{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:17:46Z","timestamp":1773929866167,"version":"3.50.1"},"reference-count":40,"publisher":"American Chemical Society (ACS)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Proteome Res."],"published-print":{"date-parts":[[2010,11,5]]},"DOI":"10.1021\/pr100815q","type":"journal-article","created":{"date-parts":[[2010,9,17]],"date-time":"2010-09-17T14:53:09Z","timestamp":1284735189000},"page":"6016-6024","source":"Crossref","is-referenced-by-count":88,"title":["Impact of Prenatal Disorders on the Metabolic Profile of Second Trimester Amniotic Fluid: A Nuclear Magnetic Resonance Metabonomic Study"],"prefix":"10.1021","volume":"9","author":[{"given":"Gon\u00e7alo","family":"Gra\u00e7a","sequence":"first","affiliation":[{"name":"CICECO\u2212Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, QOPNA Research Unit, Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, Cytogenetics Laboratory and Center of Neurosciences and Cellular Biology, Faculty of Medicine, P\u00f3lo III, University of Coimbra, 3000-354 Coimbra, Portugal, and Maternidade Bissaya Barreto, Centro Hospitalar de Coimbra, 3000 Coimbra, Portugal"}]},{"given":"Iola F.","family":"Duarte","sequence":"additional","affiliation":[{"name":"CICECO\u2212Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, QOPNA Research Unit, Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, Cytogenetics Laboratory and Center of Neurosciences and Cellular Biology, Faculty of Medicine, P\u00f3lo III, University of Coimbra, 3000-354 Coimbra, Portugal, and Maternidade Bissaya Barreto, Centro Hospitalar de Coimbra, 3000 Coimbra, Portugal"}]},{"given":"Ant\u00f3nio S.","family":"Barros","sequence":"additional","affiliation":[{"name":"CICECO\u2212Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, QOPNA Research Unit, Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, Cytogenetics Laboratory and Center of Neurosciences and Cellular Biology, Faculty of Medicine, P\u00f3lo III, University of Coimbra, 3000-354 Coimbra, Portugal, and Maternidade Bissaya Barreto, Centro Hospitalar de Coimbra, 3000 Coimbra, Portugal"}]},{"given":"Brian J.","family":"Goodfellow","sequence":"additional","affiliation":[{"name":"CICECO\u2212Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, QOPNA Research Unit, Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, Cytogenetics Laboratory and Center of Neurosciences and Cellular Biology, Faculty of Medicine, P\u00f3lo III, University of Coimbra, 3000-354 Coimbra, Portugal, and Maternidade Bissaya Barreto, Centro Hospitalar de Coimbra, 3000 Coimbra, Portugal"}]},{"given":"S\u00edlvia O.","family":"Diaz","sequence":"additional","affiliation":[{"name":"CICECO\u2212Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, QOPNA Research Unit, Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, Cytogenetics Laboratory and Center of Neurosciences and Cellular Biology, Faculty of Medicine, P\u00f3lo III, University of Coimbra, 3000-354 Coimbra, Portugal, and Maternidade Bissaya Barreto, Centro Hospitalar de Coimbra, 3000 Coimbra, Portugal"}]},{"given":"Joana","family":"Pinto","sequence":"additional","affiliation":[{"name":"CICECO\u2212Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, QOPNA Research Unit, Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, Cytogenetics Laboratory and Center of Neurosciences and Cellular Biology, Faculty of Medicine, P\u00f3lo III, University of Coimbra, 3000-354 Coimbra, Portugal, and Maternidade Bissaya Barreto, Centro Hospitalar de Coimbra, 3000 Coimbra, Portugal"}]},{"given":"Isabel M.","family":"Carreira","sequence":"additional","affiliation":[{"name":"CICECO\u2212Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, QOPNA Research Unit, Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, Cytogenetics Laboratory and Center of Neurosciences and Cellular Biology, Faculty of Medicine, P\u00f3lo III, University of Coimbra, 3000-354 Coimbra, Portugal, and Maternidade Bissaya Barreto, Centro Hospitalar de Coimbra, 3000 Coimbra, Portugal"}]},{"given":"Eul\u00e1lia","family":"Galhano","sequence":"additional","affiliation":[{"name":"CICECO\u2212Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, QOPNA Research Unit, Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, Cytogenetics Laboratory and Center of Neurosciences and Cellular Biology, Faculty of Medicine, P\u00f3lo III, University of Coimbra, 