{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:07:05Z","timestamp":1773270425079,"version":"3.50.1"},"reference-count":440,"publisher":"American Chemical Society (ACS)","issue":"1","funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["GR\/R19366\/01"],"award-info":[{"award-number":["GR\/R19366\/01"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["GR\/R43853\/01"],"award-info":[{"award-number":["GR\/R43853\/01"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["280106-CrySys"],"award-info":[{"award-number":["280106-CrySys"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["NCET-12-0106"],"award-info":[{"award-number":["NCET-12-0106"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","award":["260141"],"award-info":[{"award-number":["260141"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21075034"],"award-info":[{"award-number":["21075034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21275046"],"award-info":[{"award-number":["21275046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DTI"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Org. Process Res. Dev."],"published-print":{"date-parts":[[2015,1,16]]},"DOI":"10.1021\/op500261y","type":"journal-article","created":{"date-parts":[[2015,1,8]],"date-time":"2015-01-08T20:39:53Z","timestamp":1420749593000},"page":"3-62","source":"Crossref","is-referenced-by-count":395,"title":["Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review"],"prefix":"10.1021","volume":"19","author":[{"given":"Levente L.","family":"Simon","sequence":"first","affiliation":[{"name":"BASF Schweiz AG, 4133 Schweizerhalle, Switzerland"}]},{"given":"Hajnalka","family":"Pataki","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, M\u0171egyetem rkp. 3, H-1111 Budapest, Hungary"}]},{"given":"Gy\u00f6rgy","family":"Marosi","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, M\u0171egyetem rkp. 3, H-1111 Budapest, Hungary"}]},{"given":"Fabian","family":"Meemken","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Applied Biosciences, ETH Z\u00fcrich, Vladimir-Prelog-Weg 1, 8093 Z\u00fcrich, Switzerland"}]},{"given":"Konrad","family":"Hungerb\u00fchler","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Applied Biosciences, ETH Z\u00fcrich, Vladimir-Prelog-Weg 1, 8093 Z\u00fcrich, Switzerland"}]},{"given":"Alfons","family":"Baiker","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Applied Biosciences, ETH Z\u00fcrich, Vladimir-Prelog-Weg 1, 8093 Z\u00fcrich, Switzerland"}]},{"given":"Srinivas","family":"Tummala","sequence":"additional","affiliation":[{"name":"Chemical Development, Bristol-Myers Squibb Company, One Squibb Dr, New Brunswick, New Jersey 08903, United States"}]},{"given":"Brian","family":"Glennon","sequence":"additional","affiliation":[{"name":"Synthesis and Solid State Pharmaceutical Centre, School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4, Ireland"},{"name":"APC Ltd, Belfield Innovation Park, Dublin 4, Ireland"}]},{"given":"Martin","family":"Kuentz","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Institute of Pharma Technology, University of Applied Sciences and Arts Northwestern Switzerland, Gr\u00fcndenstrasse 40, 4132 Muttenz, Switzerland"}]},{"given":"Gerry","family":"Steele","sequence":"additional","affiliation":[{"name":"PharmaCryst Consulting Ltd., Loughborough, Leicestershire LE11 3HN, U.K."}]},{"given":"Herman J. M.","family":"Kramer","sequence":"additional","affiliation":[{"name":"Intensified Reaction & Separation Systems, Delft University of Technology, Leeghwaterstraat 39, 2628 CB Delft, The Netherlands"}]},{"given":"James W.","family":"Rydzak","sequence":"additional","affiliation":[{"name":"GlaxoSmithKline Pharmaceuticals, 709 Swedeland Rd, King of Prussia, Pennsylvania 19406, United States"}]},{"given":"Zengping","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemo\/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, PR China"}]},{"given":"Julian","family":"Morris","sequence":"additional","affiliation":[{"name":"Centre for Process Analytics & Control Technology, School of Chemical Engineering & Advanced Materials, Newcastle University, Newcastle upon Tyne, Tyne and Wear NE17RU, U.K."}]},{"given":"Francois","family":"Kjell","sequence":"additional","affiliation":[{"name":"Siemens nv\/sa, Industry Automation \u2212 SIPAT Industry Software, Marie Curie Square 30, 1070 Brussels, Belgium"}]},{"given":"Ravendra","family":"Singh","sequence":"additional","affiliation":[{"name":"CAPEC-PROCESS, Department of Chemical and Biochemical Engineering, Technical University of Denmark (DTU), Building 229, DK-2800 Lyngby, Denmark"}]},{"given":"Rafiqul","family":"Gani","sequence":"additional","affiliation":[{"name":"CAPEC-PROCESS, Department of Chemical and Biochemical Engineering, Technical University of Denmark (DTU), Building 229, DK-2800 Lyngby, Denmark"}]},{"given":"Krist V.","family":"Gernaey","sequence":"additional","affiliation":[{"name":"CAPEC-PROCESS, Department of Chemical and Biochemical Engineering, Technical University of Denmark (DTU), Building 229, DK-2800 Lyngby, Denmark"}]},{"given":"Marjatta","family":"Louhi-Kultanen","sequence":"additional","affiliation":[{"name":"Department of Chemical Technology, Lappeenranta University of Technology, P.O. Box 20, FI-53851 Lappeenranta, Finland"}]},{"given":"John","family":"O\u2019Reilly","sequence":"additional","affiliation":[{"name":"Roche Ireland Limited, Clarecastle, Co. Clare, Ireland"}]},{"given":"Niklas","family":"Sandler","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Laboratory, Department of Biosciences, Abo Akademi University, Artillerigatan 6, 20520 Turku, Finland"}]},{"given":"Osmo","family":"Antikainen","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Yliopistonkatu 4, 00100 Helsinki, Finland"}]},{"given":"Jouko","family":"Yliruusi","sequence":"additional","affiliation":[{"name":"Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Yliopistonkatu 4, 00100 Helsinki, Finland"}]},{"given":"Patrick","family":"Frohberg","sequence":"additional","affiliation":[{"name":"Center of Engineering Science, Thermal Process Engineering, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany"}]},{"given":"Joachim","family":"Ulrich","sequence":"additional","affiliation":[{"name":"Center of Engineering Science, Thermal Process Engineering, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany"}]},{"given":"Richard D.","family":"Braatz","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States"}]},{"given":"Tom","family":"Leyssens","sequence":"additional","affiliation":[{"name":"Institute of Condensed Matter and Nanosciences, Universit\u00e9 Catholique de Louvain, Place Louis Pasteur 1, 1348 Louvain-la-Neuve, Belgium"}]},{"given":"Moritz","family":"von Stosch","sequence":"additional","affiliation":[{"name":"REQUIMTE - Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 1099-085 Caparica, Portugal"},{"name":"HybPAT, Caparica, Portugal"}]},{"given":"Rui","family":"Oliveira","sequence":"additional","affiliation":[{"name":"REQUIMTE - Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, 1099-085 Caparica, Portugal"},{"name":"HybPAT, Caparica, Portugal"}]},{"given":"Reginald B. H.","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Chemical and Engineering Sciences, A*Star, 1 Pesek Road, Singapore 627833"},{"name":"Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576"}]},{"given":"Huiquan","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration (FDA), Silver Spring, Maryland 20993, United States"}]},{"given":"Mansoor","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Product Quality Research, Office of Testing and Research, Office of Pharmaceutical Science, Center for Drug Evaluation and Research, US Food and Drug Administration (FDA), Silver Spring, Maryland 20993, United States"}]},{"given":"Des","family":"O\u2019Grady","sequence":"additional","affiliation":[{"name":"Mettler Toledo AutoChem, 7075 Samuel Morse Drive, Columbia, Maryland 20146, United States"}]},{"given":"Anjan","family":"Pandey","sequence":"additional","affiliation":[{"name":"Mettler Toledo AutoChem, 7075 Samuel Morse Drive, Columbia, Maryland 20146, United States"}]},{"given":"Remko","family":"Westra","sequence":"additional","affiliation":[{"name":"FMC Technologies B.V., Delta 101, 6825 MN Arnhem, The Netherlands"}]},{"given":"Emmanuel","family":"Delle-Case","sequence":"additional","affiliation":[{"name":"University of Tulsa, 800 South Tucker Drive, Tulsa, Oklahoma 74104, United States"}]},{"given":"Detlef","family":"Pape","sequence":"additional","affiliation":[{"name":"ABB Corporate Research Center, Segelhofstrasse 1K, 5405, D\u00e4ttwil, Baden, Switzerland"}]},{"given":"Daniele","family":"Angelosante","sequence":"additional","affiliation":[{"name":"ABB Corporate Research Center, Segelhofstrasse 1K, 5405, D\u00e4ttwil, Baden, Switzerland"}]},{"given":"Yannick","family":"Maret","sequence":"additional","affiliation":[{"name":"ABB Corporate Research Center, Segelhofstrasse 1K, 5405, D\u00e4ttwil, Baden, Switzerland"}]},{"given":"Olivier","family":"Steiger","sequence":"additional","affiliation":[{"name":"ABB Corporate Research Center, Segelhofstrasse 1K, 5405, D\u00e4ttwil, Baden, Switzerland"}]},{"given":"Mikl\u00f3s","family":"Lenner","sequence":"additional","affiliation":[{"name":"ABB Corporate Research Center, Segelhofstrasse 1K, 5405, D\u00e4ttwil, Baden, Switzerland"}]},{"given":"Kaoutar","family":"Abbou-Oucherif","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47906, United States"}]},{"given":"Zoltan K.","family":"Nagy","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47906, United States"},{"name":"Chemical Engineering Department, Loughborough University, Loughborough, LE11 3TU, U.K."}]},{"given":"James D.","family":"Litster","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47906, United States"}]},{"given":"Vamsi Krishna","family":"Kamaraju","sequence":"additional","affiliation":[{"name":"Synthesis and Solid State Pharmaceutical Centre, School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Dublin 4, Ireland"},{"name":"Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576"}]},{"given":"Min-Sen","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576"}]}],"member":"316","published-online":{"date-parts":[[2015,1,8]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1039\/c0ay00257g","volume":"2","author":"Chew W.","year":"2010","journal-title":"Anal. Methods"},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2174\/157341206778699582","volume":"2","author":"Munson J.","year":"2006","journal-title":"Curr. Pharm. Anal."},{"key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.jprocont.2011.06.024","volume":"21","author":"Chen Z.","year":"2011","journal-title":"J. Process Control"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jpba.2012.02.003","volume":"69","author":"De Bleye C.","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.talanta.2006.12.023","volume":"72","author":"Luypaert J.","year":"2007","journal-title":"Talanta"},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijpharm.2010.12.012","volume":"417","author":"De Beer T.","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.jpba.2007.03.023","volume":"44","author":"Roggo Y.","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.jfoodeng.2007.12.022","volume":"87","author":"Huang H.","year":"2008","journal-title":"J. Food Eng."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1205\/cherd06234","volume":"85","author":"Yu Z. Q.","year":"2007","journal-title":"Chem. Eng. Res. Des."