{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:34:32Z","timestamp":1775792072182,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis Sci"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1023\/a:1005625504535","type":"journal-article","created":{"date-parts":[[2002,12,28]],"date-time":"2002-12-28T16:20:03Z","timestamp":1041092403000},"page":"430-437","source":"Crossref","is-referenced-by-count":15,"title":["Prevention of Deleterious Effects of Reperfusion Injury Using One-Week High-Dose Allopurinol"],"prefix":"10.1007","volume":"46","author":[{"given":"Cem","family":"Terzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Ayhan","family":"Kuzu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Ke\u015f\u015faf","family":"A\u015flar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u0130. Taner","family":"Kale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adil","family":"Tanik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"K\u00f6ksoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"300313_CR1","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1097\/00003246-199309000-00023","volume":"21","author":"MH Schoenberg","year":"1993","unstructured":"Schoenberg MH, Beger HG: Reperfusion injury after intestinal ischemia. Crit Care Med 21:1376\u20131387, 1993","journal-title":"Crit Care Med"},{"key":"300313_CR2","first-page":"631","volume":"81","author":"PA Grace","year":"1994","unstructured":"Grace PA: Ischemia-reperfusion injury. Br J Surg 81: 631\u2013647, 1994","journal-title":"Br J Surg"},{"key":"300313_CR3","first-page":"337","volume":"41","author":"BJ Zimmerman","year":"1994","unstructured":"Zimmerman BJ, Granger DN: Oxygen free radicals and the gastrointestinal tract: Role in ischemia reperfusion injury. Hepato-Gastroenterol 41:337\u2013342, 1994","journal-title":"Hepato-Gastroenterol"},{"key":"300313_CR4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/00003246-199302001-00016","volume":"20","author":"HJ Schiller","year":"1993","unstructured":"Schiller HJ, Reilly PM, Bulkley GB: Antioxidant therapy. Crit Care Med 20:92\u2013102, 1993","journal-title":"Crit Care Med"},{"key":"300313_CR5","first-page":"420","volume":"44","author":"BR Lucchesi","year":"1994","unstructured":"Lucchesi BR: Complement, neutrophils and free radicals: Mediators of reperfusion injury. Drug Res 44:420\u2013431, 1994","journal-title":"Drug Res"},{"key":"300313_CR6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/089419300272249","volume":"13","author":"C K\u00f6ksoy","year":"2000","unstructured":"K\u00f6ksoy C, Kuzu MA, Kesenci M, Uyde\u015f-Do\u011fan BS, Aydemir-Koksoy A, Demirpence E: Effects of intestinal ischemia reperfusion injury on major conduit arteries. J Invest Surg 13:35\u201343, 2000","journal-title":"J Invest Surg"},{"key":"300313_CR7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00000658-200001000-00015","volume":"231","author":"C K\u00f6ksoy","year":"2000","unstructured":"K\u00f6ksoy C, Kuzu MA, Erg\u016dn H, Demirpence E, Z\u00fclfikaro\u011flu B. Intestinal ischemia-reperfusion impairs vasomotor functions of pulmonary vascular bed. Ann Surg 231:105\u2013111, 2000","journal-title":"Ann Surg"},{"key":"300313_CR8","doi-asserted-by":"crossref","first-page":"c1783","DOI":"10.1152\/ajpcell.1997.273.6.C1783","volume":"273","author":"T Qian","year":"1997","unstructured":"Qian T, Nieminen AL, Herman B, Lemasters JJ: Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes. Am J Physiol 273:c1783\u2013c1792, 1997","journal-title":"Am J Physiol"},{"key":"300313_CR9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1161\/01.RES.81.2.137","volume":"81","author":"WR MacLellan","year":"1997","unstructured":"MacLellan WR, Schneider MD: Death by Design. Programmed