{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T14:52:04Z","timestamp":1775227924821,"version":"3.50.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Comput Aided Mol Des"],"published-print":{"date-parts":[[1999,7]]},"DOI":"10.1023\/a:1008071118697","type":"journal-article","created":{"date-parts":[[2002,12,22]],"date-time":"2002-12-22T12:45:23Z","timestamp":1040561123000},"page":"355-371","source":"Crossref","is-referenced-by-count":23,"title":["Automated docking of 82 N-benzylpiperidine derivatives to mouse acetylcholinesterase and comparative molecular field analysis with 'natural' alignment"],"prefix":"10.1007","volume":"13","author":[{"given":"Philippe","family":"Bernard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitri B.","family":"Kireev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques R.","family":"Chr\u00e9tien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre-Louis","family":"Fortier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucien","family":"Coppet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"185445_CR1","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1136\/bmj.288.6422.961","volume":"288","author":"M.N. Rosser","year":"1984","unstructured":"Rosser, M.N., Iversen, L.L., Reynolds, G.P., Mountjoy, C.A. and Roth, M., Br. Med. J., 288 (1984) 961.","journal-title":"Br. Med. J."},{"key":"185445_CR2","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/978-1-4615-8699-9_9","volume-title":"The Peripheral Nervous System","author":"E. I. Barnard","year":"1974","unstructured":"Barnard, E.A., In Hubbard, J.I. (Ed.) The Peripheral Nervous System, Plenum, New York, NY, 1974, pp. 201\u2013224."},{"key":"185445_CR3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1471-4159.1983.tb11311.x","volume":"40","author":"N.R. Sims","year":"1983","unstructured":"Sims, N.R., Bowen, D.M., Allen, S.J., Smith, C.C.T., Neary, D., Thomas, D.J. and Davison, A.N., J. Neurochem., 40 (1983) 503.","journal-title":"J. Neurochem."},{"key":"185445_CR4","first-page":"408","volume":"42","author":"E.K. Perry","year":"1986","unstructured":"Perry, E.K., Br. Med. Bull., 42 (1986) 408.","journal-title":"Br. Med. Bull."},{"key":"185445_CR5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/ddr.430120302","volume":"12","author":"R.E. Becker","year":"1988","unstructured":"Becker, R.E. and Giacobini, E., Drug Dev. Res., 12 (1988) 163.","journal-title":"Drug Dev. Res."},{"key":"185445_CR6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1002\/ddr.430050108","volume":"5","author":"C.A. Johns","year":"1985","unstructured":"Johns, C.A., Haroutunian, V., Greenwald, B.S., Mohs, R.C., Davis, B.M., Kanof, P., Horvath, T.B. and Davis, K.L., Drug. Dev. Res., 5 (1985) 77.","journal-title":"Drug. Dev. Res."},{"key":"185445_CR7","first-page":"29","volume":"20","author":"M.B. Brennan","year":"1997","unstructured":"Brennan, M.B., Chem. Eng. News, 20 (1997) 29.","journal-title":"Chem. Eng. News"},{"key":"185445_CR8","first-page":"197","volume":"28","author":"V. John","year":"1993","unstructured":"John, V., Lieberburg, I. and Thorsett, E.D., Annu. Rep. Med. Chem., 28 (1993) 197.","journal-title":"Annu. Rep. Med. Chem."},{"key":"185445_CR9","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1021\/jm00169a008","volume":"33","author":"H. Sugimoto","year":"1990","unstructured":"Sugimoto, H., Tsuchiya, T., Sugumi, H., Higurashi, K., Karibe, N., Iimura, Y., Sasaki, A., Kawakami, Y., Nakamura, T., Araki, S., Yamanishi, Y. and Yamatsu, K., J. Med. Chem., 33 (1990) 1880.","journal-title":"J. Med. Chem."},{"key":"185445_CR10","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1021\/jm00102a005","volume":"35","author":"H. Sugimoto","year":"1992","unstructured":"Sugimoto, H., Tsuchiya, T., Sugumi, H., Higurashi, K., Karibe, N., Iimura, Y., Sasaki, A., Kawakami, Y., Araki, S., Yamanishi, Y. and Yamatsu, K., J. Med. Chem., 35 (1992) 4542.","journal-title":"J. Med. Chem."