{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:32:24Z","timestamp":1760851944882,"version":"3.41.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Comput Aided Mol Des"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1023\/a:1011187320095","type":"journal-article","created":{"date-parts":[[2002,12,23]],"date-time":"2002-12-23T08:43:03Z","timestamp":1040632983000},"page":"297-307","source":"Crossref","is-referenced-by-count":20,"title":["Differentiation of \u03b4, \u03bc, and \u03ba opioid receptor agonists based on pharmacophore development and computed physicochemical properties"],"prefix":"10.1007","volume":"15","author":[{"given":"Marta","family":"Filizola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo O.","family":"Villar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilda H.","family":"Loew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"323392_CR1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0022-3565(24)38179-0","volume":"289","author":"P.Y. Law","year":"1999","unstructured":"Law, P.Y. and Loh, H.H., J. Pharmacol. Exp. Ther., 289 (1999) 607.","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"323392_CR2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/bse0330065","volume":"33","author":"D. Massotte","year":"1998","unstructured":"Massotte, D. and Kieffer, B.L., Essays Biochem., 33 (1998) 65.","journal-title":"Essays Biochem."},{"key":"323392_CR3","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0196-9781(98)00126-0","volume":"19","author":"L.M. Harrison","year":"1998","unstructured":"Harrison, L.M., Kastin, A.J. and Zadina, J.E., Peptides, 19 (1998) 1603.","journal-title":"Peptides"},{"issue":"4Suppl","key":"323392_CR4","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/S0893-133X(00)00143-3","volume":"23","author":"B.A. Jordan","year":"2000","unstructured":"Jordan, B.A., Cvejic, S. and Devi, L.A., Neuropsychopharmacology, 23(4 Suppl) (2000) S5.","journal-title":"Neuropsychopharmacology"},{"key":"323392_CR5","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/(SICI)1097-0282(1999)51:6<426::AID-BIP5>3.0.CO;2-G","volume":"51","author":"H.I. Mosberg","year":"1999","unstructured":"Mosberg, H.I., Biopolymers, 51 (1999) 426.","journal-title":"Biopolymers"},{"key":"323392_CR6","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0195-5616(08)70005-6","volume":"30","author":"P.J. Pascoe","year":"2000","unstructured":"Pascoe, P.J., Vet. Clin. North Am. Small Anim. Pract., 30 (2000) 757.","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"323392_CR7","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/protein\/12.11.927","volume":"12","author":"M. Filizola","year":"1999","unstructured":"Filizola, M., Laakkonen, L. and Loew, G.H., Protein Eng., 12 (1999) 927.","journal-title":"Protein Eng."},{"key":"323392_CR8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0014-2999(96)00894-1","volume":"318","author":"P.A. Maguire","year":"1996","unstructured":"Maguire, P.A. and Loew, G.H., Eur. J. Pharmacol., 318 (1996) 505.","journal-title":"Eur. J. Pharmacol."},{"key":"323392_CR9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0014-2999(96)00571-7","volume":"312","author":"S.W. Chen","year":"1996","unstructured":"Chen, S.W., Maguire, P.A., Davies, M.F. and Loew, G.H., Eur. J. Pharmacol., 312 (1996) 241.","journal-title":"Eur. J. Pharmacol."},{"key":"323392_CR10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1093\/protein\/9.7.573","volume":"9","author":"I. Alkorta","year":"1996","unstructured":"Alkorta, I. and Loew, G.H., Protein Eng., 9 (1996) 573.","journal-title":"Protein Eng."