.00234.x","volume":"97","author":"Takeshita F.","year":"2006","journal-title":"Cancer Sci."},{"issue":"1","key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nm1164","volume":"11","author":"Bitko V.","year":"2005","journal-title":"Nat. Med."},{"issue":"2","key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1002\/bdrc.20069","volume":"78","author":"Fjose A.","year":"2006","journal-title":"Birth Defects Res., C"},{"issue":"2","key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nrd2742","volume":"8","author":"Whitehead K. A.","year":"2009","journal-title":"Nat. Rev. Drug Discovery"},{"issue":"6","key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.biomaterials.2006.11.004","volume":"28","author":"Liu X.","year":"2007","journal-title":"Biomaterials"},{"issue":"4","key":"ref29\/cit29","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.ymthe.2006.04.010","volume":"14","author":"Howard K. A.","year":"2006","journal-title":"Mol. Ther."},{"issue":"2","key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1088\/1748-6041\/1\/2\/004","volume":"1","author":"Sell S. A.","year":"2006","journal-title":"Biomed. Mater."},{"issue":"1","key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0169-409X(00)00123-X","volume":"47","author":"Janes K. A.","year":"2001","journal-title":"Adv. Drug Delivery Rev."},{"issue":"1","key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0169-409X(00)00133-2","volume":"46","author":"Pouton C. W.","year":"2001","journal-title":"Adv. Drug Delivery Rev."},{"issue":"7","key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nmat2442","volume":"8","author":"Nel A. E.","year":"2009","journal-title":"Nat. Mater."},{"issue":"1","key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0005-2736(01)00362-5","volume":"1514","author":"Ishii T.","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"issue":"3","key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.jconrel.2005.05.004","volume":"106","author":"Huang M.","year":"2005","journal-title":"J. Controlled Release"},{"issue":"2","key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0378-5173(98)00378-0","volume":"178","author":"Richardson S. C.","year":"1999","journal-title":"Int. J. Pharm."},{"issue":"7","key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/S0142-9612(02)00507-0","volume":"24","author":"Corsi K.","year":"2003","journal-title":"Biomaterials"},{"issue":"6","key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.ymthe.2005.02.010","volume":"11","author":"Moghimi S. M.","year":"2005","journal-title":"Mol. Ther."},{"issue":"14","key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/sj.gt.3301492","volume":"8","author":"Koping-Hoggard M.","year":"2001","journal-title":"Gene Ther."},{"issue":"8","key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1016\/j.actbio.2009.04.021","volume":"5","author":"Moreira C.","year":"2009","journal-title":"Acta Biomater."},{"issue":"8","key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.biomaterials.2005.08.007","volume":"27","author":"Lietz M.","year":"2006","journal-title":"Biomaterials"},{"issue":"29","key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1016\/j.biomaterials.2009.07.007","volume":"30","author":"Ribeiro-Resende V. T.","year":"2009","journal-title":"Biomaterials"},{"issue":"4","key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.biomaterials.2007.10.003","volume":"29","author":"Andersen M. O.","year":"2008","journal-title":"Biomaterials"},{"issue":"9","key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1359-6446(01)01739-1","volume":"6","author":"Anchordoquy T. J.","year":"2001","journal-title":"Drug Discovery Today"},{"issue":"9518","key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S0140-6736(06)68438-9","volume":"367","author":"Atala A.","year":"2006","journal-title":"Lancet"},{"issue":"9","key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1089\/ten.2005.11.1589","volume":"11","author":"Lin C. Y.","year":"2005","journal-title":"Tissue Eng."},{"issue":"4","key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.mcn.2009.01.004","volume":"40","author":"Suggate E. L.","year":"2009","journal-title":"Mol. Cell Neurosci."},{"issue":"3","key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.mcn.2004.11.002","volume":"28","author":"Ahmed Z.","year":"2005","journal-title":"Mol. Cell Neurosci."},{"issue":"4","key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1523\/JNEUROSCI.23-04-01416.2003","volume":"23","author":"Fournier A. E.","year":"2003","journal-title":"J. Neurosci."}],"container-title":["Nano Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/nl1016909","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T05:44:27Z","timestamp":1680500667000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/nl1016909"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,26]]},"references-count":49,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10,13]]}},"alternative-id":["10.1021\/nl1016909"],"URL":"https:\/\/doi.org\/10.1021\/nl1016909","relation":{},"ISSN":["1530-6984","1530-6992"],"issn-type":[{"value":"1530-6984","type":"print"},{"value":"1530-6992","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,26]]}}}