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.addr.2003.10.012","volume":"56","author":"Yu L. X.","year":"2004","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1021\/op049783p","volume":"9","author":"Barrett P.","year":"2005","journal-title":"Org. Process Res. Dev."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.cherd.2013.07.018","volume":"91","author":"Nagy Z. K.","year":"2013","journal-title":"Chem. Eng. Res. Des."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jpba.2008.08.014","volume":"48","author":"Gendrin C.","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1098\/rsta.2003.1321","volume":"362","author":"Taday P. F.","year":"2004","journal-title":"Philos. Trans. R. Soc., A"},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11095-006-9146-7","volume":"24","author":"Shekunov B. Y.","year":"2007","journal-title":"Pharm. Res."},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.jpba.2008.07.023","volume":"48","author":"De Beer T. R. M.","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1007\/s00216-010-4181-y","volume":"398","author":"Bluma A.","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1205\/cherd06229","volume":"85","author":"F\u00e9votte G.","year":"2007","journal-title":"Chem. Eng. Res. Des."},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1208\/s12249-010-9566-x","volume":"12","author":"Riley B. S.","year":"2011","journal-title":"AAPS PharmSciTech"},{"key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.ejpb.2012.09.008","volume":"83","author":"Burggraeve A.","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.ijpharm.2013.01.062","volume":"457","author":"Knop K.","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ijpharm.2011.02.019","volume":"417","author":"Rajalahti T.","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/btpr.561","volume":"27","author":"Rathore A. S.","year":"2011","journal-title":"Biotechnol. Prog."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ijpharm.2013.08.074","volume":"457","author":"Tomba E.","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s12010-012-9950-y","volume":"169","author":"Challa S.","year":"2013","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","DOI":"10.1002\/9780470689592","volume-title":"Process analytical technology: spectroscopic tools and implementation strategies for the chemical and pharmaceutical industries","author":"Bakeev K. A.","year":"2010","edition":"2"},{"key":"ref27\/cit27","doi-asserted-by":"crossref","DOI":"10.1002\/9783527645206","volume-title":"Industrial Crystallization Process Monitoring and Control","author":"Chianese A.","year":"2012"},{"key":"ref28\/cit28","unstructured":"FDA. PAT Guidance for Industry\u2014A Framework for Innovative Pharmaceutical Development, Manufacturing and Quality Assurance;FDA:Rockville, MD, 2004; p16."},{"key":"ref29\/cit29","first-page":"49","volume":"15","author":"Reid G. L.","year":"2012","journal-title":"Am. Pharm. Rev."},{"key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1021\/op100337v","volume":"15","author":"Assirelli M.","year":"2011","journal-title":"Org. Process Res. Dev."},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1021\/op049910h","volume":"8","author":"Lobben P. C.","year":"2004","journal-title":"Org. Process Res. Dev."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1021\/op900095n","volume":"13","author":"Cote A.","year":"2009","journal-title":"Org. Process Res. Dev."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1021\/op2001172","volume":"15","author":"Barrios Sosa A. C.","year":"2011","journal-title":"Org. Process Res. Dev."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1021\/op200114t","volume":"15","author":"McCabe Dunn J. M.","year":"2011","journal-title":"Org. Process Res. Dev."},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1021\/op049784h","volume":"9","author":"Wiss J.","year":"2005","journal-title":"Org. Process Res. Dev."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1021\/op300347w","volume":"17","author":"Feth M. P.","year":"2013","journal-title":"Org. Process Res. Dev."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1021\/op0402127","volume":"9","author":"Sistare F.","year":"2005","journal-title":"Org. Process Res. Dev."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","unstructured":"Guenard, R.; Thurau, G.Chapter 2, Implementation of PAT. InProcess Analytical Technology, Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries,2nd ed.Bakeev, K. A., Ed.Wiley:New York, 2010; pp17.","DOI":"10.1002\/9780470689592.ch2"},{"key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cep.2013.04.003","volume":"70","author":"Helmdach L.","year":"2013","journal-title":"Chem. Eng. Process.: Process Intensification"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/aic.690450110","volume":"45","author":"Alvarez J.","year":"1999","journal-title":"AIChE J."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1021\/op300055g","volume":"16","author":"Kadam S. S.","year":"2012","journal-title":"Org. Process Res. Dev."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1021\/op300326b","volume":"17","author":"Adlington N. K.","year":"2013","journal-title":"Org. Process Res. Dev."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","unstructured":"Miller, C. E.Chapter 12, Chemometrics in Process Analytical Technology. InProcess Analytical Technology, Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries,2nd ed.Bakeev, K. A., Ed.Wiley:New York, 2010; p353.","DOI":"10.1002\/9780470689592.ch12"},{"key":"ref44\/cit44","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.cherd.2010.11.013","volume":"89","author":"Kadam S. S.","year":"2011","journal-title":"Chem. Eng. Res. Des."},{"key":"ref45\/cit45","doi-asserted-by":"crossref","first-page":"12258","DOI":"10.1021\/ie3034587","volume":"52","author":"Muteki K.","year":"2013","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1021\/cg301673g","volume":"13","author":"Duffy D.","year":"2013","journal-title":"Cryst. Growth Des."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1021\/op100142k","volume":"14","author":"Hao H.","year":"2010","journal-title":"Org. Process Res. Dev."},{"key":"ref48\/cit48","unstructured":"Guideline on the use of Near Infrared Spectroscopy (NIRS) by the pharmaceutical industry and the data requirements for new submissions and variations;European Medicines Agency:London, 2012; p28."},{"key":"ref49\/cit49","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.jpba.2013.05.015","volume":"83","author":"Schaefer C.","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref50\/cit50","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1021\/ie980058a","volume":"37","author":"Clarke-Pringle T. L.","year":"1998","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref51\/cit51","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0959-1524(95)00054-2","volume":"6","author":"Crowley T. J.","year":"1996","journal-title":"J. Process Control"},{"key":"ref52\/cit52","first-page":"13","author":"Chen J.","year":"2010","journal-title":"Am. Pharm. Rev."},{"key":"ref53\/cit53","doi-asserted-by":"crossref","unstructured":"Mojica, C. A.; St Pierre Berry, L.; Sistare, F.Chapter 23, Process Analytical Technology in the Manufacture of Bulk Active Pharmaceuticals - Promise, Practise and Challenges. InProcess Chemistry in the Pharmaceutical Industry, Challenges in an ever changing climate;Gadamasetti, K.; Braish, T., Eds.CRC Press:Boca Raton, FL, 2008; Vol.2, pp361.","DOI":"10.1201\/9781420008357.ch23"},{"key":"ref54\/cit54","first-page":"1","author":"Woodcock J.","year":"2004","journal-title":"Am. Pharm. Rev."},{"key":"ref55\/cit55","unstructured":"FDA PharmaceuticalCGMPs for the 21st Century\u2013A Risk-BasedApproach. Final Report, (2004, http:\/\/www.fda.gov\/downloads\/Drugs\/DevelopmentApprovalProcess\/Manufacturing\/QuestionsandAnswersonCurrentGoodManufacturingPracticescGMPforDrugs\/UCM176374.pdf(accessed Dec 15, 2014)."},{"key":"ref56\/cit56","unstructured":"FDA AdvancingRegulatory Science at FDA: A Strategic PlanAugust (2011, http:\/\/www.fda.gov\/downloads\/ScienceResearch\/SpecialTopics\/RegulatoryScience\/UCM268225.pdf(accessed Dec 15, 2014)."},{"key":"ref57\/cit57","unstructured":"FDA Guidance forIndustry. PAT\u2014A Framework for InnovativePharmaceutical Development, Manufacturing, and Quality Assurance, (2004, http:\/\/www.fda.gov\/downloads\/Drugs\/ GuidanceComplianceRegulatoryInformation\/Guidances\/ucm070305.pdf(accessed Dec 23, 2014)."},{"key":"ref58\/cit58","unstructured":"FDA; ICH Guidance for Industry. Q8(R2)Pharmaceutical Development, (2009, http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/ucm073507.pdf(accessed Dec 15, 2014)."},{"key":"ref59\/cit59","unstructured":"FDA; ICH Guidancefor Industry. Q11 Development and Manufactureof Drug Substances, (2012, http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM261078.pdf(accessed Dec 15, 2014)."},{"key":"ref60\/cit60","unstructured":"ICH HarmonisedTripartite Guideline, The Common TechnicalDocument for the Registration of Pharmaceuticals for Human Use: Quality\u2013M4Q(R1). (2002, http:\/\/www.ich.org\/fileadmin\/Public_Web_Site\/ICH_Products\/CTD\/M4_R1_Quality\/M4Q__R1_.pdf(accessed Dec 15, 2014)."},{"key":"ref61\/cit61","unstructured":"FDA Guidelinefor Submitting Supporting Documentation inDrug Applications for the Manufacture of Drug Substances. (1987, http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM070632.pdf(accessed Dec 15, 2014)."},{"key":"ref62\/cit62","unstructured":"FDA Guidance forIndustry. Alternate Source of the ActivePharmaceutical Ingredient in Pending ANDAs. (2000, http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/ucm072853.pdf(accessed Dec 15, 2014)."},{"key":"ref63\/cit63","unstructured":"FDA Guidance forIndustry. ANDAs: Pharmaceutical Solid Polymorphism. (2007, http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM072866.pdf(accessed Dec 15, 2014)."},{"key":"ref64\/cit64","unstructured":"FDA Guidance forIndustry. ANDAs: Impurities in Drug Substances. (2009, http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM172002.pdf(accessed Dec 15, 2014)."},{"key":"ref65\/cit65","unstructured":"FDA Guidance forIndustry. Regulatory Classification ofPharmaceutical Co-Crystals. (2013, http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM281764.pdf(accessed Dec 15, 2014)."},{"key":"ref66\/cit66","doi-asserted-by":"crossref","DOI":"10.3182\/20050703-6-CZ-1902.02228","volume-title":"Use of PAT for Active Pharmaceutical Ingredient Crystallization Process Control","author":"Wu H.","year":"2005"},{"key":"ref67\/cit67","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1021\/cg500547m","volume":"14","author":"Yu Z. Q.","year":"2014","journal-title":"Cryst. Growth Des."},{"key":"ref68\/cit68","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ces.2013.11.031","volume":"107","author":"Chaudhury A.","year":"2014","journal-title":"Chem. Eng. Sci."},{"key":"ref69\/cit69","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12247-014-9172-7","volume":"9","author":"Chaudhury A.","year":"2014","journal-title":"J. Pharm. Sci. Innovation"},{"key":"ref70\/cit70","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1002\/jps.21646","volume":"98","author":"Wu H.","year":"2009","journal-title":"J. Pharm. Sci."