{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:07:27Z","timestamp":1753884447113,"version":"3.41.2"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2000,5]]},"DOI":"10.1023\/a:1005553914878","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T17:31:09Z","timestamp":1040491869000},"page":"1019-1027","source":"Crossref","is-referenced-by-count":25,"title":["48-Hour Hemodynamic Effects of Octreotide on Postprandial Splanchnic Hyperemia in Patients with Liver Cirrhosis and Portal Hypertension"],"prefix":"10.1007","volume":"45","author":[{"given":"Diether","family":"Ludwig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabina","family":"Sch\u00e3del","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Br\u0169ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernhard","family":"Schiefer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduard F.","family":"Stange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"223556_CR1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/hep.1840080335","volume":"8","author":"SS Lee","year":"1988","unstructured":"Lee SS, Hadengue A, Moreau R, Sayegh R, Hillon P, Lebrec D: Postprandial hemodynamic responses in patients with cirrhosis. Hepatology 8:647-651, 1988","journal-title":"Hepatology"},{"key":"223556_CR2","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1053\/gast.1996.v111.pm8898644","volume":"111","author":"JC Garcia Pagan","year":"1996","unstructured":"Garcia Pagan JC, Santos C, Barbera JA, Luca A, Roca J, Rodriguez-Roisin R, Bosch J, Rodes J: Physical exercise increases portal pressure in patients with cirrhosis and portal hypertension. Gastroenterology 111:1300-1306, 1996","journal-title":"Gastroenterology"},{"key":"223556_CR3","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0016-5085(92)91807-G","volume":"102","author":"A Abillos","year":"1992","unstructured":"Abillos A, Banares R, Barrios C, Clemente G, Rossi I, Escartin P, Bosch J: Oral administration of clonidine in patients with alcoholic cirrhosis. Hemodynamic and liver function effects. Gastroenterology 102:248-254, 1992","journal-title":"Gastroenterology"},{"key":"223556_CR4","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0168-8278(98)80236-5","volume":"28","author":"T Iwao","year":"1998","unstructured":"Iwao T, Oho K, Sakai T, Sato M, Nakano R, Yamayaki M, Toyonaga A, Tanikawa K: Noninvasive hemodynamic measurements of superior mesenteric artery in the prediction of portal pressure response to propranolol. J Hepatol 28:847-855, 1998","journal-title":"J Hepatol"},{"key":"223556_CR5","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/hep.1840130417","volume":"13","author":"C Sabba","year":"1991","unstructured":"Sabba C, Ferraioli G, Genecin P, Colombato L, Buonamico P, Lerner E, Taylor KJ, Groszmann RJ: Evaluation of postprandial hyperemia in superior mesenteric artery and portal vein in healthy and cirrhotic humans: An operator-blind echo-Doppler study. Hepatology 13:714-718, 1991","journal-title":"Hepatology"},{"key":"223556_CR6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0140-6736(93)91758-E","volume":"342","author":"JJ Sung","year":"1993","unstructured":"Sung JJ, Chung SC, Lai C-W, Chan FK, Leung JW, Yung M-Y, Kassianides C, Li AK: Octreotide infusion or emergency sclerotherapy for variceal haemorrhage. Lancet 342:637-641, 1993","journal-title":"Lancet"},{"key":"223556_CR7","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1136\/gut.41.4.526","volume":"41","author":"SA Jenkins","year":"1997","unstructured":"Jenkins SA, Shields R, Davies M, Elias E, Turnbull AJ, Bassendine MF, James OF, Iredale JP, Vyas SK, Arthur MJ, Kingsnorth AN, Sutton R: A multicenter randomised trial comparing octreotide and injection sclerotherapy in the management and outcome of acute variceal hemorrhage. Gut 41:526-533, 1997","journal-title":"Gut"},{"key":"223556_CR8","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1002\/hep.510280507","volume":"28","author":"G D'Amico","year":"1998","unstructured":"D'Amico G, Politi F, Morabito A, D'Antoni A, Guerrera D, Giannuoli G, Traina M, Vizzini G, Pasta L, Pagliaro L: Liver Study Group of V Cervello Hospital: Octreotide compared with placebo in a treatment strategy for early rebleeding in cirrhosis. A double blind, randomised pragmatic trial. Hepatology 28:1206-1214, 1998","journal-title":"Hepatology"},{"key":"223556_CR9","first-page":"489","volume":"2","author":"PA McCormick","year":"1990","unstructured":"McCormick PA, Dick R, Siringo S, Wagstaff D, Chesta J, McIntyre