{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T10:10:02Z","timestamp":1749204602927,"version":"3.41.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2003,7,1]],"date-time":"2003-07-01T00:00:00Z","timestamp":1057017600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Comput Neurosci"],"published-print":{"date-parts":[[2003,7]]},"DOI":"10.1023\/a:1024470718603","type":"journal-article","created":{"date-parts":[[2003,9,15]],"date-time":"2003-09-15T17:22:37Z","timestamp":1063646557000},"page":"43-51","source":"Crossref","is-referenced-by-count":13,"title":["A Novel Mechanism for Irregular Firing of a Neuron in Response to Periodic Stimulation: Irregularity in the Absence of Noise"],"prefix":"10.1007","volume":"15","author":[{"given":"John R.","family":"Clay","sequence":"first","affiliation":[]}],"member":"297","reference":[{"key":"5138984_CR1","doi-asserted-by":"crossref","first-page":"8616","DOI":"10.1073\/pnas.92.19.8616","volume":"92","author":"M Abeles","year":"1995","unstructured":"Abeles M, Bergman H, Gat I, Meilijson I, Seidmann E, Tishby N, Vaadia E (1995) Cortical activity flips among quasi-stationary states. Proc. Natl. Acad. Sci. USA 92: 8616-8620.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"5138984_CR2","first-page":"1322","volume":"34","author":"WJ Adelman","year":"1975","unstructured":"Adelman WJ, Fitzjugh R (1975) Solutions of the Hodgkin-Huxley equations modified for potassium accumulation in a periaxonal space. Fed. Proc. 34: 1322-1329.","journal-title":"Fed. Proc."},{"doi-asserted-by":"crossref","unstructured":"Chik DTW, Wang YQ, Wang ZD (2001) Stochastic resonance in a Hodgkin-Huxley neuron in the absence of external noise. Phys. Rev. E 64: Art. no. 021913.","key":"5138984_CR3","DOI":"10.1103\/PhysRevE.64.021913"},{"key":"5138984_CR4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0022-5193(77)90266-1","volume":"64","author":"JR Clay","year":"1977","unstructured":"Clay JR (1977) Monte Carlo simulation of membrane noise: An analysis of fluctuations in graded excitation of nerve membrane. J. Theor. Biol. 64: 671-680.","journal-title":"J. Theor. Biol."},{"key":"5138984_CR5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1113\/jphysiol.1991.sp018890","volume":"444","author":"JR Clay","year":"1991","unstructured":"Clay JR (1991) A paradox concerning ion permeation of the delayed rectifier potassium ion channel in squid giant axons. J. Physiol. 444: 499-511.","journal-title":"J. Physiol."},{"key":"5138984_CR6","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1152\/jn.1998.80.2.903","volume":"80","author":"JR Clay","year":"1998","unstructured":"Clay JR (1998) Excitability of the squid giant axon revisited. J. Neurophysiol. 80: 903-913.","journal-title":"J. Neurophysiol."},{"key":"5138984_CR7","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s002490000091","volume":"29","author":"JR Clay","year":"2000","unstructured":"Clay JR (2000) Determining K+ channel activation curves from K+ channel currents. Eur. Biophys. J. 29: 555-557.","journal-title":"Eur. Biophys. J."},{"key":"5138984_CR8","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1006\/jtbi.1998.0867","volume":"197","author":"JR Clay","year":"1999","unstructured":"Clay JR, Shrier A (1999) On the role of subthreshold dynamics in neuronal signaling. J. Theor. Biol. 197: 207-216.","journal-title":"J. Theor. Biol."},{"key":"5138984_CR9","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2307\/1543333","volume":"201","author":"JR Clay","year":"2001","unstructured":"Clay JR, Shrier A (2001) Action potentials occur spontaneously in squid giant axons with moderately alkaline intracellular pH. Biol. Bull. 201: 186-192.","journal-title":"Biol. Bull."},{"key":"5138984_CR10","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s00232-001-0165-3","volume":"187","author":"JR Clay","year":"2002","unstructured":"Clay JR, Shrier A (2002) Temperature dependence of bistability in squid giant axons with alkaline intracellular pH. J. Membrane Biol. 187: 213-233.","journal-title":"J. Membrane Biol."},{"key":"5138984_CR11","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1073\/pnas.65.4.884","volume":"65","author":"KS Cole","year":"1970","unstructured":"Cole KS, Guttman R, Bezaniila F (1970) Nerve membrane excitation without threshold. Proc. Natl. Acad. Sci. USA 65: 884-891.","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"5138984_CR12","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0006-3495(77)85598-7","volume":"18","author":"JA Connor","year":"1977","unstructured":"Connor JA, Walter D, McKown R (1977) Neural repetitive firing: Modification of the Hodgkin-Huxley axon suggested by experimental results from crustacean axons. Biophys. J. 18: 81-102.","journal-title":"Biophys. J."