},{"key":"ref71\/cit71","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ijpharm.2010.11.045","volume":"405","author":"Wu H.","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref72\/cit72","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1021\/cg101556s","volume":"11","author":"Chen J.","year":"2011","journal-title":"Cryst. Growth Des."},{"key":"ref73\/cit73","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.jprocont.2008.06.002","volume":"18","author":"Nagy Z. K.","year":"2008","journal-title":"J. Process Control"},{"key":"ref74\/cit74","doi-asserted-by":"crossref","unstructured":"Wu, H.; White, M.; Khan, M. A.An Integrated Process Analytical Technology (PAT) Approach for Process Dynamics-related Measurement Error and Process Design Space Development for a Pharmaceutical Powder Blending Bed.Org. Process Res. Dev. 2014, in press","DOI":"10.1021\/op500085m"},{"key":"ref75\/cit75","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1002\/jps.21923","volume":"99","author":"Wu H.","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"ref76\/cit76","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1002\/jps.22430","volume":"100","author":"Wu H.","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"ref77\/cit77","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1021\/ie4036466","volume":"53","author":"Wu H.","year":"2014","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref78\/cit78","doi-asserted-by":"publisher","DOI":"10.1021\/op500056a"},{"key":"ref79\/cit79","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.ijpharm.2007.05.014","volume":"343","author":"Wu H.","year":"2007","journal-title":"Int. J. Pharm."},{"key":"ref80\/cit80","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/jps.21004","volume":"97","author":"Wu H.","year":"2008","journal-title":"J. Pharm. Sci."},{"key":"ref81\/cit81","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.molstruc.2012.04.019","volume":"1020","author":"Wu H.","year":"2012","journal-title":"J. Mol. Struct."},{"key":"ref82\/cit82","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1021\/cg500240j","volume":"14","author":"Iwata K.","year":"2014","journal-title":"Cryst. Growth Des."},{"key":"ref83\/cit83","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0169-409X(01)00100-4","volume":"48","author":"Morris K. R.","year":"2001","journal-title":"Adv. Drug Delivery. Rev."},{"key":"ref84\/cit84","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.addr.2003.10.009","volume":"56","author":"Zhang G. G.","year":"2004","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref85\/cit85","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/jps.20746","volume":"96","author":"Tantry J. S.","year":"2007","journal-title":"J. Pharm. Sci."},{"key":"ref86\/cit86","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1021\/mp200043u","volume":"8","author":"Arora K. K.","year":"2011","journal-title":"Mol. Pharmaceutics"},{"key":"ref87\/cit87","doi-asserted-by":"crossref","first-page":"14681","DOI":"10.1021\/la403040u","volume":"29","author":"Neville F.","year":"2013","journal-title":"Langmuir"},{"key":"ref88\/cit88","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.jpba.2006.08.030","volume":"43","author":"Tiwari M.","year":"2007","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref89\/cit89","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1002\/jps.23912","volume":"103","author":"Siddiqui A.","year":"2014","journal-title":"J. Pharm. Sci."},{"key":"ref90\/cit90","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jpba.2011.05.003","volume":"56","author":"Rao P. S.","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref91\/cit91","unstructured":"FDA Guidance forIndustry. Genotoxic and Carcinogenic Impuritiesin Drug Substances and Products: Recommended Approaches. (2008, http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM079235.pdf(accessed Dec 15, 2014)."},{"key":"ref92\/cit92","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1021\/op000023y","volume":"4","author":"Chemburkar S. R.","year":"2000","journal-title":"Org. Process Res. Dev."},{"key":"ref93\/cit93","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev-chembioeng-061010-114224","volume":"2","author":"Lee A. Y.","year":"2011","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"ref94\/cit94","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1039\/b819896a","volume":"26","author":"Liu H.","year":"2009","journal-title":"Nat. Prod. Rep."},{"key":"ref95\/cit95","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00216-011-5155-4","volume":"401","author":"Zang Q.","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"ref96\/cit96","unstructured":"FDA Guidance fro Industry. Immunogenicity-RelatedConsiderationsfor the Approval of Low Molecular Weight Heparin for NDAs and ANDAs. (2014, http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM392194.pdf(accessed Dec 15, 2014)."},{"key":"ref97\/cit97","unstructured":"FDA Guidance forIndustry. Process Validation: General Principlesand Practices. (2011, http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM070336.pdf(accessed Dec 15, 2014)."},{"key":"ref98\/cit98","doi-asserted-by":"crossref","first-page":"12585","DOI":"10.1002\/ange.201305429","volume":"125","author":"Mascia S.","year":"2013","journal-title":"Angew. Chem."},{"key":"ref99\/cit99","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/ceat.201000558","volume":"34","author":"Pertig D.","year":"2011","journal-title":"Chem. Eng. Technol."},{"key":"ref100\/cit100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11705-013-1304-y","volume":"7","author":"Ulrich J.","year":"2013","journal-title":"Frontiers Chem. Sci. Eng."},{"key":"ref101\/cit101","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/(SICI)1521-4079(199903)34:3<379::AID-CRAT379>3.0.CO;2-Z","volume":"34","author":"Omar W.","year":"1999","journal-title":"Cryst. Res. Technol."},{"key":"ref102\/cit102","first-page":"294","volume-title":"Crystal Growth of Organic Materials 4","author":"Omar W.","year":"1997"},{"key":"ref103\/cit103","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0255-2701(02)00215-5","volume":"42","author":"Titiz-Sargut S.","year":"2003","journal-title":"Chem. Eng. Process."},{"key":"ref104\/cit104","first-page":"286","volume":"51","author":"Omar W.","year":"1999","journal-title":"Chem. Technol."},{"key":"ref105\/cit105","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jcrysgro.2011.11.027","volume":"362","author":"Stelzer T.","year":"2013","journal-title":"J. Cryst. Growth"},{"key":"ref106\/cit106","unstructured":"Pertig, D.; Stelzer, T.; Ulrich, J.InImproved Correlations of Single-frequency Ultrasound Velocity and Attenuation to Most Important Suspension Properties via Phenomenological Models, Proceedings, ISIC 2011 (18th International Symposium of Industrial Crystallization), Sept 13\u201316, 2011; Biscans, B.; Mazzotti, M., Eds.; AIDIC (The Italian Association of Chemical Engineering); p158."},{"key":"ref107\/cit107","doi-asserted-by":"publisher","DOI":"10.1021\/op4001803"},{"key":"ref108\/cit108","doi-asserted-by":"crossref","DOI":"10.3109\/9780203302576","volume-title":"Dielectric Analysis of Pharmaceutical Systems","author":"Craig D. Q. M.","year":"1995"},{"key":"ref109\/cit109","volume-title":"Dielectric Behavior and Structure. Dielectric Constant and Loss, Dipole Moment and Molecular Structure","author":"Smyth C. P.","year":"1995"},{"key":"ref110\/cit110","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1006\/jcht.1997.0257","volume":"29","author":"Goodwin A. R. H.","year":"1997","journal-title":"J. Chem. Thermodyn."},{"key":"ref111\/cit111","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1063\/1.1149007","volume":"69","author":"Hourri A.","year":"1998","journal-title":"Rev. Sci. Instrum."},{"key":"ref112\/cit112","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1021\/op100182s","volume":"14","author":"He G.","year":"2010","journal-title":"Org. Process Res. Dev."},{"key":"ref113\/cit113","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1016\/j.cherd.2011.04.012","volume":"89","author":"Hermanto M. W.","year":"2011","journal-title":"Chem. Eng. Res. Des."},{"key":"ref114\/cit114","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cherd.2011.07.005","volume":"90","author":"He G.","year":"2012","journal-title":"Chem. Eng. Res. Des."},{"key":"ref115\/cit115","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ces.2013.04.015","volume":"97","author":"Hermanto M. W.","year":"2013","journal-title":"Chem. Eng. Sci."},{"key":"ref116\/cit116","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.cherd.2012.03.023","volume":"90","author":"Simon L. L.","year":"2012","journal-title":"Chem. Eng. Res. Des."},{"key":"ref117\/cit117","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1021\/op900019b","volume":"13","author":"Simon L. L.","year":"2009","journal-title":"Org. Process Res. Dev."},{"key":"ref118\/cit118","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1016\/j.ces.2010.05.045","volume":"65","author":"Simon L. L.","year":"2010","journal-title":"Chem. Eng. Sci."},{"key":"ref119\/cit119","unstructured":"Simon, L. L.; Reinlein, S.; Hungerbuhler, K.InTurbidity and endoscopy assisted monitoring of pseudopolymorphic transformation of citric acid, 18th International Symposium on Industrial Crystallization (ISIC 18), Zurich."},{"key":"ref120\/cit120","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1016\/j.ces.2009.04.016","volume":"64","author":"Simon L. L.","year":"2009","journal-title":"Chem. Eng. Sci."},{"key":"ref121\/cit121","doi-asserted-by":"crossref","first-page":"9932","DOI":"10.1021\/ie100586p","volume":"49","author":"Simon L. L.","year":"2010","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref122\/cit122","unstructured":"Simon, L. L.; Myerson, A. S.InContinuous antisolvent plug-flow crystallization of a fast growing API, 18th International Symposium on Industrial Crystallization (ISIC 18), Zurich."},{"key":"ref123\/cit123","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s11095-007-9511-1","volume":"25","author":"Yu L. X.","year":"2008","journal-title":"Pharm. Res."},{"key":"ref124\/cit124","doi-asserted-by":"crossref","first-page":"E22","DOI":"10.1208\/pt070359","volume":"7","author":"Medendorp J.","year":"2006","journal-title":"AAPS PharmSciTech"},{"key":"ref125\/cit125","doi-asserted-by":"crossref","first-page":"062001","DOI":"10.1088\/0957-0233\/19\/6\/062001","volume":"19","author":"Kaatze U.","year":"2008","journal-title":"Meas. Sci. Technol."},{"key":"ref126\/cit126","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ijpharm.2007.04.009","volume":"341","author":"Shah R. B.","year":"2007","journal-title":"Int. J. Pharm."},{"key":"ref127\/cit127","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ijpharm.2013.02.005","volume":"446","author":"Niederquell A.","year":"2013","journal-title":"Int. J. Pharm."},{"key":"ref128\/cit128","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jpba.2011.10.018","volume":"59","author":"Stillhart C.","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref129\/cit129","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3109\/02652040903079534","volume":"27","author":"Fuchs S.","year":"2010","journal-title":"J. Microencapsulation"},{"key":"ref130\/cit130","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1002\/jps.22538","volume":"100","author":"Cavegn M.","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"ref131\/cit131","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0041-624X(95)00053-6","volume":"33","author":"Tikhonov D. A.","year":"1995","journal-title":"Ultrasonics"},{"key":"ref132\/cit132","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1016\/j.ces.2008.06.028","volume":"63","author":"Tourbin M.","year":"2008","journal-title":"Chem. Eng. Sci."