{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T10:07:12Z","timestamp":1762078032707,"version":"3.41.2"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2000,4]]},"DOI":"10.1023\/a:1005475106198","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T17:25:23Z","timestamp":1040491523000},"page":"675-679","source":"Crossref","is-referenced-by-count":7,"title":["Apolipoprotein E Polymorphism in Alagille Syndrome and Progressive Familial Intrahepatic Cholestasis"],"prefix":"10.1007","volume":"45","author":[{"given":"P.","family":"Socha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Nowicka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Jankowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Rujner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Paw\u0142owska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Socha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"223032_CR1","first-page":"1","volume":"8","author":"J Davignon","year":"1988","unstructured":"Davignon J, Gregg RE, Sing CF: Apolipoprotein E polymorphism and atherosclerosis. Atherosclerosis 8:1\u201321, 1988","journal-title":"Atherosclerosis"},{"key":"223032_CR2","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0016-5085(96)70023-9","volume":"111","author":"A Bertomeu","year":"1996","unstructured":"Bertomeu A, Ros E, Zambon D, Vela M, Perez-Ayuso RM, Targarona E, Trias M, et al: Apolipoprotein E polymorphism and gallstones. Gastroenterology 111:1603\u20131610, 1996","journal-title":"Gastroenterology"},{"key":"223032_CR3","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1002\/hep.510270607","volume":"27","author":"KJ Van Erpecum","year":"1998","unstructured":"Van Erpecum KJ, Van Berge-Henegouwen GP, Eckhardt ERM, Portincasa P, Van de Heijning BJM, Dallinga-Thie GM, Groen AK: Cholesterol crystallization in human gallbladder bile: Relation to gallstone number, bile composition, and apolipoprotein E4 isoform. Hepatology 27:1508\u20131516, 1998","journal-title":"Hepatology"},{"key":"223032_CR4","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0168-8278(97)80293-0","volume":"27","author":"M Vuoristo","year":"1997","unstructured":"Vuoristo M, Farkkila M, Gylling H, Karvonen A-L, Leino R, Lehtola J, Makinen J, Mattila J, Tilvis R, Miettinen TA: Expression and therapeutic response related to apolipoprotein E polymorphism in primary biliary cirrhosis. J Hepatology 27:136\u2013142, 1997","journal-title":"J Hepatology"},{"key":"223032_CR5","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0016-5085(96)70071-9","volume":"111","author":"A Davit-Spraul","year":"1996","unstructured":"Davit-Spraul A, Pourci ML, Atger V, Cambillau M, Hadchouel M, Moatti N, Legrand A: Abnormal lipoprotein pattern in patients with Alagille syndrome depends on icterus severity. Gastroenterology 111:1023\u20131032, 1996","journal-title":"Gastroenterology"},{"key":"223032_CR6","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/j.1440-1746.1992.tb00965.x","volume":"7","author":"PA Kroon","year":"1992","unstructured":"Kroon PA, Powell EE: Liver, lipoproteins and disease: I. Biochemistry of lipoprotein metabolism. J Gastroenterol Hepatol 7:214\u2013224, 1992","journal-title":"J Gastroenterol Hepatol"},{"key":"223032_CR7","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/hep.510230435","volume":"23","author":"JF Deleuze","year":"1996","unstructured":"Deleuze JF, Jacquemin E, Dubuisson C, Cresteil D, Dumont M, Erlinger S, Bernard O, Hadchouel O: Defect of multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis. Hepatology 23:904\u2013908, 1996","journal-title":"Hepatology"},{"key":"223032_CR8","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1073\/pnas.95.1.282","volume":"95","author":"JML De Vree","year":"1998","unstructured":"De Vree JML, Jacquemin E, Sturm E, Cresteil D, Bosma PJ, Aten J, Deleuze JF, Desrochers M, Burdelski M, Bernard