},{"key":"5138984_CR13","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1162\/neco.1996.8.5.979","volume":"8","author":"B Ermentrout","year":"1996","unstructured":"Ermentrout B (1996) Type I membranes, phase resetting curves, and synchrony. Neural Comp. 8: 979-1001.","journal-title":"Neural Comp."},{"key":"5138984_CR14","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1113\/jphysiol.1956.sp005467","volume":"131","author":"B Frankenhauser","year":"1956","unstructured":"Frankenhauser B, Hodgkin AL (1956) The after effects of impulses in the giant nerve fiber of Loligo. J. Physiol. 131: 341-376.","journal-title":"J. Physiol."},{"key":"5138984_CR15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0006-3495(64)86768-0","volume":"4","author":"GL Gerstein","year":"1964","unstructured":"Gerstein GL, Mandelbrot B (1964) Random walk models for the spike activity of a single neuron. Biophys. J. 4: 41-68.","journal-title":"Biophys. J."},{"key":"5138984_CR16","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1085\/jgp.27.1.37","volume":"27","author":"DE Goldman","year":"1943","unstructured":"Goldman DE (1943) Potential, impedance, and rectification in membranes. J. Gen. Physiol. 27: 37-60.","journal-title":"J. Gen. Physiol."},{"key":"5138984_CR17","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1137\/S1111111101394040","volume":"1","author":"J Guckenheimer","year":"2002","unstructured":"Guckenheimer J, Oliva RA (2002) Chaos in the Hodgkin-Huxley model. SIAM J. Applied Dynamical Systems 1: 105-114.","journal-title":"SIAM J. Applied Dynamical Systems"},{"key":"5138984_CR18","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1113\/jphysiol.1980.sp013370","volume":"305","author":"R Guttman","year":"1980","unstructured":"Guttman R, Lewis S, Rinzel J. (1980) Control of repetitive firing in squid axon membrane as a model for a neuron oscillator. J. Physiol. 305: 377-395.","journal-title":"J. Physiol."},{"key":"5138984_CR19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1162\/neco.1995.7.2.307","volume":"7","author":"D Hansel","year":"1995","unstructured":"Hansel D, Mato G, Meunier C. (1995) Synchrony in excitable neural networks. Neural Comp. 7: 307-335.","journal-title":"Neural Comp."},{"key":"5138984_CR20","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1113\/jphysiol.1952.sp004764","volume":"117","author":"AL Hodgkin","year":"1952","unstructured":"Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. 117: 500-544.","journal-title":"J. Physiol."},{"key":"5138984_CR21","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1113\/jphysiol.1949.sp004310","volume":"108","author":"AL Hodgkin","year":"1949","unstructured":"Hodgkin AL, Katz B (1949) The effect of sodium ions on the electrical activity of the giant axon of the squid. J. Physiol. 108: 37-77.","journal-title":"J. Physiol."},{"key":"5138984_CR22","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1152\/jn.1996.75.5.1806","volume":"75","author":"GL Holt","year":"1996","unstructured":"Holt GL, Softky WR, Koch C, Douglas RJ (1996) Comparison of discharge variability in vitro and in vivo in cat visual cortex neurons. J. Neurophysiol. 75: 1806-1814.","journal-title":"J. Neurophysiol."},{"key":"5138984_CR23","doi-asserted-by":"publisher","first-page":"4074","DOI":"10.1103\/PhysRevLett.76.4074","volume":"76","author":"DT Kaplan","year":"1996","unstructured":"Kaplan DT, Clay JR, Manning T, Glass L, Guevara MR, Shrier A (1996) Subthreshold dynamics in periodically stimulated squid giant axons. Phys. Rev. Lett. 76: 4074-4077.","journal-title":"Phys. Rev. Lett."},{"key":"5138984_CR24","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1103\/PhysRevLett.67.656","volume":"67","author":"A Longtin","year":"1991","unstructured":"Longtin A, Bulsara A, Moss F (1991) Time-interval sequences in bistable systems and the noise-induced transmission of information by sensory neurons. Phys. Rev. Lett. 67: 656-659.","journal-title":"Phys. Rev. Lett."