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We found higher orotidine excretion in normal infants than in older children given the test, whereas orotate excretion was similar in both groups. The increased orotidine excretion appears to be due to the use in the infants of higher allopurinol doses per kilogram of body weight than in the children. The normalized\u2010dose dependency of the orotidine response extends even to adult age. Thus, dose\u2010normalized responses should be used in the test and there is no need for careful age\u2010matching of the controls.<\/jats:p>","DOI":"10.1023\/a:1005610325170","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T23:07:17Z","timestamp":1040512037000},"page":"662-668","source":"Crossref","is-referenced-by-count":6,"title":["Influence of dose and age on the response of the allopurinol test for ornithine carbamoyltransferase deficiency in control infants"],"prefix":"10.1002","volume":"23","author":[{"given":"E.","family":"Riudor","sequence":"first","affiliation":[{"name":"Laboratori de Metabolopaties, Hospital Materno\u2010Infantil Vall d'Hebron Universitat Aut\u00f3noma  Barcelona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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