},{"key":"ref133\/cit133","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1002\/aic.12182","volume":"56","author":"Shukla A.","year":"2010","journal-title":"AIChE J."},{"key":"ref134\/cit134","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1088\/0034-4885\/68\/3\/R04","volume":"68","author":"Waigh T. A.","year":"2005","journal-title":"Rep. Prog. Phys."},{"key":"ref135\/cit135","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S1359-0294(01)00115-7","volume":"6","author":"Harden J. L.","year":"2001","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"ref136\/cit136","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cocis.2007.07.008","volume":"12","author":"Alexander M.","year":"2007","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"ref137\/cit137","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.tifs.2007.07.014","volume":"19","author":"Corredig M.","year":"2008","journal-title":"Trends Food Sci. Technol."},{"key":"ref138\/cit138","doi-asserted-by":"crossref","first-page":"5926","DOI":"10.1039\/c1sm05274h","volume":"7","author":"Lopez-Diaz D.","year":"2011","journal-title":"Soft Matter"},{"key":"ref139\/cit139","doi-asserted-by":"crossref","first-page":"011413","DOI":"10.1103\/PhysRevE.73.011413","volume":"73","author":"Zakharov P.","year":"2006","journal-title":"Phys. Rev. E: Stat. Phys., Plasmas, Fluids"},{"key":"ref140\/cit140","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.cocis.2007.03.005","volume":"12","author":"Scheffold F.","year":"2007","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"ref141\/cit141","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijpharm.2012.01.042","volume":"426","author":"Niederquell A.","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref142\/cit142","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1208\/s12249-011-9589-y","volume":"12","author":"Niederquell A.","year":"2011","journal-title":"AAPS PharmSciTech"},{"key":"ref143\/cit143","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ppsc.200700030","volume":"26","author":"Patchigolla K.","year":"2009","journal-title":"Part. Part. Syst. Char."},{"key":"ref144\/cit144","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1002\/jps.21884","volume":"99","author":"Sandler N.","year":"2010","journal-title":"J. Pharm. Sci."},{"key":"ref145\/cit145","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/1521-4117(200208)19:4<240::AID-PPSC240>3.0.CO;2-#","volume":"19","author":"Bonifazi G.","year":"2002","journal-title":"Part. Part. Syst. Char."},{"key":"ref146\/cit146","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/(SICI)1097-0010(199810)78:2<187::AID-JSFA102>3.0.CO;2-3","volume":"78","author":"Novales B.","year":"1998","journal-title":"J. Sci. Food Agric."},{"key":"ref147\/cit147","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0169-7439(00)00100-3","volume":"54","author":"Huang J.","year":"2000","journal-title":"Chemometrics Intellig. Lab. Syst."},{"key":"ref148\/cit148","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0928-0987(02)00189-6","volume":"17","author":"Laitinen N.","year":"2002","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref149\/cit149","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0032-5910(99)00023-6","volume":"103","author":"Pons M.","year":"1999","journal-title":"Powder Technol."},{"key":"ref150\/cit150","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0032-5910(02)00177-8","volume":"128","author":"Pons M. N.","year":"2002","journal-title":"Powder Technol."},{"key":"ref151\/cit151","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1208\/pt040449","volume":"4","author":"Laitinen N.","year":"2003","journal-title":"AAPS PharmSciTech"},{"key":"ref152\/cit152","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/jps.10529","volume":"93","author":"Laitinen N.","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"ref153\/cit153","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1117\/12.7972479","volume":"19","author":"Woodham R. J.","year":"1980","journal-title":"Opt. Eng."},{"key":"ref154\/cit154","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1208\/pt010210","volume":"1","author":"Rantanen J.","year":"2000","journal-title":"AAPS PharmSciTech"},{"key":"ref155\/cit155","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ejpb.2010.06.001","volume":"76","author":"Burggraeve A.","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref156\/cit156","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1208\/s12249-008-9043-y","volume":"9","author":"N\u00e4rv\u00e4nen T.","year":"2008","journal-title":"AAPS PharmSciTech"},{"key":"ref157\/cit157","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ijpharm.2008.01.060","volume":"357","author":"N\u00e4rv\u00e4nen T.","year":"2008","journal-title":"Int. J. Pharm."},{"key":"ref158\/cit158","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1208\/s12249-011-9607-0","volume":"12","author":"Soppela I.","year":"2011","journal-title":"AAPS PharmSciTech"},{"key":"ref159\/cit159","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.ejpb.2013.03.032","volume":"85","author":"Silva A. F.","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref160\/cit160","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1517\/17425247.2011.548382","volume":"8","author":"Sandler N.","year":"2011","journal-title":"Expert Opin. Drug Delivery"},{"key":"ref161\/cit161","first-page":"635","volume":"44","author":"Burggraeve A.","year":"2011","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref162\/cit162","doi-asserted-by":"crossref","unstructured":"Pedersen, M.; McClelland, J.InOptimized capacitive MEMS microphone for photoacoustic spectroscopy (PAS) applications, Proc. SPIE 5732, Quantum Sensing and Nanophotonic Devices II, San Jose, California , 2005; Manijeh, R.; Gail, J. B., Eds.: San Jose, CA; p108.","DOI":"10.1117\/12.597136"},{"key":"ref163\/cit163","volume-title":"Particles in Gases and Liquids 2, Photoacoustic Detection of Radiation Absorbing Particles in Gases","author":"Jackson D. A.","year":"1990"},{"key":"ref164\/cit164","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.vibspec.2008.01.013","volume":"48","author":"Koskinen V.","year":"2008","journal-title":"Vib. Spectrosc."},{"key":"ref165\/cit165","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1109\/JSEN.2014.2318353","volume":"14","author":"Maret Y.","year":"2014","journal-title":"IEEE Sens. J."},{"key":"ref166\/cit166","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1039\/B204494C","volume":"12","author":"Banares M. A.","year":"2002","journal-title":"J. Mater. Chem."},{"key":"ref167\/cit167","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.cattod.2005.11.076","volume":"113","author":"Tinnemans S. J.","year":"2006","journal-title":"Catal. Today"},{"key":"ref168\/cit168","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.cattod.2007.01.072","volume":"126","author":"Tromp S. A.","year":"2007","journal-title":"Catal. Today"},{"key":"ref169\/cit169","first-page":"227","volume-title":"Advances in Catalysis","volume":"50","author":"B\u00fcrgi T.","year":"2006"},{"key":"ref170\/cit170","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1039\/b919544k","volume":"39","author":"Andanson J. M.","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"ref171\/cit171","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201402981"},{"key":"ref172\/cit172","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/chem.201303261","volume":"20","author":"Meemken F.","year":"2014","journal-title":"Chem.\u2014Eur. J."},{"key":"ref173\/cit173","doi-asserted-by":"crossref","first-page":"664","DOI":"10.2533\/chimia.2012.664","volume":"66","author":"Maeda N.","year":"2012","journal-title":"Chimia"},{"key":"ref174\/cit174","doi-asserted-by":"crossref","first-page":"84101","DOI":"10.1063\/1.4891188","volume":"85","author":"Meemken F.","year":"2014","journal-title":"Rev. Sci. Instrum."},{"key":"ref175\/cit175","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1021\/ie020346d","volume":"42","author":"Gron H.","year":"2002","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref176\/cit176","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1021\/op049959n","volume":"8","author":"Liotta V.","year":"2004","journal-title":"Org. Process Res. Dev."},{"key":"ref177\/cit177","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1021\/cg0504049","volume":"6","author":"Zhou G. X.","year":"2006","journal-title":"Cryst. Growth Des."},{"key":"ref178\/cit178","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0022-0248(97)00119-X","volume":"179","author":"Dunuwila D. D.","year":"1997","journal-title":"J. Cryst. Growth"},{"key":"ref179\/cit179","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.cherd.2010.02.010","volume":"88","author":"Barrett M.","year":"2010","journal-title":"Chem. Eng. Res. Des."},{"key":"ref180\/cit180","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/ceat.270130131","volume":"13","author":"Gutwald T.","year":"1990","journal-title":"Chem. Eng. Technol."},{"key":"ref181\/cit181","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0022-0248(94)90999-7","volume":"137","author":"Dunuwila D. D.","year":"1994","journal-title":"J. Cryst. Growth"},{"key":"ref182\/cit182","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1016\/S0009-2509(00)00508-X","volume":"56","author":"Lewiner F.","year":"2001","journal-title":"Chem. Eng. Sci."},{"key":"ref183\/cit183","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0022-0248(01)01518-4","volume":"231","author":"Togkalidou T.","year":"2001","journal-title":"J. Cryst. Growth"},{"key":"ref184\/cit184","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1021\/op015516x","volume":"6","author":"Togkalidou T.","year":"2002","journal-title":"Org. Process Res. Dev."},{"key":"ref185\/cit185","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1021\/cg0200098","volume":"2","author":"Fujiwara M.","year":"2002","journal-title":"Cryst. Growth Des."},{"key":"ref186\/cit186","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1021\/ie021037q","volume":"42","author":"Gron H.","year":"2003","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref187\/cit187","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.jprocont.2004.08.003","volume":"15","author":"Fujiwara M.","year":"2005","journal-title":"J. Process Control"},{"key":"ref188\/cit188","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jprocont.2007.10.006","volume":"18","author":"Nagy Z. K.","year":"2008","journal-title":"J. Process Control"},{"key":"ref189\/cit189","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1021\/cg800546u","volume":"9","author":"Kee N. C.","year":"2009","journal-title":"Cryst. Growth Des."},{"key":"ref190\/cit190","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1021\/cg8006537","volume":"9","author":"Kee N. C.","year":"2009","journal-title":"Cryst. Growth Des."},{"key":"ref191\/cit191","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1021\/op400187h","volume":"17","author":"Zhou G.","year":"2013","journal-title":"Org. Process Res. Dev."},{"key":"ref192\/cit192","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1021\/cg800131r","volume":"9","author":"Woo X. Y.","year":"2009","journal-title":"Cryst. Growth Des."