{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T04:03:01Z","timestamp":1749268981214,"version":"3.41.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Comput Aided Mol Des"],"published-print":{"date-parts":[[2001,12]]},"DOI":"10.1023\/a:1015976725743","type":"journal-article","created":{"date-parts":[[2002,12,29]],"date-time":"2002-12-29T01:32:18Z","timestamp":1041125538000},"page":"1105-1117","source":"Crossref","is-referenced-by-count":3,"title":["Structure-based combinatorial library design: Discovery of non-peptidic inhibitors of caspases 3 and 8"],"prefix":"10.1007","volume":"15","author":[{"given":"Martha S.","family":"Head","sequence":"first","affiliation":[]},{"given":"M. Dominic","family":"Ryan","sequence":"additional","affiliation":[]},{"given":"Dennis","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Yanhong","family":"Feng","sequence":"additional","affiliation":[]},{"given":"Cheryl A.","family":"Janson","sequence":"additional","affiliation":[]},{"given":"Nestor O.","family":"Concha","sequence":"additional","affiliation":[]},{"given":"Paul M.","family":"Keller","sequence":"additional","affiliation":[]},{"suffix":"Jr","given":"Walter E.","family":"deWolf","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"405161_CR1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1517\/14728214.3.1.317","volume":"3v","author":"M.E. Nuttall","year":"1998","unstructured":"Nuttall, M.E., Levy, M.A., James, M.F., and Winkler, J.D., Emerging Drugs, 3v (1998) 317.","journal-title":"Emerging Drugs"},{"key":"405161_CR2","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1126\/science.281.5381.1312","volume":"281v","author":"N.A. Thornberry","year":"1998","unstructured":"Thornberry, N.A. and Lazebnik, Y. Science, 281v (1998) 1312.","journal-title":"Science"},{"issue":"18","key":"405161_CR3","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1021\/jm000060f","volume":"43","author":"R.V. Talanian","year":"2000","unstructured":"Talanian, R.V., Brady, K.D., and Cryns, V.L., J. Med. Chem., 43(18), (2000) 3351.","journal-title":"J. Med. Chem."},{"volume-title":"Apoptosis: Pharmalogical Implications and Therapeutic Opportunities","year":"1997","key":"405161_CR4","unstructured":"Kaufmann, S.H. (ed.), Apoptosis: Pharmalogical Implications and Therapeutic Opportunities. Academic Press, San Diego, CA, (1997)."},{"volume-title":"When Cells Die","year":"1998","key":"405161_CR5","unstructured":"Lockshin, R.A., Zakeri, Z., and Tilly, J.L. (eds.), When Cells Die. Wiley-Liss, New York, (1998)."},{"key":"405161_CR6","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1038\/nsb0796-619","volume":"3","author":"J. Rotonda","year":"1996","unstructured":"Rotonda, J., Nicholson, D.W., Fazil, K.M., Gallant, M., Gareau, Y., Labelle, M., Peteron, E.P., Rasper, D.M., Ruel, R., Vaillancourt, J.P., Thornberry, N.A., and Becker, J.W., Nature Struct. Biol, 3, (1996) 619.","journal-title":"Nature Struct. Biol"},{"key":"405161_CR7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1074-5521(97)90258-1","volume":"4","author":"T.A. Rano","year":"1997","unstructured":"Rano, T.A., Timkey, T., Peterson, E.P., Rotonda, J., Nicholson, D.W., Beckeer, J.W., Chapman, K.T., and Thornberry, N.A., Chem. Biol., 4, (1997) 149.","journal-title":"Chem. Biol."},{"key":"405161_CR8","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.1074\/jbc.272.10.6539","volume":"272","author":"P.R.E. Mittl","year":"1997","unstructured":"Mittl, P.R.E., Di Marco, S., Krebs, J.F., Bai, X., Karanewsky, D.S., Priestle, J.P., Tomaselli, K.J., adn Gruetter, M.G., J. Biol. Chem., 272 (1997) 6539.","journal-title":"J. Biol. Chem."},{"key":"405161_CR9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1248\/cpb.47.11","volume":"47","author":"Y. Okamoto","year":"1999","unstructured":"Okamoto, Y., Anan, HK, Nakai, E., Morihira, K., Yonetoku, Y., Kurihara, H., Sakashita, H., Terai, Y., Takeuchi, M., Shibanuma, T., and Isomura, Y., Chem. Pharm. Bull., 47, (1999) 11.","journal-title":"Chem. Pharm. Bull."