{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T18:31:12Z","timestamp":1781289072845,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1997,11,1]],"date-time":"1997-11-01T00:00:00Z","timestamp":878342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1997,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Previous studies have shown that phenylketonuric patients display a deficiency in long\u2010chain polyunsaturated fatty acids. A study has now been performed on 13 cases (5 with methylmalonic acidaemia and 8 with urea cycle disorders) whose dietary treatment also implies a limitation in protein\u2010rich food. Plasma and red\u2010cell phospholipid fatty acid profiles were studied. The most relevant results were a lower percentage of docosahexaenoic acid in plasma and red\u2010cell phospholipids (0.91% \u00b1 0.53% vs 2.88% \u00b1 1.17% and 2.07% \u00b1 0.92% vs 3.62% \u00b1 1.01% (p &lt; 0.001)) and a lower percentage of arachidonic acid in plasma (5.22% \u00b1 2.02% vs 8.3% \u00b1 2.11% (p &lt; 0.001)).<\/jats:p><jats:p>A long\u2010chain polyunsaturated acid deficiency has also been confirmed in this group of metabolic patients and a dietary supplement is recommended since this population is subject to a special risk factor with regard to adequate psychomotor development. By extrapolating these data to the general population, the possibility can be inferred that long\u2010chain polyunsaturated fatty acids are semi\u2010essential in infant nutrition far beyond the breast\u2010feeding period.<\/jats:p>","DOI":"10.1023\/a:1005367701176","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T21:48:34Z","timestamp":1040507314000},"page":"783-789","source":"Crossref","is-referenced-by-count":16,"title":["Inborn errors of metabolism with a protein\u2010restricted diet: Effect on polyunsaturated fatty acids"],"prefix":"10.1002","volume":"20","author":[{"given":"P.","family":"Sanjurjo","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Cruces Hospital University of the Basque Country  Spain"},{"name":"Department of Pediatrics Cruces Hospital  Baracaldo, Vizcaya 48903 Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. I.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cruces Hospital University of the Basque Country  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Montejo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Cruces Hospital University of the Basque Country  Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1997,11]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(80)90015-8"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1995.tb13745.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.72.1.F23"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199507000-00005"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1991.tb11969.x"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92684-8"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)64849-5"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197908000-00012"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)82405-9"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.2.2.87"},{"key":"e_1_2_1_12_1","first-page":"460","article-title":"Breast\u2010fed (BF) term infants have a better visual acuity than formula fed (FF) infants at the age of 2 and 4 mo","volume":"8","author":"Jorgensen MH","year":"1994","journal-title":"FASEB J"},{"key":"e_1_2_1_13_1","first-page":"18","article-title":"Essentielle Fetts\u00e4uren: Bedeuteung f\u00fcr Medizin und Ern\u00e4hrung","volume":"7","author":"Koletzko B","year":"1986","journal-title":"Aktuel Endokr Stoffw"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198803033180905"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)38861-1"},{"key":"e_1_2_1_16_1","first-page":"425","article-title":"Erythrocyte docasahexaenoic acid correlates with the visual response of healthy, term infants","volume":"34","author":"Makrides M","year":"1993","journal-title":"Pediatr Res"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/60.2.189"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-2043-3_12"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02537290"},{"key":"e_1_2_1_20_1","first-page":"133","article-title":"Overview of physiological and pathophysiological effects of thromboxane A2","volume":"46","author":"Ogletree ML","year":"1987","journal-title":"Fed Proc"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90055-3"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01811491"},{"issue":"5","key":"e_1_2_1_23_1","first-page":"353","article-title":"Seguimiento de los \u00e1cidos grasos esenciales a lo largo de la alimentaci\u00f3n parenteral, en la que se incluye un preparado graso","volume":"19","author":"Sanjurjo P","year":"1983","journal-title":"An Esp Pediatr"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(92)91387-P"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00712012"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1645675"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1990.tb11354.x"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(73)80499-8"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1023%2FA%3A1005367701176","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1023\/A%3A1005367701176","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T03:55:12Z","timestamp":1694750112000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1023\/A%3A1005367701176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,11]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1997,11]]}},"alternative-id":["10.1023\/A:1005367701176"],"URL":"https:\/\/doi.org\/10.1023\/a:1005367701176","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,11]]}}}