{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T19:02:05Z","timestamp":1775070125414,"version":"3.50.1"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1999,11,1]],"date-time":"1999-11-01T00:00:00Z","timestamp":941414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Breast Cancer Res Treat"],"published-print":{"date-parts":[[1999,11]]},"DOI":"10.1023\/a:1006394209922","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T01:36:27Z","timestamp":1040520987000},"page":"65-69","source":"Crossref","is-referenced-by-count":38,"title":["Telomerase activity in ductal carcinoma in situ of the breast"],"prefix":"10.1007","volume":"58","author":[{"given":"B.","family":"Shpitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Zimlichman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Zemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Bomstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Zehavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Liverant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bernehim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z.","family":"Kaufman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Shapira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.pitz","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"240459_CR1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/0002-9610(94)90129-5","volume":"176","author":"T Weiner","year":"1994","unstructured":"Weiner T, Cance WG: Molecular mechanism involved in tumorigenesis and their surgical implications. Am J Surg 176: 428\u2013434, 1994","journal-title":"Am J Surg"},{"issue":"Suppl3","key":"240459_CR2","first-page":"962","volume":"72","author":"HC Pilot","year":"1993","unstructured":"Pilot HC: The molecular biology of carcinogenesis. Cancer 72 (Suppl 3): 962\u2013970, 1993","journal-title":"Cancer"},{"key":"240459_CR3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/gcc.2870140402","volume":"14","author":"I Bieche","year":"1995","unstructured":"Bieche I, Lidereau R: Genetic alterations in breast cancer. Genes, Chrom Cancer 14: 227\u2013251, 1995","journal-title":"Genes, Chrom Cancer"},{"key":"240459_CR4","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/S0039-6109(16)45185-6","volume":"70","author":"MD Lagios","year":"1990","unstructured":"Lagios MD: Duct carcinoma in situ. Surg Clin N A 70: 853\u2013871, 1990","journal-title":"Surg Clin N A"},{"key":"240459_CR5","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.7326\/0003-4819-127-11-199712010-00014","volume":"127","author":"HG Welsh","year":"1997","unstructured":"Welsh HG, Black WC: Using autopsy series to estimate the disease \u201creservoir\u201d for ductal carcinoma in situ of the breast: how much more cancer can we found. Ann Int Med 127: 1023\u20131028, 1997","journal-title":"Ann Int Med"},{"key":"240459_CR6","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/0959-8049(96)00037-8","volume":"32A","author":"T Perin","year":"1996","unstructured":"Perin T, Canzolieri V, Massarut S, et al.: Immunohistochemical evaluation of multiple biological markers in ductal carcinoma in situ of the breast. Eur J Cancer 32A: 1148\u20131155, 1996","journal-title":"Eur J Cancer"},{"key":"240459_CR7","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1038\/bjc.1998.240","volume":"77","author":"KL Marsh","year":"1998","unstructured":"Marsh KL and Varley JM: Frequent alterations of cell cycle regulators in early-stage breast lesions as detected by immunohistochemistry. Br J Cancer 77: 1460\u20131468, 1998","journal-title":"Br J Cancer"},{"key":"240459_CR8","first-page":"199","volume":"11","author":"LG Bobrow","year":"1994","unstructured":"Bobrow LG, Happerfield LC, Gregory WM, Springhall RG, Millis RR: The classification of ductal carcinoma in situ and its association with biological markers. Semin Diagnost Pathol 11: 199\u2013207, 1994","journal-title":"Semin Diagnost Pathol"},{"key":"240459_CR9","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0046-8177(97)90014-9","volume":"28","author":"L Mack","year":"1997","unstructured":"Mack L, Kerkvliet N, Doig G, et al.: Relationship of a new histological cathegorization of ductal carcinoma in situ of the breast with