N, Burroughs AK: Octreotide reduces azygos blood flow in cirrhotic patients with portal hypertension. Eur J Gastroenterol Hepatol 2:489-492, 1990","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"223556_CR10","first-page":"1180","volume":"16","author":"PA McCormick","year":"1992","unstructured":"McCormick PA, Biagini MR, Dick R, Greenslade L, Chin J, Cardin F, Wagstaff D, McIntyre N, Burroughs AK: Octreotide inhibits the meal-induced increases in the portal venous pressure of cirrhotic patients with portal hypertension: A doubleblind, placebo controlled study. Hepatology 16:1180-1186, 1992","journal-title":"Hepatology"},{"key":"223556_CR11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0168-8278(94)80142-8","volume":"21","author":"A Abillos","year":"1994","unstructured":"Abillos A, Rossi I, Iborra J, Lledo JL, Calleja JL, Barrios C, Garcia P, Escartin P: Octreotide prevents postprandial splanchnic hyperemia in patients with portal hypertension. J Hepatol 21:88-94, 1994","journal-title":"J Hepatol"},{"key":"223556_CR12","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1042\/cs0910601","volume":"91","author":"YT Huang","year":"1996","unstructured":"Huang YT, Tsai JF, Liu TB, Hong CY, Yang MC, Lin HC: Chronic administration of octreotide increases vascular responsiveness in rats with portal hypertension. Clin Sci 91:601-606, 1996","journal-title":"Clin Sci"},{"key":"223556_CR13","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1023\/A:1018866608377","volume":"43","author":"YT Huang","year":"1998","unstructured":"Huang YT, Cheng YR, Lin HC, Hou MC, Lee SD, Hong CY: Hemodynamic effects of eight-day octreotide and propranolol administration in portal hypertensive rats. Dig Dis Sci 43:358-364, 1998","journal-title":"Dig Dis Sci"},{"key":"223556_CR14","first-page":"16","volume-title":"Ultrasonics for Industry Conference Papers","author":"RG Gosling","year":"1969","unstructured":"Gosling RG, King DH, Newman DL: Transcutaneous measurement of arterial blood velocity by ultrasound. In Ultrasonics for Industry Conference Papers. Guildford, England. IPC, 1969, pp 16-32"},{"key":"223556_CR15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0168-8278(91)90067-L","volume":"13","author":"L Bolondi","year":"1991","unstructured":"Bolondi L, Gaiani S, Barbara L: Accuracy and reproducibility of portal flow measurement by Doppler US. J Hepatol 13:269-273, 1991","journal-title":"J Hepatol"},{"key":"223556_CR16","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2214\/ajr.161.3.8352105","volume":"161","author":"RC Nelson","year":"1993","unstructured":"Nelson RC, Sherbourne GM, Spencer HB, Chezmar JL: Splenic venous flow exceeding portal venous flow at Doppler sonography: Relationship to portosystemic varices. AJR 161:563-567, 1993","journal-title":"AJR"},{"key":"223556_CR17","doi-asserted-by":"crossref","first-page":"A1293","DOI":"10.1016\/S0016-5085(98)85248-7","volume":"114","author":"D Ludwig","year":"1998","unstructured":"Ludwig D, Br\u00fcning A, Terai S, Schaedel S, Feddersen A, Stange EF: Long-term hemodynamic and endocrine effects of octreotide on postprandial hyperemia in controls and cirrhotic patients: Randomised, double-blind, placebo-controlled study. Gastroenterology 114:A1293, 1998","journal-title":"Gastroenterology"},{"key":"223556_CR18","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1097\/00003246-198610000-00015","volume":"14","author":"DP Bernstein","year":"1986","unstructured":"Bernstein DP: Continuous noninvasive real-time monitoring of stroke volume and cardiac output by thoracic electrical bioimpedance. Crit Care Med 14:898-901, 1986","journal-title":"Crit Care Med"},{"key":"223556_CR19","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/00003246-198611000-00004","volume":"14","author":"PL Appel","year":"1996","unstructured":"Appel PL, Kram HB, Mackabee J, Fleming AW, Shoemaker WC: Comparison of measurements of cardiac output by bioimpedance and thermodilution in severely ill surgical patients. Crit Care Med 14:933-935, 1996","journal-title":"Crit Care Med"},{"key":"223556_CR20","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/S0168-8278(97)80110-9","volume":"26","author":"LH Ottesen","year":"1997","unstructured":"Ottesen LH, Flyvbjerg A, Jakobsen P, Bendtsen F: The pharmacokinetics of octreotide in cirrhosis and in healthy man. J Hepatol 26:1018-1025, 1997","journal-title":"J Hepatol"},{"key":"223556_CR21","first-page":"G274","volume":"262","author":"CC Sieber","year":"1992","unstructured":"Sieber CC, Mosca PG, Groszmann