OP, Elferink RPJO, Hadchouel O: Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis. Proc Natl Acad Sci USA 95:282\u2013287, 1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"223032_CR9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/hep.510260121","volume":"26","author":"LN Bull","year":"1997","unstructured":"Bull LN, Carlton VEH, Stricker NL, Baharloo S, DeYoung JA, Freimer NB, Magid MS, Kahn E, Markowitz J, DiCarlo FJ, McLoughlin L, Boyle JT, Dahms BB, Faught PR, Fitzgerald JF, Piccoli DA, Witzleben CL, O'Connell NC, Setchell KDR, Agostini RM, Jr, Kocoshis SA, Reyes J, Knisely AS: Genetic and morphological findings in progressive familial intrahepatic cholestasis (Byler disease [PFIC-1] and Byler syndrome): Evidence for heterogenity. Hepatology 26:155\u2013164, 1997","journal-title":"Hepatology"},{"key":"223032_CR10","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s004390050519","volume":"100","author":"H Arnell","year":"1997","unstructured":"Arnell H, Nemeth A, Anneren G, Dahl N: Progressive familial intrahepatic cholestasis (PFIC): Evidence for genetic heterogenity by exclusion of linkage to chromosome 18q21\u2013q22. Hum Genet 100:378\u2013381, 1997","journal-title":"Hum Genet"},{"key":"223032_CR11","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/ng0797-235","volume":"16","author":"T Oda","year":"1997","unstructured":"Oda T, Eklahloun AG, Pike BL, Okajima K, Krnatz ID, Genin A, Meltzer PS, Spinner NB, Collins FS, Chandrasekharappa SC: Mutations in the human Jagged 1 gene are responsible for Alagille syndrome. Nature Genet 16:235\u2013242, 1997","journal-title":"Nature Genet"},{"key":"223032_CR12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/ng0797-243","volume":"16","author":"L Li","year":"1997","unstructured":"Li L, Krantz ID, Deng Y, Genin A, Banta AB, Collins CC, Qi M, Trask BJ, Kuo WL, Cochran J, Costa T, Pierpont MEM, Rand EB, Piccoli DA, Hood L, Spinner NB: Alagille syndrome is caused by mutations in the human JAGGED1, which encodes a ligand for NOTCH1. Nature Genet 16:243\u2013251, 1997","journal-title":"Nature Genet"},{"key":"223032_CR13","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1093\/clinchem\/35.10.2070","volume":"35","author":"FW McDowell","year":"1989","unstructured":"McDowell FW, Wisdom BG, Trimble ER: Apolipoprotein E phenotype determined by agarose gel electrofocusing and immunoblotting. Clin Chem 35:2070\u20132073, 1989","journal-title":"Clin Chem"},{"key":"223032_CR14","first-page":"62","volume":"5","author":"L K\u0142osiewicz-Latoszek","year":"1999","unstructured":"K\u0142osiewicz-Latoszek L, Nowicka G, Paluszkiewicz J, Pachocka L, et al: Hypolipemic diet effect on lipoprotein profile in patients with hypercholesterolaemia and mixed hyperlipidaemia in relation to apolipoprotein E phenotype. Med Sci Monit 5:62\u201370, 1999","journal-title":"Med Sci Monit"},{"key":"223032_CR15","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1161\/01.ATV.14.10.1617","volume":"14","author":"L Tiret","year":"1994","unstructured":"Tiret L, Knijf P, Menzel HJ, Ehnholm C, Nicaud V, Hevekes LM for the EARS Group: Apo E polymorphism and predisposition to coronary heart disease in youths of different European populations. Arterioscler Thromb 14:1617\u20131624, 1994","journal-title":"Arterioscler Thromb"},{"key":"223032_CR16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/0016-5085(88)90301-0","volume":"95","author":"PF Whitington","year":"1988","unstructured":"Whitington PF, Whitngton GL: Partial external diversion of bile for the treatment of intractable pruritus associated with intrahepatic cholestasis. Gastroenterology 95:130\u2013136, 1988","journal-title":"Gastroenterology"},{"key":"223032_CR17","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0016-5085(82)80212-6","volume":"83","author":"M Seymour","year":"1982","unstructured":"Seymour M, Sabesin MD: Cholestatic