},{"key":"185445_CR11","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/BF00124015","volume":"8","author":"Y.-P. Pang","year":"1994","unstructured":"Pang, Y.-P. and Kozikowski, A.P., J. Comput.-Aided Mol. Design, 8 (1994) 683.","journal-title":"J. Comput.-Aided Mol. Design"},{"key":"185445_CR12","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1021\/jm00045a020","volume":"37","author":"Y. Yamamoto","year":"1994","unstructured":"Yamamoto, Y., Ishihara, Y. and Kuntz, I.D., J. Med. Chem., 37 (1994) 3141.","journal-title":"J. Med. Chem."},{"key":"185445_CR13","doi-asserted-by":"crossref","first-page":"4460","DOI":"10.1021\/jm950596e","volume":"39","author":"A. Inoue","year":"1996","unstructured":"Inoue, A., Kawai, T., Wakita, M., Iimura, Y., Sugimoto, H. and Kawakan, Y., J. Med. Chem., 39 (1996) 4460.","journal-title":"J. Med. Chem."},{"key":"185445_CR14","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1021\/jm00043a012","volume":"37","author":"A. Villalobos","year":"1994","unstructured":"Villalobos, A., Blake, J.F., Biggers, C.K., Butler, T.W., Chapin, D.S., Chen, Y.L., Ives, J.L., Jones, S.B., Liston, D.R., Nagel, A.A., Nason, D.M., Nielsen, J.A., Shalaby, I.A. and Frost White, W., J. Med. Chem., 37 (1994) 2721.","journal-title":"J. Med. Chem."},{"key":"185445_CR15","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1021\/jm950704x","volume":"39","author":"W. Tong","year":"1996","unstructured":"Tong, W., Collantes, E.R., Chen, Y. and Welsh, W.J., J. Med. Chem., 39 (1996) 380.","journal-title":"J. Med. Chem."},{"key":"185445_CR16","doi-asserted-by":"crossref","first-page":"5064","DOI":"10.1021\/jm950771r","volume":"39","author":"S.J. Cho","year":"1996","unstructured":"Cho, S.J., Serrano Garsia, M.L., Bier, J. and Tropsha, A., J. Med. Chem., 39 (1996) 5064.","journal-title":"J. Med. Chem."},{"key":"185445_CR17","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1021\/jm00081a022","volume":"35","author":"M.G. Cardozo","year":"1992","unstructured":"Cardozo, M.G., Imura, Y., Sugimoto, H., Yamanishi, Y. and Hopfinger, A.J., J. Med. Chem., 35 (1992) 584.","journal-title":"J. Med. Chem."},{"key":"185445_CR18","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1021\/ar00041a001","volume":"27","author":"I.D. Kuntz","year":"1994","unstructured":"Kuntz, I.D., Meng, E.C. and Shoichet, B.K., Acc. Chem. Res., 27 (1994) 117.","journal-title":"Acc. Chem. Res."},{"key":"185445_CR19","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.1021\/ja00226a005","volume":"110","author":"R.D. Cramer III","year":"1988","unstructured":"Cramer III, R.D., Patterson, D.E. and Bunce, J.D., J. Am. Chem. Soc., 110 (1988) 5959.","journal-title":"J. Am. Chem. Soc."},{"key":"185445_CR20","doi-asserted-by":"crossref","first-page":"4152","DOI":"10.1021\/jm00078a003","volume":"36","author":"C.L. Waller","year":"1993","unstructured":"Waller, C.L., Oprea, T.I., Giolitti, A. and Marshall, G.R., J. Med. Chem., 36 (1993) 4152.","journal-title":"J. Med. Chem."},{"key":"185445_CR21","unstructured":"The program Sybyl 6.3 is available from Tripos Associates, St. Louis, MO."},{"key":"185445_CR22","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/jcc.540070216","volume":"7","author":"S.J. Weiner","year":"1986","unstructured":"Weiner, S.J., Kollman, P.A., Nguyen, D.T. and Case, D.A., J. Comput. Chem., 7 (1986) 230.","journal-title":"J. Comput. Chem."},{"key":"185445_CR23","doi-asserted-by":"crossref","first-page":"9031","DOI":"10.1073\/pnas.90.19.9031","volume":"90","author":"M. Harel","year":"1993","unstructured":"Harel, M., Schalk, I., Ehret-Sabatier, L., Bouet, F., Goeldner, M., Hirth, C., Axelsen, P., Silman, I. and Sussman, J. L., Proc. Natl. Acad. Sci. USA, 90 (1993) 9031.