cell death in cardiovascular biology and disease. Circ Res 81:137\u2013144, 1997","journal-title":"Circ Res"},{"key":"300313_CR10","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0039-6060(99)70175-3","volume":"126","author":"WG Austen","year":"1999","unstructured":"Austen WG, Kyriakides C, Favuzza J, Wang Y, Kobzik L, Moore FD, Hechtman HB: Intestinal ischemia-reperfusion injury is mediated by the membrane attack complex. Surgery 126:343\u2013348, 1999","journal-title":"Surgery"},{"key":"300313_CR11","first-page":"323","volume":"30","author":"SM Megison","year":"1990","unstructured":"Megison SM, Horton JW, Chao H, Walker PB: High dose versus low dose enteral allopurinol for prophylaxis in mesenteric ischemia. Circ Shock 30:323\u2013329, 1990","journal-title":"Circ Shock"},{"key":"300313_CR12","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/0022-3468(90)90204-M","volume":"25","author":"SM Megison","year":"1990","unstructured":"Megison SM, Horton JW, Chao H, Walker PB: Prolonged survival and decreased mucosal injury after low dose enteral allopurinol prophylaxis in mesenteric ischemia. J Pediatr Surg 25:917\u2013921, 1990","journal-title":"J Pediatr Surg"},{"key":"300313_CR13","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/0022-4804(90)90206-H","volume":"48","author":"JG Garcia","year":"1990","unstructured":"Garcia JG, Rollan CM, Enrinquez R, Madruga MH, Hermandez EM, Nunez JFM, Alonso AG: Improved survival in intestinal ischemia by allopurinol not related to xanthine-oxidase inhibition. J Surg Res 48:144\u2013146, 1990","journal-title":"J Surg Res"},{"key":"300313_CR14","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/0022-3468(92)90542-F","volume":"27","author":"GW Vaughan","year":"1992","unstructured":"Vaughan GW, Horton JW, Walker PB: Allopurinol prevents intestinal permeability changes after ischemia-reperfusion injury. J Pediatr Surg 27:968\u2013973, 1992","journal-title":"J Pediatr Surg"},{"key":"300313_CR15","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/00007890-199108000-00009","volume":"52","author":"W Karwinshi","year":"1991","unstructured":"Karwinshi W, Fastad M, Ulvik R, Soreide O: Sixty-minute normothermic liver ischemia in rats. Transplantation 52: 231\u2013234, 1991","journal-title":"Transplantation"},{"key":"300313_CR16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000129146","volume":"23","author":"M Boros","year":"1991","unstructured":"Boros M, Bako L, Nagy S: Effect of antioxidant therapy on cyclooxygenase-derived eicosanoid release during intestinal ischemia-reperfusion. Eur Surg Res 23:141\u2013150, 1991","journal-title":"Eur Surg Res"},{"key":"300313_CR17","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1097\/00006534-199206000-00016","volume":"89","author":"LA Picard Ami Jr","year":"1992","unstructured":"Picard Ami LA Jr, MacKay ABA, Kerrigan CL: Effects of allopurinol on survival of experimental pig flaps. Plast Reconstr Surg 89:1098\u20131104, 1992","journal-title":"Plast Reconstr Surg"},{"key":"300313_CR18","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/00000637-198706000-00005","volume":"18","author":"MF Angel","year":"1987","unstructured":"Angel MF, Ramasastry SS, Swartz WM, Narayanan K, Basford RE, Futrell JW: Augmentation of skin flap survival with allopurinol. Ann Plast Surg 18:494\u2013498, 1987","journal-title":"Ann Plast Surg"},{"key":"300313_CR19","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/00006534-198402000-00023","volume":"73","author":"MJ Im","year":"1984","unstructured":"Im MJ, Shen WH, Pak CJ: Effect of allopurinol on survival of hyperemic island skin flaps. Plast Reconstr Surg 73:276\u2013278, 1984","journal-title":"Plast Reconstr Surg"},{"key":"300313_CR20","first-page":"G301","volume":"263","author":"FW