3000-354 Coimbra, Portugal, and Maternidade Bissaya Barreto, Centro Hospitalar de Coimbra, 3000 Coimbra, Portugal"}]},{"given":"Cristina","family":"Pita","sequence":"additional","affiliation":[{"name":"CICECO\u2212Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, QOPNA Research Unit, Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, Cytogenetics Laboratory and Center of Neurosciences and Cellular Biology, Faculty of Medicine, P\u00f3lo III, University of Coimbra, 3000-354 Coimbra, Portugal, and Maternidade Bissaya Barreto, Centro Hospitalar de Coimbra, 3000 Coimbra, Portugal"}]},{"given":"Ana M.","family":"Gil","sequence":"additional","affiliation":[{"name":"CICECO\u2212Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, QOPNA Research Unit, Department of Chemistry, Campus Universit\u00e1rio de Santiago, Universidade de Aveiro, 3810-193 Aveiro, Portugal, Cytogenetics Laboratory and Center of Neurosciences and Cellular Biology, Faculty of Medicine, P\u00f3lo III, University of Coimbra, 3000-354 Coimbra, Portugal, and Maternidade Bissaya Barreto, Centro Hospitalar de Coimbra, 3000 Coimbra, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2010,10,11]]},"reference":[{"issue":"4","key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1053\/j.semperi.2008.04.012","volume":"32","author":"Harman C. R.","year":"2008","journal-title":"Semin. Perinatol."},{"key":"ref2\/cit2","volume-title":"Geigy scientific tables","author":"Lind T.","year":"1981"},{"issue":"1","key":"ref3\/cit3","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/clinchem\/40.1.56","volume":"40","author":"Bock J. L.","year":"1994","journal-title":"Clin. Chem."},{"issue":"6","key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/mas.20181","volume":"27","author":"Kolialexi A.","year":"2008","journal-title":"Mass Spectrom. Rev."},{"key":"ref5\/cit5","volume-title":"Essentials of Obstetrics and Gynecology","author":"Hacker N. F.","year":"2004","edition":"4"},{"issue":"1","key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0301-2115(03)00279-3","volume":"112","author":"Groenen P. M. W.","year":"2004","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"1","key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jchromb.2005.12.020","volume":"839","author":"Tuma P.","year":"2006","journal-title":"J. Chromatogr. B"},{"issue":"5","key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1023\/B:BOLI.0000042981.52186.a9","volume":"27","author":"Kumps A.","year":"2004","journal-title":"J. Inherited Metab. Dis."},{"issue":"10","key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1080\/14767050802053289","volume":"21","author":"Bujold E.","year":"2008","journal-title":"J. Matern.-Fetal Neonat. Med."},{"issue":"5","key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1177\/1933719108316909","volume":"15","author":"Joong Shin P.","year":"2008","journal-title":"Reprod. Sci."},{"issue":"7","key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"3574","DOI":"10.1021\/pr100088k","volume":"9","author":"Cho C.-K. J.","year":"2010","journal-title":"J. Proteome Res."},{"issue":"5","key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1021\/pr700588u","volume":"7","author":"Mavrou A.","year":"2008","journal-title":"J. Proteome Res."},{"issue":"1","key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cccn.2005.04.018","volume":"360","author":"Thadikkaran L.","year":"2005","journal-title":"Clin. Chim. Acta"},{"issue":"5","key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/1099-0534(2000)12:5<289::AID-CMR3>3.0.CO;2-W","volume":"12","author":"Lindon J. C.","year":"2000","journal-title":"Concepts Magn. Reson."},{"issue":"3","key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/nbm.935","volume":"18","author":"Bollard M. E.","year":"2005","journal-title":"NMR Biomed."},{"issue":"23","key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"8956","DOI":"10.1021\/ac0713961","volume":"79","author":"Coen M.","year":"2007","journal-title":"Anal. Chem."},{"issue":"1","key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1021\/pr9006574","volume":"9","author":"Rocha C. M.","year":"2010","journal-title":"J. Proteome Res."},{"issue":"12","key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1021\/ac900545q","volume":"81","author":"Duarte I. F.","year":"2009","journal-title":"Anal. Chem."