},{"key":"ref193\/cit193","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev-chembioeng-062011-081043","volume":"3","author":"Nagy Z. K.","year":"2012","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"ref194\/cit194","first-page":"762","volume":"8","author":"Kamaraju V. K.","year":"2012","journal-title":"Proc. Adv. Control Chem. Processes"},{"key":"ref195\/cit195","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ces.2013.04.015","volume":"97","author":"Hermanto M. W.","year":"2013","journal-title":"Chem. Eng. Sci."},{"key":"ref196\/cit196","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1002\/ceat.200900550","volume":"33","author":"Alatalo H. M.","year":"2010","journal-title":"Chem. Eng. Technol."},{"key":"ref197\/cit197","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1002\/aic.12140","volume":"56","author":"Alatalo H.","year":"2010","journal-title":"AIChE J."},{"key":"ref198\/cit198","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/ceat.200900577","volume":"33","author":"Hatakka H.","year":"2010","journal-title":"Chem. Eng. Technol."},{"key":"ref199\/cit199","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1021\/cg800595v","volume":"9","author":"Abu Bakar M. R.","year":"2009","journal-title":"Cryst. Growth Des."},{"key":"ref200\/cit200","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1021\/cg100533n","volume":"10","author":"Hermanto M. W.","year":"2010","journal-title":"Cryst. Growth Des."},{"key":"ref201\/cit201","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1002\/aic.690330407","volume":"33","author":"Randolph A. D.","year":"1987","journal-title":"AIChE J."},{"key":"ref202\/cit202","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1021\/ie060967x","volume":"46","author":"Hojjati H.","year":"2007","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref203\/cit203","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.ces.2007.10.024","volume":"63","author":"Sheikhzadeh M.","year":"2008","journal-title":"Chem. Eng. Sci."},{"key":"ref204\/cit204","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1002\/aic.690490715","volume":"49","author":"Nagy Z. K.","year":"2003","journal-title":"AIChE J."},{"key":"ref205\/cit205","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/aic.12366","volume":"57","author":"Mesbah A.","year":"2011","journal-title":"AIChE J."},{"key":"ref206\/cit206","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ces.2004.12.059","volume":"61","author":"Shi D.","year":"2006","journal-title":"Chem. Eng. Sci."},{"key":"ref207\/cit207","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1002\/aic.11879","volume":"55","author":"Hermanto M. W.","year":"2009","journal-title":"AIChE J."},{"key":"ref208\/cit208","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.ces.2007.09.049","volume":"63","author":"Sheikhzadeh M.","year":"2008","journal-title":"Chem. Eng. Sci."},{"key":"ref209\/cit209","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0005-1098(88)90024-6","volume":"24","author":"De Keyser R. M. C.","year":"1988","journal-title":"Automatica"},{"key":"ref210\/cit210","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/978-3-540-72699-9_42","volume":"358","author":"De Keyser R.","year":"2007","journal-title":"Assessment Future Dir. Nonlinear Model Predict. Control"},{"key":"ref211\/cit211","first-page":"229","author":"Tamas L.","year":"2007","journal-title":"Proc. 11th Int. Conf. Intelligent Eng. Syst."},{"key":"ref212\/cit212","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/aic.12331","volume":"57","author":"Hermanto M. W.","year":"2011","journal-title":"AIChE J."},{"key":"ref213\/cit213","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1021\/ie0600487","volume":"46","author":"Srinivasan B.","year":"2007","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref214\/cit214","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1080\/00207170802460024","volume":"82","author":"Gros S.","year":"2009","journal-title":"Int. J. Control"},{"key":"ref215\/cit215","first-page":"3390","author":"Kamaraju V. K.","year":"2013","journal-title":"Proc. Eur.Control Conf."},{"key":"ref216\/cit216","doi-asserted-by":"crossref","first-page":"2801","DOI":"10.1016\/j.ces.2004.04.020","volume":"59","author":"Cheng C.","year":"2004","journal-title":"Chem. Eng. Sci."},{"key":"ref217\/cit217","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jprocont.2013.07.011","volume":"24","author":"Su Q.-L.","year":"2014","journal-title":"J. Process Control"},{"key":"ref218\/cit218","unstructured":"Su, Q. L.; Hermanto, M. W.; Braatz, R. D.; Chiu, M.S.A New Extended Prediction Self-Adaptive Control (EPSAC) Strategy for Batch Control. In 2012 AIChE Meeting, Pittsburgh, PA, 2012, 713g."},{"key":"ref219\/cit219","unstructured":"Su, Q. L.Modeling, Monitoring, and Control of pH-shift Reactive Crystallization. Ph.D. Thesis.National University of Singapore,Singapore, 2013."},{"key":"ref220\/cit220","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev-chembioeng-062011-081043","volume":"3","author":"Nagy Z. K.","year":"2012","journal-title":"Annu. Rev. Chem. Biomol. Eng."},{"key":"ref221\/cit221","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.compchemeng.2009.04.012","volume":"33","author":"Nagy Z. K.","year":"2009","journal-title":"Comput. Chem. Eng."},{"key":"ref222\/cit222","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1109\/TCST.2011.2160945","volume":"20","author":"Mesbah A.","year":"2012","journal-title":"IEEE Trans. Control Syst. Technol."},{"key":"ref223\/cit223","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1021\/cg401562t","volume":"14","author":"Yang Y.","year":"2013","journal-title":"Cryst. Growth Des."},{"key":"ref224\/cit224","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ces.2012.08.048","volume":"84","author":"Nagy Z.","year":"2012","journal-title":"Chem. Eng. Sci."},{"key":"ref225\/cit225","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1021\/cg201269c","volume":"12","author":"Saleemi A. N.","year":"2012","journal-title":"Cryst. Growth Des."},{"key":"ref226\/cit226","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1039\/c2ce06288g","volume":"14","author":"Saleemi A.","year":"2012","journal-title":"CrystEngComm"},{"key":"ref227\/cit227","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijpharm.2012.03.029","volume":"430","author":"Saleemi A. N.","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref228\/cit228","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1021\/cg800131r","volume":"9","author":"Woo X. Y.","year":"2009","journal-title":"Cryst. Growth Des."},{"key":"ref229\/cit229","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1021\/op900174b","volume":"13","author":"Bakar M. R. A.","year":"2009","journal-title":"Org. Process Res. Dev."},{"key":"ref230\/cit230","doi-asserted-by":"crossref","first-page":"3892","DOI":"10.1021\/cg1002379","volume":"10","author":"Abu Bakar M. R.","year":"2010","journal-title":"Cryst. Growth Des."},{"key":"ref231\/cit231","doi-asserted-by":"publisher","DOI":"10.1021\/op5000122"},{"key":"ref232\/cit232","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1021\/cg500017a","volume":"14","author":"Simone E.","year":"2014","journal-title":"Cryst. Growth Des."},{"key":"ref233\/cit233","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jpba.2009.07.030","volume":"51","author":"Vajna B.","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref234\/cit234","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1002\/jrs.2943","volume":"42","author":"Vajna B.","year":"2011","journal-title":"J. Raman Spectrosc."},{"key":"ref235\/cit235","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jpba.2011.05.005","volume":"56","author":"Vajna B.","year":"2011","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref236\/cit236","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ijpharm.2011.07.023","volume":"419","author":"Vajna B.","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref237\/cit237","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.aca.2011.10.065","volume":"712","author":"Vajna B.","year":"2012","journal-title":"Anal. Chim. Acta"},{"key":"ref238\/cit238","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10973-010-0936-0","volume":"102","author":"Patyi G.","year":"2010","journal-title":"J. Therm. Anal. Calorim."},{"key":"ref239\/cit239","doi-asserted-by":"publisher","DOI":"10.1021\/op500015d"},{"key":"ref240\/cit240","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1021\/cg301135z","volume":"12","author":"Pataki H.","year":"2012","journal-title":"Cryst. Growth Des."},{"key":"ref241\/cit241","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.saa.2012.04.029","volume":"95","author":"Billes F.","year":"2012","journal-title":"Spectrochim. Acta, Pt. A: Mol. Spectrosc."},{"key":"ref242\/cit242","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1021\/op300062t","volume":"17","author":"Pataki H.","year":"2012","journal-title":"Org. Process Res. Dev."},{"key":"ref243\/cit243","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jcrysgro.2011.02.027","volume":"321","author":"Mitchell N. A.","year":"2011","journal-title":"J. Cryst. Growth"},{"key":"ref244\/cit244","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0021-9797(88)90219-6","volume":"123","author":"S\u00f6hnel O.","year":"1988","journal-title":"J. Colloid Interface Sci."},{"key":"ref245\/cit245","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1021\/cg101213q","volume":"11","author":"Jiang S.","year":"2011","journal-title":"Cryst. Growth Des."},{"key":"ref246\/cit246","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.jcrysgro.2007.11.123","volume":"310","author":"Kubota N.","year":"2008","journal-title":"J. Cryst. Growth"},{"key":"ref247\/cit247","doi-asserted-by":"crossref","first-page":"7581","DOI":"10.1021\/ie900248f","volume":"48","author":"Dalvi S. V.","year":"2009","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref248\/cit248","doi-asserted-by":"crossref","first-page":"4488","DOI":"10.1021\/la011799a","volume":"18","author":"Taubert A.","year":"2002","journal-title":"Langmuir"},{"key":"ref249\/cit249","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1002\/crat.201200152","volume":"47","author":"Hou J.","year":"2012","journal-title":"Cryst. Res. Technol."},{"key":"ref250\/cit250","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1002\/jps.22439","volume":"100","author":"Liu X.","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"ref251\/cit251","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1021\/ie060637c","volume":"47","author":"Nagy Z. K.","year":"2008","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref252\/cit252","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1205\/cherd06207","volume":"85","author":"Ogrady D.","year":"2007","journal-title":"Chem. Eng. Res. Des."},{"key":"ref253\/cit253","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1021\/cg0503402","volume":"6","author":"Scholl J.","year":"2006","journal-title":"Cryst. Growth Des."},{"key":"ref254\/cit254","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.1016\/j.ces.2009.04.016","volume":"64","author":"Simon L. L.","year":"2009","journal-title":"Chem. Eng. Sci."},{"key":"ref255\/cit255","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1205\/026387602320776876","volume":"80","author":"Barrett P.","year":"2002","journal-title":"Chem. Eng. Res. Des."},{"key":"ref256\/cit256","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1205\/026387603322150552","volume":"81","author":"Parsons A. R.","year":"2003","journal-title":"Chem. Eng. Res. Des."