Leung","year":"1992","unstructured":"Leung FW, Su KC, Passaro E, Guth PH: Regional differences in gut blood flow and mucosal damage in response to ischemia and reperfusion. Am J Physiol 263:G301\u2013G335, 1992","journal-title":"Am J Physiol"},{"key":"300313_CR21","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0022-5223(94)70038-9","volume":"107","author":"KA Qayumi","year":"1994","unstructured":"Qayumi KA, Janusz MT, Dorovoni-Zis K, Lyster DM, Jamieson EWR, Poostizadeh A, Feeley EJE, Sangari-Nikbakth M: Additive effect of allopurinol and injury caused by aortic cross clamping. J Thorac Cardiovac Surg 107:1203\u20131209, 1994","journal-title":"J Thorac Cardiovac Surg"},{"key":"300313_CR22","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00000658-198607000-00005","volume":"204","author":"LG Svensson","year":"1986","unstructured":"Svensson LG, Von Ritter CM, Groeneveld HT, Rickards ES, Hunter SJ, Robinson MF, Hinder RA: Cross-clamping of the thoracic aorta: Influence of aortic shunts, laminectomy, papaverine, calcium channel blocker, allopurinol and superoxide dismutase on spinal cord blood flow and apraplegia in boboon Ann Surg 204:38\u201347, 1986","journal-title":"Ann Surg"},{"key":"300313_CR23","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3109\/08941939009140359","volume":"3","author":"AK Qayumi","year":"1990","unstructured":"Qayumi AK, Jamieson WRE, Godin DV, Lam S, Ko KM, Germann E, Van der Broek J: Response to allopurinol pretreatment in a swine model of heart-lung transplantation. J Invest Surg 3:331\u2013340, 1990","journal-title":"J Invest Surg"},{"key":"300313_CR24","first-page":"2640","volume":"28","author":"P Argibay","year":"1996","unstructured":"Argibay P, Mazza O, Bonadeo G, Cristiansen S, Hyon S: Administration of oral allopurinol as a means of preventing ischemia and reperfusion damage to the intestine. Transplant Proc 28:2640\u20132641, 1996","journal-title":"Transplant Proc"},{"key":"300313_CR25","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0002-9610(98)00198-6","volume":"176","author":"MA Kuzu","year":"1998","unstructured":"Kuzu MA, K\u00f6ksoy C, Kale IT, Tanik A, Terzi C, Elhan A: Reperfusion injury delays healing of intestinal anostomosis in a rat. Am J Surg 176:348\u2013351, 1998","journal-title":"Am J Surg"},{"key":"300313_CR26","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s002680010170","volume":"24","author":"MA Kuzu","year":"2000","unstructured":"Kuzu MA, Tanik A, Kale IT, A\u015flar AK, K\u00f6ksoy C, Terzi C: Ischemia reperfusion as a systemic phenomenon impairs the anastomotic healing in left colon. World J Surg 24:990\u2013994, 2000","journal-title":"World J Surg"},{"key":"300313_CR27","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1440-1681.1996.tb02600.x","volume":"23","author":"S Arisawa","year":"1996","unstructured":"Arisawa S, Arisawa T, Ohashi M, Nitta Y, Ikeya T, Asai J: Effect of the hydroxyl radical on fibroblast mediated collagen remodeling in vitro. Clin Exp Pharmacol Physiol 23:222\u2013228, 1996","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"300313_CR28","first-page":"250","volume":"52","author":"JJ Knightly","year":"1962","unstructured":"Knightly JJ, Agostino D, Cliffton EE: The effect of fibrinolysin and heparin on the formation of peritoneal adhesions. Surgery 52:250\u2013258, 1962","journal-title":"Surgery"},{"key":"300313_CR29","first-page":"465","volume":"73","author":"DBW De Roy van Zuidewijn","year":"1992","unstructured":"De Roy van Zuidewijn DBW, Schillings PHM, Wobbes T, de Boer HHM: Histological evaluation of wound healing in experimental intestinal anastomoses: Effects of antineoplastic agents. Int J Exp Pathol 73:465\u2013484, 1992","journal-title":"Int