{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T17:05:56Z","timestamp":1697475956200},"reference-count":35,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Inher Metab Disea"],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hair analysis can be used as a screening tool in the diagnosis of genetic diseases. The scalp hair roots of 67 normal neonates and 39 neonates with glucose\u20106\u2010phosphate dehydrogenase (G6PD) deficiency were analysed using Fourier transform infrared (FT\u2010IR) microspectroscopy to differentiate the stages of the hair growth cycle and to diagnose the genetic disorder on the basis of spectral differences. We have demonstrated that FT\u2010IR microspectroscopy is a rapid and effective noninvasive diagnostic method to differentiate scalp hair roots of normal neonates into the anagen, catagen or telogen phases of the hair growth cycle, using IR spectral differences within the 3000\u20132800 cm<jats:sup>\u22121<\/jats:sup> region and the IR peak area ratio of 2854 cm<jats:sup>\u22121<\/jats:sup>\/2873 cm<jats:sup>\u22121<\/jats:sup> or 1084 cm<jats:sup>\u22121<\/jats:sup>\/amide II band (<jats:italic>p<\/jats:italic>&lt;0.001). Moreover, G6PD\u2010deficient neonates could be accurately diagnosed from telogen phase hair roots owing to significant differences in IR peak area ratios of 2854 cm<jats:sup>\u22121<\/jats:sup>\/2873 <jats:sup>\u22121<\/jats:sup> or 1084 cm<jats:sup>\u22121<\/jats:sup>\/amide II band compared to normal values in healthy neonates. The result suggests that the application of FT\u2010IR microspectroscopy may be capable not only of differentiating the hair growth cycle into anagen, categen or telogen phases but also of detecting G6PD deficiency. Hair root analysis promises to be a useful complement to serum and urine analysis in the diagnosis of genetic diseases.<\/jats:p>","DOI":"10.1023\/a:1005622728805","type":"journal-article","created":{"date-parts":[[2002,12,21]],"date-time":"2002-12-21T23:07:17Z","timestamp":1040512037000},"page":"693-704","source":"Crossref","is-referenced-by-count":6,"title":["Differentiation of hair growth cycle from scalp hair roots for the diagnosis of glucose\u20106\u2010phosphate dehydrogenase deficiency in neonates"],"prefix":"10.1002","volume":"23","author":[{"given":"S.\u2010Y.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Medical Research and Education Veterans General Hospital\u2010Taipei  Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.\u2010M.","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Veterans General Hospital\u2010Taipei  Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.\u2010J.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Research and Education Veterans General Hospital\u2010Taipei  Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010P.","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Medical Research and Education Veterans General Hospital\u2010Taipei  Taipei Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010L.","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Veterans General Hospital\u2010Taipei  Taipei Taiwan, Republic of 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