},{"key":"ref257\/cit257","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.jcrysgro.2005.11.108","volume":"289","author":"Qu H.","year":"2006","journal-title":"J. Cryst. Growth"},{"key":"ref258\/cit258","doi-asserted-by":"crossref","first-page":"9932","DOI":"10.1021\/ie100586p","volume":"49","author":"Simon L. L.","year":"2010","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref259\/cit259","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1205\/cherd.05082","volume":"84","author":"P\u00f6ll\u00e4nen K.","year":"2006","journal-title":"Chem. Eng. Res. Des."},{"key":"ref260\/cit260","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1117\/1.1631315","volume":"13","author":"Sezgin M.","year":"2004","journal-title":"J. Electron. Imaging"},{"key":"ref261\/cit261","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1109\/83.366472","volume":"4","author":"Yen J.-C.","year":"1995","journal-title":"IEEE Trans. Image Process"},{"key":"ref262\/cit262","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1021\/ac040119g","volume":"77","author":"Chen Z.-P.","year":"2005","journal-title":"Anal. Chem."},{"key":"ref263\/cit263","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1021\/ac0610255","volume":"78","author":"Chen Z.-P.","year":"2006","journal-title":"Anal. Chem."},{"key":"ref264\/cit264","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1021\/ac800987m","volume":"80","author":"Chen Z.-P.","year":"2008","journal-title":"Anal. Chem."},{"key":"ref265\/cit265","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1021\/ac202598f","volume":"84","author":"Jin J.-W.","year":"2011","journal-title":"Anal. Chem."},{"key":"ref266\/cit266","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1021\/ac300189p","volume":"84","author":"Chen Z.-P.","year":"2012","journal-title":"Anal. Chem."},{"key":"ref267\/cit267","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.chemolab.2013.04.011","author":"Yang J.","year":"2013","journal-title":"Chemometrics Intellig. Lab. Syst."},{"key":"ref268\/cit268","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1021\/ac103145a","volume":"83","author":"Chen Z.-P.","year":"2011","journal-title":"Anal. Chem."},{"key":"ref269\/cit269","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1039\/b800104a","volume":"133","author":"Chen Z.-P.","year":"2008","journal-title":"Analyst"},{"key":"ref270\/cit270","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.aca.2011.02.014","volume":"690","author":"Du W.","year":"2011","journal-title":"Anal. Chim. Acta"},{"key":"ref271\/cit271","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1039\/C0AN00171F","volume":"136","author":"Chen Z.-P.","year":"2011","journal-title":"Analyst"},{"key":"ref272\/cit272","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.chemolab.2008.11.002","volume":"96","author":"Chen Z.-P.","year":"2009","journal-title":"Chemometrics Intellig. Lab. Syst."},{"key":"ref273\/cit273","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1021\/op100223a","volume":"15","author":"Khan S.","year":"2011","journal-title":"Org. Process Res. Dev."},{"key":"ref274\/cit274","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.compchemeng.2008.06.002","volume":"33","author":"Singh R.","year":"2009","journal-title":"Comput. Chem. Eng."},{"key":"ref275\/cit275","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.compchemeng.2009.06.021","volume":"34","author":"Singh R.","year":"2010","journal-title":"Comput. Chem. Eng."},{"key":"ref276\/cit276","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.compchemeng.2012.02.022","volume":"42","author":"Gernaey K. V.","year":"2012","journal-title":"Comput. Chem. Eng."},{"key":"ref277\/cit277","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1002\/btpr.166","volume":"25","author":"Sin G.","year":"2009","journal-title":"Biotechnol. Prog."},{"key":"ref278\/cit278","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.compchemeng.2012.02.015","volume":"42","author":"Boukouvala F.","year":"2012","journal-title":"Comput. Chem. Eng."},{"key":"ref279\/cit279","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12247-012-9143-9","volume":"8","author":"Boukouvala F.","year":"2013","journal-title":"J. Pharm. Sci. Innovation"},{"key":"ref280\/cit280","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0032-5910(71)80001-3","volume":"4","author":"Kawakita K.","year":"1971","journal-title":"Powder Technol."},{"key":"ref281\/cit281","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.compchemeng.2010.07.008","volume":"35","author":"Kimber J. A.","year":"2011","journal-title":"Comput. Chem. Eng."},{"key":"ref282\/cit282","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0032-5910(00)00250-3","volume":"111","author":"Kuentz M.","year":"2000","journal-title":"Powder Technol."},{"key":"ref283\/cit283","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.compchemeng.2013.03.003","volume":"54","author":"Samad N. A. F. A.","year":"2013","journal-title":"Comput. Chem. Eng."},{"key":"ref284\/cit284","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.compchemeng.2011.01.029","volume":"35","author":"Samad N. A. F. A.","year":"2011","journal-title":"Comput. Chem. Eng."},{"key":"ref285\/cit285","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ces.2012.06.024","volume":"80","author":"Sen M.","year":"2012","journal-title":"Chem. Eng. Sci."},{"key":"ref286\/cit286","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/843784"},{"issue":"3","key":"ref287\/cit287","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.ejpb.2013.02.019","volume":"85","author":"Singh R.","year":"2013","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref288\/cit288","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ijpharm.2012.09.009","volume":"438","author":"Singh R.","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref289\/cit289","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/bit.21869","volume":"101","author":"Sin G.","year":"2008","journal-title":"Biotechnol. Bioeng."},{"key":"ref290\/cit290","volume-title":"Bioprocess engineering principles","author":"Doran P.","year":"2006"},{"key":"ref291\/cit291","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/s12247-010-9077-z","volume":"5","author":"Hsu S.","year":"2010","journal-title":"J. Pharm. Innov."},{"key":"ref292\/cit292","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/s12247-010-9076-0","volume":"5","author":"Hsu S.","year":"2010","journal-title":"J. Pharm. Innov."},{"key":"ref293\/cit293","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.powtec.2004.03.003","volume":"140","author":"Bardin M.","year":"2004","journal-title":"Powder Technol."},{"key":"ref294\/cit294","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.talanta.2012.07.054","volume":"100","author":"Burggraeve A.","year":"2012","journal-title":"Talanta"},{"key":"ref295\/cit295","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.cherd.2011.10.022","volume":"90","author":"Ramachandran R.","year":"2012","journal-title":"Chem. Eng. Res. Des."},{"key":"ref296\/cit296","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.powtec.2008.05.005","volume":"188","author":"Sanders C. F. W.","year":"2009","journal-title":"Powder Technol."},{"key":"ref297\/cit297","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0032-5910(01)00334-5","volume":"121","author":"Gatzke E. P.","year":"2001","journal-title":"Powder Technol."},{"key":"ref298\/cit298","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1002\/rnc.1105","volume":"17","author":"Long C.","year":"2007","journal-title":"Int. J. Robust Nonlin."},{"key":"ref299\/cit299","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0032-5910(99)00220-X","volume":"108","author":"Pottmann M.","year":"2000","journal-title":"Powder Technol."},{"issue":"6","key":"ref300\/cit300","first-page":"22","volume":"27","author":"Singh R.","year":"2012","journal-title":"Pharm. Process. Mag."},{"key":"ref301\/cit301","volume-title":"GMP News, European Compliance Academic (ECE)","author":"Singh R.","year":"2012"},{"key":"ref302\/cit302","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.jpba.2008.01.013","volume":"47","author":"Eliasson C.","year":"2008","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref303\/cit303","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0731-7085(03)00345-5","volume":"33","author":"Fountain W.","year":"2003","journal-title":"J. Pharm. Biomed. Anal."},{"key":"ref304\/cit304","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.aca.2008.08.004","volume":"642","author":"Rodionova O. Y.","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"ref305\/cit305","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ijpharm.2014.06.045","volume":"473","author":"Singh R.","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref306\/cit306","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.compchemeng.2014.02.029","volume":"66","author":"Singh R.","year":"2013","journal-title":"Comput. Chem. Eng."},{"key":"ref307\/cit307","doi-asserted-by":"crossref","first-page":"5728","DOI":"10.1016\/j.ces.2010.01.036","volume":"65","author":"Vanarase A. U.","year":"2010","journal-title":"Chem. Eng. Sci."},{"key":"ref308\/cit308","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0956-7135(90)90006-X","volume":"1","author":"Scotter C.","year":"1990","journal-title":"Food Control"},{"key":"ref309\/cit309","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.aca.2006.05.034","volume":"573","author":"Vlachos N.","year":"2006","journal-title":"Anal. Chim. Acta"},{"key":"ref310\/cit310","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0260-8774(00)00134-5","volume":"47","author":"W\u00e4hlby U.","year":"2001","journal-title":"J. Food Eng."},{"key":"ref311\/cit311","volume-title":"Advanced control foundation: Tools, Techniques and Applications","author":"Blevins T.","year":"2012"},{"issue":"6","key":"ref312\/cit312","first-page":"40","volume":"37","author":"Muzzio F.","year":"2013","journal-title":"Pharm. Technol. Mag."},{"key":"ref313\/cit313","volume-title":"Guidance for industry, Q8 (R1) pharmaceutical development revision 1","author":"FDA","year":"2007"},{"key":"ref314\/cit314","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.compchemeng.2010.04.011","volume":"34","author":"Singh R.","year":"2010","journal-title":"Comput. Chem. Eng."},{"key":"ref315\/cit315","unstructured":"Sales-Cruz, M.Development of a computer aided modeling system for bio and chemical process and product design. PhD. Thesis.Technical University of Denmark,Lyngby, 2006."},{"key":"ref316\/cit316","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.compchemeng.2013.08.008","volume":"60","author":"von Stosch M.","year":"2014","journal-title":"Comput. Chem. Eng."},{"key":"ref317\/cit317","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0168-1656(00)00361-8","volume":"85","author":"Sch\u00fcgerl K.","year":"2001","journal-title":"J. Biotechnol."},{"key":"ref318\/cit318","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.biotechadv.2009.05.003","volume":"27","author":"Teixeira A. P.","year":"2009","journal-title":"Biotechnol. Adv."},{"key":"ref319\/cit319","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1002\/biot.201200226","volume":"7","author":"Carrondo M. J. T.","year":"2012","journal-title":"Biotechnol. J."