},{"issue":"21","key":"405161_CR10","doi-asserted-by":"crossref","first-page":"16007","DOI":"10.1074\/jbc.275.21.16007","volume":"275","author":"D. Lee","year":"2000","unstructured":"Lee, D., Long, S.A., Adams, J.L., Chan, G., Vaidya, K.S., Francis, T.A., Kikly, K., Winkler, J.D., Sung, C.-M., Debouck, C., Richardson, S., Levy, M.A., De-Wolf, W.E., Jr., Keller, P.M., Tomaszek, T., Head, M.S., Ryan, M.D., Haltiwanger, R.C., Liang, P.-H., Janson, C.A., McDevitt, P.J., Johanson, K., Concha, N.O., Chan, W., Abdel-Meguid, S.S., Badger, A.M., Lark, M.W., Nadeau, D.P., Suva, L.H., Gowen, M., and Nuttall, M.E., J. Biol. Chem., 275(21), (2000) 16007.","journal-title":"J. Biol. Chem."},{"key":"405161_CR11","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1021\/jm0100537","volume":"44","author":"D. Lee","year":"2001","unstructured":"Lee, D., Long, S.A., Murray, J.H., Adams, J.L., Nadeau, D.P., Nuttall, M.E., Kikly, K., Winkler, J.D., Sung, C.-M., Levy, M.A., Keller, P.M., and DeWolf, W.E., J. Med. Chem., 44, (2001) 2015.","journal-title":"J. Med. Chem."},{"key":"405161_CR12","doi-asserted-by":"crossref","first-page":"9907","DOI":"10.1021\/ja992009a","volume":"121","author":"A. Lee","year":"1999","unstructured":"Lee, A., Huang, L., and Ellman, J.A., J. Am. Chem. Soc., 121, (1999) 9907.","journal-title":"J. Am. Chem. Soc."},{"key":"405161_CR13","first-page":"317","volume":"5","author":"A.M.M. Mjali","year":"1995","unstructured":"Mjali, A.M.M., Chapman, K.T., Zhao, J., Thornberry, N.A., Peterson, E.P., and MacCoss, M., Bioorg. Med. Chem. Lett., 5, (1995) 317.","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"405161_CR14","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0968-0896(99)00009-7","volume":"7","author":"K.D. Brady","year":"1999","unstructured":"Brady, K.D., Giegel, D.A., Grinnell, C., Lunney, E., Talanian, R.V., Wong, W., and Walker, N. Bioorg. Med. Chem., 7 (1999) 621.","journal-title":"Bioorg. Med. Chem."},{"key":"405161_CR15","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1023\/A:1007907728892","volume":"11","author":"C. McMartin","year":"1997","unstructured":"McMartin, C. and Bohacek, R.S., J. Comput. Aid. Mol. Des., 11, (1997) 333.","journal-title":"J. Comput. Aid. Mol. Des."},{"key":"405161_CR16","doi-asserted-by":"crossref","unstructured":"Thompson, L.A. and Ellman, J.A., 'Straigthforward and general method for coupling alcohols to solid supports', 9333.","DOI":"10.1016\/S0040-4039(00)78535-2"},{"key":"405161_CR17","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.1021\/jo00231a027","volume":"52","author":"O. Dangles","year":"1987","unstructured":"Dangles, O., Guibe, F., Balavoine, G., Lavielle, S., and Marquet, A., J. Org. Chem., 52, (1987) 4984.","journal-title":"J. Org. Chem."},{"key":"405161_CR18","doi-asserted-by":"crossref","first-page":"6813","DOI":"10.1016\/S0040-4020(99)00344-0","volume":"55","author":"L.A. Carpino","year":"1999","unstructured":"Carpino, L.A. and El-Faham, A., Tetrehedron, 55 (1999) 6813.","journal-title":"Tetrehedron"},{"key":"405161_CR19","doi-asserted-by":"crossref","first-page":"8508","DOI":"10.1021\/bi9803325","volume":"37","author":"K.D. Brady","year":"1998","unstructured":"Brady, K.D., Biochemistry, 37 (1998) 8508.","journal-title":"Biochemistry"},{"key":"405161_CR20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0076-6879(79)63008-2","volume":"63","author":"W.W. Cleland","year":"1979","unstructured":"Cleland, W.W., Meth. Enzymol., 63 (1979) 103.","journal-title":"Meth. Enzymol."}],"container-title":["Journal of Computer-Aided Molecular Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1015976725743.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1015976725743\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1015976725743.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T08:43:41Z","timestamp":1749199421000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1015976725743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["405161"],"URL":"https:\/\/doi.org\/10.1023\/a:1015976725743","relation":{},"ISSN":["0920-654X","1573-4951"],"issn-type":[{"type":"print","value":"0920-654X"},{"type":"electronic","value":"1573-4951"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}