{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:37:28Z","timestamp":1759541848620},"reference-count":48,"publisher":"American Chemical Society (ACS)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem. Res. Toxicol."],"published-print":{"date-parts":[[2009,1,19]]},"DOI":"10.1021\/tx8002577","type":"journal-article","created":{"date-parts":[[2008,11,24]],"date-time":"2008-11-24T10:58:07Z","timestamp":1227524287000},"page":"129-135","source":"Crossref","is-referenced-by-count":14,"title":["Cross-Functioning between the Extraneuronal Monoamine Transporter and Multidrug Resistance Protein 1 in the Uptake of Adrenaline and Export of 5-(Glutathion<i>-S-<\/i>yl)adrenaline in Rat Cardiomyocytes"],"prefix":"10.1021","volume":"22","author":[{"given":"Vera Marisa","family":"Costa","sequence":"first","affiliation":[{"name":"REQUIMTE (Rede de Qu\u00edmica e Tecnologia), Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal, REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal, Neurosciences Center of Coimbra, Department of Biochemistry, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal, and CEBIMED, Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal"}]},{"given":"Lu\u00edsa Maria","family":"Ferreira","sequence":"additional","affiliation":[{"name":"REQUIMTE (Rede de Qu\u00edmica e Tecnologia), Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal, REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal, Neurosciences Center of Coimbra, Department of Biochemistry, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal, and CEBIMED, Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal"}]},{"given":"Paula S\u00e9rio","family":"Branco","sequence":"additional","affiliation":[{"name":"REQUIMTE (Rede de Qu\u00edmica e Tecnologia), Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal, REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal, Neurosciences Center of Coimbra, Department of Biochemistry, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal, and CEBIMED, Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal"}]},{"given":"F\u00e9lix","family":"Carvalho","sequence":"additional","affiliation":[{"name":"REQUIMTE (Rede de Qu\u00edmica e Tecnologia), Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal, REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal, Neurosciences Center of Coimbra, Department of Biochemistry, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal, and CEBIMED, Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal"}]},{"given":"Maria Lourdes","family":"Bastos","sequence":"additional","affiliation":[{"name":"REQUIMTE (Rede de Qu\u00edmica e Tecnologia), Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal, REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal, Neurosciences Center of Coimbra, Department of Biochemistry, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal, and CEBIMED, Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal"}]},{"given":"Rui Albuquerque","family":"Carvalho","sequence":"additional","affiliation":[{"name":"REQUIMTE (Rede de Qu\u00edmica e Tecnologia), Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal, REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal, Neurosciences Center of Coimbra, Department of Biochemistry, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal, and CEBIMED, Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal"}]},{"given":"M\u00e1rcia","family":"Carvalho","sequence":"additional","affiliation":[{"name":"REQUIMTE (Rede de Qu\u00edmica e Tecnologia), Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal, REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal, Neurosciences Center of Coimbra, Department of Biochemistry, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal, and CEBIMED, Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal"}]},{"given":"Fernando","family":"Remi\u00e3o","sequence":"additional","affiliation":[{"name":"REQUIMTE (Rede de Qu\u00edmica e Tecnologia), Toxicology Department, Faculty of Pharmacy, University of Porto, Porto, Portugal, REQUIMTE, Departamento de Qu\u00edmica, Faculdade de Ci\u00eancias e Tecnologia, Universidade Nova de Lisboa, Caparica, Portugal, Neurosciences Center of Coimbra, Department of Biochemistry, Faculty of Sciences and Technology, University of Coimbra, Coimbra, Portugal, and CEBIMED, Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal"}]}],"member":"316","published-online":{"date-parts":[[2008,11,24]]},"reference":[{"key":"ref1\/cit1","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1021\/tx025518q","volume":"15","author":"Remi\u00e3o F.","year":"2002","journal-title":"Chem. Res. Toxicol."