},{"key":"ref320\/cit320","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/biot.201000356","volume":"6","author":"Glassey J.","year":"2011","journal-title":"Biotechnol. J."},{"key":"ref321\/cit321","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/biot.201300385","volume":"9","author":"von Stosch M.","year":"2014","journal-title":"Biotechnol. J."},{"key":"ref322\/cit322","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12247-010-9090-2","volume":"5","author":"Kumar Akkisetty P.","year":"2010","journal-title":"J. Pharm. Sci. Innovation"},{"key":"ref323\/cit323","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1007\/s11947-010-0477-3","volume":"5","author":"Saraceno A.","year":"2012","journal-title":"Food Bioprocess Technol."},{"key":"ref324\/cit324","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1080\/07373937.2012.684085","volume":"30","author":"Freire J. T.","year":"2012","journal-title":"Drying Technol."},{"key":"ref325\/cit325","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/aic.12331","volume":"57","author":"Hermanto M. W.","year":"2011","journal-title":"AlChE J."},{"key":"ref326\/cit326","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s00449-013-1029-9","volume":"37","author":"Ferreira A. R.","year":"2014","journal-title":"Bioprocess Biosyst. Eng."},{"key":"ref327\/cit327","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00449-007-0161-9","volume":"31","author":"Gnoth S.","year":"2008","journal-title":"Bioprocess Biosyst. Eng."},{"key":"ref328\/cit328","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.compchemeng.2006.05.018","volume":"31","author":"Laursen S. \u00d6.","year":"2007","journal-title":"Comput. Chem. Eng."},{"key":"ref329\/cit329","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/btpr.706","volume":"28","author":"von Stosch M.","year":"2012","journal-title":"Biotechnol. Prog."},{"key":"ref330\/cit330","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jbiotec.2005.04.024","volume":"118","author":"Teixeira A.","year":"2005","journal-title":"J. Biotechnol."},{"key":"ref331\/cit331","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jbiotec.2007.08.020","volume":"132","author":"Teixeira A. P.","year":"2007","journal-title":"J. Biotechnol."},{"key":"ref332\/cit332","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1471-2105-8-30","volume":"8","author":"Teixeira A.","year":"2007","journal-title":"BMC Bioinform."},{"key":"ref333\/cit333","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s10616-010-9291-z","volume":"62","author":"Aehle M.","year":"2010","journal-title":"Cytotechnology"},{"key":"ref334\/cit334","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s004490100246","volume":"24","author":"Patnaik P.","year":"2001","journal-title":"Bioprocess Biosyst. Eng."},{"key":"ref335\/cit335","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/biot.201300236","volume":"9","author":"Formenti L. R.","year":"2014","journal-title":"Biotechnol. J."},{"key":"ref336\/cit336","doi-asserted-by":"crossref","first-page":"7336","DOI":"10.1021\/ie060181z","volume":"45","author":"Simon L. L.","year":"2006","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref337\/cit337","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0952-1976(98)00011-6","volume":"11","author":"Braake H. A. B. t.","year":"1998","journal-title":"Eng. Appl. Artif. Intel."},{"key":"ref338\/cit338","volume-title":"3rd Portuguese Bioengineering Meeting","author":"von Stosch M.","year":"2013"},{"key":"ref339\/cit339","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1021\/cg100135j","volume":"10","author":"Kadam S. S.","year":"2010","journal-title":"Cryst. Growth Des."},{"key":"ref340\/cit340","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/j.cherd.2010.11.013","volume":"89","author":"Kadam S. S.","year":"2011","journal-title":"Chem. Eng. Res. Des."},{"key":"ref341\/cit341","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/(SICI)1521-4117(199802)15:1<56::AID-PPSC56>3.0.CO;2-U","volume":"15","author":"Bermingham S. K.","year":"1998","journal-title":"Part. Part. Syst. Char."},{"key":"ref342\/cit342","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/1521-4117(200204)19:1<17::AID-PPSC17>3.0.CO;2-1","volume":"19","author":"Neumann A. M.","year":"2002","journal-title":"Part. Part. Syst. Char."},{"key":"ref343\/cit343","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1016\/j.ces.2011.06.049","volume":"66","author":"Kalbasenka A.","year":"2011","journal-title":"Chem. Eng. Sci."},{"key":"ref344\/cit344","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jprocont.2010.11.013","volume":"21","author":"Mesbah A.","year":"2011","journal-title":"J. Process Control"},{"key":"ref345\/cit345","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.ces.2012.02.013","volume":"77","author":"Ferguson S.","year":"2012","journal-title":"Chem. Eng. Sci."},{"key":"ref346\/cit346","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/ceat.201000465","volume":"34","author":"Borchert C.","year":"2011","journal-title":"Chem. Eng. Technol."},{"key":"ref347\/cit347","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1002\/aic.11555","volume":"54","author":"Variankaval N.","year":"2008","journal-title":"AIChE J."},{"key":"ref348\/cit348","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1021\/op0500077","volume":"9","author":"Birch M.","year":"2005","journal-title":"Org. Process Res. Dev."},{"key":"ref349\/cit349","first-page":"15","volume":"11","author":"Broadhead J.","year":"2013","journal-title":"GMP Review"},{"key":"ref350\/cit350","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1021\/op100209c","volume":"14","author":"Castagnoli C.","year":"2010","journal-title":"Org. Process Res. Dev."},{"key":"ref351\/cit351","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1039\/b212062c","author":"Bonnett P.","year":"2003","journal-title":"Chem. Commun."},{"key":"ref352\/cit352","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1021\/op050107c","volume":"9","author":"Deneau E.","year":"2005","journal-title":"Org. Process Res. Dev."},{"key":"ref353\/cit353","unstructured":"Juppo, A.; Steele, G.Preparation of Crystalline N,N\u2032-Disubstituted Oxabispidines and Their Use as Cardiovascular AgentsWO 2006\/137772A1, 2006."},{"key":"ref354\/cit354","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jcrysgro.2011.04.009","volume":"342","author":"Herman C.","year":"2012","journal-title":"J. Cryst. Growth"},{"key":"ref355\/cit355","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1021\/ie000962e","volume":"41","author":"Lewiner F.","year":"2002","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref356\/cit356","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1021\/op049782x","volume":"9","author":"De Smet K.","year":"2005","journal-title":"Org. Process Res. Dev."},{"key":"ref357\/cit357","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1021\/op000210w","volume":"4","author":"Wang F.","year":"2000","journal-title":"Org. Process Res. Dev."},{"key":"ref358\/cit358","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1021\/cg0342516","volume":"4","author":"Ono T.","year":"2004","journal-title":"Cryst. Growth Des."},{"key":"ref359\/cit359","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1021\/cg800232x","volume":"8","author":"Barthe S. C.","year":"2008","journal-title":"Cryst. Growth Des."},{"key":"ref360\/cit360","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1021\/op060046y","volume":"10","author":"Kobayashi R.","year":"2006","journal-title":"Org. Process Res. Dev."},{"key":"ref361\/cit361","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1021\/jp013044i","volume":"106","author":"Davey R. J.","year":"2002","journal-title":"J. Phys. Chem. B"},{"key":"ref362\/cit362","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1021\/op2000628","volume":"15","author":"Barrett M.","journal-title":"Org. Process Res. Dev."},{"key":"ref363\/cit363","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1016\/j.jcrysgro.2009.04.018","volume":"311","author":"Qu H.","year":"2009","journal-title":"J. Cryst. Growth"},{"key":"ref364\/cit364","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.1021\/ie071642z","volume":"47","author":"Qu H.","year":"2008","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref365\/cit365","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1039\/b817299d","volume":"11","author":"Han B.","year":"2009","journal-title":"CrystEngComm"},{"key":"ref366\/cit366","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1021\/cg060686s","volume":"7","author":"Qu H. Y.","year":"2007","journal-title":"Cryst. Growth Des."},{"key":"ref367\/cit367","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1021\/cg0600593","volume":"6","author":"Qu H. Y.","year":"2006","journal-title":"Cryst. Growth Des."},{"key":"ref368\/cit368","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.ijpharm.2006.05.013","volume":"321","author":"Qu H.","year":"2006","journal-title":"Int. J. Pharm."},{"key":"ref369\/cit369","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1021\/op0500887","volume":"9","author":"O\u2019Sullivan B.","year":"2005","journal-title":"Org. Process Res. Dev."},{"key":"ref370\/cit370","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1021\/op8001257","volume":"12","author":"Jia C.-Y.","year":"2008","journal-title":"Org. Process Res. Dev."},{"key":"ref371\/cit371","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1021\/op300320a","volume":"17","author":"Zhao J.","year":"2013","journal-title":"Org. Process Res. Dev."},{"key":"ref372\/cit372","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1021\/cg2003029","volume":"11","author":"Thirunahari S.","year":"2011","journal-title":"Cryst. Growth Des."},{"key":"ref373\/cit373","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1021\/op100228f","volume":"14","author":"Su W.","year":"2010","journal-title":"Org. Process Res. Dev."},{"key":"ref374\/cit374","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1021\/cg301456m","volume":"13","author":"O\u2019Mahony M. A.","year":"2013","journal-title":"Cryst. Growth Des."},{"key":"ref375\/cit375","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1021\/cg201665z","volume":"12","author":"O\u2019Mahony M. A.","year":"2012","journal-title":"Cryst. Growth Des."},{"key":"ref376\/cit376","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1021\/cg0503402","volume":"6","author":"Scholl J.","year":"2006","journal-title":"Cryst. Growth Des."},{"key":"ref377\/cit377","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1021\/op300359p","volume":"17","author":"Helmdach L.","year":"2013","journal-title":"Org. Process Res. Dev."},{"key":"ref378\/cit378","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1021\/op200168g","volume":"16","author":"Herman C.","year":"2012","journal-title":"Org. Process Res. Dev."},{"key":"ref379\/cit379","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1021\/op100294f","volume":"15","author":"Herman C.","year":"2011","journal-title":"Org. Process Res. Dev."},{"key":"ref380\/cit380","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.jct.2010.12.006","volume":"43","author":"Herman C.","year":"2011","journal-title":"J. Chem. Thermodyn."},{"key":"ref381\/cit381","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1021\/cg201291k","volume":"12","author":"Springuel G.","year":"2012","journal-title":"Cryst. Growth Des."},{"key":"ref382\/cit382","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1021\/cg300307z","volume":"12","author":"Springuel G.","year":"2012","journal-title":"Cryst. Growth Des."