RJ: Effect of somatostatin on mesenteric vascular resistance in normal and portal hypertensive rats. Am J Physiol 262:G274-G277, 1992","journal-title":"Am J Physiol"},{"key":"223556_CR22","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0168-8278(05)80516-1","volume":"17","author":"PA McCormick","year":"1993","unstructured":"McCormick PA, Seifalian AM, Stansby G, McGann G, Collins P, Chin J, McIntyre N, Dick R, Burroughs AK: Superior mesenteric artery blood flow in man measured with intraarterial Doppler catheters: Effect of octreotide. J Hepatol 17:20-27, 1993","journal-title":"J Hepatol"},{"key":"223556_CR23","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1136\/gut.35.3_Suppl.S1","volume":"35","author":"AG Harris","year":"1994","unstructured":"Harris AG: Somatostatin and somatostatin analogues: Pharmacokinetics and pharmacodynamic effects. Gut 35:S1-S4, 1994","journal-title":"Gut"},{"key":"223556_CR24","first-page":"G251","volume":"265","author":"Y Li","year":"1993","unstructured":"Li Y, Owyang C: Somatostatin inhibits pancreatic enzyme secretion at a central vagal site. Am J Physiol 265:G251-G257, 1993","journal-title":"Am J Physiol"},{"key":"223556_CR25","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0168-8278(98)80287-0","volume":"28","author":"D Ludwig","year":"1998","unstructured":"Ludwig D, Schwarting K, Korbel CM, Br\u00fcning A, Schiefer B, Stange EF: The postprandial portal flow is related to the severity of portal hypertension and liver cirrhosis. J Hepatol 28:631-638, 1998","journal-title":"J Hepatol"},{"key":"223556_CR26","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.2165\/00003495-199200442-00003","volume":"44","author":"MP MacMathuna","year":"1992","unstructured":"MacMathuna MP: Mechanisms and consequences of portal hypertension. Drugs 44:S1-S13, 1992","journal-title":"Drugs"},{"key":"223556_CR27","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1148\/radiology.201.3.8939220","volume":"201","author":"T Iwao","year":"1996","unstructured":"Iwao T, Toyonaga A, Oho K, Sakai T, Tayama C, Masumoto H, Sato M, Nakahara K, Tanikawa K: Postprandial splanchnic hemodynamic response in patients with cirrhosis of the liver: Evaluation with \u201ctriple-vessel\u201d duplex US. Radiology 201:711-715, 1996","journal-title":"Radiology"},{"key":"223556_CR28","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/0016-5085(92)90191-Z","volume":"102","author":"F Bendtsen","year":"1992","unstructured":"Bendtsen F, Simonsen L, Henriksen JH: Effect on hemodynamics of a liquid meal alone and in combination with propranolol in cirrhosis. Gastroenterology 102:1017-1023, 1992","journal-title":"Gastroenterology"},{"key":"223556_CR29","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/hep.510280406","volume":"28","author":"P Taourel","year":"1998","unstructured":"Taourel P, Blanc P, Dauzat M, Chabre M, Pradel J, Gallix B, Larrey D, Bruel J-M: Doppler study of mesenteric, hepatic, and portal circulation in alcoholic cirrhosis. Relationship between quantitative Doppler measurements and the severity of portal hypertension and liver failure. Hepatology 28:932-936, 1998","journal-title":"Hepatology"},{"key":"223556_CR30","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/hrt.61.6.506","volume":"61","author":"H Kelbaek","year":"1989","unstructured":"Kelbaek H, Munck O, Christensen NJ, Godtfredsen J: Central haemodynamics after a meal. Br Heart J 61:506-509, 1989","journal-title":"Br Heart J"},{"key":"223556_CR31","first-page":"H220","volume":"238","author":"RH Gallavan","year":"1980","unstructured":"Gallavan RH, Chou CC, Kvietys P, Sit SP: Regional blood flow during ingestion in the conscious dog. Am J Physiol 238:H220-H225, 1980","journal-title":"Am J Physiol"},{"key":"223556_CR32","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1136\/gut.33.3.364","volume":"33","author":"S O'Brien","year":"1992","unstructured":"O'Brien S, Keogan M, Patchett S, McCormick PA, Afdhal N, Hegarty JE: Postprandial changes in portal haemodynamics in patients with cirrhosis. Gut 33:364-367, 1992","journal-title":"Gut"},{"key":"223556_CR33","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/hep.1840210507","volume":"21","author":"PA McCormick","year":"1995","unstructured":"McCormick PA, Chin J, Greenslade L, Karatapanis S, Dick R, McIntyre N, Burroughs AK: Cardiovascular effects of octreotide in patients with hepatic cirrhosis. Hepatology 21:1255-1260, 1995","journal-title":"Hepatology"},{"key":"223556_CR34","first-page":"G191","volume":"258","author":"MP