},{"key":"ref2\/cit2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0891-5849(92)90182-G","volume":"13","author":"Bindoli A.","year":"1992","journal-title":"Free Radical Biol. Med."},{"key":"ref3\/cit3","first-page":"269","volume-title":"Cardiovascular Toxicology","author":"Dhalla S. N.","year":"2001"},{"key":"ref4\/cit4","doi-asserted-by":"crossref","first-page":"79S","DOI":"10.1016\/0002-9343(91)90288-9","volume":"91","author":"Flaherty J. T.","year":"1991","journal-title":"Am. J. Med."},{"key":"ref5\/cit5","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1021\/tx7000916","volume":"20","author":"Costa V. M.","year":"2007","journal-title":"Chem. Res. Toxicol."},{"key":"ref6\/cit6","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1021\/tx049960f","volume":"17","author":"Carvalho M.","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"ref7\/cit7","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1385\/CT:1:3:195","volume":"1","author":"Remi\u00e3o F.","year":"2001","journal-title":"Cardiovasc. Toxicol."},{"key":"ref8\/cit8","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1021\/tx049924g","volume":"17","author":"Remi\u00e3o F.","year":"2004","journal-title":"Chem. Res. Toxicol."},{"key":"ref9\/cit9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3109\/10408449209146309","volume":"22","author":"Monks T. J.","year":"1992","journal-title":"Crit. Rev. Toxicol."},{"key":"ref10\/cit10","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1021\/tx9700937","volume":"10","author":"Monks T. J.","year":"1997","journal-title":"Chem. Res. Toxicol."},{"key":"ref11\/cit11","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1046\/j.1471-4159.1998.71052112.x","volume":"71","author":"Spencer J. P. E.","year":"1998","journal-title":"J. Neurochem."},{"key":"ref12\/cit12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1046\/j.1471-4159.2002.00808.x","volume":"81","author":"Spencer J. P. E.","year":"2002","journal-title":"J. Neurochem."},{"key":"ref13\/cit13","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00204-002-0381-3","volume":"76","author":"Carvalho M.","year":"2002","journal-title":"Arch. Toxicol."},{"key":"ref14\/cit14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1124\/jpet.105.092577","volume":"316","author":"Capela J. P.","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref15\/cit15","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/j.neuroscience.2007.03.028","volume":"146","author":"Capela J. P.","year":"2007","journal-title":"Neuroscience"},{"key":"ref16\/cit16","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1523\/JNEUROSCI.19-04-01484.1999","volume":"19","author":"LaVoie M. J.","year":"1999","journal-title":"J. Neurosci."},{"key":"ref17\/cit17","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1139\/y04-060","volume":"82","author":"Ghosh S.","year":"2004","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"ref18\/cit18","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0005-2736(76)90160-7","volume":"455","author":"Juliano R. L.","year":"1976","journal-title":"Biochim. Biophys. Acta"},{"key":"ref19\/cit19","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1126\/science.1360704","volume":"258","author":"Cole S. P.","year":"1992","journal-title":"Science"},{"key":"ref20\/cit20","first-page":"5337","volume":"58","author":"Allikmets R.","year":"1998","journal-title":"Cancer Res."},{"key":"ref21\/cit21","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1146\/annurev.biochem.71.102301.093055","volume":"71","author":"Borst P.","year":"2002","journal-title":"Annu. Rev. Biochem."},{"key":"ref22\/cit22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(02)00169-2","volume":"55","author":"Schinkel A. H.","year":"2003","journal-title":"Adv. Drug Delivery Rev."},{"key":"ref23\/cit23","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.taap.2004.09.008","volume":"204","author":"Ballatori N.","year":"2005","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref24\/cit24","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.taap.2004.10.012","volume":"204","author":"Leslie E. M.","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref25\/cit25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.pharmthera.2006.10.003","volume":"113","author":"McDevitt C. A.","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"ref26\/cit26","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.tips.2006.06.008","volume":"27","author":"Cole S. P. C.","year":"2006","journal-title":"Trends Pharmacol. Sci."