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"185445_CR24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1126\/science.271.5246.163","volume":"271","author":"D.A. Dougherty","year":"1996","unstructured":"Dougherty, D.A., Science, 271 (1996) 163.","journal-title":"Science"},{"key":"185445_CR25","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/jcc.540100804","volume":"10","author":"M. Clarc","year":"1989","unstructured":"Clarc, M., Cramer III, R.D. and Van Opdenbosch, N., J. Comput. Chem., 10 (1989) 982.","journal-title":"J. Comput. Chem."},{"key":"185445_CR26","doi-asserted-by":"crossref","first-page":"2802","DOI":"10.1021\/jm00015a002","volume":"38","author":"A. Villalobos","year":"1995","unstructured":"Villalobos, A., Butler, T.W., Chapin, D.S., Chen, Y.L., DeMattos, S.B., Ives, J.L., Jones, S.B., Liston, D.R., Nagel, A.A., Nason, D.M., Nielsen, J.A., Ramirez, A.D., Shalaby, I.A. and Frost White, W., J. Med. Chem., 38 (1995) 2802.","journal-title":"J. Med. Chem."},{"key":"185445_CR27","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1021\/ja00299a024","volume":"107","author":"M.J.S. Dewar","year":"1985","unstructured":"Dewar, M.J.S., Zoebisch, E.G., Healy, E.F. and Stewart, J.J.P., J. Am. Chem. Soc., 107 (1985) 3902.","journal-title":"J. Am. Chem. Soc."},{"key":"185445_CR28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/qsar.19880070105","volume":"7","author":"R.D. Cramer","year":"1988","unstructured":"Cramer, R.D., Bunce, J.D., Patterson, D.E. and Frank, I.E., Quant. Struct.-Act. Relat., 7 (1988) 18.","journal-title":"Quant. Struct.-Act. Relat."},{"key":"185445_CR29","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1126\/science.1678899","volume":"253","author":"J.L. Sussman","year":"1991","unstructured":"Sussman, J.L., Harel, M., Frolow, F., Oefner, C., Goldman, A., Toker, L. and Silman, I., Science, 253 (1991) 872.","journal-title":"Science"},{"key":"185445_CR30","doi-asserted-by":"crossref","first-page":"17083","DOI":"10.1016\/S0021-9258(19)85305-X","volume":"268","author":"A. Ordentlich","year":"1993","unstructured":"Ordentlich, A., Barak, D., Kronman, Ch., Flashner, Y., Leitner, M., Segal, Y., Ariel, N., Cohen, S., Velan, B. and Shafferman, A., J. Biol. Chem., 268 (1993) 17083.","journal-title":"J. Biol. Chem."},{"key":"185445_CR31","doi-asserted-by":"crossref","first-page":"12074","DOI":"10.1021\/bi00096a018","volume":"32","author":"Z. Radic","year":"1993","unstructured":"Radic, Z., Pickering, N.A., Vellom, D.C., Camp, Sh. and Taylor, P., Biochemistry, 32 (1993) 12074.","journal-title":"Biochemistry"},{"key":"185445_CR32","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1248\/cpb.39.3225","volume":"39","author":"Y. Ishihara","year":"1991","unstructured":"Ishihara, Y., Kato, K. and Goto, G., Chem. Pharm. Bull., 39 (1991) 3225.","journal-title":"Chem. Pharm. Bull."},{"key":"185445_CR33","doi-asserted-by":"crossref","first-page":"3645","DOI":"10.1021\/jm00018a025","volume":"38","author":"D.M. Fink","year":"1995","unstructured":"Fink, D.M., Bores, G.M., Effland, R.C., Huger, F.P., Kurys, B.E., Rush, D.K. and Selk, D.E., J. Med. Chem., 38 (1995) 3645.","journal-title":"J. Med. Chem."},{"key":"185445_CR34","first-page":"49","volume-title":"Chemometric Methods in Drug Design","author":"S. Clementi","year":"1995","unstructured":"Clementi, S. and Wold, S., In Van de Waterbeemd, H. (Ed.) Chemometric Methods in Drug Design, VCH, Weinheim, 1995, pp. 49\u201362."}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1008071118697.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1008071118697\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1008071118697.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T11:38:24Z","timestamp":1749123504000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1008071118697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["185445"],"URL":"https:\/\/doi.org\/10.1023\/a:1008071118697","relation":{},"ISSN":["0920-654X","1573-4951"],"issn-type":[{"value":"0920-654X","type":"print"},{"value":"1573-4951","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]}}}