J Exp Pathol"},{"key":"300313_CR30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000171483","volume":"13","author":"JS Levine","year":"1995","unstructured":"Levine JS, Jacobson ED: Intestinal ischemic disorders. Dig Dis 13:3\u201324, 1995","journal-title":"Dig Dis"},{"key":"300313_CR31","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1023\/A:1026633510390","volume":"44","author":"I Takeyoshi","year":"1999","unstructured":"Takeyoshi I, Iwanami K, Ohwada S, Kawashima Y, Kawati K, Aiba M, Kobayashi J, Koyoma T, Matsumoto K, Satoh S, Morishita Y. Effect of FRI67653 on small bowel ischemiareperfusion injury on dogs. Dig Dis Sci 44:2334\u20132343, 1999","journal-title":"Dig Dis Sci"},{"key":"300313_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/jsre.1998.5510","volume":"82","author":"IJ Miner","year":"1999","unstructured":"Miner IJ, Motamen-Tavaf H, Stojadinovic A and Donohwe-Shea T: Ischemia-reperfusion protects the rat small intestine against subsequent injury. J Surg Res 82:1\u201310, 1999","journal-title":"J Surg Res"},{"key":"300313_CR33","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0022-4804(90)90257-3","volume":"49","author":"SM Megison","year":"1990","unstructured":"Megison SM, Horton JW, Chao H, Walker PB: A new model for intestinal ischemia in the rat. J Surg Res 49:168\u2013174, 1990","journal-title":"J Surg Res"},{"key":"300313_CR34","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1152\/jappl.1997.83.2.530","volume":"83","author":"P Rothenbach","year":"1997","unstructured":"Rothenbach P, Turnage RH, Iglesias J, Riva A, Bartula L, Myers S: Downstream effects of splanchnic ischemiareperfusion injury on renal function and eicosanoid release. J Appl Physiol 83:530\u2013536, 1997","journal-title":"J Appl Physiol"},{"key":"300313_CR35","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0006-291X(87)91112-0","volume":"148","author":"DK Das","year":"1987","unstructured":"Das DK, Engelman RM, Clement R, Otani H, Prasad MR, Rao PS: Role of xanthine oxidase inhibitor as free radical scavenger: A novel mechanism of action of allopurinol and oxypurinol in myocardial salvage. Biochem Biophys Res Commun 148:314\u2013319, 1987","journal-title":"Biochem Biophys Res Commun"},{"key":"300313_CR36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0014-5793(87)81458-8","volume":"213","author":"PC Moorhouse","year":"1987","unstructured":"Moorhouse PC, Grotveld M, Halliwell B, Quinlan JG, Gutteridge JM: Allopurinol and oxypurinol are hydroxyl radical scavengers. FEBS Lett 213:23\u201328, 1987","journal-title":"FEBS Lett"},{"key":"300313_CR37","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/978-1-4757-1433-3_41","volume-title":"Purine Metabolism in Man","author":"JS Cameron","year":"1974","unstructured":"Cameron JS, Simmonds HA, Hatfield PJ, Jones AS, Caderhead A: The big as an animal model for purine metabolic studies. In Purine Metabolism in Man. P Sperling, A de Vries, JB Wyngaarden (eds). New York, Plenum Press, 1974, p 691"}],"container-title":["Digestive Diseases and Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005625504535.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1023\/A:1005625504535\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1023\/A:1005625504535.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,14]],"date-time":"2025-07-14T02:59:55Z","timestamp":1752461995000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1023\/A:1005625504535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["300313"],"URL":"https:\/\/doi.org\/10.1023\/a:1005625504535","relation":{},"ISSN":["0163-2116","1573-2568"],"issn-type":[{"value":"0163-2116","type":"print"},{"value":"1573-2568","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}