{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T10:55:52Z","timestamp":1725620152302},"reference-count":10,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2000,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early signs of renal dysfunction in glycogen storage disease type Ia (GSD Ia) are glomerular hyperfiltration and proteinuria. In a non\u2010randomized study, the effect of captopril on the improvement of proteinuria in GSD Ia patients with microalbuminuria was investigated. A positive effect has been shown for the insulin\u2010dependent diabetes mellitus patients. Microalbuminuria was defined as albumin\/creatinine ratio (mg\/mmol) more than 2.5 in spot urine. Nineteen (52.7%) out of 36 patients had microalbuminuria, and 8 patients received captopril at a dose of 1mg\/kg per day. Microalbuminuria was evaluated periodically during the follow\u2010up period. Of the captopril\u2010treated patients, one was lost to follow\u2010up. In the remaining 7 patients, urinary albumin excretion normalized in 3 patients (42.9%) and decreased at least by 50% in another 3 patients (42.8%) after 6 months of treatment. One patient, who was the oldest, did not have any benefit. In untreated patients, only two patients had a decrease in microalbuminuria of more than 50%. Patients with microalbuminuria had significantly higher blood lactate (p&lt;0.05) and plasma triglyceride (p&lt;0.01) concentrations and significantly lower blood bicarbonate concentration (p&lt;0.05) than those patients without it. Additionally, the patients with microalbuminuria had been diagnosed earlier than those without microalbuminuria (p&lt;0.05). Patients with microalbuminuria have more severe clinical and laboratory findings than those without microalbuminuria. Captopril at a dose of 1 mg\/kg per day seems to be effective in at least 50% of GSD Ia patients with microalbuminuria.<\/jats:p>","DOI":"10.1023\/a:1005608113270","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T23:07:17Z","timestamp":1040512037000},"page":"459-463","source":"Crossref","is-referenced-by-count":10,"title":["Short\u2010term effect of captopril on microalbuminuria in children with glycogen storage disease type Ia"],"prefix":"10.1002","volume":"23","author":[{"given":"H.","family":"\u00d6zen","sequence":"first","affiliation":[{"name":"Division of Paediatric Gastroenterology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Ciliv","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Ko\u00e7ak","sequence":"additional","affiliation":[{"name":"Division of Paediatric Gastroenterology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130. N.","family":"Saltik","sequence":"additional","affiliation":[{"name":"Division of Paediatric Gastroenterology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Y\u00fcce","sequence":"additional","affiliation":[{"name":"Division of Paediatric Gastroenterology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"G\u00fcrakan","sequence":"additional","affiliation":[{"name":"Division of Paediatric Gastroenterology Hacettepe University School of Medicine  Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2000,7]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"388A","article-title":"Pilot study of captopril in patients with renal disease associated with glycogen storage disease, type I (GSD\u2010I)","volume":"23","author":"Baker L","year":"1988","journal-title":"Pediatr Res"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00852851"},{"key":"e_1_2_1_4_1","first-page":"935","volume-title":"The Metabolic and Molecular Basis of Inherited Disease","author":"Chen Y\u2010T","year":"1995"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198801073180102"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-03147-6_5"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00868717"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198512263132601"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.11.1357"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005346824368"},{"key":"e_1_2_1_11_1","first-page":"201","article-title":"Type I glycogenesis with renal tubular dysfunction (presentation of two cases)","volume":"35","author":"Y\u00fcce A","year":"1993","journal-title":"Turk J Pediatr"}],"container-title":["Journal of Inherited Metabolic Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1023%2FA%3A1005608113270","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1023\/A%3A1005608113270","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T20:23:04Z","timestamp":1694809384000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1023\/A%3A1005608113270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["10.1023\/A:1005608113270"],"URL":"https:\/\/doi.org\/10.1023\/a:1005608113270","archive":["Portico"],"relation":{},"ISSN":["0141-8955","1573-2665"],"issn-type":[{"value":"0141-8955","type":"print"},{"value":"1573-2665","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}