},{"key":"5138984_CR25","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.7770778","volume":"268","author":"ZF Mainen","year":"1995","unstructured":"Mainen ZF, Sejnowski TJ (1995) Reliability of spike timing in neocortical neurons. Science 268: 1503-1506.","journal-title":"Science"},{"key":"5138984_CR26","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1093\/cercor\/7.6.487","volume":"7","author":"LG Nowak","year":"1997","unstructured":"Nowak LG, Sanchez-Vives MV, McCormick DA (1997) Influence of low and high frequency inputs on spike timing in visual cortical neurons. Cereb. Cortex 7: 487-501.","journal-title":"Cereb. Cortex"},{"key":"5138984_CR27","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1152\/jn.1993.69.5.1661","volume":"69","author":"AD Reyes","year":"1993","unstructured":"Reyes AD, Fetz EE (1993a) Two modes of interspike interval shortening by brief transient depolarizations in cat neocortical neurons. J. Neurophysiol. 69: 1661-1672.","journal-title":"J. Neurophysiol."},{"key":"5138984_CR28","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1152\/jn.1993.69.5.1673","volume":"69","author":"AD Reyes","year":"1993","unstructured":"Reyes AD, Fetz, EE (1993b) Effects of transient depolarizing potentials on the firing rate of cat neocortical neurons. J. Neuropphysiol. 69: 1673-1683.","journal-title":"J. Neuropphysiol."},{"key":"5138984_CR29","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0025-5564(80)90109-1","volume":"49","author":"J Rinzel","year":"1980","unstructured":"Rinzel J, Miller R (1980) Numerical calculation of stable and unstable periodic solutions to the Hodgkin-Huxley equations. Math. Biosci. 49: 27-59.","journal-title":"Math. Biosci."},{"key":"5138984_CR30","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1023\/A:1011200713411","volume":"11","author":"M Rudolph","year":"2001","unstructured":"Rudolph M, Destexhe A (2001) Do neocortical pyramidal neurons display stochastic resonance? J. Comp. Neurosci. 11: 19-42.","journal-title":"J. Comp. Neurosci."},{"key":"5138984_CR31","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1038\/35079702","volume":"411","author":"MF Shlesinger","year":"2001","unstructured":"Shlesinger MF (2001) Physics in the noise. Nature 411: 641.","journal-title":"Nature"},{"key":"5138984_CR32","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0167-2789(90)90090-C","volume":"43","author":"RM Siegel","year":"1990","unstructured":"Siegel RM (1990) Non-linear dynamical system theory and primary visual cortical processing. Physica D 43: 385-395.","journal-title":"Physica D"},{"key":"5138984_CR33","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1023\/A:1008967807741","volume":"9","author":"PN Steinmetz","year":"2000","unstructured":"Steinmetz PN, Manwani A, Koch C, London M, Segev I (2000) Subthreshold voltage noise due to channel fluctuations in active neuronal membranes. J. Comp. Neurosci. 9: 133-148.","journal-title":"J. Comp. Neurosci."},{"key":"5138984_CR34","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/S0006-3495(91)82186-5","volume":"60","author":"CA Vandenberg","year":"1991","unstructured":"Vandenberg CA, Bezanilla F (1991) A sodium channel gating model based on single channel, macroscopic ionic, and gating currents in the squid giant axon. Biophys. J. 60: 1511-1533.","journal-title":"Biophys. J."},{"key":"5138984_CR35","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1038\/373033a0","volume":"373","author":"K Wiesenfeld","year":"1995","unstructured":"Wiesenfeld K, Moss F (1995) Stochastic resonance and the benefits of noise: From ice ages to crayfish and SQUIDS. Nature 373: 33-36.","journal-title":"Nature"},{"key":"5138984_CR36","volume-title":"The Mathematica Book","author":"S Wolfram","year":"1999","unstructured":"Wolfram S (1999) The Mathematica Book, 4th ed. Wolfram Media\/Cambridge Univ. Press, New York.","edition":"4th ed."}],"container-title":["Journal of Computational Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1024470718603.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1024470718603\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1024470718603.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T09:32:12Z","timestamp":1749202332000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1024470718603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,7]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["5138984"],"URL":"https:\/\/doi.org\/10.1023\/a:1024470718603","relation":{},"ISSN":["0929-5313","1573-6873"],"issn-type":[{"type":"print","value":"0929-5313"},{"type":"electronic","value":"1573-6873"}],"subject":[],"published":{"date-parts":[[2003,7]]}}}