},{"key":"ref383\/cit383","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1021\/cg201581z","volume":"12","author":"Leyssens T.","year":"2012","journal-title":"Cryst. Growth Des."},{"key":"ref384\/cit384","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1021\/cg800183v","volume":"8","author":"Horst J. H. t.","year":"2008","journal-title":"Cryst. Growth Des."},{"key":"ref385\/cit385","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1021\/cg801019d","volume":"9","author":"Gagniere E.","year":"2009","journal-title":"Cryst. Growth Des."},{"key":"ref386\/cit386","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1021\/op100314g","volume":"15","author":"Leyssens T.","year":"2011","journal-title":"Org. Process Res. Dev."},{"key":"ref387\/cit387","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jcrysgro.2010.12.027","volume":"316","author":"Gagniere E.","year":"2011","journal-title":"J. Cryst. Growth"},{"key":"ref388\/cit388","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1039\/b715396a","volume":"10","author":"Childs S. L.","year":"2008","journal-title":"CrystEngComm"},{"key":"ref389\/cit389","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1021\/cg901232h","volume":"10","author":"Good D. J.","year":"2010","journal-title":"Cryst. Growth Des."},{"key":"ref390\/cit390","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1021\/cg100198u","volume":"10","author":"Yu Z. Q.","year":"2010","journal-title":"Cryst. Growth Des."},{"key":"ref391\/cit391","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1021\/cg3014859","volume":"13","author":"Zhang S.","year":"2013","journal-title":"Cryst. Growth Des."},{"key":"ref392\/cit392","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1021\/mp050099m","volume":"3","author":"Rodriguez-Hornedo N.","year":"2006","journal-title":"Mol. Pharmaceutics"},{"key":"ref393\/cit393","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1021\/cg200745q","volume":"11","author":"Yu Z. Q.","year":"2011","journal-title":"Cryst. Growth Des."},{"key":"ref394\/cit394","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1042\/BA20040044","volume":"41","author":"H\u00e4kkinen A.","year":"2005","journal-title":"Biotechnol. Appl. Biochem."},{"key":"ref395\/cit395","first-page":"144","volume":"8","author":"H\u00e4kkinen A.","year":"2008","journal-title":"Filtration"},{"key":"ref396\/cit396","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.seppur.2007.06.017","volume":"59","author":"Louhi-Kultanen M.","year":"2008","journal-title":"Sep. Purif. Technol."},{"key":"ref397\/cit397","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/pat.787","volume":"17","author":"Bishop A.","year":"2006","journal-title":"Polym. Adv. Technol."},{"key":"ref398\/cit398","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1023\/A:1023450006281","volume":"20","author":"Verreck G.","year":"2003","journal-title":"Pharm. Res."},{"key":"ref399\/cit399","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3144\/expresspolymlett.2010.92","volume":"4","author":"Nagy Z. K.","year":"2010","journal-title":"Express Polym. Lett."},{"key":"ref400\/cit400","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/jps.22731","volume":"101","author":"Nagy Z. K.","year":"2012","journal-title":"J. Pharm. Sci."},{"key":"ref401\/cit401","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ejps.2013.04.034","volume":"49","author":"Vigh T.","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref402\/cit402","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/jps.23374","volume":"102","author":"Nagy Z. K.","year":"2013","journal-title":"J. Pharm. Sci."},{"key":"ref403\/cit403","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ijpharm.2008.01.036","volume":"357","author":"Tumuluri V. S.","year":"2008","journal-title":"Int. J. Pharm."},{"key":"ref404\/cit404","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.ejpb.2010.09.015","volume":"77","author":"Saerens L.","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref405\/cit405","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijpharm.2010.12.012","volume":"417","author":"De Beer T.","year":"2011","journal-title":"Int. J. Pharm."},{"key":"ref406\/cit406","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1366\/0003702011953559","volume":"55","author":"Stephens J.","year":"2001","journal-title":"Appl. Spectrosc."},{"key":"ref407\/cit407","unstructured":"Pataki, H.Innovative crystallization of drugs using PAT technology. PhD Thesis,Budapest University of Technology and Economics,Budapest, 2013."},{"key":"ref408\/cit408","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00253-003-1274-y","volume":"61","author":"Elander R.","year":"2003","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref409\/cit409","unstructured":"Li, F.; Shen, A.; Amanullah, A.Pharmaceutical Sciences Encyclopedia;Wiley:New York, 2010; p466"},{"key":"ref410\/cit410","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/biot.200700214","volume":"3","author":"Dingermann T.","year":"2008","journal-title":"Biotechnol. J."},{"key":"ref411\/cit411","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/07388550500513677","volume":"26","author":"Scarff M.","year":"2006","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref412\/cit412","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00253-005-0213-5","volume":"69","author":"Grimm L.","year":"2005","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"ref413\/cit413","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF00369471","volume":"14","author":"Larsson G.","year":"1996","journal-title":"Bioprocess Eng."},{"key":"ref414\/cit414","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0168-1656(00)00365-5","volume":"85","author":"Enfors S.-O.","year":"2001","journal-title":"J. Biotechnol."},{"key":"ref415\/cit415","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.biotechadv.2011.03.007","volume":"29","author":"Lencastre Fernandes R.","year":"2011","journal-title":"Biotechnol. Adv."},{"key":"ref416\/cit416","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0734-9750(98)00015-9","volume":"17","author":"Lee J.","year":"1999","journal-title":"Biotechnol. Adv."},{"key":"ref417\/cit417","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0167-7799(97)01136-0","volume":"15","author":"Olsson L.","year":"1997","journal-title":"Trends Biotechnol."},{"key":"ref418\/cit418","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/07388550500248563","volume":"25","author":"Madrid R.","year":"2005","journal-title":"Crit. Rev. Biotechnol."},{"key":"ref419\/cit419","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10295-008-0346-5","volume":"35","author":"Kiviharju K.","year":"2008","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"ref420\/cit420","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s10295-011-0957-0","volume":"38","author":"R\u00f8nnest N. P.","year":"2011","journal-title":"J. Ind. Microbiol. Biotechnol."},{"key":"ref421\/cit421","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/(SICI)1097-0290(19981005)60:1<24::AID-BIT3>3.0.CO;2-2","volume":"60","author":"Bittner C.","year":"1998","journal-title":"Biotechnol. Bioeng."},{"key":"ref422\/cit422","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1021\/bp025734p","volume":"19","author":"Pearson A. P.","year":"2003","journal-title":"Biotechnol. Prog."},{"key":"ref423\/cit423","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1475-2859-12-100","volume":"12","author":"Brognaux A.","year":"2013","journal-title":"Microb. Cell Fact."},{"key":"ref424\/cit424","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0168-1656(01)00257-7","volume":"88","author":"Skibsted E.","year":"2001","journal-title":"J. Biotechnol."},{"key":"ref425\/cit425","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/bit.21170","volume":"96","author":"Haack M. B.","year":"2007","journal-title":"Biotechnol. Bioeng."},{"key":"ref426\/cit426","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0032-9592(01)00223-0","volume":"37","author":"Sivakesava S.","year":"2001","journal-title":"Process Biochem."},{"key":"ref427\/cit427","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.vibspec.2003.12.015","volume":"35","author":"Lee H. L.","year":"2004","journal-title":"Vib. Spectrosc."},{"key":"ref428\/cit428","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1002\/btpr.280","volume":"25","author":"Cervera A. E.","year":"2009","journal-title":"Biotechnol. Prog."},{"key":"ref429\/cit429","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/bit.260400219","volume":"40","author":"Strudsholm K.","year":"1992","journal-title":"Biotechnol. Bioeng."},{"key":"ref430\/cit430","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/elsc.200401910","volume":"4","author":"Peuker T.","year":"2004","journal-title":"Eng. Life Sci."},{"key":"ref431\/cit431","unstructured":"Pitk\u00e4nen, J. P.; Hokkanen, A.; Heimala, P.; Kauhaniemi, J.; Kolari, K.; Savolahti, P.; Uusitalo, J.Sample port, multi-layer filter, sampling method, and use of sample port in sampling. FI20095568, PCT\/FI2010\/050410, 2009."},{"key":"ref432\/cit432","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1021\/bp00027a008","volume":"10","author":"Oeggerli A.","year":"1994","journal-title":"Biotechnol. Prog."},{"key":"ref433\/cit433","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1002\/biot.201100506","volume":"7","author":"Luttmann R.","year":"2012","journal-title":"Biotechnol. J."},{"key":"ref434\/cit434","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/mren.200900048","volume":"4","author":"Xalter R.","year":"2010","journal-title":"Macromol. React. Eng."},{"key":"ref435\/cit435","doi-asserted-by":"crossref","first-page":"7457","DOI":"10.1021\/ie900679m","volume":"48","author":"Sum A. K.","year":"2009","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref436\/cit436","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.petrol.2010.11.020","volume":"75","author":"Martinez-Palou R.","year":"2011","journal-title":"J. Pet. Sci. Eng."},{"key":"ref437\/cit437","doi-asserted-by":"crossref","first-page":"503","DOI":"10.2516\/ogst:2004035","volume":"59","author":"Gateau P.","year":"2006","journal-title":"Oil Gas Sci. Technol."},{"key":"ref438\/cit438","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1021\/ef3014986","volume":"27","author":"Nguyen D.","year":"2013","journal-title":"Energy Fuels"},{"key":"ref439\/cit439","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.1016\/j.ces.2009.08.013","volume":"64","author":"Turner D. J.","year":"2009","journal-title":"Chem. Eng. Sci."},{"key":"ref440\/cit440","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/mren.200900048","volume":"4","author":"Xalter R.","year":"2009","journal-title":"Macromol. React. Eng."}],"container-title":["Organic Process Research &amp; Development"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/op500261y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T12:56:51Z","timestamp":1717678611000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/op500261y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,8]]},"references-count":440,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1,16]]}},"alternative-id":["10.1021\/op500261y"],"URL":"https:\/\/doi.org\/10.1021\/op500261y","relation":{},"ISSN":["1083-6160","1520-586X"],"issn-type":[{"value":"1083-6160","type":"print"},{"value":"1520-586X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,8]]}}}