size and the immunohistochemical expression of p53, c-erbB-2, bcl-2 and Ki-67. Hum Pathol 28: 947\u2013979, 1997","journal-title":"Hum Pathol"},{"key":"240459_CR10","first-page":"399","volume":"4","author":"S Kyo","year":"1998","unstructured":"Kyo S, Takakura M, Tanaka M, et al.: Quantitative differences in telomerase activity among malignant, premalignant and benign ovarian lesions. Clin Cancer Res 4: 399\u2013405, 1998","journal-title":"Clin Cancer Res"},{"key":"240459_CR11","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/jnci\/90.4.316","volume":"90","author":"AJ Cheng","year":"1998","unstructured":"Cheng AJ, Tang R, Wang JY, See LC, Wang TC: Possible role of telomerase activation in the cancer predisposition of patients with hereditary non-polyposis colorectal cancers. J Natl Cancer Inst 90: 316\u2013321, 1998","journal-title":"J Natl Cancer Inst"},{"key":"240459_CR12","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1200\/JCO.1998.16.6.2238","volume":"16","author":"GB Wisman","year":"1998","unstructured":"Wisman GB, Hollema H, de Long S, et al.: Telomerase activity as biomarker for (pre)neoplastic cervical disease in scrapings and frozen sections from patients with abnormal cervical smears. J Clin Oncol 16: 2238\u20132245, 1998","journal-title":"J Clin Oncol"},{"key":"240459_CR13","first-page":"570","volume":"39","author":"E Hiyama","year":"1998","unstructured":"Hiyama E, Hiyama K, Shay JW, Yokoyama T: Telomerase activity and expression of its components in human neuroblastoma. Proc Am Assoc Cancer Res 39: 570, 1998","journal-title":"Proc Am Assoc Cancer Res"},{"key":"240459_CR14","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/(SICI)1097-0142(19980401)82:7<1319::AID-CNCR15>3.0.CO;2-9","volume":"82","author":"K Yashima","year":"1998","unstructured":"Yashima K, Ashfaq R, Nowak J, et al.: Telomerase activity and expression of its RNA component in cervical lesions. Cancer 82: 1319\u20131327, 1998","journal-title":"Cancer"},{"key":"240459_CR15","first-page":"619","volume":"58","author":"W Zhang","year":"1998","unstructured":"Zhang W, Kapusta LR, Slingerland JM, Klotz LH: Telomerase activity in prostate cancer, prostatic intraepithelial hyperplasia, and benign prostatic epithelium. Cancer Res 58: 619\u2013921, 1998","journal-title":"Cancer Res"},{"key":"240459_CR16","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1126\/science.270.5242.1601","volume":"270","author":"VA Zakian","year":"1995","unstructured":"Zakian VA: Telomeres: beginning to understand the end. Science 270: 1601\u20131607, 1995","journal-title":"Science"},{"key":"240459_CR17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/337331a0","volume":"337","author":"CW Greider","year":"1989","unstructured":"Greider CW, Blackburn EH: A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331\u2013337, 1989","journal-title":"Nature"},{"key":"240459_CR18","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1126\/science.7605428","volume":"266","author":"NW Kim","year":"1994","unstructured":"Kim NW, Piatyszek MA, Prowse KR, et al.: Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011\u20132015, 1994","journal-title":"Science"},{"key":"240459_CR19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/jnci\/87.2.84","volume":"87","author":"MS Rhyu","year":"1995","unstructured":"Rhyu MS: Telomeres, telomerases and immortality. J Natl Cancer Inst 87: 884\u2013894, 1995","journal-title":"J Natl Cancer Inst"},{"key":"240459_CR20","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1073\/pnas.95.1.90","volume":"95","author":"CW Greider","year":"1998","unstructured":"Greider CW: Telomerase activity, cell proliferation and cancer. Proc Natl Acad Sci USA 95: 90\u201392, 1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"240459_CR21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0168-9525(92)90232-S","volume":"8","author":"WE Write","year":"1992","unstructured":"Write WE, Shay JW: Telomere positional effects and the regulation of cellular senescence. Trends Genet 8: 193\u2013197, 1992","journal-title":"Trends Genet"},{"key":"240459_CR22","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0959-8049(97)00062-2","volume":"33","author":"JW