{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:03:24Z","timestamp":1787997804943,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1998,4,1]],"date-time":"1998-04-01T00:00:00Z","timestamp":891388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two patients with lysinuric protein intolerance (LPI) had near\u2010fatal generalized varicella infection with severe interstitial pneumonitis, hepatitis, decreased platelet count, bleeding and hypoalbuminaemia. Active haemolysis resulted in anaemia and massive haemoglobinuria. Serum lactate dehydrogenase activity and ferritin concentration, which in patients with LPI in normal circumstances exceed the upper reference values 3\u2010fold to 10\u2010fold, increased to &gt;10 000U\/L and &gt;10 000 \u00b5g\/L, respectively. The patients were treated with fresh frozen plasma, red\u2010cell transfusions and intravenous acyclovir for 14 days, and recovered clinically in a month. Retrospectively, 3 of the 32 other known Finnish patients with LPI had had varicella infection that had been more severe than that in the other children in the family or in subjects in the neighbourhood and had led to hospital admission. Varicella antibodies were measured in 24 patients; 5 had no antibodies and 5 had very low antibody titres. Primary vaccination of three patients with living varicella vaccine increased antibody titres measurably in one patient. We suggest that patients with LPI who have no varicella zoster antibodies should be treated with acyclovir if exposed to varicella and should be (re)vaccinated against chickenpox.<\/jats:p>","DOI":"10.1023\/a:1005335423939","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T21:48:34Z","timestamp":1040507314000},"page":"103-111","source":"Crossref","is-referenced-by-count":31,"title":["Varicella and varicella immunity in patients with lysinuric protein intolerance"],"prefix":"10.1002","volume":"21","author":[{"given":"M.","family":"Lukkarinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"N\u00e4nt\u00f6\u2010Salonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Ruuskanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Lauteala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"S\u00e4k\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nuutinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Simell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1998,4]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1542\/peds.92.2.219","article-title":"Postexposure prophylaxis of varicella in family contact by oral acyclovir","volume":"92","author":"Asano Y","year":"1993","journal-title":"Pediatrics"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1993.03500070078033"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.4.661"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000248823"},{"key":"e_1_2_1_6_1","first-page":"69","article-title":"Active immunization against varicella of children with acute leukaemia or other malignancies on maintenance chemotherapy","volume":"61","author":"Haas RJ","year":"1985","journal-title":"Post grad Med J"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007193230304"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(65)92446-3"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199010043231401"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)92136-4"},{"key":"e_1_2_1_11_1","first-page":"384","volume-title":"Immunology Disorders in Infants and Children","author":"Shearer W","year":"1989"},{"key":"e_1_2_1_12_1","first-page":"137","article-title":"Acyclovir treatment of disseminated varicella in childhood malignant neoplasms","volume":"139","author":"Shulman S","year":"1985","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90358-7"},{"key":"e_1_2_1_14_1","first-page":"2497","volume-title":"The Metabolic Basis of Inherited Disease","author":"Simell O","year":"1989"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.87.3.609-613.1964"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-0786(89)90048-6"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1023%2FA%3A1005335423939","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1023\/A%3A1005335423939","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T22:48:13Z","timestamp":1694818093000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1023\/A%3A1005335423939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,4]]}},"alternative-id":["10.1023\/A:1005335423939"],"URL":"https:\/\/doi.org\/10.1023\/a:1005335423939","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4]]}}}