{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:30:04Z","timestamp":1762176604200,"version":"3.40.4"},"reference-count":30,"publisher":"American Chemical Society (ACS)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Nat. Prod."],"published-print":{"date-parts":[[2012,11,26]]},"DOI":"10.1021\/np3004003","type":"journal-article","created":{"date-parts":[[2012,10,25]],"date-time":"2012-10-25T13:50:25Z","timestamp":1351173025000},"page":"1915-1921","source":"Crossref","is-referenced-by-count":43,"title":["Jatrophane Diterpenes from<i>Euphorbia mellifera<\/i>and Their Activity as P-Glycoprotein Modulators on Multidrug-Resistant Mouse Lymphoma and Human Colon Adenocarcinoma Cells"],"prefix":"10.1021","volume":"75","author":[{"given":"In\u00eas","family":"Valente","sequence":"first","affiliation":[{"name":"Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Avenida Prof. Gama Pinto 1649-003, Lisbon, Portugal"}]},{"given":"Mariana","family":"Reis","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Avenida Prof. Gama Pinto 1649-003, Lisbon, Portugal"}]},{"given":"No\u00e9lia","family":"Duarte","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Avenida Prof. Gama Pinto 1649-003, Lisbon, Portugal"}]},{"given":"Julianna","family":"Serly","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, D\u00f3m t\u00e9r 10, H-6720 Szeged, Hungary"}]},{"given":"Jos\u00e9ph","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, D\u00f3m t\u00e9r 10, H-6720 Szeged, Hungary"}]},{"given":"Maria-Jos\u00e9 U.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Avenida Prof. Gama Pinto 1649-003, Lisbon, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2012,10,25]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1517\/17425255.4.2.205","volume":"4","author":"Shukla S.","year":"2008","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2174\/138945011795378540","volume":"12","author":"Shukla S.","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.tips.2009.07.003","volume":"30","author":"Hall M. D.","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"298","DOI":"10.2174\/156800909788166619","volume":"9","author":"Mayur Y. C.","year":"2009","journal-title":"Curr. Cancer Drug Targets"},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1021\/cr078350s","volume":"108","author":"Shi Q. W.","year":"2008","journal-title":"Chem. Rev."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1016\/j.phytochem.2006.06.030","volume":"67","author":"Jassbi A. R.","year":"2006","journal-title":"Phytochemistry"},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1055\/s-2005-873196","volume":"72","author":"Duarte N.","year":"2006","journal-title":"Planta Med."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.bmc.2006.09.028","volume":"15","author":"Duarte N.","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"9323","DOI":"10.1016\/j.bmc.2008.08.071","volume":"16","author":"Duarte N.","year":"2008","journal-title":"Bioorg. Med. Chem."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1021\/jm0111301","volume":"45","author":"Hohmann J.","year":"2002","journal-title":"J. Med. Chem."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1021\/np030036f","volume":"66","author":"Hohmann J.","year":"2003","journal-title":"J. Nat. Prod."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1021\/jm030951y","volume":"47","author":"Corea G.","year":"2004","journal-title":"J. Med. Chem."},{"key":"ref13\/cit13","first-page":"1756","volume":"6","author":"Barile E.","year":"2008","journal-title":"Org. Mol. Chem."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1039\/p19900000185","author":"Ferreira M. J. U","year":"1990","journal-title":"J. Chem. Soc., Perkin Trans. 1"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/hlca.19910740622","volume":"74","author":"Ferreira M. J. U","year":"1991","journal-title":"Helv. Chim. Acta"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1055\/s-2004-815464","volume":"70","author":"Valente C.","year":"2004","journal-title":"Planta Med."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1016\/S0040-4039(01)92490-6","volume":"22","author":"Yamamura S.","year":"1981","journal-title":"Tetrahedron Lett."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1055\/s-2003-38875","volume":"69","author":"Valente C.","year":"2003","journal-title":"Planta Med."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1021\/np010015q","volume":"64","author":"Liu L.","year":"2001","journal-title":"J. Nat. Prod."},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"3386","DOI":"10.1002\/hlca.200390282","volume":"86","author":"Hohmann J.","year":"2003","journal-title":"Helv. Chim. Acta"},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1016\/S0040-4039(01)93196-X","volume":"29","author":"Uemura D.","year":"1974","journal-title":"Tetrahedron Lett."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.3390\/molecules14114454","volume":"14","author":"Wu Q.","year":"2009","journal-title":"Molecules"},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0031-9422(00)90659-9","volume":"35","author":"Greca M.","year":"1994","journal-title":"Phytochemistry"},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0031-9422(97)00070-8","volume":"45","author":"Cabrera G.","year":"1997","journal-title":"Phytochemistry"},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jccs.200000050","volume":"47","author":"Chang Y.","year":"2000","journal-title":"J. Chin. Chem. Soc."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"84","DOI":"10.56808\/3027-7922.2187","volume":"33","author":"Deepralard K.","year":"2009","journal-title":"Thai J. Pharm. Sci."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1080\/14786410600905816","volume":"20","author":"Begum A. S.","year":"2006","journal-title":"Nat. Prod. Res."},{"key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.1016\/j.bmc.2007.05.036","volume":"15","author":"Voigt B.","year":"2007","journal-title":"Bioorg. Med. Chem."},{"key":"ref29\/cit29","first-page":"1967","volume":"41","author":"Tsuruo T.","year":"1981","journal-title":"Cancer Res."},{"key":"ref30\/cit30","first-page":"637","volume":"20","author":"Engi H.","year":"2006","journal-title":"In Vivo"}],"container-title":["Journal of Natural Products"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/np3004003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T17:17:59Z","timestamp":1745083079000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/np3004003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,25]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11,26]]}},"alternative-id":["10.1021\/np3004003"],"URL":"https:\/\/doi.org\/10.1021\/np3004003","relation":{},"ISSN":["0163-3864","1520-6025"],"issn-type":[{"type":"print","value":"0163-3864"},{"type":"electronic","value":"1520-6025"}],"subject":[],"published":{"date-parts":[[2012,10,25]]}}}