},{"key":"323392_CR11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3727\/107156995819562772","volume":"1","author":"A. Agarwal","year":"1995","unstructured":"Agarwal, A., Beatty, M.F., Maguire, P.A. and Loew, G.H., Analgesia, 1 (1995) 247.","journal-title":"Analgesia"},{"key":"323392_CR12","first-page":"28","volume":"11","author":"G. Loew","year":"1996","unstructured":"Loew, G., Agarwal, A., Huang, P., Beatty, M., Maguire, P. and Alkorta, I., Chem. Des. Automat. News, 11 (1996) 28.","journal-title":"Chem. Des. Automat. News"},{"key":"323392_CR13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1008067209563","volume":"11","author":"P. Huang","year":"1997","unstructured":"Huang, P., Kim, S. and Loew, G.H., J. Comput. Aided Mol. Des., 11 (1997) 21.","journal-title":"J. Comput. Aided Mol. Des."},{"key":"323392_CR14","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/(SICI)1097-0282(199606)38:6<759::AID-BIP7>3.0.CO;2-Q","volume":"38","author":"T.M. Chao","year":"1996","unstructured":"Chao, T.M., Perez, J.J. and Loew, G.H., Biopolymers, 38 (1996) 759.","journal-title":"Biopolymers"},{"key":"323392_CR15","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1126\/science.1335167","volume":"258","author":"C.K. Evans","year":"1992","unstructured":"Evans, C.K., Keith, D.E., Morrison, H., Magendzo, K. and Edwards, R.H., Science, 258 (1992) 1952.","journal-title":"Science"},{"key":"323392_CR16","doi-asserted-by":"crossref","first-page":"12048","DOI":"10.1073\/pnas.89.24.12048","volume":"89","author":"B.L. Kieffer","year":"1992","unstructured":"Kieffer, B.L., Befort, K., Gaveriaux-Guff, C. and Hirth, C.G., Proc. Natl. Acad. Sci. USA, 89 (1992) 12048.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"323392_CR17","doi-asserted-by":"crossref","first-page":"6736","DOI":"10.1073\/pnas.90.14.6736","volume":"90","author":"K. Yasuda","year":"1993","unstructured":"Yasuda, K., Rainor, K., Kong, H., Breder, J., Takeda, J., Reisine, T. and Bell, G.I., Proc. Natl. Acad. Sci. USA, 90 (1993) 6736.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"323392_CR18","doi-asserted-by":"crossref","unstructured":"Meng, F., Xie, G.X., Thompson, R.C., Mansour, A., Goldstein, A., Watson, S.J. and Akil, H., Proc. Natl. Acad. Sci. USA, 90 (1993).","DOI":"10.1073\/pnas.90.21.9954"},{"key":"323392_CR19","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0026-895X(25)13175-1","volume":"44","author":"Y. Chen","year":"1993","unstructured":"Chen, Y., Mestek, A., Liu, J., Hurley, J.A. and Yu, L., Mol. Pharmacol., 44 (1993) 8.","journal-title":"Mol. Pharmacol."},{"key":"323392_CR20","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0014-5793(93)81011-N","volume":"327","author":"K. Fukuda","year":"1993","unstructured":"Fukuda, K., Kato, S., Mori, K., Nishi, M. and Takeshima, H., FEBS Lett., 327 (1993) 311.","journal-title":"FEBS Lett."},{"key":"323392_CR21","doi-asserted-by":"crossref","first-page":"PL463","DOI":"10.1016\/0024-3205(94)90138-4","volume":"54","author":"R.J. Knapp","year":"1994","unstructured":"Knapp, R.J., Malatynska, E., Fang, L., Li, X., Babin, E., Nguyen, M., Santoro, G., Varga, E.V., Hruby, V.J., Roeske, W.R. and Yamamura, H.I., Life Sci., 54 (1994) PL463.","journal-title":"Life Sci."},{"key":"323392_CR22","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0014-5793(94)80368-4","volume":"338","author":"J.B. Wang","year":"1994","unstructured":"Wang, J.B., Johnson, P.S., Persico, A.M., Hawkins, A.L., Griffin, C.A. and Uhl, G.R., FEBS Lett., 338 (1994) 217.","journal-title":"FEBS Lett."},{"key":"323392_CR23","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1006\/bbrc.1994.2091","volume":"202","author":"E. Mansson","year":"1994","unstructured":"Mansson, E., Bare, L. and Yang, D., Biochem. Biophys. Rec. Commun., 202 (1994) 1431.","journal-title":"Biochem. Biophys. Rec. Commun."