lipoproteins-their pathogenesis and significance. Gastroenterology 83:704\u2013709, 1982","journal-title":"Gastroenterology"},{"key":"223032_CR18","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/0026-0495(82)90146-9","volume":"31","author":"CJ Fielding","year":"1982","unstructured":"Fielding CJ, Frohlich J, Moser K, Fielding PE: Promotion of sterol efflux and net transport by apolipoprotein E in lecithin: cholesterol acyltransferase deficiency. Metabolism 31:1023\u20131028, 1982","journal-title":"Metabolism"},{"key":"223032_CR19","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","volume":"240","author":"RW Mahley","year":"1988","unstructured":"Mahley RW: Apolipoprotein E. Cholesterol transport protein with expanding role in cell biology. Science 240:622\u2013630, 1988","journal-title":"Science"},{"key":"223032_CR20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1365-2362.1990.tb02261.x","volume":"20","author":"B Angelin","year":"1990","unstructured":"Angelin B, Holmquist L, Leijd B, Einarsson K: Bile acid metabolism in familial dysbetalipoproteinemia: studies in subjects with the apolipoprotein E-2\/2 phenotype. Eur J Clin Invest 20:143\u2013149, 1990","journal-title":"Eur J Clin Invest"},{"key":"223032_CR21","first-page":"134","volume":"18","author":"PF Whitington","year":"1994","unstructured":"Whitington PF, Freese DK, Alonso EM, Schwarzenberg SJ, Sharp HL: Clinical and biochemical findings in progressive familial intrahepatic cholestasis. J Pediatr Gastroenterol Nutr 18:134\u2013142, 1994","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"223032_CR22","first-page":"35","volume":"1","author":"J Rujner","year":"1994","unstructured":"Rujner J, Pawlowska J, Socha J, Chipczy\u0144ska B, Chodurska E, Tomczak E, Wr\u00f3blewska M: Alagille syndrome: Clinical and biochemical characteristic of 27 children. Hepatol Pol 1:35\u201342, 1994","journal-title":"Hepatol Pol"},{"key":"223032_CR23","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/hep.510250303","volume":"25","author":"E Jacquemin","year":"1997","unstructured":"Jacquemin E, Hermans D, Myara A, Habes D, Debray D, Hadchouel M, Sokal EM, Bernard O: Ursodeoxycholic acid therapy in pediatic patients with progressive familial intrahepatoc cholestasis. Hepatology 25:519\u2013523, 1997","journal-title":"Hepatology"},{"key":"223032_CR24","first-page":"137","volume":"9","author":"J Socha","year":"1995","unstructured":"Socha J, Jankowska I, Paw\u0142owska J, Socha P, \u015awiatkowska E: Application of ursodeoxycholic acid in children with cholestasis. Pediatr Pol Suppl 9:137\u2013140, 1995","journal-title":"Pediatr Pol Suppl"},{"key":"223032_CR25","first-page":"476","volume":"19","author":"MB Krawinkel","year":"1994","unstructured":"Krawinkel MB, Santer R, Oldigs HD: Ursodeoxycholic acid: Effect on xanthomas in Alagille-Watson syndrome. J Pediatr Gastroenterol Nutr 19:476\u2013478, 1994","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"223032_CR26","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0022-3476(98)70227-6","volume":"133","author":"SS Gidding","year":"1998","unstructured":"Gidding SS, Stone NJ, Bookstein LC, Laskarzewski PM, Stein EA: Month-to-month variability of lipids, lipoproteins, and apolipoproteins and the impact of acute infection in adolescents. J Pediatr 133:242\u2013246, 1998","journal-title":"J Pediatr"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005475106198.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1005475106198\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005475106198.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:15:12Z","timestamp":1752462912000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1005475106198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["223032"],"URL":"https:\/\/doi.org\/10.1023\/a:1005475106198","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}