},{"issue":"1","key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"e4251","DOI":"10.1371\/journal.pone.0004251","volume":"4","author":"Tiziani S.","year":"2009","journal-title":"PLoS ONE"},{"issue":"11","key":"ref20\/cit20","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1080\/004982599238047","volume":"29","author":"Nicholson J. K.","year":"1999","journal-title":"Xenobiotica"},{"issue":"6","key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1002\/jmri.21592","volume":"28","author":"Joe B. N.","year":"2008","journal-title":"J. Magn. Reson. Imaging"},{"issue":"4","key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.jpedsurg.2006.02.020","volume":"41","author":"Clifton M. S.","year":"2006","journal-title":"J. Pediatr. Surg."},{"issue":"2","key":"ref23\/cit23","first-page":"62","volume":"6","author":"Sims C. J.","year":"1996","journal-title":"J. Matern.-Fetal Invest."},{"issue":"8","key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"4144","DOI":"10.1021\/pr900386f","volume":"8","author":"Gra\u00e7a G.","year":"2009","journal-title":"J. Proteome Res."},{"issue":"21","key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"8367","DOI":"10.1021\/ac071278d","volume":"79","author":"Gra\u00e7a G.","year":"2007","journal-title":"Anal. Chem."},{"issue":"15","key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"6085","DOI":"10.1021\/ac800907f","volume":"80","author":"Gra\u00e7a G.","year":"2008","journal-title":"Anal. Chem."},{"issue":"2","key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1021\/pr060594q","volume":"6","author":"Trygg J.","year":"2007","journal-title":"J. Proteome Res."},{"issue":"3","key":"ref28\/cit28","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1366\/0003702001949500","volume":"54","author":"Norgaard L.","year":"2000","journal-title":"Appl. Spectrosc."},{"issue":"4","key":"ref29\/cit29","first-page":"8","volume":"6","author":"Lemon J.","year":"2010","journal-title":"R-News"},{"issue":"2","key":"ref30\/cit30","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1097-0223(199702)17:2<149::AID-PD48>3.0.CO;2-S","volume":"17","author":"Star J.","year":"1997","journal-title":"Prenatal Diagn."},{"issue":"2","key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.ajog.2004.08.011","volume":"192","author":"Cetin I.","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1152\/physiolgenomics.00194.2006","volume":"29","author":"Salek R. M.","year":"2007","journal-title":"Physiol. Genomics"},{"issue":"3","key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s11306-010-0203-1","volume":"6","author":"Zhao X.","year":"2010","journal-title":"Metabolomics"},{"issue":"5","key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1134\/S1062359006050037","volume":"33","author":"Shestopalov A.","year":"2006","journal-title":"Biol. Bull."},{"issue":"1","key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000013956","volume":"73","author":"Ogihara T.","year":"1998","journal-title":"Neonatology"},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1161\/01.HYP.0000141085.98320.01","volume":"44","author":"Raijmakers M. T. M.","year":"2004","journal-title":"Hypertension"},{"issue":"10","key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1097\/OGX.0b013e318181a79f","volume":"63","author":"Sakata M.","year":"2008","journal-title":"Obstet. Gynecol. Surv."},{"issue":"8","key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0026-0495(03)00148-3","volume":"52","author":"Anne A. M. W. v. K.","year":"2003","journal-title":"Metab., Clin. Exp."},{"issue":"3","key":"ref39\/cit39","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0378-3782(85)90055-6","volume":"10","author":"Hallman M.","year":"1985","journal-title":"Early Hum. Dev."},{"issue":"11","key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.clinbiochem.2007.03.004","volume":"40","author":"Longini M.","year":"2007","journal-title":"Clin. Biochem."}],"container-title":["Journal of Proteome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/pr100815q","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,2]],"date-time":"2023-04-02T17:33:20Z","timestamp":1680456800000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/pr100815q"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,11]]},"references-count":40,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2010,11,5]]}},"alternative-id":["10.1021\/pr100815q"],"URL":"https:\/\/doi.org\/10.1021\/pr100815q","relation":{},"ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,11]]}}}