{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T17:17:54Z","timestamp":1785777474340,"version":"3.56.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bone marrow transplantation (BMT) was performed in 10 patients with Hunter disease (mucopolysaccharidosis type II, iduronate\u20102\u2010sulphatase deficiency). The donor was an HLA\u2010identical sibling in 2 cases, an HLA\u2010nonidentical relative in 6 cases, a volunteer unrelated donor in 1 case, and details were not available in 1 case. Only three patients have survived for more than 7 years post BMT; however, this high mortality probably resulted from poor donor selection. In two, there has been a steady progression of physical disability and mental handicap. One patient has maintained normal intellectual development, with only mild physical disability. It is possible that BMT may be useful in selected patients with MPS II.<\/jats:p>","DOI":"10.1023\/a:1005525931994","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T22:31:09Z","timestamp":1040509869000},"page":"638-648","source":"Crossref","is-referenced-by-count":135,"title":["Long\u2010term follow\u2010up following bone marrow transplantation for Hunter disease"],"prefix":"10.1002","volume":"22","author":[{"given":"A.","family":"Vellodi","sequence":"first","affiliation":[{"name":"Metabolic Unit Great Ormond Street Hospital for Children NHS Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Young","sequence":"additional","affiliation":[{"name":"Chemical Pathology Royal Manchester Children's Hospital, Pendlebury  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Willink Biochemical Genetics Unit Royal Manchester Children's Hospital, Pendlebury  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Lidchi","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine Royal Manchester Children's Hospital, Pendlebury  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Winchester","sequence":"additional","affiliation":[{"name":"Biochemistry, Endocrinology and Metabolism Unit Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Wraith","sequence":"additional","affiliation":[{"name":"Department of Psychological Medicine Royal Manchester Children's Hospital, Pendlebury  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1999,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3908"},{"key":"e_1_2_1_3_1","first-page":"653","article-title":"Long\u2010term follow\u2010up of a patient transplanted for Hunter\u00cfs disease type IIB: a case report and literature review","volume":"14","author":"Bergstrom SK","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1996)7:3<266::AID-HUMU12>3.0.CO;2-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1996.7.3-283"},{"key":"e_1_2_1_6_1","first-page":"227","article-title":"Bone marrow transplantation in Hunter syndrome (mucopolysaccharidosis type II): two\u2010year follow\u2010up of the first Italian patient and review of the literature","volume":"17","author":"Coppa GV","year":"1995","journal-title":"Pediatr Med Chir"},{"key":"e_1_2_1_7_1","volume-title":"7th International Congress of Inborn Errors of Metabolism","author":"Dobrenis K","year":"1997"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7610.1992.tb00942.x"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1996)7:1<76::AID-HUMU14>3.0.CO;2-P"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1380020603"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-200X.1994.tb03125.x"},{"key":"e_1_2_1_12_1","first-page":"203","volume-title":"Treatment of Genetic Diseases","author":"Krivit W","year":"1991"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70202-0"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.58.11.911"},{"key":"e_1_2_1_15_1","first-page":"2465","volume-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"Neufeld EF","year":"1995"},{"key":"e_1_2_1_16_1","first-page":"1202","article-title":"Mucopolysacharidosis type II (Hunter syndrome): mutation \u2018hot spots\u2019 in the iduronate\u20102\u2010sulfatase gene","volume":"59","author":"Rathmann M","year":"1996","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.26.5.309"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.1380060403"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00710053"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/6.3.479"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.79.3.237"},{"key":"e_1_2_1_22_1","first-page":"161","volume-title":"Bone Marrow Transplantation in Practice","author":"Vellodi A","year":"1992"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.76.2.92"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(77)90126-7"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00194643"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320440625"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.57.11.828"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.19.6.401"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.19.6.408"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1983.tb13794.x"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1023%2FA%3A1005525931994","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1023\/A%3A1005525931994","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:58:20Z","timestamp":1694746700000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1023\/A%3A1005525931994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,6]]}},"alternative-id":["10.1023\/A:1005525931994"],"URL":"https:\/\/doi.org\/10.1023\/a:1005525931994","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}