Pizcueta","year":"1990","unstructured":"Pizcueta MP, Casamitjana R, Bosch J, Rodes J: Decreased systemic vascular sensitivity to norepinephrine in portal hypertensive rats: Role of hyperglucagonism. Am J Physiol 258:G191-G195, 1990","journal-title":"Am J Physiol"},{"key":"223556_CR35","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1136\/gut.32.4.361","volume":"32","author":"C Sieber","year":"1991","unstructured":"Sieber C, Beglinger C, Jaeger K, Hildebrand P, Stalder GA: Regulation of postprandial mesenteric blood flow in humans. Gut 32:361-366, 1991","journal-title":"Gut"},{"key":"223556_CR36","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1023\/A:1026698001921","volume":"43","author":"M Sabat","year":"1998","unstructured":"Sabat M, Guarner C, Soriano G, Bulbena O, Novella TN, Ortiz J, Ricart E, Villanueva C, Rosello J, Rodriguez J, Balanzo J: Effect of subcutaneous administration of octreotide on endogenous vasoactive systems and renal function in cirrhotic patients with ascites. Dig Dis Sci 43:2184-2189, 1998","journal-title":"Dig Dis Sci"},{"key":"223556_CR37","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1053\/gast.1996.v110.pm8566602","volume":"110","author":"M Pinzani","year":"1996","unstructured":"Pinzani, M, Milani S, de Franco R, Grappone C, Caligiuri A, Gentilini A, Tosti-Guerra C, Maggi M, Failli P, Ruocco C, Gentilini P: Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology 110:534-548, 1996","journal-title":"Gastroenterology"},{"key":"223556_CR38","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/hep.510280308","volume":"28","author":"P Sogni","year":"1998","unstructured":"Sogni P, Moreau R, Gomola A, Gadano A, Cailmail S, Calmus Y, Clozel M, Lebrec D: Beneficial hemodynamic effects of bosentan, a mixed ET(A) and ET(B) receptor antagonist, in portal hypertensive rats. Hepatology 28:655-659, 1998","journal-title":"Hepatology"},{"key":"223556_CR39","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/BF03349845","volume":"19","author":"J Donckier","year":"1996","unstructured":"Donckier J, Stoleru L, Selvais P, Galanti L, Van Mechelen H, Ketelslegers JM, Charlier AA: Effects of octreotide on cardiovascular hormones and haemodynamics in conscious dogs. J Endocrinol Invest 19:106-113, 1996","journal-title":"J Endocrinol Invest"},{"key":"223556_CR40","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0168-8278(95)80327-0","volume":"23","author":"S Moller","year":"1995","unstructured":"Moller S, Gulber V, Henriksen JH, Gerbes AL: Endothelin-1 an endothelin-3 in cirrhosis: relations to systemic and splanchnic haemodynamics. J Hepatol 23:135-144, 1995","journal-title":"J Hepatol"},{"key":"223556_CR41","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/hep.510270405","volume":"27","author":"C Mottet","year":"1998","unstructured":"Mottet C, Sieber CC, Nauer A, Drewe J, Fried R, Larsen F, Beglinger C: Hemodynamic effects of the somatostatin analog lanreotide in humans: Placebo-controlled, cross-over doseranging echo-Doppler study. Hepatology 27:920-925, 1998","journal-title":"Hepatology"},{"key":"223556_CR42","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1002\/hep.510230541","volume":"23","author":"CC Sieber","year":"1996","unstructured":"Sieber CC, Lee FY, Groszmann RJ: Long-term octreotide treatment prevents vascular hyporeactivity in portal-hypertensive rats. Hepatology 23:1218-1223, 1996","journal-title":"Hepatology"},{"key":"223556_CR43","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1002\/hep.510280612","volume":"28","author":"J Fort","year":"1998","unstructured":"Fort J, Oberti F, Pilette C, Veal N, Gallois Y, Douay O, Rousselet MC, Rosenbaum J, Cales P: Antifibrotic and hemodynamic effects of the early and chronic administration of octreotide in two models of liver fibrosis in rats. Hepatology 28:1525-1531, 1998","journal-title":"Hepatology"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005553914878.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1005553914878\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005553914878.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T03:06:10Z","timestamp":1752462370000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1005553914878"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["223556"],"URL":"https:\/\/doi.org\/10.1023\/a:1005553914878","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"type":"print","value":"0163-2116"},{"type":"electronic","value":"1573-2568"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}