Shay","year":"1997","unstructured":"Shay JW, Bacchetti S: A survey of telomerase in human cancer. Eur J Cancer 33: 787\u2013791, 1997","journal-title":"Eur J Cancer"},{"key":"240459_CR23","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/jcp.50.2.106","volume":"50","author":"JW Shay","year":"1997","unstructured":"Shay JW, Gazdar AF: Telomerase in the early detection of cancer. J Clin Pathol 50: 106\u2013109, 1997","journal-title":"J Clin Pathol"},{"key":"240459_CR24","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/jnci\/89.9.618","volume":"89","author":"RA Breslow","year":"1997","unstructured":"Breslow RA, Shay JW, Gazdar AF, Srivastava S: Telomerase and early detection of cancer: a national cancer institute workshop. J Natl Cancer Inst 89: 618\u2013623, 1997","journal-title":"J Natl Cancer Inst"},{"key":"240459_CR25","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/jnci\/88.2.116","volume":"88","author":"E Hiyama","year":"1996","unstructured":"Hiyama E, Gollahon LS, Kataoka T, et al.: Telomerase activity in human breast tumors. J Natl Cancer Inst 88: 116\u2013122, 1996","journal-title":"J Natl Cancer Inst"},{"key":"240459_CR26","first-page":"11","volume":"3","author":"AK Bednarek","year":"1997","unstructured":"Bednarek AK, Sahin A, Brenner AJ, Johnston DA, Aldaz CM: Analysis of telomerase activity levels in breast cancer: positive detection in the in situ breast carcinoma stage. Clin Cancer Res 3: 11\u201316. 1997","journal-title":"Clin Cancer Res"},{"key":"240459_CR27","first-page":"229","volume":"4","author":"K Yashima","year":"1998","unstructured":"Yashima K, Milchgrub S, Gollahon LS, et al.:Telomerase enzyme activity and RNA expression during the multistage pathogenesis of breast cancer. Clin Cancer Res 4: 229\u2013234, 1998","journal-title":"Clin Cancer Res"},{"key":"240459_CR28","first-page":"113","volume":"1198","author":"P Devilee","year":"1994","unstructured":"Devilee P, Cornellisse C: Somatic genetic changes in human breast cancer. Biochim Biophys Acta 1198: 113\u2013130, 1994","journal-title":"Biochim Biophys Acta"},{"key":"240459_CR29","first-page":"543","volume":"39","author":"CB Umbricht","year":"1998","unstructured":"Umbricht CB, Sherman M, Dome J, Adey C, Kim N, Sukumar S: Telomerase activity in preinvasive breast cancer. Proc Am Assoc Cancer Res 39: 543, 1998","journal-title":"Proc Am Assoc Cancer Res"},{"key":"240459_CR30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s001090050085","volume":"75","author":"AJ Klingelhutz","year":"1997","unstructured":"Klingelhutz AJ: Telomerase activation and cancer. J Mol Med 75: 45\u201349, 1997","journal-title":"J Mol Med"},{"key":"240459_CR31","doi-asserted-by":"crossref","first-page":"13677","DOI":"10.1073\/pnas.94.25.13677","volume":"94","author":"CD Belair","year":"1997","unstructured":"Belair CD, Yager TR, Lopez PM, Reznikoff CA: Telomerase activity: a biomarker of cell proliferation, not malignant transformation. Proc Natl Acad Sci USA 94: 13677\u201313682, 1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"240459_CR32","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1073\/pnas.92.11.4818","volume":"92","author":"KR Prowse","year":"1995","unstructured":"Prowse KR, Greider CW: Development and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci 92: 4818\u20134822, 1995","journal-title":"Proc Natl Acad Sci"}],"container-title":["Breast Cancer Research and Treatment"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1006394209922.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1006394209922\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1023\/A:1006394209922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1006394209922.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:23:43Z","timestamp":1750479823000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1006394209922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,11]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,11]]}},"alternative-id":["240459"],"URL":"https:\/\/doi.org\/10.1023\/a:1006394209922","relation":{},"ISSN":["0167-6806","1573-7217"],"issn-type":[{"value":"0167-6806","type":"print"},{"value":"1573-7217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,11]]}}}