},{"key":"323392_CR24","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/S0188-0128(99)00041-X","volume":"30","author":"A. Ulloa-Aguirre","year":"1999","unstructured":"Ulloa-Aguirre, A., Stanislaus, D., Janovick, J. and Conn, P.M., Arch. Med. Res., 30 (1999) 420.","journal-title":"Arch. Med. Res."},{"key":"323392_CR25","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1210\/edrv.21.1.0390","volume":"21","author":"U. Gether","year":"2000","unstructured":"Gether, U., Endocr. Rev., 21 (2000) 90.","journal-title":"Endocr. Rev."},{"key":"323392_CR26","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1093\/protein\/10.9.1019","volume":"10","author":"D. Strahs","year":"1997","unstructured":"Strahs, D. and Weinstein, H., Protein Eng., 10 (1997) 1019.","journal-title":"Protein Eng."},{"key":"323392_CR27","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/S0006-3495(98)77552-6","volume":"75","author":"I.D. Pogozheva","year":"1998","unstructured":"Pogozheva, I.D., Lomize, A.L. and Mosberg, H.I., Biophys. J., 75 (1998) 612.","journal-title":"Biophys. J."},{"key":"323392_CR28","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1006\/abbi.1999.1529","volume":"375","author":"B.S. Zhorov","year":"2000","unstructured":"Zhorov, B.S. and Ananthanarayanan, V.S., Arch. Biochem. Biophys., 375 (2000) 31.","journal-title":"Arch. Biochem. Biophys."},{"key":"323392_CR29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1023\/A:1008079823736","volume":"13","author":"M. Filizola","year":"1999","unstructured":"Filizola, M., Carteni-Farina, M. and Perez, J.J., J. Comput. Aided Mol. Des., 13 (1999) 397.","journal-title":"J. Comput. Aided Mol. Des."},{"key":"323392_CR30","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1023\/A:1018977414572","volume":"10","author":"G.H. Loew","year":"1993","unstructured":"Loew, G.H., Villar, H.O. and Alkorta, I., Pharm. Res., 10 (1993) 475.","journal-title":"Pharm. Res."},{"key":"323392_CR31","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0968-0896(00)00223-6","volume":"9","author":"M. Filizola","year":"2001","unstructured":"Filizola, M., Villar, H.O. and Loew, G.H., Bioorg. Med. Chem., 9 (2001) 69.","journal-title":"Bioorg. Med. Chem."},{"key":"323392_CR32","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1016\/S0968-0896(00)00185-1","volume":"8","author":"D.L. Harris","year":"2000","unstructured":"Harris, D.L. and Loew, G.H., Bioorg. Med. Chem. 8 (2000) 2527.","journal-title":"Bioorg. Med. Chem."},{"key":"323392_CR33","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3891\/acta.chem.scand.30b-0549","volume":"30","author":"E. Bye","year":"1976","unstructured":"Bye, E., Acta Chem. Scand. Ser. B, 30 (1976) 549.","journal-title":"Acta Chem. Scand. Ser. B"},{"key":"323392_CR34","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1107\/S0567740876003981","volume":"32","author":"R.J. Sime","year":"1976","unstructured":"Sime, R.J., Dobler, M. and Sime, R.L., Acta Crystallogr. B, 32 (1976) 809.","journal-title":"Acta Crystallogr. B"},{"key":"323392_CR35","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1135\/cccc19941361","volume":"59","author":"A. Jegorov","year":"1994","unstructured":"Jegorov, A., Sobotik, R., Pakhomova, S., Ondracek, J., Novotny, J., Husak, M. and Kratochvil, B., Collect. Czech. Chem. Commun., 59 (1994) 1361.","journal-title":"Collect. Czech. Chem. Commun."},{"key":"323392_CR36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF01200881","volume":"11","author":"J. Donohue","year":"1981","unstructured":"Donohue, J. and Stallings, W.J., J. Cryst. Mol. Struct., 11 (1981) 69.","journal-title":"J. Cryst. Mol. Struct."