{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T01:20:49Z","timestamp":1784164849547,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[1998,6,1]],"date-time":"1998-06-01T00:00:00Z","timestamp":896659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1998,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We have utilized stable isotopes to measure in vivo rates of urea\u2010genesis. In one testing procedure, <jats:sup>15<\/jats:sup>NH<jats:sub>4<\/jats:sub>Cl was administered orally to con\u2010trols and to heterozygotes for ornithine transcarbamylase deficiency. Controls produced [<jats:sup>15<\/jats:sup>N]urea at a rate that was greater than that of symptomatic carriers, but indistinguishable from that of asymptomatic carriers. In contrast, both symptomatic and asymptomatic heterozygotes produced [5\u2010<jats:sup>15<\/jats:sup>N]glutamine more rapidly than the controls. Ureagenesis could also be measured by administering sodium [1\u2010<jats:sup>13<\/jats:sup>C]acetate to a healthy adult and measuring subsequent formation of [<jats:sup>13<\/jats:sup>C]urea. The latter approach involves the use of isotope ratio mass spectrometry to determine isotopic abundance. This technique is much more sensitive than gas chromatography\u2013mass spectrometry for the measurement of isotopic label, a consideration that makes the method more suitable for the study of subjects in whom ureagenesis is severely compromised, for example the human male neonate with a near complete deficiency of ornithine transcarbamylase.<\/jats:p>","DOI":"10.1023\/a:1005345205403","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T21:48:34Z","timestamp":1040507314000},"page":"21-29","source":"Crossref","is-referenced-by-count":18,"title":["In vivo measurement of ureagenesis with stable isotopes"],"prefix":"10.1002","volume":"21","author":[{"given":"M.","family":"Yudkoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Daikhin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X.","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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