},{"key":"ref27\/cit27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0163-7258(01)00144-9","volume":"91","author":"Eisenhofer G.","year":"2001","journal-title":"Pharmacol. Ther."},{"key":"ref28\/cit28","first-page":"18","volume":"24","author":"Iversen L. L.","year":"1965","journal-title":"Br. J. Pharmacol."},{"key":"ref29\/cit29","first-page":"11125","author":"Malmfors T.","year":"1967","journal-title":"Circ. Res."},{"key":"ref30\/cit30","volume-title":"Goodman & Gilman\u2019s The Pharmacological Basis of Therapeutics","author":"Westfall T. C.","year":"2006"},{"key":"ref31\/cit31","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1124\/mol.105.016832","volume":"68","author":"Engel K.","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"ref32\/cit32","doi-asserted-by":"crossref","first-page":"50042","DOI":"10.1074\/jbc.M407913200","volume":"279","author":"Engel K.","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref33\/cit33","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/bmc.796","volume":"21","author":"Silva R.","year":"2007","journal-title":"Biomed. Chromatogr."},{"key":"ref34\/cit34","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jchromb.2004.11.040","volume":"816","author":"Varma M. V. S.","year":"2005","journal-title":"J. Chromatogr. B"},{"key":"ref35\/cit35","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF00408656","volume":"163","author":"Obst O.","year":"1996","journal-title":"Mol. Cell. Biochem."},{"key":"ref36\/cit36","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/s00204-003-0510-7","volume":"78","author":"Carvalho M.","year":"2004","journal-title":"Arch. Toxicol."},{"key":"ref37\/cit37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.taap.2006.08.004","volume":"217","author":"Decl\u00e8ves X.","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref38\/cit38","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.taap.2006.08.005","volume":"217","author":"Schutte M. E.","year":"2006","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref39\/cit39","first-page":"985","volume":"8","author":"Gruber A.","year":"1994","journal-title":"Leukemia"},{"key":"ref40\/cit40","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1177\/002215540205001008","volume":"50","author":"Meissner K.","year":"2002","journal-title":"J. Histochem. Cytochem."},{"key":"ref41\/cit41","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1369\/jhc.4A6542.2005","volume":"53","author":"Lazarowski A. J.","year":"2005","journal-title":"J. Histochem. Cytochem."},{"key":"ref42\/cit42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1369\/jhc.6A7026.2006","volume":"55","author":"Laguens R. P.","year":"2007","journal-title":"J. Histochem. Cytochem."},{"key":"ref43\/cit43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0887-2333(99)00087-9","volume":"14","author":"Estevez M. D.","year":"2000","journal-title":"Toxicol in Vitro"},{"key":"ref44\/cit44","first-page":"268","volume":"3","author":"Sukhai M.","year":"2000","journal-title":"Pharm. Pharm. Sci."},{"key":"ref45\/cit45","first-page":"69","volume":"37","author":"Goldstein D. S.","year":"2003","journal-title":"Endocr. Regul."},{"key":"ref46\/cit46","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1124\/jpet.103.049270","volume":"305","author":"Goldstein D. S.","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"ref47\/cit47","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S0021-9258(19)85010-X","volume":"264","author":"Yang C. P.","year":"1989","journal-title":"J. Biol. Chem."},{"key":"ref48\/cit48","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/jps.21114","volume":"97","author":"Shirasaka Y.","year":"2006","journal-title":"J. Pharm. Sci."}],"container-title":["Chemical Research in Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pubs.acs.org\/doi\/pdf\/10.1021\/tx8002577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T20:48:24Z","timestamp":1678308504000},"score":1,"resource":{"primary":{"URL":"https:\/\/pubs.acs.org\/doi\/10.1021\/tx8002577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11,24]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1,19]]}},"alternative-id":["10.1021\/tx8002577"],"URL":"https:\/\/doi.org\/10.1021\/tx8002577","relation":{},"ISSN":["0893-228X","1520-5010"],"issn-type":[{"value":"0893-228X","type":"print"},{"value":"1520-5010","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,11,24]]}}}