},{"key":"323392_CR37","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3987\/COM-94-S(B)70","volume":"39","author":"J.L. Flippen-Anderson","year":"1994","unstructured":"Flippen-Anderson, J.L., George, C., Bertha, C.M. and Rice, K.C., Heterocycles, 39 (1994) 751.","journal-title":"Heterocycles"},{"key":"323392_CR38","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/BF01262807","volume":"9","author":"O.M. Peeters","year":"1979","unstructured":"Peeters, O.M., Blaton, N.M., DeRanter, C.J., van Herk, A.M. and Goubitz, K., J. Crystallogr. Mol. Struct., 9 (1979) 153.","journal-title":"J. Crystallogr. Mol. Struct."},{"key":"323392_CR39","first-page":"91","volume":"30","author":"J.P. Tollenaere","year":"1986","unstructured":"Tollenaere, J.P., Moereels, H. and van Loon, M., Prog. Drug Res., 30 (1986) 91.","journal-title":"Prog. Drug Res."},{"key":"323392_CR40","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/jcc.540040211","volume":"4","author":"B.R. Brooks","year":"1983","unstructured":"Brooks, B.R., Bruccoleri, R.E., Olafson, B.D., States, D.J., Swaminathan, S. and Karplus, M., J. Comput. Chem., 4 (1983) 187.","journal-title":"J. Comput. Chem."},{"key":"323392_CR41","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1023\/A:1008055202136","volume":"12","author":"M. Vieth","year":"1998","unstructured":"Vieth, M., Hirst, J.D. and Brooks III, C.L., J. Comp. Aid. Mol. Des., 12 (1998) 563.","journal-title":"J. Comp. Aid. Mol. Des."},{"key":"323392_CR42","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1023\/A:1008007507641","volume":"12","author":"J. Bostrom","year":"1998","unstructured":"Bostrom, J., Norrby, P.O. and Liljefors, T., J. Comp. Aid. Mol. Des., 12 (1998) 383.","journal-title":"J. Comp. Aid. Mol. Des."},{"key":"323392_CR43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00128336","volume":"4","author":"J.J.P. Stewart","year":"1990","unstructured":"Stewart, J.J.P., J. Comput.-Aided. Mol. Design, 4 (1990) 1.","journal-title":"J. Comput.-Aided. Mol. Design"},{"key":"323392_CR44","volume-title":"J. Development and Application of New Substituent Parameters in Drug Design","author":"A. Verloop","year":"1976","unstructured":"Verloop, A., Hoogenstraaten, W. and Tipker, J. Development and Application of New Substituent Parameters in Drug Design., Academic Press, New York, 1976."},{"key":"323392_CR45","unstructured":"Hawkins, G.D., Giesen, D.J., Lynch, G.C., Chambers, C.C., Rossi, I., Storer, J.W., Li, J., Zhu, T., Rinaldi, D., Liotard, D.A., Cramer, C.J. and Truhlar, D.G., (1998)."},{"key":"323392_CR46","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1021\/jm9903702","volume":"43","author":"G. Subramanian","year":"2000","unstructured":"Subramanian, G., Paterlini, M.G., Portoghese, P.S. and Ferguson, D.M., J. Med. Chem., 43 (2000) 381.","journal-title":"J. Med. Chem."},{"key":"323392_CR47","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/jcc.540120605","volume":"12","author":"A. Kantola","year":"1991","unstructured":"Kantola, A., Villar, H.O. and Loew, G.H., J. Comp. Chem., 12 (1991) 681.","journal-title":"J. Comp. Chem."},{"key":"323392_CR48","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/qua.560440209","volume":"44","author":"I. Alkorta","year":"1992","unstructured":"Alkorta, I. and Villar, H.O., Int. J. Quant. Chem., 44 (1992) 203.","journal-title":"Int. J. Quant. Chem."}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1011187320095.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1011187320095\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1011187320095.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,5]],"date-time":"2025-06-05T11:32:45Z","timestamp":1749123165000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1011187320095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["323392"],"URL":"https:\/\/doi.org\/10.1023\/a:1011187320095","relation":{},"ISSN":["0920-654X","1573-4951"],"issn-type":[{"type":"print","value":"0920-654X"},{"type":"electronic","value":"1573-4951"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}